PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 165 productos de "PDE"
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K134
CAS:<p>K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.</p>Fórmula:C22H29N3O4Pureza:98%Forma y color:SolidPeso molecular:399.48PAT-048
CAS:<p>PAT-048 is an effective and selective autotaxin inhibitor.</p>Fórmula:C22H18ClF2N3O2SPureza:98%Forma y color:SolidPeso molecular:461.91Propentofylline
CAS:<p>Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.</p>Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Forma y color:Off-White SolidPeso molecular:306.36Deltasonamide 2
CAS:<p>Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Fórmula:C30H39ClN6O4S2Pureza:98%Forma y color:SolidPeso molecular:647.25Deltasonamide 2 (TFA)
CAS:<p>Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.</p>Fórmula:C32H40ClF3N6O6S2Pureza:98%Forma y color:SolidPeso molecular:761.28PDE9-IN-1
CAS:<p>PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).</p>Fórmula:C17H23FN6O2Pureza:99.86%Forma y color:SolidPeso molecular:362.4Tilivapram
CAS:<p>Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.</p>Fórmula:C16H15Cl2N3O4Pureza:99.87%Forma y color:SolidPeso molecular:384.21AN3199
CAS:<p>AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.</p>Fórmula:C17H18BNO5Pureza:99.45%Forma y color:SolidPeso molecular:327.14Imazodan hydrochloride
CAS:<p>Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.</p>Fórmula:C13H13ClN4OPureza:98.97%Forma y color:SolidPeso molecular:276.72BAY 73-6691
CAS:<p>BAY 73-6691 is an inhibitor of brain penetrant PDE9A.</p>Fórmula:C15H12ClF3N4OForma y color:SolidPeso molecular:356.73Lirimilast
CAS:<p>Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.</p>Fórmula:C17H12Cl2N2O6SPureza:98%Forma y color:SolidPeso molecular:443.26WAY127093B racemate
CAS:<p>WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.</p>Fórmula:C23H28N4O4Pureza:99.67%Forma y color:SolidPeso molecular:424.49PDE7-IN-2
CAS:<p>PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.</p>Fórmula:C14H11ClN2O3SPureza:98%Forma y color:SolidPeso molecular:322.77(R)-DNMDP
CAS:<p>(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.</p>Fórmula:C15H20N4O3Forma y color:SolidPeso molecular:304.34Autotaxin-IN-1
CAS:<p>Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.</p>Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45Senazodan hydrochloride
CAS:<p>Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.</p>Fórmula:C15H15ClN4OPureza:99.93%Forma y color:SolidPeso molecular:302.76KD-027
CAS:<p>KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.</p>Fórmula:C25H35N7O6SPureza:99.55%Forma y color:SolidPeso molecular:561.65ATX inhibitor 5
CAS:<p>ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.</p>Fórmula:C22H18ClF3N6OPureza:98.77%Forma y color:SolidPeso molecular:474.87PF-04822163
CAS:<p>PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.</p>Fórmula:C19H17ClN2O2Pureza:99.55%Forma y color:SolidPeso molecular:340.8Imazodan
CAS:<p>Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.</p>Fórmula:C13H12N4OPureza:98% - 98.31%Forma y color:SolidPeso molecular:240.26PDE IV-IN-1
CAS:<p>PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary disease</p>Fórmula:C20H23ClN4O2Pureza:99.79%Forma y color:SolidPeso molecular:386.88Tanimilast
CAS:<p>Tanimilast (CHF-6001) is a potent PDE4 inhibitor with IC50 of 0.026 nM, used topically for obstructive lung disease.</p>Fórmula:C30H30Cl2F2N2O8SPureza:98.34%Forma y color:SolidPeso molecular:687.54uk-50001
CAS:<p>UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.</p>Fórmula:C26H24F3N3O4Pureza:99.90%Forma y color:SolidPeso molecular:499.48PDE4B-IN-2
CAS:<p>PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.</p>Fórmula:C19H18ClN3O2SPureza:99.32%Forma y color:SolidPeso molecular:387.88Nanterinone
CAS:<p>Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.</p>Fórmula:C15H15N3OPureza:99.53%Forma y color:SolidPeso molecular:253.3Dovramilast
CAS:<p>Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.</p>Fórmula:C24H28N2O6SPureza:98.75% - 99.62%Forma y color:SolidPeso molecular:472.55Verofylline
CAS:<p>Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for the</p>Fórmula:C12H18N4O2Pureza:98.33% - 98.83%Forma y color:SolidPeso molecular:250.3Carbazeran
CAS:<p>Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.</p>Fórmula:C18H24N4O4Pureza:99.3%Forma y color:SolidPeso molecular:360.41AWD 12-281
CAS:<p>AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).</p>Fórmula:C22H14Cl2FN3O3Pureza:99.25% - 99.85%Forma y color:SolidPeso molecular:458.27Autotaxin-IN-3
CAS:<p>Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.</p>Fórmula:C22H21N9O2Pureza:99.54% - 99.79%Forma y color:SolidPeso molecular:443.46Filaminast
CAS:<p>Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.</p>Fórmula:C15H20N2O4Pureza:98.53% - 98.93%Forma y color:SolidPeso molecular:292.33MK-0873
CAS:<p>MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.</p>Fórmula:C25H18N4O3Pureza:98.40%Forma y color:SolidPeso molecular:422.44Mopidamol
CAS:<p>Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimental</p>Fórmula:C19H31N7O4Pureza:99.05% - 99.78%Forma y color:SolidPeso molecular:421.49Isomazole
CAS:<p>Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.</p>Fórmula:C14H13N3O2SPureza:98.66%Forma y color:SolidPeso molecular:287.34Tofimilast
CAS:<p>Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.</p>Fórmula:C18H21N5SPureza:99.55%Forma y color:SolidPeso molecular:339.46Dasantafil
CAS:<p>Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.</p>Fórmula:C22H28BrN5O5Pureza:99.4% - 99.50%Forma y color:SolidPeso molecular:522.39PF-04447943
CAS:<p>PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.</p>Fórmula:C20H25N7O2Pureza:99.36% - 99.59%Forma y color:SolidPeso molecular:395.46GSK356278
CAS:<p>GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.</p>Fórmula:C21H25N7O2SPureza:99.90% - 99.97%Forma y color:SolidPeso molecular:439.53MK-8189
CAS:<p>MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.</p>Fórmula:C19H22N6OSPureza:99.38% - 99.67%Forma y color:SolidPeso molecular:382.48Autotaxin-IN-5
CAS:<p>Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Fórmula:C30H29N9O2Pureza:98%Forma y color:SolidPeso molecular:547.61Gisadenafil
CAS:<p>Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.</p>Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Forma y color:SolidPeso molecular:519.62PDE5-IN-2
CAS:<p>PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)</p>Fórmula:C25H21N3O6SPureza:98%Forma y color:SolidPeso molecular:491.52CI-1044
CAS:<p>CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).</p>Fórmula:C23H19N5O2Forma y color:SolidPeso molecular:397.43BIO-32546
CAS:<p>BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.</p>Fórmula:C28H31F6NO3Pureza:98.03%Forma y color:SolidPeso molecular:543.54Gisadenafil besylate
CAS:<p>Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.</p>Fórmula:C29H39N7O8S2Forma y color:SolidPeso molecular:677.79Difamilast
CAS:<p>Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).</p>Fórmula:C23H24F2N2O5Pureza:99.64%Forma y color:SolidPeso molecular:446.44Siguazodan
CAS:<p>Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.</p>Fórmula:C14H16N6OPureza:99.62% - 99.87%Forma y color:SolidPeso molecular:284.32Adibendan
CAS:<p>Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.</p>Fórmula:C16H14N4OPureza:99.52% - >99.99%Forma y color:SolidPeso molecular:278.31Autotaxin-IN-4
CAS:<p>Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.</p>Fórmula:C22H21N9O2Pureza:98%Forma y color:SolidPeso molecular:443.46PF-04957325
CAS:<p>PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.</p>Fórmula:C14H15F3N8OSPureza:99.02%Forma y color:SolidPeso molecular:400.38
