PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 178 productos para "PDE".
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PDE4B-IN-2
CAS:PDE4B-IN-2 (A 33), an oral PDE4B inhibitor, IC50: 15 nM; less potent on PDE4D (IC50: 1.7 µM), has anti-inflammatory properties.Fórmula:C19H18ClN3O2SPureza:99.32%Forma y color:Yellow SolidPeso molecular:387.88Ref: TM-T36832
1mg34,00€5mg74,00€1mL*10mM (DMSO)82,00€10mg105,00€25mg205,00€50mg334,00€100mg537,00€500mg1.134,00€Dovramilast
CAS:Dovramilast (CC-11050) is a PDE4 inhibitor that reduces the production of pro-inflammatory mediators in lupus erythematosus.Fórmula:C24H28N2O6SPureza:98.75% - 99.62%Forma y color:SolidPeso molecular:472.55uk-50001
CAS:UK-50001 is a PDE4 inhibitor for treating inflammation, allergies, respiratory issues, and wounds.Fórmula:C26H24F3N3O4Pureza:99.90%Forma y color:SolidPeso molecular:499.48Ref: TM-T67815
1mg150,00€5mg360,00€1mL*10mM (DMSO)445,00€10mg540,00€25mg863,00€50mg1.153,00€100mg1.575,00€500mg3.142,00€Tofimilast
CAS:Tofimilast (CP-325366), a PDE4 inhibitor, is used potentially for the treatment of asthma and chronic obstructive pulmonary disease.Fórmula:C18H21N5SPureza:99.55%Forma y color:SolidPeso molecular:339.46AWD 12-281
CAS:AWD 12-281 is a PDE4 inhibitor with anti-inflammatory activity and bronchodilator activity for the study of chronic obstructive pulmonary disease (COPD).Fórmula:C22H14Cl2FN3O3Pureza:99.25% - 99.85%Forma y color:SolidPeso molecular:458.27Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Fórmula:C16H14N4OPureza:99.52% - >99.99%Forma y color:SolidPeso molecular:278.31PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Fórmula:C14H15F3N8OSPureza:99.02%Forma y color:SolidPeso molecular:400.38Ref: TM-T12422
1mg130,00€1mL*10mM (DMSO)195,00€5mg222,00€10mg334,00€25mg578,00€50mg838,00€100mg1.251,00€MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Fórmula:C19H22N6OSPureza:99.38% - 99.67%Forma y color:SolidPeso molecular:382.48BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Fórmula:C28H31F6NO3Pureza:98.4%Forma y color:SolidPeso molecular:543.54Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Fórmula:C29H39N7O8S2Forma y color:White SolidPeso molecular:677.79PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Fórmula:C25H21N3O6SPureza:98%Forma y color:SolidPeso molecular:491.52Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Fórmula:C23H24F2N2O5Pureza:99.47% - 99.64%Forma y color:White SolidPeso molecular:446.44GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Fórmula:C21H25N7O2SPureza:99.90% - 99.97%Forma y color:White SolidPeso molecular:439.53Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C30H29N9O2Pureza:98%Forma y color:SolidPeso molecular:547.61Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C22H21N9O2Pureza:98%Forma y color:SolidPeso molecular:443.46CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Fórmula:C23H19N5O2Forma y color:SolidPeso molecular:397.43Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Fórmula:C14H16N6OPureza:99.62% - 99.87%Forma y color:SolidPeso molecular:284.32Ref: TM-T12913
2mg38,00€5mg59,00€1mL*10mM (DMSO)64,00€10mg94,00€25mg175,00€50mg280,00€100mg434,00€200mg612,00€Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Forma y color:SolidPeso molecular:519.62Ref: TM-T15381
1mg175,00€5mg394,00€1mL*10mM (DMSO)492,00€10mg582,00€25mg888,00€50mg1.243,00€100mg1.674,00€PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Fórmula:C18H20ClN5OPureza:98.75%Forma y color:SolidPeso molecular:357.84Ref: TM-T28352
1mg37,00€5mg70,00€1mL*10mM (DMSO)79,00€10mg88,00€25mg144,00€50mg207,00€100mg309,00€200mg440,00€TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Fórmula:C26H19F3N4OPureza:99.21%Forma y color:SolidPeso molecular:460.45Ref: TM-T13189
1mg87,00€2mg114,00€5mg177,00€1mL*10mM (DMSO)178,00€10mg264,00€25mg460,00€50mg668,00€100mg945,00€500mg1.783,00€
