CFTR
El CFTR es una proteína de canal de cloruro que regula el transporte de iones cloruro y bicarbonato a través de las membranas de las células epiteliales, desempeñando un papel crucial en el mantenimiento del equilibrio de fluidos en los tejidos. Las mutaciones en el gen CFTR conducen a la fibrosis quística, un trastorno genético caracterizado por la producción de moco espeso que puede obstruir las vías respiratorias y provocar graves problemas respiratorios y digestivos. En CymitQuimica, ofrecemos una selección de moduladores de CFTR para apoyar su investigación en fibrosis quística, transporte de iones y trastornos genéticos.
Se han encontrado 66 productos para "CFTR".
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Elexacaftor
CAS:Elexacaftor (VX-445) is a cystic fibrosis transmembrane conductance regulator (CFTR) corrector.Cost-effective and quality-assured.Fórmula:C26H34F3N7O4SPureza:98.87% - 99.87%Forma y color:SolidPeso molecular:597.65Ref: TM-T14935
1mg93,00€2mg130,00€5mg230,00€1mL*10mM (DMSO)304,00€10mg371,00€25mg730,00€50mg1.018,00€100mg1.369,00€Glibenclamide
CAS:Glibenclamide (Glyburide) is an antidiabetic sulfonylurea derivative with actions similar to those of chlorpropamide.Fórmula:C23H28ClN3O5SPureza:99.05% - 99.75%Forma y color:White SolidPeso molecular:494WAY-326766
CAS:WAY-326766 increases ion transport through mutant CFTR and can be used to alter the lifespan of eukaryotes.WAY-326766 can be used to treat cystic fibrosis (CF).Fórmula:C21H23N3O5Pureza:99.87%Forma y color:SolidPeso molecular:397.42Cavosonstat
CAS:Cavosonstat (N91115) is an oral GSNOR inhibitor aiding CFTR in cystic fibrosis.Fórmula:C16H10ClNO3Pureza:99.64%Forma y color:Yellow SolidPeso molecular:299.71Crofelemer
CAS:Crofelemer (Provir) is an orally active antidiarrheal agent. It targets the cystic fibrosis transmembrane conductance regulator (CFTR) and calcium-activated chloride channels (CACC), which are responsible for chloride and fluid secretion in the gastrointestinal tract. Crofelemer is applicable for research in diarrhea-related conditions.Forma y color:SolidCP-628006
CAS:CP-628006 is a small molecule CFTR potentiator that effectively restores ATP-dependent channel gating to G551D-CFTR, the mutant form found in cystic fibrosis.Fórmula:C32H35F3N2O2Forma y color:SolidPeso molecular:536.639kCAL01
CAS:kCAL01 is a CAL inhibitor with a Ki value of 2.3 μM and holds potential for research in cystic fibrosis (CF).Fórmula:C36H57N11O9Forma y color:SolidPeso molecular:787.91H2-Gamendazole
CAS:H2-Gamendazole: inhibits spermatogenesis, cancer therapy, targets heat shock proteins & EF1α, regulates Hsp90.Fórmula:C18H13Cl2F3N2O2Pureza:97.39%Forma y color:SolidPeso molecular:417.21Ref: TM-T72076
1mg73,00€5mg180,00€1mL*10mM (DMSO)203,00€10mg269,00€25mg477,00€50mg642,00€100mg880,00€200mg1.161,00€Zatonacaftor
CAS:Zatonacaftor, a cystic fibrosis transmembrane regulator (CFTR) modulator, is utilized in the research of cystic fibrosis [1] [2].Fórmula:C24H27N3O4SForma y color:SolidPeso molecular:453.55(R)-Crinecerfont
CAS:4-(2-chloro-4-methoxy-5-methylphenyl)-N-[(1A)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]-5-methyl-N-(2-propyn-1-yl)-2-thiazolamine is an enantiomericFórmula:C27H28ClFN2OSPureza:99.02%Forma y color:Orange SolidPeso molecular:483.04Ref: TM-T60126
500mgA consultar1mg109,00€2mg163,00€5mg241,00€1mL*10mM (DMSO)289,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€(Rac)-Tezacaftor
CAS:(Rac)-Tezacaftor, a racemate, corrects F508del CFTR for cystic fibrosis research.Fórmula:C26H27F3N2O6Forma y color:SolidPeso molecular:520.5CFTR activator 2
CAS:CFTR activator 2 (WAY-326769) is an activator of mutant CFTR (cystic fibrosis transmembrane conductance regulator), which increases ion transport activity and can be used for research into cystic fibrosis (CF).Fórmula:C27H27N3O3Pureza:99.70%Forma y color:SolidPeso molecular:441.52Astressin 2B
CAS:CRF2 antagonist with IC50 of 1.3 nM; >500 nM for CRF1. Aids gastric emptying.Fórmula:C183H307N49O53Pureza:98%Forma y color:SolidPeso molecular:4041.69Vanzacaftor
CAS:Vanzacaftor is a CFTR modulator improving protein processing and surface trafficking, restoring chloride transport and aiding cystic fibrosis therapy research.Fórmula:C32H39N7O4SPureza:99.14%Forma y color:White SolidPeso molecular:617.76Ref: TM-T74417
1mg177,00€5mg324,00€1mL*10mM (DMSO)440,00€10mg480,00€25mg707,00€50mg1.071,00€100mg1.648,00€Crinecerfont hydrochloride
CAS:SSR-125543, a potent CRF1 receptor non-peptide antagonist, effective in CAH research, taken orally.Fórmula:C27H29Cl2FN2OSForma y color:SolidPeso molecular:519.5Lubiprostone
CAS:Lubiprostone (RU-0211), an activator of ClC-2 chloride channels, is used in the therapy of idiopathic chronic constipation.Fórmula:C20H32F2O5Pureza:97.31% - 98.54%Forma y color:SolidPeso molecular:390.46Lumacaftor
CAS:Lumacaftor (VRT 826809) is a CFTR modulator that corrects the folding and trafficking of CFTR protein.Fórmula:C24H18F2N2O5Pureza:99.48% - 99.68%Forma y color:SolidPeso molecular:452.41PPQ-102
CAS:PPQ-102 (CFTR Inhibitor), an effective CFTR inhibitor, can completely inhibit CFTR chloride current (IC50: 90 nM).Fórmula:C26H22N4O3Pureza:98.80% - ≥95%Forma y color:Yellow SolidPeso molecular:438.48Nesolicaftor
CAS:Nesolicaftor (PTI-428) specifically enhances cystic fibrosis transmembrane conductance regulator protein synthesis.Fórmula:C18H18N4O4Pureza:99.79%Forma y color:White SolidPeso molecular:354.36Ref: TM-T16681
1mg90,00€5mg203,00€1mL*10mM (DMSO)225,00€10mg358,00€25mg617,00€50mg878,00€100mg1.189,00€CFTR(inh)-172
CAS:CFTR(inh)-172 (CFTR Inhibitor-172) is a voltage-independent, selective CFTR inhibitor.Fórmula:C18H10F3NO3S2Pureza:98% - 99.72%Forma y color:SolidPeso molecular:409.4Ref: TM-T2355
1mg34,00€2mg43,00€5mg63,00€1mL*10mM (DMSO)65,00€10mg92,00€25mg178,00€50mg340,00€100mg502,00€CFTR corrector 2
CAS:CFTR corrector 2 (FDL169) is a novel and potent CFTR corrector for treating cystic fibrosis (CF) patients who carry the F508del mutation.Fórmula:C27H23FN4O4Pureza:99.66%Forma y color:White SolidPeso molecular:486.49Ref: TM-T5312
2mg37,00€5mg55,00€1mL*10mM (DMSO)59,00€10mg80,00€25mg147,00€50mg215,00€100mg318,00€200mg444,00€GlyH-101
CAS:GlyH-101 is a cell-permeable glycinyl hydrazone compound that blocks CFTR with Ki of 1.4 uM.Fórmula:C19H15Br2N3O3Pureza:98.71% - 98.78%Forma y color:SolidPeso molecular:493.15Ref: TM-T2451
1mg34,00€5mg71,00€1mL*10mM (DMSO)80,00€10mg103,00€25mg210,00€50mg354,00€100mg530,00€200mg755,00€Ivacaftor
CAS:Ivacaftor (VX-770) (VX-770) is a potentiator of CFTR targeting G551D-CFTR (EC50: 100 nM) and F508del-CFTR (EC50: 25 nM) in Fisher rat thyroid cells,Fórmula:C24H28N2O3Pureza:99% - 99.98%Forma y color:White SolidPeso molecular:392.49Ref: TM-T2588
1mg35,00€2mg50,00€5mg77,00€1mL*10mM (DMSO)84,00€10mg120,00€25mg195,00€50mg288,00€100mg416,00€200mg600,00€Tezacaftor
CAS:Tezacaftor (VX661) is a small molecule that can be used as a corrector of the cystic fibrosis transmembrane conductance regulator (CFTR) gene function.Fórmula:C26H27F3N2O6Pureza:98.84% - >99.99%Forma y color:SolidPeso molecular:520.5Ref: TM-T2263
1mg38,00€2mg50,00€5mg78,00€1mL*10mM (DMSO)94,00€10mg116,00€25mg200,00€50mg324,00€100mg477,00€GLPG1837
CAS:GLPG1837 (ABBV-974) is an effective CFTR potentiator, with EC50s of 3 nM and 339 nM for F508del and G551D CFTR, respectively.Fórmula:C16H20N4O3SPureza:99.64% - 99.91%Forma y color:SolidPeso molecular:348.42Glibenclamide potassium
CAS:Glibenclamide potassium, a more soluble form of Glibenclamide, exists as anhydrous and hydrate salts.Fórmula:C23H27ClKN3O5SForma y color:SolidPeso molecular:532.09IOWH-032
CAS:IOWH-032 (IOWH032) , a synthetic CFTR inhibitor, has been investigated for the treatment of cholera, diarrhea, and secretory diarrhea.Fórmula:C22H15Br2N3O4Pureza:99% - >99.99%Forma y color:SolidPeso molecular:545.18KM11060
CAS:KM11060 is a novel corrector of the F508del-CFTR trafficking defect, Correcting F508del-CFTR trafficking, increasing the amount of functional CFTR at the plasmaFórmula:C19H17Cl2N3O2SPureza:99.08%Forma y color:SolidPeso molecular:422.33Icenticaftor
CAS:Icenticaftor (QBW251) is an orally active potentiator of CFTR channel.Fórmula:C12H13F6N3O3Pureza:99.76%Forma y color:SolidPeso molecular:361.24Ref: TM-T9499
1mg152,00€1mL*10mM (DMSO)248,00€5mg313,00€10mg469,00€25mg750,00€50mg1.054,00€100mg1.494,00€200mg2.025,00€Ataluren
CAS:Ataluren (PTC124) is a novel, orally administered drug that targets nonsense mutations.Fórmula:C15H9FN2O3Pureza:99.16% - 99.84%Forma y color:SolidPeso molecular:284.24Ref: TM-T1805
5mg35,00€1mL*10mM (DMSO)40,00€10mg54,00€25mg88,00€50mg117,00€100mg178,00€200mg213,00€500mg359,00€SRI-41315
CAS:SRI-41315 is an eRF1 degrader that acts as a molecular glue at the ribosomal decoding center.SRI-41315 induces extended pauses at the termination codon.Fórmula:C22H19N3O2Pureza:99.87%Forma y color:White SolidPeso molecular:357.41Ref: TM-T2S1837
1mg49,00€1mL*10mM (DMSO)73,00€5mg89,00€10mg154,00€25mg250,00€50mg371,00€100mg552,00€200mg785,00€(R)-Olacaftor
CAS:(R)-Olacaftor (VX-440) is a CFTR modulator with promise for researching cystic fibrosis.Fórmula:C29H34FN3O4SForma y color:SolidPeso molecular:539.66SRI-37240
CAS:SRI-37240 suppresses CFTR nonsense mutations, aids in fixing premature termination codons, works with G418.Fórmula:C24H23N3O2Pureza:98.73%Forma y color:SolidPeso molecular:385.46Ivacaftor-D9
CAS:Ivacaftor-D9 is a deuterated compound of ivacaftor used for isotope tracing. Ivacaftor is an effective, orally administered CFTR modulator, cystic fibrosis.Fórmula:C24H19D9N2O3Pureza:99.13%Forma y color:White SolidPeso molecular:401.55AF-2785
CAS:In epididymal epithelial cells, AF-2785 inhibits cystic fibrosis transmembrane conductance regulator Cl(-) channels.Fórmula:C17H12Cl2N2O2Pureza:98%Forma y color:SolidPeso molecular:347.2CFTR corrector 9
CAS:CFTR corrector 9 is a CF modulator used to research cystic fibrosis and related disorders.Fórmula:C16H14N2O4Pureza:99.75%Forma y color:SolidPeso molecular:298.29Corrector C4
CAS:Corrector C4, a corrector commonly used to study cystic fibrosis mutants, works by alleviating the interaction between CFTR transmembrane domain mutants andFórmula:C21H17ClN4O2S2Pureza:99.98%Forma y color:SolidPeso molecular:456.97Galicaftor
CAS:ABBV-2222 is a CFTR corrector which is studied for the treatment of cystic fibrosis (CF).Fórmula:C28H21F4NO7Pureza:98.84%Forma y color:Yellow SolidPeso molecular:559.46Ref: TM-T22252
1mg92,00€5mg192,00€1mL*10mM (DMSO)236,00€10mg313,00€25mg625,00€50mg982,00€100mg1.639,00€Posenacaftor sodium
CAS:Posenacaftor (PTI-801) sodium, a CFTR modulator for CF research, corrects CFTR protein folding and trafficking.Fórmula:C27H27NNaO5Forma y color:SolidPeso molecular:468.505GLPG2451
CAS:GLPG2451 is an effective CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) enhancer, potentiates cold-rescued F508del CFTR (EC50=11.1 nM).Fórmula:C16H16F3N3O5SPureza:99.13%Forma y color:White SolidPeso molecular:419.38Ref: TM-T13705
1mg98,00€5mg234,00€1mL*10mM (DMSO)258,00€10mg358,00€25mg737,00€50mg1.099,00€100mg1.468,00€(R)-Posenacaftor sodium
CAS:(R)-Posenacaftor sodium is a modulator for correcting cystic fibrosis protein folding.Fórmula:C27H27NNaO5Forma y color:SolidPeso molecular:468.505Posenacaftor
CAS:Posenacaftor (PTI-801) regulates CFTR protein for cystic fibrosis research.Fórmula:C27H27NO5Forma y color:SolidPeso molecular:445.51GLPG-3221
CAS:GLPG-3221, a potent oral CFTR corrector for cystic fibrosis treatment, has an EC50 of 105 nM.Fórmula:C30H37F3N2O6Pureza:98%Forma y color:SolidPeso molecular:578.62Bamocaftor
CAS:Bamocaftor corrects CFTR in CF, restoring F508del-CFTR function, used with tezacaftor and VX-561 for F508del/MF patients.Fórmula:C28H32F3N5O4SPureza:99.71%Forma y color:SolidPeso molecular:591.65Ref: TM-T30293
1mg334,00€5mg802,00€1mL*10mM (DMSO)1.035,00€10mg1.099,00€25mg1.611,00€50mg2.187,00€100mg2.952,00€PG01
CAS:PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.Fórmula:C28H29N3O2Pureza:99.79%Forma y color:SolidPeso molecular:439.55Ref: TM-T16516
1mg55,00€1mL*10mM (DMSO)144,00€5mg148,00€10mg215,00€25mg344,00€50mg465,00€100mg630,00€200mg850,00€Crinecerfont
CAS:Crinecerfont (SSR-125543) is a CRF1 antagonist, useful in congenital adrenal hyperplasia research.Fórmula:C27H28ClFN2OSPureza:97.79% - 98.55%Forma y color:SolidPeso molecular:483.04VRT-325
CAS:VRT-325 aids in dimerizing NBDs and folding TMDs, speeding up CF cell monolayer repair.Fórmula:C27H34N4O4SPureza:99.15% - 99.58%Forma y color:SolidPeso molecular:510.65UCCF-853
CAS:UCCF-853 是一种小分子 CFTR 调节剂，可用于研究囊性纤维化。Fórmula:C14H8ClF3N2OPureza:99.82%Forma y color:SolidPeso molecular:312.67VRT-532
CAS:VRT-532 (CFpot-532) is an effective modulator of CFTR and is commonly used in studies of cystic fibrosis (CF) caused by CFTR defects.Fórmula:C16H14N2OPureza:99.88% - 99.93%Forma y color:SolidPeso molecular:250.3Ref: TM-T29114
1mg70,00€1mL*10mM (DMSO)138,00€5mg156,00€10mg225,00€25mg371,00€50mg504,00€100mg662,00€200mg875,00€
