MEK
MEK es una quinasa de doble especificidad que juega un papel central en la vía de señalización MAPK/ERK al activar ERK mediante fosforilación. La señalización de MEK es crucial para regular el crecimiento, la supervivencia y la diferenciación celular. La actividad aberrante de MEK se ha implicado en diversos cánceres y trastornos del desarrollo, lo que la convierte en un objetivo terapéutico importante. En CymitQuimica, ofrecemos una variedad de inhibidores y moduladores de MEK para apoyar su investigación en oncología, señalización celular y desarrollo terapéutico.
Se han encontrado 75 productos de "MEK"
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(2Z,3Z)-U0126
CAS:U0126 selectively inhibits MEK1/2, blocks MAPK/ERK signaling, and suppresses Ki-ras-induced cell growth, with IC50s of 72 nM and 58 nM for MEK1/2.Fórmula:C18H16N6S2Forma y color:SolidPeso molecular:380.49Avutometinib potassium
CAS:Avutometinib potassium, a MEKi, blocks Delta and Omicron infection in airway cells, potentially lessening disease severity.Fórmula:C21H17FKN5O5SForma y color:SolidPeso molecular:509.55BAY-846
CAS:BAY-846: allosteric MEK inhibitor, long-lasting, highly bioavailable, low brain entry, effective in K-Ras A549 model.Fórmula:C19H13F4IN4O4SForma y color:SolidPeso molecular:596.29MS934
CAS:<p>MS934, a novel VHL-recruiting MEK 1/2 degrader, exhibits potent anti-proliferative effects on HT-29 cell growth, achieving a GI50 of 0.023 μM.</p>Fórmula:C52H69F3IN7O6SPureza:98%Forma y color:SolidPeso molecular:1104.11RO4927350
CAS:RO4927350 is a potent, selective MEK1/2 inhibitor, blocking MAPK pathway in vitro/vivo and showing notable antitumor effects.Fórmula:C27H28N4O6SForma y color:SolidPeso molecular:536.6MEK-IN-6 hydrate
CAS:MEK-IN-6 hydrate (compound 69), a MEK inhibitor, exhibits an IC50 value of 2 nM in A375 cells [1].Fórmula:C18H22FN3O5SPureza:98%Forma y color:SolidPeso molecular:411.45GSK1790627
CAS:GSK1790627, the N-deacetylated metabolite of Trametinib, represents an orally active MEK inhibitor that promotes autophagy and triggers apoptosis [1].Fórmula:C24H21FIN5O3Forma y color:SolidPeso molecular:573.36Cobimetinib racemate
CAS:Cobimetinib racemate (Cobimetinib (racemate)) (GDC-0973 racemate) is a selective inhibitor of MEK.Cobimetinib racemate is also known as a mitogen-activatedFórmula:C21H21F3IN3O2Pureza:98.00% - 99.71%Forma y color:SolidPeso molecular:531.31Nedometinib
CAS:<p>Nedometinib (NFX-179) is a MEK1 inhibitor with anticancer and antitumor activities, which can be used to study malignant tumors.</p>Fórmula:C17H16FIN4O3Pureza:99.18%Forma y color:SolidPeso molecular:470.24MEK1/2-IN-2
MEK1/2-IN-2 is a potent, ATP-competitive MEK1/2 inhibitor that exhibits equal inhibitory effects on wild-type MEK1/2 and a group of MEK1/2 mutant cells.Fórmula:C28H22ClFN6OForma y color:SolidPeso molecular:512.97EBI-1051
CAS:EBI-1051 is a highly potent and orally efficacious inhibitor of MEK (IC50: 3.9 nM).Fórmula:C18H15F2IN2O5Pureza:98%Forma y color:SolidPeso molecular:504.22Luvometinib
CAS:Luvometinib is an inhibitor of the mitogen-activated protein kinase (MEK) with antitumor activity.Fórmula:C26H22F2IN5O4SForma y color:SolidPeso molecular:665.45MEK4 inhibitor-2
CAS:MEK4 Inhibitor-2, a novel MEK4 inhibitor, demonstrates efficacy against pancreatic adenocarcinoma, exhibiting an IC50 value of 83 nM.Fórmula:C20H15FN4O3SForma y color:SolidPeso molecular:410.42Refametinib R enantiomer
CAS:<p>Refametinib R enantiomer (RDEA119 R enantiomer) is an MEK inhibitor with an EC50 of 2.0-15 nM.Refametinib (R enantiomer) has anticancer activity and can be used</p>Fórmula:C19H20F3IN2O5SPureza:99.86%Forma y color:SolidPeso molecular:572.34G-479
CAS:<p>G-479, a potent MEK inhibitor and improved analogue of GDC-0623, has distributed polarity enhancing bioactivity.</p>Fórmula:C16H15FIN5O4Forma y color:SolidPeso molecular:487.22
