PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 170 productos de "PDE"
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8-CPT-Cyclic AMP sodium
CAS:8-CPT-Cyclic AMP sodium is an activator of cAMP-dependent PKA and cAMP receptor activator, an inhibitor of cAMP-specific phosphodiesterase (PDE VA).Fórmula:C16H14ClN5NaO6PSForma y color:White PowderPeso molecular:493.79ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Fórmula:C22H19N3O4Pureza:98%Forma y color:SolidPeso molecular:389.4Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.4%Forma y color:SolidPeso molecular:603.75K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Fórmula:C22H29N3O4Pureza:98%Forma y color:SolidPeso molecular:399.48Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C30H39ClN6O4S2Pureza:98%Forma y color:SolidPeso molecular:647.25PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:99.55%Forma y color:SolidPeso molecular:340.8(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Fórmula:C15H20N4O3Forma y color:SolidPeso molecular:304.34Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Fórmula:C13H13ClN4OPureza:98.97%Forma y color:SolidPeso molecular:276.72ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Fórmula:C22H18ClF3N6OPureza:99.73%Forma y color:SolidPeso molecular:474.87Ref: TM-T10409
1mg46,00€5mg94,00€1mL*10mM (DMSO)96,00€10mg149,00€25mg245,00€50mg338,00€100mg460,00€200mg622,00€Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Fórmula:C13H12N4OPureza:98% - 98.31%Forma y color:SolidPeso molecular:240.26Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C32H40ClF3N6O6S2Pureza:98%Forma y color:SolidPeso molecular:761.28Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Forma y color:Off-White SolidPeso molecular:306.36Ref: TM-T19812
2mgA consultar1mg65,00€5mg69,00€1mL*10mM (DMSO)77,00€10mg105,00€25mg195,00€50mg359,00€100mg523,00€BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Fórmula:C15H12ClF3N4OForma y color:SolidPeso molecular:356.73Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Fórmula:C23H28N4O4Pureza:99.67%Forma y color:SolidPeso molecular:424.49Ref: TM-T13331
1mg50,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg155,00€25mg224,00€50mg315,00€100mg424,00€200mg560,00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Fórmula:C14H11ClN2O3SPureza:98%Forma y color:SolidPeso molecular:322.77Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Fórmula:C16H15Cl2N3O4Pureza:99.87%Forma y color:SolidPeso molecular:384.21PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Fórmula:C17H23FN6O2Pureza:99.86%Forma y color:SolidPeso molecular:362.4Ref: TM-T12395
1mg40,00€1mL*10mM (DMSO)88,00€5mg89,00€10mg130,00€25mg222,00€50mg324,00€100mg470,00€200mg665,00€Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Fórmula:C15H15ClN4OPureza:99.93%Forma y color:SolidPeso molecular:302.76PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Fórmula:C22H18ClF2N3O2SPureza:98%Forma y color:SolidPeso molecular:461.91
