Canal de potasio
Los canales de potasio son un grupo diverso de proteínas de membrana que facilitan el flujo de iones de potasio (K+) a través de la membrana celular. Estos canales desempeñan un papel crucial en el mantenimiento del potencial de membrana en reposo, la regulación del volumen celular y el control de la excitabilidad de las neuronas y las células musculares. Los canales de potasio están involucrados en varios procesos fisiológicos, incluyendo la regulación del ritmo cardíaco, la secreción de insulina y la liberación de neurotransmisores. La disfunción de los canales de potasio está relacionada con condiciones como arritmias, epilepsia e hipertensión. En CymitQuimica, ofrecemos una amplia gama de moduladores de canales de potasio para apoyar su investigación en electrofisiología, salud cardiovascular y neurobiología.
Se han encontrado 276 productos de "Canal de potasio"
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Dendrotoxin K TFA
<p>Dendrotoxin K TFA, a Kv1.1 channel blocker, modulates glutamate release in CA3 neurons by time-dependently regulating the presynaptic spike waveform [1].</p>Fórmula:C294H462N84O75S6·XC2HF3OC2Pureza:98%Forma y color:SolidPeso molecular:6559.66 (free base)BKCa activator-1
<p>BKCa activator-1 (Compound 51b) is an orally active activator of BKCa calcium-activated potassium channels with an EC50 of 2.82 μM. It promotes K+ efflux, leading to cell membrane hyperpolarization and inhibition of smooth muscle contraction. In a spontaneous hypertensive rat (SHR) model, it alleviates urinary incontinence and exhibits antitussive effects in a guinea pig cough model.</p>Fórmula:C22H23F7N2O3Forma y color:SolidPeso molecular:496.418Ebio3
<p>Ebio3 is a selective potassium ion channel (KCNQ2) inhibitor with an IC50 of 1.2 nM. It binds to the KCNQ2 channel via its hydrophobic tail, causing the inward movement of the S6 helix, which results in the closure of the internal gate. The inhibitory effect of Ebio3 is equally effective on pathogenic KCNQ2 mutants, such as R75C and I238L, reducing their outward current by approximately 80%. Ebio3 holds potential for research in neurological disorders like epilepsy.</p>Fórmula:C19H23F2N3O2Forma y color:SolidPeso molecular:363.4KNa1.1-IN-2
CAS:<p>KNa1.1-IN-2 (Compound Z05) is a selective KNa1.1 channel inhibitor capable of penetrating the blood-brain barrier, and exhibits significant efficacy on hERG channels. It binds to KNa1.1 channels, effectively blocking channel activity caused by Gain-of-function (GOF) mutations, thus intervening in KCNT1-related seizures. Additionally, it inhibits the GOF mutant Y796H, making KNa1.1-IN-2 a promising candidate for research into KCNT1-associated epilepsy disorders.</p>Fórmula:C24H27NOForma y color:SolidPeso molecular:345.48Vesnarinone HCl
<p>Vesnarinone HCl is an oral PDE3 inhibitor improving heart contractility, affecting calcium and potassium flux. Used in heart failure research.</p>Fórmula:C22H26ClN3O4Pureza:99.17%Forma y color:SoildPeso molecular:431.91Ebio2
<p>Ebio2 is an effective activator of KCNQ2.</p>Fórmula:C17H19F2N3O2Forma y color:SolidPeso molecular:335.349Iberiotoxin
CAS:<p>Selective blocker of the big conductance Ca2+-activated K+ channel.</p>Fórmula:C179H274N50O55S7Pureza:98%Forma y color:SolidPeso molecular:4230Cromakalim
CAS:<p>Cromakalim (BRL 34915) is an ATP-dependent K(+) channel opener, a smooth muscle relaxant with antiepileptic activity.</p>Fórmula:C16H18N2O3Pureza:99.39%Forma y color:SolidPeso molecular:286.33Nateglinide D5
CAS:<p>Nateglinide D5 is a deuterium labeled Nateglinide.</p>Fórmula:C19H27NO3Pureza:98%Forma y color:SolidPeso molecular:322.45QO-58
CAS:<p>QO-58 is a novel Kv7 activator (opener) that activates neuronal Kv7/KCNQ/M channels, danti-nociceptive effects on inflammatory pain</p>Fórmula:C18H8Cl2F4N4OPureza:99.17%Forma y color:SolidPeso molecular:443.18Flecainide
CAS:<p>Flecainide is an orally administered antiarrhythmic agent acting as a sodium channel blocker and IKr inhibitor,PSVT.</p>Fórmula:C17H20F6N2O3Pureza:99.896%Forma y color:SolidPeso molecular:414.34Neosolaniol
CAS:<p>Neosolaniol, a type A trichothecene mycotoxin produced by Fusarium species, strongly induces an anorectic (loss of appetite) response.</p>Fórmula:C19H26O8Pureza:98%Forma y color:SolidPeso molecular:382.4KCNQ1 activator-1
CAS:<p>N-[4-(4-Methoxyphenyl)-2-thiazolyl]-2-piperidinecarboxamide is a potent KCNQ1 activator for LQTS research.</p>Fórmula:C22H23N3O4S2Pureza:99.71%Forma y color:SolidPeso molecular:457.57Endoxifen Z-isomer hydrochloride
CAS:<p>Endoxifen Z-isomer hydrochloride (Endoxifen HCl) is the active metabolite of Tamoxifen, which is an effective and selective estrogen receptor antagonist.</p>Fórmula:C25H28ClNO2Forma y color:SolidPeso molecular:409.95Clamikalant sodium
CAS:<p>Clamikalant sodium (HMR 1098) is an ATP-dependent potassium channel (KATP) cardiac-selective blocker, used in the study of arrhythmias.</p>Fórmula:C19H21ClN3NaO5S2Pureza:99.95%Forma y color:SolidPeso molecular:493.96Oxypeucedanin
CAS:<p>1.</p>Fórmula:C16H14O5Pureza:98.66% - 98.85%Forma y color:SolidPeso molecular:286.28Ibutilide Fumarate
CAS:<p>Ibutilide Fumarate is a class III antiarrhythmic, prolonging action potentials by enhancing sodium influx, and can extend QT interval.</p>Fórmula:(C20H36N2O3S)2·C4H4O4Pureza:99.68% - 99.74%Forma y color:SolidPeso molecular:885.23Guanosine 5'-diphosphate disodium salt
CAS:<p>5'-GDP-Na2: a nucleoside diphosphate, iron mobilizer, blocks hepcidin-ferroportin, affects IL-6/stat-3.</p>Fórmula:C10H13N5Na2O11P2Pureza:99.40%Forma y color:White PowderPeso molecular:487.16XE 991 dihydrochloride
CAS:<p>XE 991 dihydrochloride is a Kv7 (KCNQ) channel blocker.</p>Fórmula:C26H22Cl2N2OPureza:98.68%Forma y color:SolidPeso molecular:449.37SKA-31
CAS:<p>SKA-31 (Naphtho[1,2-d]thiazol-2-ylamine) is an activator of KCa3.1 and KCa2 channels (EC50s: 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2 respectively).</p>Fórmula:C11H8N2SPureza:99.38%Forma y color:SolidPeso molecular:200.26Ropivacaine hydrochloride monohydrate
CAS:<p>Ropivacaine hydrochloride monohydrate (LEA-103 HCl) is an anaesthetic agent and blocks impulse conduction through inhibiting sodium ion influx reversibly.</p>Fórmula:C17H29ClN2O2Pureza:99.94% - 99.95%Forma y color:White SolidPeso molecular:328.88Cholesterol myristate
CAS:<p>Cholesterol myristate, a natural steroid in Chinese medicine, affects GABAA, nicotinic receptors, and potassium channels.</p>Fórmula:C41H72O2Pureza:99.65%Forma y color:SolidPeso molecular:597.01Quinidine sulfate dihydrate
CAS:<p>Quinidine sulfate dihydrate (Pitayine Sodium) is a potent and selective cytochrome P450db inhibitor</p>Fórmula:C40H54N4O10SPureza:99.85%Forma y color:White To Light Yellow Crystal PowdePeso molecular:782.9ML277
CAS:<p>ML277 (CID-53347902) was identified as a potent activator of KCNQ1 channels (EC(50)=260 nM).</p>Fórmula:C23H25N3O4S2Pureza:99.35%Forma y color:SolidPeso molecular:471.59APD668
CAS:<p>APD668 is a potent GPR119 agonist with EC50 of 2.7 nM and 33 nM for hGPR119 and ratGPR119, respectively.</p>Fórmula:C21H24FN5O5SPureza:99.74% - 99.97%Forma y color:SolidPeso molecular:477.51Amifampridine
CAS:<p>Amifampridine blocks nerve potassium channels, extends action potentials, boosts acetylcholine release, and treats rare muscle diseases.</p>Fórmula:C5H7N3Pureza:99.82%Forma y color:Slightly Beige PowderPeso molecular:109.13TKIM
CAS:<p>TKIM is a TWIK-related potassium channel 1 (TREK-1) inhibitor, binding to the pocket of the intermediate (IM) state of TREK-1.</p>Fórmula:C18H14ClN3O2SPureza:99.47%Forma y color:SolidPeso molecular:371.84ICA-069673
CAS:<p>ICA-069673 is an activator of KCNQ2/Q3 potassium channel (IC50: 0.69 μM).</p>Fórmula:C11H6ClF2N3OPureza:99.04% - 99.68%Forma y color:SolidPeso molecular:269.63NS309
CAS:<p>NS309 activates SK/KCa2, IK/KCa3.1 (0.12-1.2 μM EC50, 10-90 nM EC50), and Kv11.1 channels; doesn't affect BK/KCa1.1; modulates neuronal firing.</p>Fórmula:C8H4Cl2N2O2Pureza:97.55%Forma y color:SolidPeso molecular:231.04BAPTA-AM
CAS:<p>BAPTA-AM is a calcium chelator that is cell-permeable and selective, blocking hERG, hKv1.3, and hKv1.5 channels (IC50=1.3/1.45/1.23 μM).</p>Fórmula:C34H40N2O18Pureza:98% - 99.47%Forma y color:White Powder Or Crystalline PowderPeso molecular:764.68Quinidine
CAS:<p>Quinidine is a stereoisomer of the antimalarial agent quinine and a class Ia antiarrhythmic agent. for the treatment of abnormal heart rhythms and also malaria.</p>Fórmula:C20H24N2O2Pureza:97.03% - 99.99%Forma y color:Crystals With 2 5 Mol Water Of Crystallization; Crystals From Dilute Alcohol Physical Description Crystals Or White Powder (Ntp 1992)Peso molecular:324.42Talatisamine
CAS:<p>Talatisamine and TEA mitigate Aβ oligomer effects on I(K), bolstering cell survival and reducing K(+) loss-induced apoptosis; promising for further study.</p>Fórmula:C24H39NO5Pureza:98.62% - 99.44%Forma y color:SolidPeso molecular:421.57VU0134992
CAS:<p>VU0134992 is an Kir4.1 blocker with an IC50 value of 0.97 μM</p>Fórmula:C20H31BrN2O2Pureza:99.86%Forma y color:SolidPeso molecular:411.38Endoxifen (Z-isomer)
CAS:<p>Endoxifen Z-isomer (EDX) is a key active metabolite of tamoxifen with higher affinity and specificity to estrogen receptors that inhibits aromatase activity.</p>Fórmula:C25H27NO2Pureza:99.19% - 99.81%Forma y color:SolidPeso molecular:373.49Paederosidic acid methyl ester
CAS:<p>Paederosidic acid methyl ester has antinociception, is possibly related to the pathway of NO-cGMP-ATP sensitive K(+) channels.</p>Fórmula:C19H26O12SPureza:99.67% - 99.91%Forma y color:SolidPeso molecular:478.4720(S)-Ginsenoside Rg3
CAS:<p>20(S)-Ginsenoside Rg3 (Rg3) possess an ability to inhibit the lung metastasis of tumor cells via inhibition of the adhesion and invasion of tumor cells.</p>Fórmula:C42H72O13Pureza:98.11% - 99.93%Forma y color:SolidPeso molecular:785.01KCNQ2/3 activator-1
CAS:<p>KCNQ2/3 activator-1 is a Kv7.2/Kv7.3 (KCNQ2/3) potassium channel activator.</p>Fórmula:C23H29FN2OPureza:99.16% - 99.47%Forma y color:SolidPeso molecular:368.492,2,2-Trichloroethanol
CAS:<p>2,2,2-Trichloroethanol is an agonist of the nonclassical K2P channels TREK-1 and TRAAK.</p>Fórmula:C2H3Cl3OPureza:99.74%Forma y color:LiquidPeso molecular:149.4Yoda 1
CAS:<p>Yoda 1 is an agonist of the Piezo1 channel that agonizes human- and mouse-derived Piezo1. Yoda 1 is also an inhibitor of GlyT2. Cost-effective, quality assurance.</p>Fórmula:C13H8Cl2N4S2Pureza:98% - 99.98%Forma y color:SolidPeso molecular:355.27Quinine hydrochloride dihydrate
CAS:<p>Quinine hydrochloride dihydrate (Quinine HCl Dihydrate) is a white crystalline K+ channel blocker, used to treat malaria.</p>Fórmula:C20H24N2O2·HCl·2H2OPureza:99.91%Forma y color:White To Light Yellow Crystal PowderPeso molecular:396.91Kv2-IN-A1
CAS:<p>Kv2-IN-A1 is an inhibitor of Kv2.1 and Kv2.2.</p>Fórmula:C20H17ClN4OSPureza:98.83%Forma y color:SolidPeso molecular:396.89Almitrine mesylate
CAS:<p>Almitrine mesylate targets Ca2+-dependent K+ channels in rat cells, used for chronic lung hypoxemia.</p>Fórmula:C28H37F2N7O6S2Pureza:99.96%Forma y color:CoaPeso molecular:669.76Azimilide Dihydrochloride
CAS:<p>Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the IKs and IKr with antiarrhythmic activity.</p>Fórmula:C23H30Cl3N5O3Pureza:97.59% - ≥95%Forma y color:SolidPeso molecular:530.88ML365
CAS:<p>ML365 is a novel selective small molecule inhibitor of TASK1(KCNK3).</p>Fórmula:C22H20N2O3Pureza:98.78%Forma y color:SolidPeso molecular:360.41VU0071063
CAS:<p>VU0071063 is a Kir6.2/SUR1 activator.</p>Fórmula:C18H22N4O2Pureza:99.33%Forma y color:SolidPeso molecular:326.39Quinine dihydrochloride
CAS:<p>Quinine dihydrochloride (Quinine bimuriate) is a primary alkaloid of various species of Cinchona (Rubiaceae).</p>Fórmula:C20H26Cl2N2O2Pureza:99.79% - 99.97%Forma y color:White SolidPeso molecular:397.34Sematilide hydrochloride
CAS:<p>Sematilide hydrochloride (CK-1752) is a class III antiarrhythmic. It is a selectively delayed rectifier K+ current (IKr) channel blocker.</p>Fórmula:C14H24ClN3O3SPureza:99.14%Forma y color:SolidPeso molecular:349.87Dofetilide
CAS:<p>Dofetilide (UK 68789), a class III antiarrhythmic sulfonamide, blocks Ikr cardiac channels, prolongs action potential, and treats atrial fibrillation/flutter.</p>Fórmula:C19H27N3O5S2Pureza:97.85% - 99.06%Forma y color:Off-White Or Yellowish Crystalline PowderPeso molecular:441.56AUT1
CAS:<p>AUT1 (AUT-1) is a novel specific modulator of Kv3 channels (EC50: 4.7 and 4.9 uM for Kv3.1b and Kv3.2a).</p>Fórmula:C18H19N3O4Pureza:99.8% - 99.95%Forma y color:SolidPeso molecular:341.36Iptakalim Hydrochloride
CAS:<p>Iptakalim, a lipophilic para-amino compound, is a novel ATP-sensitive potassium channel (KATP) opener, as well as an α4β2-containing nicotinic acetylcholine</p>Fórmula:C9H22ClNPureza:98%Forma y color:SolidPeso molecular:179.731
