PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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RS-25344
CAS:RS-25344: a strong PDE4 blocker, curbs eosinophil movement, boosts sperm motility in vitro.Fórmula:C19H13N5O4Pureza:98.98%Forma y color:SolidPeso molecular:375.34Ref: TM-T9239
1mg84,00€5mg168,00€1mL*10mM (DMSO)177,00€10mg245,00€25mg404,00€50mg567,00€100mg767,00€200mg1.018,00€Lotamilast
CAS:Lotamilast (RVT-501) is a phosphodiesterase 4 (PDE-4) inhibitor (IC50: 2.8 nM) potentially for the treatment of atopic dermatitis.Fórmula:C26H24N4O5Pureza:97.03% - 99.29%Forma y color:SolidPeso molecular:472.49Enpp-1-IN-1
CAS:Enpp-1-IN-1 is an inhibitor of Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1)Fórmula:C17H17N3O3SPureza:97.52%Forma y color:White SolidPeso molecular:343.4Ref: TM-T7888
1mg126,00€5mg260,00€1mL*10mM (DMSO)286,00€10mg394,00€25mg677,00€50mg954,00€100mg1.288,00€GSK256066 Trifluoroacetate
CAS:GSK 256066 Trifluoroacetate: selective PDE4 inhibitor, IC50: 3.2 pM for PDE4B, treats COPD.Fórmula:C29H27F3N4O7SForma y color:SolidPeso molecular:632.61Crisaborole-D4
Crisaborole-d4 (AN-2728-d4) is the deuterated form of Crisaborole. Crisaborole is a PDE4 inhibitor and also a cytokine release inhibitor.Fórmula:C14H6D4BNO3Forma y color:White SolidPeso molecular:255.07ent-Tadalafil
CAS:ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS).Fórmula:C22H19N3O4Pureza:98%Forma y color:SolidPeso molecular:389.4Deltarasin
CAS:Deltarasin is a small molecular inhibitor of KRAS-PDEδ interaction with Kd of 38 nM for binding to purified PDEδ.Fórmula:C40H37N5OPureza:99.4%Forma y color:SolidPeso molecular:603.75PDE9-IN-1
CAS:PDE9-IN-1 is a selective and orally bioavailable Inhibitor of PDE9A(IC50 of 8.7 nM).Fórmula:C17H23FN6O2Pureza:99.86%Forma y color:SolidPeso molecular:362.4Ref: TM-T12395
1mg40,00€1mL*10mM (DMSO)88,00€5mg89,00€10mg130,00€25mg222,00€50mg324,00€100mg470,00€200mg665,00€BAY 73-6691
CAS:BAY 73-6691 is an inhibitor of brain penetrant PDE9A.Fórmula:C15H12ClF3N4OForma y color:SolidPeso molecular:356.73ATX inhibitor 5
CAS:ATX inhibitor 5: potent, oral autotaxin blocker, IC50 15.3 nM, curbs CCl4 liver fibrosis.Fórmula:C22H18ClF3N6OPureza:99.73%Forma y color:SolidPeso molecular:474.87Ref: TM-T10409
1mg46,00€5mg94,00€1mL*10mM (DMSO)96,00€10mg149,00€25mg245,00€50mg338,00€100mg460,00€200mg622,00€Tilivapram
CAS:Tilivapram is a PDE4 (phosphodiesterase IV) inhibitor that can be used in the study of mental illness.Fórmula:C16H15Cl2N3O4Pureza:99.87%Forma y color:White SolidPeso molecular:384.21Trequinsin hydrochloride
CAS:Azetirelin (YM 14673) is a new thyrotropin-releasing hormone (TRH) analog.Fórmula:C24H28ClN3O3Pureza:99.91% - 99.95%Forma y color:SolidPeso molecular:441.95Ref: TM-T23476
2mg85,00€5mg126,00€1mL*10mM (DMSO)138,00€10mg203,00€25mg442,00€50mg737,00€100mg1.071,00€Deltasonamide 2 (TFA)
CAS:Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C32H40ClF3N6O6S2Pureza:98%Forma y color:SolidPeso molecular:761.28WAY127093B racemate
CAS:WAY127093B racemate is the racemate of WAY127093B. WAY127093B is a phosphodiesterase IV inhibitor with oral activity in rats and guinea pigs.Fórmula:C23H28N4O4Pureza:99.67%Forma y color:SolidPeso molecular:424.49Ref: TM-T13331
1mg50,00€5mg105,00€1mL*10mM (DMSO)116,00€10mg155,00€25mg224,00€50mg315,00€100mg424,00€200mg560,00€PDE7-IN-2
CAS:PDE7-IN-2 is an inhibitor of phosphodiesterase 7 (IC50 = 2.1 µM) and can be used in Parkinson's disease studies.Fórmula:C14H11ClN2O3SPureza:98%Forma y color:Yellow SolidPeso molecular:322.77PF-04822163
CAS:PF-04822163 is a potent inhibitor of PDE1 with IC50 value of 0.0024 μM.Fórmula:C19H17ClN2O2Pureza:99.55%Forma y color:White SolidPeso molecular:340.8Imazodan hydrochloride
CAS:Imazodan hydrochloride (CI-914 HCl) is a potent and selective type III phosphodiesterase inhibitor used in the treatment of chronic congestive heart failure.Fórmula:C13H13ClN4OPureza:98.97%Forma y color:SolidPeso molecular:276.72Imazodan
CAS:Imazodan is a compound with positive inotropic activity and is a type III phosphodiesterase inhibitor that can be used to study heart failure.Fórmula:C13H12N4OPureza:97.04% - 98.31%Forma y color:Yellow SolidPeso molecular:240.26PAT-048
CAS:PAT-048 is an effective and selective autotaxin inhibitor.Fórmula:C22H18ClF2N3O2SPureza:98%Forma y color:SolidPeso molecular:461.91Propentofylline
CAS:Propentofylline (Hextol) has neuroprotective, antiproliferative and anti-inflammatory activities and can be used in the study of Alzheimer's disease.Fórmula:C15H22N4O3Pureza:99.76% - 99.86%Forma y color:SolidPeso molecular:306.36
