CFTR
El CFTR es una proteína de canal de cloruro que regula el transporte de iones cloruro y bicarbonato a través de las membranas de las células epiteliales, desempeñando un papel crucial en el mantenimiento del equilibrio de fluidos en los tejidos. Las mutaciones en el gen CFTR conducen a la fibrosis quística, un trastorno genético caracterizado por la producción de moco espeso que puede obstruir las vías respiratorias y provocar graves problemas respiratorios y digestivos. En CymitQuimica, ofrecemos una selección de moduladores de CFTR para apoyar su investigación en fibrosis quística, transporte de iones y trastornos genéticos.
Se han encontrado 64 productos de "CFTR"
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Elexacaftor
CAS:<p>Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.</p>Fórmula:C26H34F3N7O4SPureza:98.87% - 99.87%Forma y color:SolidPeso molecular:597.65Glibenclamide
CAS:<p>Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.</p>Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Forma y color:SolidPeso molecular:494.00Vanzacaftor
CAS:<p>Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.</p>Fórmula:C32H39N7O4SPureza:99.14%Forma y color:SolidPeso molecular:617.76Astressin 2B
CAS:<p>CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.</p>Fórmula:C183H307N49O53Pureza:98%Forma y color:SolidPeso molecular:4041.69CFTR activator 2
CAS:<p>CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).</p>Fórmula:C27H27N3O3Pureza:99.70%Forma y color:SolidPeso molecular:441.52(Rac)-Tezacaftor
CAS:<p>(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.</p>Fórmula:C26H27F3N2O6Forma y color:SolidPeso molecular:520.5Crofelemer
CAS:<p>Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.</p>Forma y color:SolidCP-628006
CAS:<p>CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.</p>Fórmula:C32H35F3N2O2Forma y color:SolidPeso molecular:536.639H2-Gamendazole
CAS:<p>H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.</p>Fórmula:C18H13Cl2F3N2O2Pureza:97.36%Forma y color:SolidPeso molecular:417.21Zatonacaftor
CAS:<p>Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].</p>Fórmula:C24H27N3O4SForma y color:SolidPeso molecular:453.554-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine
CAS:<p>4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomeric</p>Fórmula:C27H28ClFN2OSPureza:99.02%Forma y color:SoildPeso molecular:483.04WAY-326766
CAS:<p>WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).</p>Fórmula:C21H23N3O5Pureza:98.76%Forma y color:SolidPeso molecular:397.42Crinecerfont hydrochloride
CAS:<p>SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.</p>Fórmula:C27H29Cl2FN2OSForma y color:SolidPeso molecular:519.5(R)-BPO-27
CAS:(R)-BPO-27 is an orally active and potent ATP-competitive CFTR inhibitor (IC50: 4 nM) for the study of diarrhoea and polycystic kidney.Fórmula:C26H18BrN3O6Pureza:99.1%Forma y color:SolidPeso molecular:548.34Ataluren
CAS:<p>Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.</p>Fórmula:C15H9FN2O3Pureza:99.16% - 99.84%Forma y color:SolidPeso molecular:284.24PPQ-102
CAS:<p>PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).</p>Fórmula:C26H22N4O3Pureza:99.7% - ≥95%Forma y color:SolidPeso molecular:438.48GlyH-101
CAS:<p>GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.</p>Fórmula:C19H15Br2N3O3Pureza:98.71% - 98.78%Forma y color:SolidPeso molecular:493.15Ivacaftor
CAS:<p>Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,</p>Fórmula:C24H28N2O3Pureza:99% - 99.98%Forma y color:SolidPeso molecular:392.49GLPG1837
CAS:<p>GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.</p>Fórmula:C16H20N4O3SPureza:99.64% - 99.91%Forma y color:SolidPeso molecular:348.42Lumacaftor
CAS:<p>Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.</p>Fórmula:C24H18F2N2O5Pureza:99.48% - 99.68%Forma y color:SolidPeso molecular:452.41Glibenclamide potassium
CAS:<p>Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.</p>Fórmula:C23H27ClKN3O5SForma y color:SolidPeso molecular:532.09CFTR corrector 2
CAS:<p>CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.</p>Fórmula:C27H23FN4O4Pureza:99.66%Forma y color:SolidPeso molecular:486.49Lubiprostone
CAS:<p>Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.</p>Fórmula:C20H32F2O5Pureza:97.31% - 98.54%Forma y color:White Odorless Crystals Or Crystalline PowderPeso molecular:390.46IOWH-032
CAS:<p>IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.</p>Fórmula:C22H15Br2N3O4Pureza:98.92% - ≥95%Forma y color:SolidPeso molecular:545.18KM11060
CAS:<p>KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasma</p>Fórmula:C19H17Cl2N3O2SPureza:98.86%Forma y color:SolidPeso molecular:422.33Icenticaftor
CAS:<p>Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.</p>Fórmula:C12H13F6N3O3Pureza:99.76%Forma y color:SolidPeso molecular:361.24CFTR(inh)-172
CAS:<p>CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.</p>Fórmula:C18H10F3NO3S2Pureza:98% - 99.72%Forma y color:SolidPeso molecular:409.4Nesolicaftor
CAS:<p>Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.</p>Fórmula:C18H18N4O4Pureza:99.79%Forma y color:SolidPeso molecular:354.36Tezacaftor
CAS:<p>Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.</p>Fórmula:C26H27F3N2O6Pureza:98.84% - >99.99%Forma y color:SolidPeso molecular:520.5SRI-41315
CAS:<p>SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.</p>Fórmula:C22H19N3O2Pureza:99.87%Forma y color:SolidPeso molecular:357.41GLPG-3221
CAS:<p>GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.</p>Fórmula:C30H37F3N2O6Pureza:98%Forma y color:SolidPeso molecular:578.62CFTR corrector 9
CAS:<p>CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.</p>Fórmula:C16H14N2O4Pureza:98.24%Forma y color:SolidPeso molecular:298.29Posenacaftor
CAS:<p>Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.</p>Fórmula:C27H27NO5Forma y color:SolidPeso molecular:445.51Posenacaftor sodium
CAS:<p>Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.</p>Fórmula:C27H27NNaO5Forma y color:SolidPeso molecular:468.505Corrector C4
CAS:<p>Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants and</p>Fórmula:C21H17ClN4O2S2Pureza:98.36%Forma y color:SolidPeso molecular:456.97Galicaftor
CAS:<p>ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).</p>Fórmula:C28H21F4NO7Pureza:98%Forma y color:SolidPeso molecular:559.46(R)-Posenacaftor sodium
CAS:<p>(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.</p>Fórmula:C27H27NNaO5Forma y color:SolidPeso molecular:468.505(R)-Olacaftor
CAS:<p>(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.</p>Fórmula:C29H34FN3O4SForma y color:SolidPeso molecular:539.66Ivacaftor-D9
CAS:<p>CTP-656, a cystic fibrosis transmembrane conductance regulator (CFTR) channel activator, is used potentially for the treatment of cystic fibrosis.</p>Fórmula:C24H19D9N2O3Forma y color:SolidPeso molecular:401.55AF-2785
CAS:<p>In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.</p>Fórmula:C17H12Cl2N2O2Pureza:98%Forma y color:SolidPeso molecular:347.2SRI-37240
CAS:<p>SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.</p>Fórmula:C24H23N3O2Pureza:98.73%Forma y color:SolidPeso molecular:385.46VRT-532
CAS:<p>VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.</p>Fórmula:C16H14N2OPureza:99.88% - 99.93%Forma y color:SolidPeso molecular:250.3Bamocaftor
CAS:<p>Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.</p>Fórmula:C28H32F3N5O4SPureza:99.71%Forma y color:SolidPeso molecular:591.65Crinecerfont
CAS:<p>Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.</p>Fórmula:C27H28ClFN2OSPureza:98.01% - 98.55%Forma y color:SolidPeso molecular:483.04UCCF-853
CAS:<p>UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。</p>Fórmula:C14H8ClF3N2OPureza:99.82%Forma y color:SolidPeso molecular:312.67PG01
CAS:<p>PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.</p>Fórmula:C28H29N3O2Pureza:99.87%Forma y color:SolidPeso molecular:439.55CFTR corrector 8
CAS:<p>CFTR corrector 8: potent for cystic fibrosis research, modulates CFTR protein.</p>Fórmula:C29H27F2NO7Pureza:99.57%Forma y color:SolidPeso molecular:539.52CFTR corrector 12
CAS:<p>CFTR corrector 12 is a CFTR corrector that rescues all mutant proteins except M760R ABCA3 and can be used to study cystic fibrosis.</p>Fórmula:C19H21ClN4O2S2Pureza:99.47%Forma y color:SolidPeso molecular:436.98CP 154526
CAS:<p>CRF1 receptor antagonist</p>Fórmula:C23H33ClN4Pureza:98%Forma y color:SolidPeso molecular:400.99DNDS
CAS:<p>DNDS is a channel blocker of voltage-dependent cystic fibrosis transmembrane conductance regulator (CFTR).</p>Fórmula:C14H8N2Na2O10S2Pureza:99.92%Forma y color:Physical Description White Powder (Ntp 1992)Peso molecular:474.33(R)-Vanzacaftor
CAS:<p>(R)-Vanzacaftor ((R)-VX-121) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator [1].</p>Fórmula:C32H39N7O4SForma y color:SolidPeso molecular:617.76Chromanol 293B
CAS:slow delayed rectifier K+ current (IKs) blockerFórmula:C15H20N2O4SPureza:98%Forma y color:SolidPeso molecular:324.4BPO-27 racemate
CAS:<p>BPO-27 racemate (BPO-27 (racemate)) is an effective CFTR inhibitor with IC50 of 8 nM.</p>Fórmula:C26H18BrN3O6Pureza:97.67% - 98.86%Forma y color:SolidPeso molecular:548.34CRF1 receptor antagonist-1
CAS:<p>CRF1 Receptor Antagonist-1 (Compound 2), a CRF1 receptor antagonist, is utilized in research pertaining to congenital adrenal hyperplasia (CAH) [1].</p>Fórmula:C27H28ClFN2O2SPureza:98%Forma y color:SolidPeso molecular:499.04(R)-Elexacaftor
CAS:<p>(R)-Elexacaftor (compound 37) is the enantiomer of Elexacaftor (compound 1). (R)-Elexacaftor is a CFTR modulator with an EC50 of 0.29 μM for CFTR dF508.</p>Fórmula:C26H34F3N7O4SPureza:98.991%Forma y color:SolidPeso molecular:597.65CFTR corrector 6
CAS:<p>CFTR corrector 6, a potent CFTR potentiator, aids cystic fibrosis research and related disorders.</p>Fórmula:C22H13F4N9Forma y color:SolidPeso molecular:479.39CFTR corrector 4
CAS:<p>Potent, oral CFTR corrector 4 targets cystic fibrosis, increasing cell surface CFTR levels.</p>Fórmula:C29H27F2NO7Pureza:99.32%Forma y color:SolidPeso molecular:539.52CFTR corrector 15
CAS:<p>CFTR Corrector 15 (Compound 4172) serves as a corrector for cystic fibrosis transmembrane conductance regulator (CFTR). When used in combination with VX-809, it addresses the folding defects of F508del-CFTR. CFTR Corrector 15 is also applicable in the research of cystic fibrosis.</p>Fórmula:C24H22ClN5O2SForma y color:SolidPeso molecular:479.98CFTR corrector 17
CAS:<p>CFTRcorrector 17 (example 17) is a regulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It is utilized in the study of diseases mediated by CFTR.</p>Fórmula:C18H15FN2O2Forma y color:SolidPeso molecular:310.32CFTR corrector 16
CAS:<p>CFTRcorrector 16 (Compound 39) is a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR), utilized in the research of cystic fibrosis disease.</p>Fórmula:C27H26ClN5O2SForma y color:SolidPeso molecular:520.05ARN23765
CAS:<p>ARN23765 is an F508del-CFTR corrector with an EC50 of 38 pM in human bronchial epithelial cells. It enhances the maturation and function of F508del-CFTR at the cell membrane, influencing ion transport and secretion, thereby addressing the pathological mechanisms of cystic fibrosis (CF).</p>Fórmula:C30H22F5N3O6Forma y color:SolidPeso molecular:615.504CFTR corrector 18
CAS:<p>CFTRcorrector 18 (Compound I-99) acts as a modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). It enhances the processing and trafficking of CFTR, thereby increasing the amount of CFTR present on the cell surface. CFTRcorrector 18 holds potential for research in cystic fibrosis (CF).</p>Fórmula:C38H40N6O5SForma y color:SolidPeso molecular:692.826Crinecerfont tosylate
CAS:<p>Crinecerfont tosylate is an effective oral CRF1 receptor antagonist. It is applicable to studies involving congenital adrenal hyperplasia (CAH).</p>Fórmula:C34H36ClFN2O4S2Forma y color:SolidPeso molecular:655.242
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