PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Fórmula:C23H32N4O4Pureza:99.85%Forma y color:SolidPeso molecular:428.52AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Fórmula:C25H23N5O3Pureza:99.87%Forma y color:SolidPeso molecular:441.48Ref: TM-T14217
25mgA consultar50mgA consultar1mg34,00€2mg44,00€5mg70,00€1mL*10mM (DMSO)78,00€10mg100,00€CDC801
CAS:CDC801 is an inhibitor of PDE4 and TNF-α with IC50s of 1.1 μM and 2.5 μM, respectively.Fórmula:C23H24N2O5Pureza:99.61%Forma y color:SolidPeso molecular:408.45Ref: TM-T10730
1mg161,00€2mg215,00€5mg335,00€1mL*5mM (DMSO)375,00€10mg479,00€25mg718,00€50mg964,00€100mg1.305,00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonaryFórmula:C24H35N5O3Pureza:99.83%Forma y color:White SolidPeso molecular:441.57Ref: TM-T13193
1mg124,00€5mg304,00€1mL*10mM (DMSO)334,00€10mg439,00€25mg665,00€50mg883,00€100mg1.215,00€500mg2.440,00€Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Fórmula:C21H15Cl2F2N3O2SPureza:99.9%Forma y color:SolidPeso molecular:482.33Ref: TM-T63190
1mg73,00€5mg161,00€1mL*10mM (DMSO)166,00€10mg235,00€25mg420,00€50mg627,00€100mg880,00€200mg1.161,00€Vizenpistat
CAS:Vizenpistat is an ENPP1 inhibitor utilized in tumor research.Fórmula:C15H21N5O4SForma y color:SolidPeso molecular:367.42Z21090
CAS:Z21090 (ZL40) is a highly effective inhibitor of PDE 4, exhibiting an IC 50 value of 37.4 nM, and possesses oral bioavailability. It is significant in the study of alcohol-related diseases [1].Fórmula:C12H14ClN3O3Forma y color:SolidPeso molecular:283.71Thioquinapiperifil dihydrochloride
CAS:Thioquinapiperifil dihydrochloride is a potent, selective PDE-5 inhibitor (IC50: 0.074 nM) for research.Fórmula:C24H29ClN6OSPureza:99.81%Forma y color:Yellow SolidPeso molecular:485.05Ref: TM-T9773
1mg55,00€5mg123,00€1mL*10mM (DMSO)140,00€10mg177,00€25mg289,00€50mg371,00€100mg522,00€200mg687,00€PF-00489791
CAS:PF-00489791 (PF4634817) is a long-acting PDE5 inhibitor with hypotensive activity for the study of diabetic nephropathy.Fórmula:C20H28N8O4SPureza:99.97%Forma y color:Yellow SolidPeso molecular:476.55Z21115
CAS:Z21115 is an orally effective phosphodiesterase 4 (PDE4) inhibitor that can inhibit PDE4D7 with an IC50 of 10.5 nM. It suppresses the expression of IL-6, TNF-α, and iNOS induced by Lipopolysaccharide. In a DSS-induced mouse colitis model, Z21115 demonstrates anti-inflammatory activity without significant toxicity at doses up to 1 g/kg.Fórmula:C20H20F2N2O4Peso molecular:390.38BMS-341400 mesylate
CAS:BMS-341400 mesylate (Compound 6) is an orally active selective phosphodiesterase 5 (PDE5) inhibitor with an IC50 value of 0.3 nM and is useful in the study of erectile dysfunction.Fórmula:C24H26ClN9O5SForma y color:SolidPeso molecular:588.039Tovinontrine
CAS:Tovinontrine (IMR-687) (IMR-687) is a potent and selective inhibitor of phosphodiesterase-9 (PDE9), designed to target sickle cell disease treatment.Fórmula:C21H26N6O2Pureza:98.8%Forma y color:SolidPeso molecular:394.47PDE5-IN-15
CAS:PDE5-IN-15 (compound 21) is a xanthine derivative and PDE5 inhibitor with IC50 values of 0.002 μM for hPDE5, 0.180 μM for bPDE6, 2.85 μM for bPDE1, and 2.22 μM for hPDE3. It exhibits good oral bioavailability in dogs and is applicable in research related to male erectile dysfunction.Fórmula:C21H23N5O3Peso molecular:393.44TAK-915
CAS:TAK-915: potent, brain-ready PDE2A inhibitor, 0.61 nM IC50, 4100x selectivity over PDE1A.Fórmula:C19H18F4N4O5Pureza:98%Forma y color:SolidPeso molecular:458.36PDE1-IN-7
CAS:PDE1-IN-7 (Compound 13h), with an IC50 value of 10 nM, selectively inhibits bPDE1. This compound demonstrates significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model and is useful for research purposes in studying liver fibrosis [1].Fórmula:C32H36F2N2O6SForma y color:SolidPeso molecular:614.7NHTD
CAS:NHTD, a KRAS-PDEδ inhibitor, exerts its function by targeting the isoprenyl binding pocket of PDEδ, which alters the cellular localization of KRAS. This modification restricts the proliferation of cancer cells with KRAS mutations and induces cell apoptosis (Apoptosis). NHTD is utilized in the study of KRAS-driven non-small cell lung cancer (NSCLC).Fórmula:C24H26N2O5Forma y color:SolidPeso molecular:422.47Deltasonamide 2 hydrochloride
Deltasonamide 2 hydrochloride is a competitive high-affinity PDEδ inhibitor with a Kd of approximately 385 pM.Fórmula:C30H40Cl2N6O4S2Pureza:98%Forma y color:SolidPeso molecular:683.71ASP9831
CAS:ASP9831 is an orally active PDE4 inhibitor. It suppresses LPS-induced TNF-α production and exhibits anti-inflammatory properties. ASP9831 is useful in the study of steatohepatitis.Fórmula:C20H23N3O3Forma y color:SolidPeso molecular:353.42
