ERK
ERK es una proteína clave en la vía de señalización MAPK (Mitogen-Activated Protein Kinase), que está involucrada en la transmisión de señales desde los receptores de la superficie celular hasta el ADN en el núcleo celular. ERK juega un papel crucial en la regulación de varios procesos celulares, incluyendo la proliferación, diferenciación y supervivencia. La desregulación de la señalización ERK está asociada con el desarrollo de cáncer y otras enfermedades, lo que la convierte en un objetivo importante para la intervención terapéutica. En CymitQuimica, ofrecemos una selección de inhibidores y moduladores de ERK de alta calidad para apoyar su investigación en señalización celular, oncología y desarrollo terapéutico.
Se han encontrado 205 productos de "ERK"
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Firazorexton
CAS:Firazorexton is a potent orexin type 2 receptor (OX2R) agonist.Fórmula:C22H25F3N2O4SForma y color:SolidPeso molecular:470.51PROTAC MEK1 Degrader-1
CAS:PROTAC MEK1 Degrader-1, a targeted protein degradation agent, combines a MEK1 inhibitor with a von Hippel-Lindau ligand to effectively inhibit ERK1/2Fórmula:C53H66FIN8O11S2Pureza:98%Forma y color:SolidPeso molecular:1201.17BTX6654
BTX-6654 is a cereblon-based bifunctional SOS1 PROTAC degrader. This compound exhibits antiproliferative activity against cells with various KRAS mutations by reducing the expression of downstream signaling markers pERK and pS6.Fórmula:C50H57F4N9O5Forma y color:SolidPeso molecular:940.04PROTAC HPK1 Degrader-5
PROTACHPK1 Degrader-5 is a potent, orally active HPK1 PROTAC degrader with a DC50 of 5.0 nM and a Dmax of at least 99%. It significantly inhibits HPK1 by degrading it, reducing SLP76 phosphorylation, and enhancing ERK pathway activation, which in turn stimulates the release of IL-2 and IFN-γ. This compound effectively counteracts immune suppression induced by PGE2, NECA, or TGF-β. Alone, PROTACHPK1 Degrader-5 is capable of suppressing tumor growth in MC38 syngeneic mouse models. It is used in research for immunotherapy applications in cancers such as colorectal cancer.Forma y color:Odour SolidROCK-IN-5
CAS:ROCK-IN-5 (I-B-37) inhibits kinases like ROCK/ERK/GSK; may aid in cardiac and neuro disease studies.Fórmula:C16H11ClFN3OSPureza:99.72% - 99.86%Forma y color:SolidPeso molecular:347.79Olomoucine
CAS:Olomoucine hinders Cdk2, Cdc2, CDK5, ERK1, regulates the cell cycle, and fights melanoma; IC50s: 3-25 µM.
Fórmula:C15H18N6OPureza:99.77%Forma y color:White Crystalline PowderPeso molecular:298.34PD 198306
CAS:PD 198306: a MEK inhibitor with antihyperalgesic properties, reduces Streptozocin-boosted active ERK1.Fórmula:C18H16F3IN2O2Pureza:99.66%Forma y color:SolidPeso molecular:476.23Ref: TM-T21980
1mg64,00€5mg138,00€10mg188,00€25mg330,00€50mg472,00€100mg655,00€500mg1.293,00€1mL*10mM (DMSO)160,00€Fulipiftide
CAS:Fulipiftide is a short peptide derived from pigment epithelium-derived factor (PEDF). It stimulates the amplification of nuclear stem cell factor+TSPC by activating the ERK2 and STAT3 signaling pathways. Fulipiftide also exhibits anti-inflammatory properties and is applicable in research on acute tendon injuries.
Fórmula:C144H227N41O47Forma y color:SolidPeso molecular:3284.59Anti-inflammatory agent 31
Andrographolide derivative 31 is an anti-inflammatory that blocks NF-κB, PI3K/Akt, and ERK1/2 MAPK, and restores GSH levels to protect the liver.Fórmula:C19H30O3Forma y color:SolidPeso molecular:306.44Kinase Inhibitor Library
A unique collection of 2720 kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidRef: TM-L1600
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarPPM-3
PPM-3, a selective PROTAC ERK5 degrader, exhibits a potent inhibitory concentration (IC 50) of 62.4 nM.
Fórmula:C54H69N11O6SPureza:98%Forma y color:SolidPeso molecular:1000.26ERK1/2 inhibitor 3
CAS:ERK1/2 inhibitor 3, a strong ERK1/2 blocker, may aid in cancer and inflammation research.Fórmula:C28H31ClFN5O6SForma y color:SolidPeso molecular:620.09ERα degrader-2
CAS:ERα degrader-2 is an estrogen receptor (SERD) degrader with anticancer activity that inhibits ERα for the prevention and treatment of HER-positive breast cancFórmula:C29H27F3N2O2Pureza:99.71%Forma y color:SolidPeso molecular:492.53TRPM4 inhibitor 8
CAS:TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion.Fórmula:C11H17BrN2Pureza:99.84%Forma y color:SolidPeso molecular:257.17Ref: TM-T9776
5mg44,00€10mg62,00€25mg90,00€50mg170,00€100mg268,00€200mg403,00€500mg660,00€1mL*10mM (DMSO)48,00€PERK-IN-2
CAS:PERK-IN-2 is a potent inhibitor of PERK(IC50 of 0.2 nM).Fórmula:C23H18F3N5OPureza:98%Forma y color:SolidPeso molecular:437.42GPR34 receptor antagonist 3
Compound 5e, a GPR34 receptor antagonist, exhibits selective inhibition of lysophosphatidylserine-induced ERK1/2 phosphorylation in a dose-dependent manner,Forma y color:Odour SolidSBI-810 hydrochloride
CAS:SBI-810 hydrochloride is a β-arrestin-2 (βarr2)-biased allosteric modulator of NTSR1 (neurotensin receptor 1), exerting analgesic effects.Fórmula:C27H35ClN4O2Pureza:99.42%Forma y color:SolidPeso molecular:483.05Pamoic acid disodium
CAS:Pamoic acid disodium is a GPR35 agonist.Fórmula:C23H16NaO6Pureza:99.73%Forma y color:Yellow PowderPeso molecular:411.36EM127
CAS:EM127: covalent SMYD3 inhibitor, KD 13μM, impedes ERK1/2, hinders SMYD3 gene regulation, long-term methyltransferase reduction, potential in cancer study.Fórmula:C14H18ClN3O3Pureza:97.55%Forma y color:SolidPeso molecular:311.76EphB2 Protein, Human, Recombinant (His)
EphB2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag.Forma y color:Lyophilized PowderPeso molecular:59.2 kDa (predicted); 65-75 kDa (reducing condition, due to glycosylation)
