PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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Prinoxodan
CAS:Prinoxodan is a PDE3 inhibitor; elevates cAMP; cardiotonic agent; vasodilatory activity; heart failure research.Fórmula:C13H14N4O2Pureza:98.99%Forma y color:White SolidPeso molecular:258.28Senazodan hydrochloride
CAS:Senazodan hydrochloride (Senazodan HCl) is a Ca2+ sensitizer and phosphodiesterase 3 (PDE3) inhibitor used in the study of cardiovascular diseases.Fórmula:C15H15ClN4OPureza:99.93%Forma y color:SolidPeso molecular:302.76Lirimilast
CAS:Lirimilast: oral PDE4 inhibitor (IC50: 49 nM), anti-inflammatory, treats asthma/COPD.Fórmula:C17H12Cl2N2O6SPureza:99.68%Forma y color:SolidPeso molecular:443.26Autotaxin-IN-1
CAS:Autotaxin-IN-1: strong inhibitor for osteoarthritis pain; IC50=2.2 nM; good PK and PK/PD.Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45KD-027
CAS:KD-027 is a novel and long-acting PDE5A(phosphodiesterase 5A) inhibitor with potential antihypertensive activity.Fórmula:C25H35N7O6SPureza:99.55%Forma y color:SolidPeso molecular:561.65(R)-DNMDP
CAS:(R)-DNMDP is a potent and selective cancer cytotoxic agent that directly binds PDE3A and has an EC50 500-fold lower than that of (S)-DNMDP against HeLa.Fórmula:C15H20N4O3Forma y color:SolidPeso molecular:304.34Deltasonamide 2
CAS:Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM.Fórmula:C30H39ClN6O4S2Pureza:98%Forma y color:SolidPeso molecular:647.25K134
CAS:K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.Fórmula:C22H29N3O4Pureza:98%Forma y color:SolidPeso molecular:399.48AN3199
CAS:AN3199 is a selective inhibitor of PDE4 with an IC50 of 94.5 nM.Fórmula:C17H18BNO5Pureza:99.45%Forma y color:SolidPeso molecular:327.14Autotaxin-IN-3
CAS:Autotaxin-IN-3 is an inhibitor of Autotaxin (IC50 = 2.4 nM) which is responsible for the increase in lysophosphatidic acid in ascites and plasma.Fórmula:C22H21N9O2Pureza:99.54% - 99.79%Forma y color:SolidPeso molecular:443.46Ref: TM-T10415
2mg43,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg96,00€25mg173,00€50mg269,00€100mg432,00€200mg592,00€Verofylline
CAS:Verofylline (Verofyllinum) is an orally available, long-acting, multiacting, methylxanthine-substituted bronchodilator with inhibitory effects on PDE4 for theFórmula:C12H18N4O2Pureza:98.4% - 99.8%Forma y color:White SolidPeso molecular:250.3Filaminast
CAS:Filaminast (UNII-CDD69JC61J) is an analog of a phosphodiesterase 4 inhibitor (PDE4 inhibitor) and roliplam, which is used as an anti-asthma drug.Fórmula:C15H20N2O4Pureza:98.93% - 99.99%Forma y color:SolidPeso molecular:292.33Ref: TM-T31792
1mg156,00€1mL*10mM (DMSO)333,00€5mg366,00€10mg487,00€25mg737,00€50mg982,00€100mg1.324,00€200mg1.791,00€Nanterinone
CAS:Nanterinone: oral phosphodiesterase inhibitor, improves acute heart failure hemodynamics.Fórmula:C15H15N3OPureza:99.96%Forma y color:SolidPeso molecular:253.3PF-04447943
CAS:PF-04447943, a selective PDE9A inhibitor (IC50=12nM), may aid sickle cell anemia research with its anti-inflammatory properties.Fórmula:C20H25N7O2Pureza:97.01% - 99.36%Forma y color:SolidPeso molecular:395.46Isomazole
CAS:Isomazole is a novel orally available phosphodiesterase (PDE) inhibitor with calcium-sensitizing properties that inhibits PDE3 and PDE4.Fórmula:C14H13N3O2SPureza:98.66%Forma y color:Yellow SolidPeso molecular:287.34Dasantafil
CAS:Dasantafil (SCH446132) is a small molecule phosphodiesterase-5A (PDE5A) inhibitor used to treat genitourinary disorders and study erectile dysfunction.Fórmula:C22H28BrN5O5Pureza:99.4% - 99.50%Forma y color:SolidPeso molecular:522.39Mopidamol
CAS:Mopidamol (RA 233) is a phosphodiesterase inhibitor, a dipyridamole derivative, with anticancer activity that prevents retinal vascular defects in experimentalFórmula:C19H31N7O4Pureza:99.31% - 99.78%Forma y color:SolidPeso molecular:421.49MK-0873
CAS:MK-0873 is a novel and potent selective phosphodiesterase 4 (PDE4) inhibitor.Fórmula:C25H18N4O3Pureza:99.14%Forma y color:SolidPeso molecular:422.44Carbazeran
CAS:Carbazeran (UK-31,557) is an inhibitor of PDE2 and PDE3 and can be used for studies about metabolic diseases.Fórmula:C18H24N4O4Pureza:99.3%Forma y color:SolidPeso molecular:360.41PDE IV-IN-1
CAS:PDE IV-IN-1 is a potent phosphodiesterase 4 (PDE4) inhibitor with anti-inflammatory activity for the treatment of asthma, chronic obstructive pulmonary diseaseFórmula:C20H23ClN4O2Pureza:99.79%Forma y color:SolidPeso molecular:386.88Ref: TM-T10201
1mg225,00€5mg480,00€1mL*10mM (DMSO)540,00€10mg642,00€25mg964,00€50mg1.288,00€100mg1.738,00€200mg2.332,00€
