Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 257 productos de "Canal de sodio"
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Huwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Fórmula:C174H278N52O51S6Pureza:98%Forma y color:SolidPeso molecular:4106.79Halazone
CAS:Halazone (Pantocid) is fine white powder with an odor of chlorine. It has been widely used to disinfect drinking water.Fórmula:C7H5Cl2NO4SPureza:98.64%Forma y color:Physical Description Fine White Powder With An Odor Of Chlorine (Ntp 1992)Peso molecular:270.09ω-Conotoxin CVIB
CAS:ω-Conotoxin CVIB is an antagonist of non-selective N- and P/Q-type voltage-gated calcium channels (VGCCs).Fórmula:C102H173N41O32S7Pureza:98%Forma y color:SolidPeso molecular:2710.18Pterinotoxin-1
Pterinotoxin-1 is a peptide toxin that functions as an inhibitor of sodium channels [1].Fórmula:C163H251N49O53S7Pureza:98%Forma y color:SolidPeso molecular:3969.49Aah II
Aah II, a sodium channel modulator, is a toxin derived from the venom of the scorpion Androctonus australis [1] [2].Fórmula:C313H457N89O95S8Pureza:98%Forma y color:SolidPeso molecular:7243.04OD1
Activates rat Nav1.7, human Nav1.4, rat Nav1.6 (EC50: 7, 10, 47 nM); minimal on Nav1.2, 1.3, 1.5 (EC50 >3 μM); blocks fast inactivation; triggers pain.Fórmula:C308H466N90O95S8Pureza:98%Forma y color:SolidPeso molecular:7206.1Phrixotoxin 3
CAS:Potent NaV blocker: IC50 - 0.6 nM (NaV1.2), 42 nM (NaV1.3), 72 nM (NaV1.5); voltage-dependent inhibition.Fórmula:C176H269N51O48S6Pureza:98%Forma y color:SolidPeso molecular:4059.74Jingzhaotoxin-V
Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodiumFórmula:C157H243N47O37S7Pureza:98%Forma y color:SolidPeso molecular:3605.36Scorpion toxin Tf2
Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion Tityus fasciolatus, acts as an activator of the neuronal voltage-Fórmula:C309H438N80O87S9Pureza:98%Forma y color:SolidPeso molecular:6953.86Jingzhaotoxin XI
Jingzhaotoxin XI (JZTX-XI) is a potent inhibitor of sodium conductance, exhibiting an IC50 value of 124 nM, and notably retards the rapid inactivation of Na_v1.Fórmula:C158H234N44O47S7Pureza:98%Forma y color:SolidPeso molecular:3726.27µ-Conotoxin BuIIIC
CAS:μ-Conotoxin BuIIIC (Mu-Conotoxin BuIIIC) effectively inhibits the NaV1.4 sodium channel [1].Fórmula:C116H189N49O34S6Pureza:98%Forma y color:SolidPeso molecular:3006.44Sodium Channel Targeted Library
A unique collection of xnum sodium channel blockers and agonists for high throughput and high content screening;Forma y color:Odour SolidRef: TM-L7400
1mgA consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarGpTx-1 TFA
GpTx-1 TFA is a polypeptide NaV1.7 sodium channel antagonist isolated from the venom of the Chilean spider Grammostola porter. It exhibits potent inhibitory activity on the NaV1.7 channel with an IC50 value of 10 nM, demonstrating excellent selectivity over NaV1.4 (IC50 = 0.301 μM) and NaV1.5 (IC50 = 4.20 μM) with >20-fold and >950-fold selectivity, respectively.Forma y color:Odour Solidδ-Buthitoxin-Hj2a
δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].Fórmula:C304H458N90O93S8Pureza:98%Forma y color:SolidPeso molecular:7117.96Lifarizine FA
Lifarizine FA is a sodium channel blocker used in the treatment of neurological disorders and cardiovascular diseases, study of stroke.Fórmula:C30H34N4O2Pureza:99.55%Forma y color:SolidPeso molecular:482.62Jingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neuronsFórmula:C154H219N39O45S7Pureza:98%Forma y color:SolidPeso molecular:3561.08µ-Conotoxin-CnIIIC acetate
µ-Conotoxin-CnIIIC acetate is a NaV1.4 sodium channel antagonist, a conotoxin peptide consisting of 22 amino acids, used for muscle relaxation and pain relief.Fórmula:C92H139N35O28S6·xC2H4O2Pureza:99.94%Forma y color:SolidPeso molecular:2375.70 (free base)GX 201
CAS:GX 201 is a selective NaV1.7 inhibitor, IC50 of < 3.2 nM for hNaV1.7.Fórmula:C25H27ClF4N2O4SPureza:99.81%Forma y color:SolidPeso molecular:563Hainantoxin-III
CAS:Jingzhaotoxin-V is a peptide that suppresses potassium currents in Xenopus laevis oocytes, exhibiting an IC50 of 604.2 nM, while concurrently targeting bothFórmula:C154H228N44O45S6Pureza:98%Forma y color:SolidPeso molecular:3608.12μ-Conotoxin SxIIIC
μ-Conotoxin SxIIIC, an irreversible NaV channel inhibitor, is derived from Conus striolatus and is useful in researching neurological disorders, includingFórmula:C90H142N42O27S6Pureza:98%Forma y color:SolidPeso molecular:2436.75
