Canal de sodio
Los canales de sodio son proteínas de membrana esenciales que permiten el paso de iones de sodio (Na+) a través de la membrana celular, generando y propagando señales eléctricas en neuronas, células musculares y otros tejidos excitables. Estos canales son vitales para la iniciación y conducción de potenciales de acción, lo que los hace cruciales en procesos como la transmisión de impulsos nerviosos, la contracción muscular y la función cardíaca. La desregulación de los canales de sodio puede llevar a trastornos neurológicos, arritmias y condiciones de dolor crónico. En CymitQuimica, ofrecemos una variedad de moduladores de canales de sodio para apoyar su investigación en neurobiología, cardiología y manejo del dolor.
Se han encontrado 259 productos de "Canal de sodio"
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Scorpion toxin Tf2
Scorpion toxin Tf2, a β-scorpion toxin first identified in the venom of the Brazilian scorpion Tityus fasciolatus, acts as an activator of the neuronal voltage-Fórmula:C309H438N80O87S9Pureza:98%Forma y color:SolidPeso molecular:6953.86NHE-1-IN-2
NHE-1-IN-2 (compound 7g) is a potent NHE-1 inhibitor with an IC50 of 0.78 μM. It mitigates left ventricular systolic dysfunction in mouse models of heart failure.Fórmula:C23H20ClN3O3Forma y color:SolidPeso molecular:421.11932ProTx II
CAS:Selective NaV1.7 inhibitor, alters activation, reduces current, 100x more selective for 1.7 over other Na+ channels.
Fórmula:C168H250N46O41S8Pureza:98%Forma y color:SolidPeso molecular:3826.595-Tridecanol
CAS:5-Tridecanol blocks ion flux in sodium channels.Fórmula:C13H28OPureza:97.87%Forma y color:SolidPeso molecular:200.36µ-Conotoxin-CnIIIC
CAS:μ-Conotoxin-CnIIIC, a 22-residue conopeptide derived from Conus consors, acts as a potent and persistent NaV1.4 channel blocker, exhibiting analgesic,Fórmula:C92H139N35O28S6Pureza:98%Forma y color:SolidPeso molecular:2375.7Jingzhaotoxin-34
Jingzhaotoxin-34, a 35-residue neurotoxic polypeptide, selectively inhibits tetrodotoxin-sensitive (TTX-S) sodium currents in rat dorsal root ganglion neuronsFórmula:C154H219N39O45S7Pureza:98%Forma y color:SolidPeso molecular:3561.08Solpecainol
CAS:solpecainol is a sodium channel blocker used in the study of neurological and cardiovascular diseases.Fórmula:C18H23NO3Pureza:99.71%Forma y color:SoildPeso molecular:301.38δ-Buthitoxin-Hj1a
δ-Buthitoxin-Hj1a, a scorpion-venom peptide, functions as a potent agonist for the NaV1.1 channel, exhibiting an EC50 value of 17 nM.Fórmula:C326H482N92O96S8Pureza:98%Forma y color:SolidPeso molecular:7482.39Crotamine
Crotamine, a 42 amino acid toxin featuring three disulfide bridges, functions as a Na+ channel modulator with analgesic properties.Fórmula:C214H326N64O54S7Pureza:98%Forma y color:SolidPeso molecular:4883.73Trapencaine
CAS:Trapencaine is a newly synthesized carbamate type local anesthetic that induces conformational changes in sodium channels on hypertrophic cell membranes.Fórmula:C22H34N2O3Pureza:97.68%Forma y color:SolidPeso molecular:374.52Ion Channel Targeted Library
A unique collection of 931 compounds targeting ion channels for research in ion channels-related diseases and ion channel drug discovery;
Forma y color:Odour SolidZoniporide
CAS:Zoniporide (CP-597396) is an NHE-1 inhibitor that inhibits platelet swelling and can be used in the study of cardiovascular diseases.Fórmula:C17H16N6OPureza:99.74%Forma y color:SolidPeso molecular:320.35δ-Theraphotoxin-Hm1a toxin
δ-Theraphotoxin-Hm1a is a selective NaV1.1 activator that induces pain and touch sensitivity, with potential applications in irritable bowel syndrome research [Fórmula:C170H240N48O53S6Pureza:98%Forma y color:SolidPeso molecular:3996.4Jingzhaotoxin-V
Jingzhaotoxin-V, a 29-residue polypeptide from Chilobrachys jingzhao spider venom, selectively inhibits tetrodotoxin-resistant and tetrodotoxin-sensitive sodiumFórmula:C157H243N47O37S7Pureza:98%Forma y color:SolidPeso molecular:3605.36Huwentoxin-IV
CAS:Selective NaV1.7 blocker; also inhibits NaV1.2, 1.3; less effect on NaV1.4, 1.5. Binds to neurotoxin site, traps voltage sensor. IC50: 26-338 nM.Fórmula:C174H278N52O51S6Pureza:98%Forma y color:SolidPeso molecular:4106.79Batrachotoxin
CAS:Batrachotoxin (BTX), a potent neurotoxin and cardiotoxin, is found in the skin of the Colombian dart frog (Phyllobates aurotaenia). As an activator of sodium channels (sodium channel), it interferes with normal sodium channel closure by binding to voltage-gated sodium channels (sodium channel) on the cell membrane. This interaction causes a continuous influx of sodium ions into the cells, leading to persistent depolarization.Fórmula:C31H42N2O6Forma y color:SolidPeso molecular:538.67Dc1a
Dc1a, a toxin isolated from the desert bush spider Diguetia canities [1], potently facilitates the opening of the German cockroach Na v channel (BgNa v 1).Fórmula:C276H414N76O84S8Pureza:98%Forma y color:SolidPeso molecular:6397.22Tap1a
Theraphotoxin-Tap1a (Tap1a) is a spider venom-derived peptide that acts as an inhibitor of sodium channels, displaying IC50 values of 80 nM for Na v 1.7 and 301Fórmula:C174H258N52O55S7Pureza:98%Forma y color:SolidPeso molecular:4182.68SLC26A3-IN-2
CAS:Vilobelimab (CaCP-29) is a human-mouse chimeric IgG antibody targeting human complement component 5a, a C5a inhibitor that inhibits neutrophil activation.Fórmula:C19H13ClN2O2SPureza:99.86%Forma y color:SolidPeso molecular:368.84δ-Buthitoxin-Hj2a
δ-Buthitoxin-Hj2a, a potent scorpion-venom peptide, acts as a NaV1.1 agonist with an EC50 value of 32 nM and is employed in Dravet syndrome (DS) research [1].Fórmula:C304H458N90O93S8Pureza:98%Forma y color:SolidPeso molecular:7117.96
