Glucoquinasa
La glucocinasa (GK) es una enzima que cataliza la fosforilación de la glucosa a glucosa-6-fosfato, un paso crítico en la glucólisis. La GK se expresa predominantemente en el hígado y el páncreas, donde desempeña un papel clave en la regulación de los niveles de glucosa en sangre. Los inhibidores de GK son de interés en el estudio de trastornos metabólicos como la diabetes, ya que pueden modular el metabolismo de la glucosa y la secreción de insulina. En CymitQuimica, ofrecemos inhibidores de glucocinasa para apoyar su investigación en diabetes, metabolismo y desarrollo terapéutico.
Se han encontrado 54 productos de "Glucoquinasa"
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Dorzagliatin
CAS:<p>Dorzagliatin (HMS5552) is a dual-acting glucokinase (GK) activator. It also improves glycaemic control and pancreatic β-cell function in type 2 diabetes.</p>Fórmula:C22H27ClN4O5Pureza:98.67% - 99.45%Forma y color:SolidPeso molecular:462.93KAN0438757
CAS:<p>KAN0438757 is a selective and potent inhibitor of the metabolic kinase PFKFB3 with an IC50 of 0.19 μM.</p>Fórmula:C21H18FNO7SPureza:99.34%Forma y color:SolidPeso molecular:447.43Oxfendazole
CAS:<p>Oxfendazole (RS-8858), a broad spectrum benzimidazole anthelmintic, protects livestock against roundworm, strongyles and pinworms.</p>Fórmula:C15H13N3O3SPureza:98.99% - 99.17%Forma y color:White To Yellowish PowderPeso molecular:315.35WAY-640509
CAS:<p>WAY-640509 is a glucocerebrosidase inhibitor.</p>Fórmula:C25H23N5O4SPureza:99.36%Forma y color:SolidPeso molecular:489.55MK-0941 free base
CAS:<p>MK-0941: an oral glucokinase activator for type 2 diabetes with potent glucose-lowering effects.</p>Fórmula:C21H24N4O6SPureza:98.75%Forma y color:SolidPeso molecular:460.5MitoPQ
CAS:<p>MitoPQ (MitoParaquat) inhibits insulin-stimulated glucose uptake and plasma membrane translocation in myotubes and can be used to study oxidative stress.</p>Fórmula:C39H46I3N2PPureza:99.91% - ≥98%Forma y color:SolidPeso molecular:954.48ML251
CAS:<p>ML251, potent inhibitor, targets T. brucei PFK (IC50=0.37μM) & T. cruzi PFK (IC50=0.13μM), aids parasite research.</p>Fórmula:C17H13Cl2N3O4SPureza:99.87%Forma y color:SolidPeso molecular:426.27ML266
CAS:<p>ML266: GCase chaperone, non-inhibiting, IC50=2.5 µM, aids mutant protein transport, may help in Gaucher disease study.</p>Fórmula:C24H22BrN3O4Pureza:99.58%Forma y color:SolidPeso molecular:496.35(1S,2R)-Globalagliatin
CAS:<p>(1S,2R)-Globalagliatin is a highly potent glucokinase (GK) activator for the study of type 2 diabetes.</p>Fórmula:C28H37N3O3S3Pureza:99.09% - >99.99%Forma y color:SoildPeso molecular:559.81WAY-615145
CAS:WAY-615145 is a compound that activates glucokinase.Fórmula:C16H18N2OSPeso molecular:286.39AP-III-a4 hydrochloride
CAS:<p>AP-III-a4 hydrochloride (ENOblock hydrochloride) is a direct enolase (enolase) inhibitor that inhibit metastasis and affect glucose homeostasis.</p>Fórmula:C31H44ClFN8O3Pureza:98%Forma y color:SolidPeso molecular:631.18ADP-specific glucokinase
CAS:<p>ADP-specific glucokinase, expressed in thermophilic archaea, is an ADP-specific enzyme that catalyzes the conversion of glucose to glucose-6-phosphate, thereby facilitating glycolysis. This enzyme can activate T cells and enhance the phagocytic activity of macrophages. It is used in research related to metabolic disorders, neurological diseases, and tumors.</p>Forma y color:SolidGlucokinase Protein, Human, Recombinant
<p>Glucokinase belongs to the bacterial glucokinase family.</p>Forma y color:Lyophilized PowderPeso molecular:52.2 kDa (predicted); 52.2 kDa (reducing conditions)Anti-Glucokinase Antibody (3U461)
<p>Anti-Glucokinase Antibody (3U461) is a Rabbit antibody targeting Glucokinase. Anti-Glucokinase Antibody (3U461) can be used in ELISA.</p>Forma y color:Odour LiquidAnti-Glucokinase Antibody (5Q209)
<p>Anti-Glucokinase Antibody (5Q209) is a Mouse antibody targeting Glucokinase. Anti-Glucokinase Antibody (5Q209) can be used in ELISA.</p>Forma y color:Odour LiquidPF-04991532
CAS:<p>PF-04991532 is a hepatoselective glucokinase activator that reduces plasma glucose and AMP concentrations in the Goto-Kakizaki rat model.</p>Fórmula:C18H19F3N4O3Pureza:99.99%Forma y color:SolidPeso molecular:396.365MPN
CAS:<p>5MPN is a PFKFB4 inhibitor that inhibits the F6P binding site and suppresses the proliferation of myeloma cells.</p>Fórmula:C15H19N3O4Pureza:98.92% - 99.69%Forma y color:SolidPeso molecular:305.33Cadisegliatin
CAS:<p>Cadisegliatin (TTP-399) may activate liver GK to lower blood sugar in type 2 diabetes studies.</p>Fórmula:C21H33N3O4S2Forma y color:SolidPeso molecular:455.63ML198
CAS:<p>ML198: Activates & chaperones glucocerebrosidase; a potential Gaucher disease treatment lead.</p>Fórmula:C17H14N4OPureza:98.31%Forma y color:SolidPeso molecular:290.32Globalagliatin
CAS:<p>Globalagliatin (LY2608204) has been used in trials studying the treatment of Diabetes Mellitus, Type 2.</p>Fórmula:C28H37N3O3S3Pureza:98% - 99.49%Forma y color:SolidPeso molecular:559.81AM-2394
CAS:<p>AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate.</p>Fórmula:C22H25N5O4Pureza:99.01% - 99.62%Forma y color:SolidPeso molecular:423.463PO
CAS:<p>3PO inhibits PFKFB3 (IC50: 22.9 µM) and cancer cell growth (IC50: 1.4-24 µM), reducing glucose uptake and key cellular metabolites.</p>Fórmula:C13H10N2OPureza:99.56% - 99.67%Forma y color:SolidPeso molecular:210.23Palmitelaidic Acid
CAS:Palmitelaidic Acid (trans-Palmitoleic acid) is one of the most abundant fatty acids in serum and tissue.Fórmula:C16H30O2Pureza:99.76%Forma y color:SolidPeso molecular:254.41(E)-3PO
CAS:<p>(E)-3PO is a PFKFB3 (6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase) inhibitor.</p>Fórmula:C13H10N2OPureza:98.8% - 98.92%Forma y color:SolidPeso molecular:210.23PFK-015
CAS:<p>PFK-015 (PFK15) is an effective inhibitor of PFKFB3 (IC50: 110 nM) and inhibits PFKFB3 activity in Y cells (IC50: 20 nM).</p>Fórmula:C17H12N2OPureza:99.7% - 99.85%Forma y color:SolidPeso molecular:260.29Genz-123346 free base
CAS:<p>Genz 123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1.</p>Fórmula:C24H38N2O4Pureza:99.41%Forma y color:SolidPeso molecular:418.57AMG-3969
CAS:<p>AMG-3969 is an effective glucokinase-glucokinase regulatory protein interaction (GK-GKRP) disruptor (IC50: 4 nM).</p>Fórmula:C21H20F6N4O3SPureza:99.65%Forma y color:SolidPeso molecular:522.46Glucokinase activator 1
CAS:<p>Glucokinase activator 1 is a liver-directed glucokinase activator (EC50: 34 nM).</p>Fórmula:C27H20F2N2O7S2Pureza:98%Forma y color:SolidPeso molecular:586.58RO-28-1675
CAS:<p>RO-28-1675 is a direct and selective glucokinase activator, the GK/GKRP complex,insulin secretion and type 2 diabetes.</p>Fórmula:C18H22N2O3S2Pureza:98.13%Forma y color:SolidPeso molecular:378.51PSN-GK1
CAS:<p>PSN-GK1 is a potent activator of glucokinase (EC50: 0.13 μM).</p>Fórmula:C20H23FN2O4S2Pureza:98%Forma y color:SolidPeso molecular:438.54GKA-22
CAS:<p>GKA-22 is a human glucokinase allosteric activator in the absence of glucose.</p>Fórmula:C22H22N2O5SPureza:98%Forma y color:SolidPeso molecular:426.49Piragliatin
CAS:<p>Piragliatin (RO4389620) activates glucokinase, boosts insulin, and lowers glucose in type 2 diabetes.</p>Fórmula:C19H20ClN3O4SForma y color:SolidPeso molecular:421.9IHVR-11029
CAS:<p>IHVR-11029 inhibits ER α-glucosidase, combats hemorrhagic fever viruses, and hinders enveloped virus morphogenesis.</p>Fórmula:C18H27F2NO5Forma y color:SolidPeso molecular:375.41GKA-71
CAS:<p>GKA-71 is an effective glucokinase activator (GKA).</p>Fórmula:C21H23N3O6S2Forma y color:SolidPeso molecular:477.55Glucokinase activator 3
CAS:<p>Glucokinase activator 3: potent GK activator, AC50=38 nM, potential for type 2 diabetes research.</p>Fórmula:C26H33N2O9PS2Forma y color:SolidPeso molecular:612.65PF-04279405
CAS:<p>PF-04279405 is a potent and selective glucokinase activator.</p>Fórmula:C25H25FN4O4Forma y color:SolidPeso molecular:464.49Cefetrizole
CAS:<p>Ceftezole is an α-Glucosidase inhibitor (IC50: 2.1 μM; Ki: 0.578 μM).</p>Fórmula:C16H15N5O4S3Pureza:98%Forma y color:SolidPeso molecular:437.52YZ9
CAS:<p>Y29 is a potent PFKFB3 inhibitor with an IC50 of 0.183 µM, and acts as a competitive inhibitor against Fru-6-P with a Ki of 0.094 µM[1].</p>Fórmula:C12H10O5Pureza:99.59%Forma y color:SolidPeso molecular:234.2AMG-1694
CAS:<p>AMG-1694 disrupts GK-GKRP complex, enhancing GK activity with 7 nM IC50; normalizes glucose in diabetic rodents without affecting normoglycemic animals.</p>Fórmula:C23H30F3N3O4S2Pureza:98.37%Forma y color:SolidPeso molecular:533.63AR453588
CAS:<p>AR453588 is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Fórmula:C25H25N7O2S2Forma y color:SolidPeso molecular:519.64AZD1092
CAS:<p>AZD1092 is the glucokinase enzyme activator.</p>Fórmula:C24H26N4O5Pureza:98%Forma y color:SolidPeso molecular:450.49AR453588 hydrochloride
CAS:<p>AR453588 hydrochloride is an orally bioavailable anti-diabetic glucokinase activator (EC50: 42 nM) with anti-hyperglycemic activity.</p>Fórmula:C25H26ClN7O2S2Pureza:98%Forma y color:SolidPeso molecular:556.1CM-10-18
CAS:<p>CM-10-18: potent ER α-glucosidase inhibitor, strong antiviral against hemorrhagic fever viruses, protects mice from dengue fatality.</p>Fórmula:C17H35NO5Forma y color:SolidPeso molecular:333.46PF-04937319
CAS:<p>PF-04937319 activates glucokinase (EC50=154.4μM) with low hypoglycemia risk, researched for type 2 diabetes treatment.</p>Fórmula:C22H20N6O4Pureza:99.89%Forma y color:SolidPeso molecular:432.43AZD-1656
CAS:<p>AZD-1656 is a glucokinase activator (GKA) that can cause dose-limiting hypoglycemia in normal animals used in embryofetal development studies and type 2</p>Fórmula:C24H26N6O5Pureza:97.07% - 99.37%Forma y color:SolidPeso molecular:478.5KDM4-IN-2
CAS:<p>KDM4-IN-2 is a potent and selective KDM4/KDM5 dual inhibitor with Kis of 4 and 7 nM for KDM4A and KDM5B, respectively.</p>Fórmula:C25H26N6OPureza:98%Forma y color:SolidPeso molecular:426.51WAY-297848
CAS:<p>WAY-297848 is a novel glucokinase activator for the prevention or treatment of hyperglycemia, diabetes mellitus, obesity, dyslipidemia, and metabolic syndrome.</p>Fórmula:C13H13ClN2O2SPureza:98.19%Forma y color:SolidPeso molecular:296.77Glucokinase activator 7
CAS:<p>Glucokinase activator7 is an activator of glucose kinase (Glucokinase) and can be utilized in research on diabetes and hyperglycemia [refer to compound on page 176].</p>Fórmula:C14H13N3O2SForma y color:SolidPeso molecular:287.337GKA50 quarterhydrate
<p>GKA50 quarterhydrate: glucokinase activator, EC50 of 33 nM, boosts insulin, cuts glucose in rats.</p>Fórmula:C26H30N2O7Forma y color:SolidPeso molecular:469.01Gcase activator 2
CAS:<p>Gcase activator 2 is a β-glucocerebrosidase activator that induces dimerization of GCase, increases lysosomal substrate metabolism.</p>Fórmula:C21H24N4O2Pureza:99.51% - 99.76%Forma y color:SolidPeso molecular:364.44
