Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 259 productos de "Canal de sodio"
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GDC-0310
CAS:GDC-0310 is a selective, orally available Nav1.7 inhibitor with an IC50 of 0.6 nM for human Nav1.7, suitable for pain research.Fórmula:C25H29Cl2FN2O4SPureza:99.877%Forma y color:SolidPeso molecular:543.48Sodium Channel inhibitor 4
CAS:Sodium Channel Inhibitor 4 is a compound that functions as a sodium channel inhibitor [1].Fórmula:C19H18ClN3O4S2Pureza:98%Forma y color:SolidPeso molecular:451.95Funapide
CAS:Funapide (TV 45070) is a potent Nav1.7 inhibitor, potentially treating inflammation and various pains.Fórmula:C22H14F3NO5Pureza:99.91%Forma y color:SolidPeso molecular:429.35Ref: TM-T15358
1mg120,00€5mg289,00€10mg439,00€25mg708,00€50mg954,00€100mg1.288,00€1mL*10mM (DMSO)318,00€Aneratrigine hydrochloride
CAS:Aneratrigine hydrochloride is a Nav 1.9 blocker that may be used to prevent or treat sodium channel blocker-related disorders.Fórmula:C19H21Cl2F2N5O2S2Pureza:98.37% - 99.16%Forma y color:SolidPeso molecular:524.43VGSCs-IN-1
CAS:VGSCs-IN-1, a VGSC inhibitor and Riluzole analog, exhibits good blocking activity on Nav1.4 and can be used to study cellular excitability disorders.Fórmula:C12H12F3N3OSPureza:99.88%Forma y color:SolidPeso molecular:303.3Zilvetrigine
CAS:Zilvetrigine is a sodium channel (sodium channel) blocker. It can be used as an analgesic.Fórmula:C20H20ClN3O2Forma y color:SolidPeso molecular:369.845Lubeluzole dihydrochloride
CAS:Lubeluzole (dihydrochloride) acts as a neuroprotective agent by blocking neuronal voltage-gated sodium channels and also affects cardiac sodium channels, exhibiting both tonic and blocking effects. This compound is considered promising in the research of antiarrhythmic agents.Fórmula:C22H27Cl2F2N3O2SForma y color:SolidPeso molecular:506.44(R)-Duloxetine
CAS:(R)-Duloxetine, an isomer of Duloxetine, induces tonic and use-dependent blockade of neuronal Na+ channels. This compound is utilized in pain research.Fórmula:C18H19NOSForma y color:SolidPeso molecular:297.42Olisutrigine bromide
CAS:Olisutrigine bromide is a sodium channel blocker used as an analgesic.Fórmula:C25H35BrN2Forma y color:SolidPeso molecular:443.463PF-05661014
CAS:PF-05661014, a demethylated analogue of PF-06526290, selectively inhibits Nav1.3 and Nav1.7 currents by stabilizing the inactivated state through interaction with the D4 VSD. This compound is utilized in research focused on sodium channel modulation.Fórmula:C17H16N4O3S2Forma y color:SolidPeso molecular:388.46LBA-3
CAS:LBA-3, a selective and orally active inhibitor of the sodium-coupled citrate transporter SLC13A5, exhibits an IC50 of 67 nM. This compound effectively reduces triglyceride and total cholesterol levels in both oleic and palmitic acid (OPA)-stimulated AML12 cells and PCN-stimulated primary mouse hepatocytes, as well as in mouse models, without showing detectable toxicity. Additionally, LBA-3 is permeable to the blood-brain barrier [1].Fórmula:C18H18O5Forma y color:SolidPeso molecular:314.33Vormatrigine
CAS:Vormatrigine effectively inhibits sodium channels (sodium channel).Fórmula:C16H12F6N4O2Forma y color:SolidPeso molecular:406.28Nav1.8-IN-5
CAS:Nav1.8-IN-5 (Example 1), a voltage-gated sodium channel Nav1.8 inhibitor, is applicable in the research of Nav1.8-mediated diseases including pain, pain-related disorders, and cardiovascular diseases (such as atrial fibrillation) [1].Fórmula:C23H15F4N3O2Forma y color:SolidPeso molecular:441.38Quinacainol dihydrochloride
CAS:Quinacainol dihydrochloride (PK 10139 dihydrochloride) is the bis(2 hydrochloride) salt form of Quinacainol. It acts as an inhibitor of the sodium current, with an EC50 of 95 µM. This compound displays antiarrhythmic activity by modulating the electrophysiological properties of the heart.
Fórmula:C21H32Cl2N2OForma y color:SolidPeso molecular:399.398Olorigliflozin
CAS:Olorigliflozin is a sodium glucose co-transporter (SGLT) inhibitor with antihyperglycemic properties.Fórmula:C23H27ClO7Forma y color:SolidPeso molecular:450.909ErSO-TFPy
CAS:ErSO-TFPy activates the sodium ion channel TRPM4, resulting in an imbalance of intracellular calcium and sodium ions. It exhibits low nanomolar-level cytotoxicity (IC50 = 5-25 nM) by inducing necrosis in ERα+ breast cancer cell lines. Additionally, ErSO-TFPy shows antitumor activity in mouse models.Fórmula:C19H13F7N2O2Forma y color:SolidPeso molecular:434.307Nav1.7 blocker 1
CAS:Nav1.7 blocker 1 (example 41), an effective Na+ channel (Na v) blocker, exhibits a potent IC50 value of 0.037 μM. This compound is utilized in pain research, encompassing neuropathic, postoperative, and inflammatory pain among others [1].Fórmula:C22H21FN4O4Peso molecular:424.42Suzetrigine
CAS:Suzetrigine (VX-548) is an oral NaV1.8 inhibitor with analgesic properties for acute pain research.Fórmula:C21H20F5N3O4Pureza:98.08% - 99.27%Forma y color:SolidPeso molecular:473.39Ref: TM-T69552
1mg58,00€5mg114,00€10mg170,00€25mg266,00€300g129.112,00€50mg457,00€100mg747,00€200mg1.026,00€1mL*10mM (DMSO)118,00€PF-06761281
CAS:PF-06761281 is a partially selective sodium-coupled citrate transporter protein (NaCT/SLC13A5) inhibitor, oral, reducing plasma glucose concentration.Fórmula:C13H17NO6Forma y color:SolidPeso molecular:283.28
