MEK
MEK es una quinasa de doble especificidad que juega un papel central en la vía de señalización MAPK/ERK al activar ERK mediante fosforilación. La señalización de MEK es crucial para regular el crecimiento, la supervivencia y la diferenciación celular. La actividad aberrante de MEK se ha implicado en diversos cánceres y trastornos del desarrollo, lo que la convierte en un objetivo terapéutico importante. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de MEK para apoyar su investigación en oncología, señalización celular y desarrollo terapéutico.
Se han encontrado 75 productos de "MEK"
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SL327
CAS:SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier.Fórmula:C16H12F3N3SPureza:97.98% - >99.99%Forma y color:SolidPeso molecular:335.35PD184161
CAS:PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1].Fórmula:C17H13BrClF2IN2O2Pureza:99.40%Forma y color:SolidPeso molecular:557.56BI-847325
CAS:BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively.Fórmula:C29H28N4O2Pureza:97.13% - 97.54%Forma y color:SolidPeso molecular:464.56U0126-EtOH
CAS:U0126-etoh (U0126 Ethanol) is a non-ATP competitive inhibitor of MEK1 (IC50=72 nM) and MEK2 (IC50=58 nM) with selectivity, inhibit autophagy. Low-Cost!Fórmula:C18H16N6S2·C2H6OPureza:99.72% - 99.88%Forma y color:SolidPeso molecular:426.6trans-Zeatin
CAS:trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrientFórmula:C10H13N5OPureza:97.13% - 98.96%Forma y color:White To Light Yellow Crystal PowderPeso molecular:219.24Cobimetinib
CAS:Cobimetinib (GDC-0973) is a MEK1 inhibitor with selective and oral activity. Cobimetinib exhibits antitumor activity. Cost-effective and quality-assured.Fórmula:C21H21F3IN3O2Pureza:98% - 99.61%Forma y color:SolidPeso molecular:531.31U0126
CAS:U0126, an effective and selective non-competitive inhibitor of MAP kinase, inhibits MEK-1 and MEK-2 with IC50 values of 0.07 and 0.06 μM respectively.Fórmula:C18H16N6S2Pureza:99.61%Forma y color:White SolidPeso molecular:380.49APS-2-79 hydrochloride
CAS:APS-2-79 hydrochloride (APS-2-79 HCl) is a MAPK antagonist that modulating KSR-dependent MAPK signalling by antagonizing RAF heterodimerization.Fórmula:C23H21N3O3·HClPureza:98.64% - 99.55%Forma y color:SolidPeso molecular:423.89Isorhamnetin
CAS:<p>Isorhamnetin (3-methylquercetin) is the methylated metabolite of quercetin.</p>Fórmula:C16H12O7Pureza:99.20% - >99.99%Forma y color:SolidPeso molecular:316.26PD318088
CAS:<p>PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-</p>Fórmula:C16H13BrF3IN2O4Pureza:99.81%Forma y color:SolidPeso molecular:561.09CI-1040
CAS:CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM).Fórmula:C17H14ClF2IN2O2Pureza:99.64%Forma y color:Off-White To Pale Beige SolidPeso molecular:478.66RO4987655
CAS:RO4987655 (RG7167) is an orally active and highly selective MEK inhibitor (IC50: 5.2 nM for MEK1/MEK2).Fórmula:C20H19F3IN3O5Pureza:98.21%Forma y color:SolidPeso molecular:565.28GW284543
CAS:GW284543 (UNC10225170) is a selective inhibitor of MEK5 .Fórmula:C23H20N2O3Pureza:99.75%Forma y color:SolidPeso molecular:372.42Trametiglue
CAS:Trametiglue, a potent Trametinib derivative, selectively targets KSR-MEK and RAF-MEK through unique binding.Fórmula:C25H24FIN6O5SForma y color:SolidPeso molecular:666.46JTP-70902
CAS:<p>JTP-70902 is a protein kinase inhibitor with antineoplastic activity.</p>Fórmula:C24H21BrFN5O5SForma y color:SolidPeso molecular:590.42(R)-PD 0325901CL
CAS:<p>(R)-PD 0325901CL, a PD 0325901CL isomer, is a MEK inhibitor used in cancer research, effective against cancer cells in vitro and in vivo.</p>Fórmula:C16H14ClF2IN2O4Forma y color:SolidPeso molecular:498.65MEK-IN-1
CAS:MEK-IN-1 is a MEK inhibitor.Fórmula:C24H20N4O4Pureza:98%Forma y color:SolidPeso molecular:428.44MEK inhibitor
CAS:MEK inhibitor is a MEK receptor and cell cycle protein/CDK complex inhibitor with antitumor activity that can be used to study tumor cell proliferation.Fórmula:C26H26N4O2Pureza:97.48%Forma y color:SolidPeso molecular:426.51MEK-IN-4
CAS:<p>MEK-IN-4 is a MEK inhibitor that can be used to study inflammatory diseases and cancer.</p>Fórmula:C21H18N4OSPureza:98.35% - 99.16%Forma y color:SolidPeso molecular:374.46
