Caseína quinasa
Las caseína quinasas son una familia de quinasas de proteínas serina/treonina que regulan varios procesos celulares, incluyendo la reparación del ADN, los ritmos circadianos y la transducción de señales. Estas quinasas están involucradas en la fosforilación de numerosas proteínas y están implicadas en enfermedades como el cáncer, los trastornos neurodegenerativos y los síndromes metabólicos. En CymitQuimica, ofrecemos una selección de inhibidores de caseína quinasa para apoyar su investigación en transducción de señales, regulación del ciclo celular y desarrollo terapéutico.
Se han encontrado 130 productos de "Caseína quinasa"
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CK1δ-IN-5
CAS:<p>CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.</p>Fórmula:C22H21N5Forma y color:SolidPeso molecular:355.436Casein kinase 1δ-IN-27
CAS:<p>Casein kinase1δ-IN-27 (Compound 8) is an inhibitor of casein kinase 1 (CK1), effectively inhibiting CK1α, CK1δ, CK1ε, and p38α with IC50 values of 22, 16.5, 9.41, and 14.8 nM, respectively. It also suppresses DUX4 expression, with an IC50 of 10 nM.</p>Fórmula:C21H19FN6Forma y color:SolidPeso molecular:374.414CK1δ-IN-7
CAS:<p>CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).</p>Fórmula:C23H23N5OForma y color:SolidPeso molecular:385.462p38α inhibitor 8
CAS:<p>p38α inhibitor8 (Compound 1) demonstrates inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.21 µM and 0.202 µM, respectively.</p>Fórmula:C17H13FN6Forma y color:SolidPeso molecular:320.324dCK1α-2
<p>dCK1α-2 is an orally effective CK1α molecular glue (Molecular Glue) degrader that targets p53 pathway-related targets. It demonstrates antitumor efficacy in mouse models by enhancing the expression of p53-related genes.</p>Fórmula:C24H24ClN5O4Forma y color:SolidPeso molecular:481.93CK1δ-IN-9
CAS:<p>CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.</p>Fórmula:C16H12FN5Forma y color:SolidPeso molecular:293.298Casein kinase 1δ-IN-31
CAS:<p>Casein kinase1δ-IN-31 (Compound 16) is an inhibitor of casein kinase (CK), specifically targeting CK1α, CK1δ, and p38α, with IC50 values of 196 nM, 17 nM, and 18 nM, respectively. Additionally, Casein kinase1δ-IN-31 inhibits Double Homeobox 4 (DUX4) with an IC50 of 1200 nM.</p>Fórmula:C17H13FN4Forma y color:SolidPeso molecular:292.31MGD-28
CAS:<p>MGD-28 is a Cullin-CRBN-dependent IKZF family protein degrader for IKZF1 (Ikaros), IKZF2 (Helios), IKZF3 (Aiolos) ,and CK1α, antiproliferative.</p>Fórmula:C33H34FN7O3Pureza:99.39%Forma y color:SolidPeso molecular:595.67CK1δ-IN-10
CAS:<p>CK1δ-IN-10 (Compound 85) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ (CSNKID), with an IC50 value of 0.255 μM.</p>Fórmula:C17H11F4N5Forma y color:SolidPeso molecular:361.296Casein kinase 1δ-IN-16
CAS:<p>Casein kinase1δ-IN-16 (compound 506) is an inhibitor of casein kinase 1δ (CK1δ). This compound is applicable in research related to neurodegenerative diseases.</p>Fórmula:C17H12N4S2Forma y color:SolidPeso molecular:336.434CK1δ-IN-8
CAS:<p>CK1δ-IN-8 (Compound 429) is a CK1δ inhibitor suitable for Alzheimer's disease research.</p>Fórmula:C14H9N3O2S2Forma y color:SolidPeso molecular:315.37Casein kinase 1δ-IN-30
CAS:<p>Casein kinase1δ-IN-30 (Compound 581) is an inhibitor of casein kinase 1δ (CK1δ). It can be utilized in research related to neurodegenerative diseases.</p>Fórmula:C18H15BrN6O2SForma y color:SolidPeso molecular:459.32p38α MAPK/CK1δ inhibitor-1
CAS:<p>p38αMAPK/CK1δ inhibitor-1 (Compound 3) exhibits inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.185 µM and 0.089 µM, respectively.</p>Fórmula:C24H17FN6O2Forma y color:SolidPeso molecular:440.429Casein kinase 1δ-IN-18
CAS:<p>Casein kinase1δ-IN-18 (compound 660) is an inhibitor of casein kinase 1δ (CK1δ), which can be utilized for research in neurodegenerative diseases.</p>Fórmula:C16H12ClN3O2S2Forma y color:SolidPeso molecular:377.868(R,R)-BMS-986397
CAS:<p>(R,R)-BMS-986397 is a CK1α degrader with a DC50 ranging from 0.1 to 0.5 pM. This compound is applicable in leukemia research.</p>Fórmula:C21H16ClF3N4O4Forma y color:SolidPeso molecular:480.82DEG-35
CAS:<p>DEG-35 is a CRBN-dependent bifunctional degrader targeting IKZF2 and CK1α, with DC50 values of 1.4 nM and 4.4 nM for CK1α and IKZF2, respectively. It activates the p53 apoptotic pathway and is applicable for research related to acute myeloid leukemia (AML).</p>Fórmula:C25H21N3O5Forma y color:SolidPeso molecular:443.45AMG-548 dihydrochloride
<p>AMG-548 dihydrochloride, an oral p38α inhibitor (Ki: 0.5 nM), selectively targets p38β, γ, δ, inhibits TNFα (IC50: 3 nM), and suppresses Wnt signaling.</p>Fórmula:C29H29Cl2N5OForma y color:SolidPeso molecular:534.48Casein kinase 1δ-IN-26
CAS:<p>Casein kinase1δ-IN-26 (compound 505) is a potent inhibitor of casein kinase 1δ. This compound is applicable in research related to neurodegenerative disorders such as Alzheimer’s disease.</p>Fórmula:C16H13N3O4SForma y color:SolidPeso molecular:343.357AMG-548 hydrochloride
<p>AMG-548 hydrochloride: orally active, p38α inhibitor (Ki=0.5 nM), 1000x less for p38γ/δ, also blocks TNFα (IC50=3 nM) & inhibits casein kinase 1 δ/ε.</p>Fórmula:C29H28ClN5OForma y color:SolidPeso molecular:498.02CK2 inhibitor 3
<p>CK2 inhibitor 3: potent CK2 blocker, IC50 of 280 nM, suppresses tumor cell growth, highly selective among 320 kinases.</p>Fórmula:C13H9BrN4O3SForma y color:SolidPeso molecular:381.2
