MEK
MEK es una quinasa de doble especificidad que juega un papel central en la vía de señalización MAPK/ERK al activar ERK mediante fosforilación. La señalización de MEK es crucial para regular el crecimiento, la supervivencia y la diferenciación celular. La actividad aberrante de MEK se ha implicado en diversos cánceres y trastornos del desarrollo, lo que la convierte en un objetivo terapéutico importante. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de MEK para apoyar su investigación en oncología, señalización celular y desarrollo terapéutico.
Se han encontrado 75 productos de "MEK"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Trametinib
CAS:Trametinib (GSK1120212), an ATP-noncompetitive MEK 1/2 inhibitor (IC50: 0.7/0.9 nM), weakly inhibits >180 kinases.Fórmula:C26H23FIN5O4Pureza:98% - 99.96%Forma y color:SolidPeso molecular:615.39zapnometinib
CAS:Zapnometinib (ATR-002) is a MEK inhibitor.Fórmula:C13H7ClF2INO2Pureza:99.67%Forma y color:SolidPeso molecular:409.55Ro 5126766
CAS:RO5126766 (CH5126766) is a dual RAF/MEK inhibitor with IC50 of 8.2 nM, 19 nM, 56 nM, and 160 nM for BRAF V600E, BRAF, CRAF, and MEK1, respectively. Phase 1.Fórmula:C21H18FN5O5SPureza:98.3% - 98.81%Forma y color:SolidPeso molecular:471.46anemarsaponin B
CAS:<p>Anemarsaponin B has anti-inflammatory effect in LPS-treated RAW 264.7macrophages, the effect is associated with the inhibition of NF-κB transcriptional activity</p>Fórmula:C45H74O18Pureza:99.06% - 99.81%Forma y color:SolidPeso molecular:903.06BIX02189
CAS:BIX 02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM).Fórmula:C27H28N4O2Pureza:97.84%Forma y color:SolidPeso molecular:440.54PD98059
CAS:PD98059 is an MEK inhibitor that inhibits MEK1 and MEK2 (IC50=2/50 μM) and is non-ATP-competitive.Fórmula:C16H13NO3Pureza:98.63% - >99.99%Forma y color:Yellow SolidPeso molecular:267.28Pimasertib
CAS:<p>Pimasertib (AS703026) is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.</p>Fórmula:C15H15FIN3O3Pureza:98.25% - 99.57%Forma y color:SolidPeso molecular:431.2Refametinib
CAS:Refametinib (RDEA119) (RDEA119, Bay 86-9766) is an effective, ATP non-competitive and specific inhibitor of MEK1/2 (IC50: 19/47 nM).Fórmula:C19H20F3IN2O5SPureza:99.85% - >99.99%Forma y color:SolidPeso molecular:572.34RGB-286638 free base
CAS:RGB-286638 free base inhibits CDKs (1-5 nM), weaker on CDK7/6.Fórmula:C29H35N7O4Pureza:98% - 99.91%Forma y color:SolidPeso molecular:545.63Selumetinib
CAS:Selumetinib (AZD6244) is a selectivity and non-ATP-competitive MEK1/2 inhibitor. Selumetinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H15BrClFN4O3Pureza:98.1% - 99.90%Forma y color:White Or Pale White SolidPeso molecular:457.68TAK-733
CAS:TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.Fórmula:C17H15F2IN4O4Pureza:98.31% - 99.53%Forma y color:SolidPeso molecular:504.23APS-2-79
CAS:APS-2-79: KSR-dependent MEK inhibitor, blocks ATP biotin at KSR2, IC50 of 120 nM, disrupts Ras-MAPK signaling.Fórmula:C23H21N3O3Forma y color:SolidPeso molecular:387.43Trametinib (DMSO solvate)
CAS:<p>Trametinib (DMSO solvate) (GSK-1120212 (DMSO solvate)) is a Highly Potent and Selective MEK Inhibitor that specifically inhibits MEK1/2(IC50 :2 nM)</p>Fórmula:C28H29FIN5O5SPureza:98.82% - 99.92%Forma y color:SolidPeso molecular:693.53Binimetinib
CAS:Binimetinib (ARRY-162) is a MEK1/2 inhibitor (IC50=12 nM) with selective and oral activity. Binimetinib has antitumor activity. Cost-effective and quality-assured.Fórmula:C17H15BrF2N4O3Pureza:98.03% - >99.99%Forma y color:SolidPeso molecular:441.23GW 284543 hydrochloride
CAS:GW 284543 hydrochloride is a selective inhibitor of MEK5 .Fórmula:C23H21ClN2O3Pureza:99.73%Forma y color:SolidPeso molecular:408.87Mirdametinib
CAS:<p>Mirdametinib (PD325901) is an MEK inhibitor (IC50=0.33 nM) with selective, non-ATP-competitive, and oral activity.</p>Fórmula:C16H14F3IN2O4Pureza:99.11% - 99.63%Forma y color:White PowderPeso molecular:482.19GDC-0623
CAS:GDC-0623 (RG 7421) is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.Fórmula:C16H14FIN4O3Pureza:98.95% - 99.02%Forma y color:SolidPeso molecular:456.21AZD8330
CAS:AZD8330 (ARRY-704) is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.Fórmula:C16H17FIN3O4Pureza:98.72%Forma y color:SolidPeso molecular:461.23Aurothiomalate sodium
CAS:<p>Sodium aurothiomalate (Miochrysin) inhibits PKC-ι, TrxR; used as an anti-rheumatic and has anti-tumor properties.</p>Fórmula:C4H3AuNa2O4SPureza:99.66%Forma y color:SoildPeso molecular:390.07Pimasertib HCl
CAS:Pimasertib HCl, an oral MEK1/2 inhibitor, may thwart tumor growth by blocking RAS/RAF/MEK/ERK signaling.Fórmula:C15H16ClFIN3O3Forma y color:SolidPeso molecular:467.66
