PDE
Las fosfodiesterasas (PDEs) son enzimas que hidrolizan nucleótidos cíclicos, como el AMPc y el GMPc, en sus formas inactivas, desempeñando un papel clave en la regulación de las vías de señalización intracelular. Los inhibidores de PDE se utilizan en el tratamiento de diversas afecciones, como enfermedades cardiovasculares, disfunción eréctil y trastornos respiratorios, debido a su capacidad para modular los niveles de nucleótidos cíclicos. En CymitQuimica, ofrecemos una gama de inhibidores de PDE para apoyar su investigación en señalización celular, farmacología y desarrollo terapéutico.
Se han encontrado 170 productos de "PDE"
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MK-8189
CAS:MK-8189 is a potent and selective pyrimidine PDE10A inhibitor, with excellent PDE (phosphodiesterase) selectivity for the treatment of schizophrenia.Fórmula:C19H22N6OSPureza:99.38% - 99.67%Forma y color:SolidPeso molecular:382.48PDE5-IN-2
CAS:PDE5-IN-2 is a potent, highly selective, and orally active inhibitor of PDE5(IC50 of 0.31 nM)Fórmula:C25H21N3O6SPureza:98%Forma y color:SolidPeso molecular:491.52Difamilast
CAS:Difamilast is a selective inhibitor of phosphodiesterase-4 (PDE4) with particularly efficient inhibition of subtype B (IC50=11.2 nM).Fórmula:C23H24F2N2O5Pureza:99.47% - 99.64%Forma y color:SolidPeso molecular:446.44GSK356278
CAS:GSK356278: selective PDE4A/B/D inhibitor, pIC50~8.7, anti-inflammatory, anxiolytic, cognition-enhancing.Fórmula:C21H25N7O2SPureza:99.90% - 99.97%Forma y color:SolidPeso molecular:439.53Autotaxin-IN-5
CAS:Autotaxin-IN-5 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C30H29N9O2Pureza:98%Forma y color:SolidPeso molecular:547.61PF-04957325
CAS:PF-04957325 is an inhibitor of PDE8.PF-04957325 has an IC50 of 0.7 nM for PDE8A.PF-04957325 can be used for the study of autoimmune encephalomyelitis.Fórmula:C14H15F3N8OSPureza:99.02%Forma y color:SolidPeso molecular:400.38Ref: TM-T12422
1mg130,00€1mL*10mM (DMSO)195,00€5mg222,00€10mg334,00€25mg578,00€50mg838,00€100mg1.251,00€Autotaxin-IN-4
CAS:Autotaxin-IN-4 is an Autotaxin inhibitor. It has the potential to treat idiopathic pulmonary fibrosis.Fórmula:C22H21N9O2Pureza:98%Forma y color:SolidPeso molecular:443.46Siguazodan
CAS:Siguazodan (SKF 94836) is an effective, selective, orally active phosphodiesterase III ((PDE-III)) inhibitor with an IC50 of 117 nM.Fórmula:C14H16N6OPureza:99.62% - 99.87%Forma y color:SolidPeso molecular:284.32Ref: TM-T12913
2mg38,00€5mg59,00€1mL*10mM (DMSO)64,00€10mg94,00€25mg175,00€50mg280,00€100mg434,00€200mg612,00€Adibendan
CAS:Adibendan (Adibendanum) is a selective inhibitor of PDE3 with an IC50 of 2.0 μM.Fórmula:C16H14N4OPureza:99.52% - >99.99%Forma y color:SolidPeso molecular:278.31Gisadenafil
CAS:Gisadenafil (UK-369003) is a selective inhibitor of phosphodiesterase 5 (PDE5) with an IC50 of 3.6 nM and prevents degradation of cGMP.Fórmula:C23H33N7O5SPureza:98.82% - 99.50%Forma y color:SolidPeso molecular:519.62Ref: TM-T15381
1mg175,00€5mg394,00€1mL*10mM (DMSO)492,00€10mg582,00€25mg888,00€50mg1.243,00€100mg1.674,00€CI-1044
CAS:CI-1044 is an inhibitor of PDE4 (IC50s: 0.29, 0.08, 0.56, 0.09 μM for PDE4A5, PDE4B2, PDE4C2 and PDE4D3).Fórmula:C23H19N5O2Forma y color:SolidPeso molecular:397.43BIO-32546
CAS:BIO-32546 (S-isomer) is a highly potent regulator of autotaxin (ATX) with an IC50 value of 1 nM.Fórmula:C28H31F6NO3Pureza:98.4%Forma y color:SolidPeso molecular:543.54Gisadenafil besylate
CAS:Gisadenafil besylate (UK 369003-26) is a potent and orally active PDE5 inhibitor, for lower urinary tract symptoms associated with benign prostatic hyperplasia.Fórmula:C29H39N7O8S2Forma y color:SolidPeso molecular:677.79TP-10
CAS:TP-10 is a selective inhibitor of PDE10A against other PDEs with IC50 of 0.8 nM.Fórmula:C26H19F3N4OPureza:99.21%Forma y color:SolidPeso molecular:460.45Ref: TM-T13189
1mg87,00€2mg114,00€5mg177,00€1mL*10mM (DMSO)178,00€10mg264,00€25mg460,00€50mg668,00€100mg945,00€500mg1.783,00€Enpp-1-IN-16
CAS:Enpp-1-IN-16 is an ENPP1 inhibitor, yo anti-cancer activity.Enpp-1-IN-16 can be used to study insulin resistance and chondrocalcinosis.Fórmula:C23H32N4O4Pureza:99.87%Forma y color:SolidPeso molecular:428.52Cudetaxestat
CAS:Cudetaxestat (BLD-0409) is a potent inhibitor of orally active autotaxin.Fórmula:C21H15Cl2F2N3O2SPureza:99.9%Forma y color:SolidPeso molecular:482.33Ref: TM-T63190
1mg73,00€5mg161,00€1mL*10mM (DMSO)166,00€10mg235,00€25mg420,00€50mg627,00€100mg880,00€200mg1.161,00€PDE9-IN-(S)-C33
CAS:PDE9-IN-(S)-C33: potent PDE9 inhibitor with 11 nM IC50, for CNS diseases and diabetes study.Fórmula:C18H20ClN5OPureza:98.75%Forma y color:SolidPeso molecular:357.84Ref: TM-T28352
1mg37,00€5mg70,00€1mL*10mM (DMSO)79,00€10mg88,00€25mg144,00€50mg207,00€100mg309,00€200mg440,00€TPN171
CAS:TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6, which has the potential for the treatment of pulmonary
Fórmula:C24H35N5O3Pureza:>99.99%Forma y color:SolidPeso molecular:441.57AMG 579
CAS:AMG 579 is an efficacious and selective inhibitor of PDE10A (IC50 = 0.1 nM).Fórmula:C25H23N5O3Pureza:99.87%Forma y color:SolidPeso molecular:441.48Ref: TM-T14217
25mgA consultar50mgA consultar1mg34,00€2mg44,00€5mg70,00€1mL*10mM (DMSO)78,00€10mg100,00€PDE1-IN-7
CAS:PDE1-IN-7 (Compound 13h), with an IC50 value of 10 nM, selectively inhibits bPDE1. This compound demonstrates significant anti-fibrotic effects in a BDL-induced liver fibrosis rat model and is useful for research purposes in studying liver fibrosis [1].Fórmula:C32H36F2N2O6SForma y color:SolidPeso molecular:614.7
