Caseína quinasa
Las caseína quinasas son una familia de quinasas de proteínas serina/treonina que regulan varios procesos celulares, incluyendo la reparación del ADN, los ritmos circadianos y la transducción de señales. Estas quinasas están involucradas en la fosforilación de numerosas proteínas y están implicadas en enfermedades como el cáncer, los trastornos neurodegenerativos y los síndromes metabólicos. En CymitQuimica, ofrecemos una selección de inhibidores de caseína quinasa para apoyar su investigación en transducción de señales, regulación del ciclo celular y desarrollo terapéutico.
Se han encontrado 143 productos para "Caseína quinasa".
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Casein kinase 1δ-IN-10
CAS:Casein kinase 1δ-IN-10 is an inhibitor of casein kinase 1δ (CK1δ).Fórmula:C21H17N3O3Pureza:98%Forma y color:SolidPeso molecular:359.38Casein kinase 1δ-IN-4
CAS:Casein kinase 1δ-IN-4 is a selective CK1δ inhibitor; modulates circadian rhythm; used for sleep disorders and cancer.Fórmula:C16H12N6SPureza:99.89%Forma y color:White SolidPeso molecular:320.37XL413 hydrochloride
CAS:XL413 hydrochloride (BMS-863233 Hydrochloride) is a potent, selective and ATP competitive inhibitor of Cdc7. XL413 hydrochloride also inhibits CK2 and PIM1.Fórmula:C14H13Cl2N3O2Pureza:98.81% - 99.8%Forma y color:SolidPeso molecular:326.18Ref: TM-T6735
1mg50,00€5mg109,00€10mg152,00€25mg268,00€50mg447,00€100mg672,00€200mg888,00€500mg1.369,00€Dinoxyline
CAS:Dinoxyline is a potent dopamine receptor agonist, with dissociation constants (Ki values) for D1, D2, D3, and D4 receptors being 7 nM, 6 nM, 5 nM, and 43 nM, respectively. It is utilized in neuroscience research.Fórmula:C15H13NO3Forma y color:SolidPeso molecular:255.27Casein Kinase II Inhibitor IV Hydrochloride
CAS:Casein Kinase II Inhibitor IV HCl promotes keratinocyte differentiation, potential for skin disorder therapy.Fórmula:C24H24ClN5O3Pureza:98%Forma y color:SolidPeso molecular:465.93CK2-IN-3
CK2-IN-3: potent, selective CK2 inhibitor; Kd=12 nM, IC50: 1.51 μM (CK2α), 7.64 μM (CK2α'). For cancer research.Fórmula:C22H26N4O7Forma y color:SolidPeso molecular:458.46Casein kinase 1δ-IN-23
CAS:Casein kinase1δ-IN-23 (compound 423) is an effective inhibitor of casein kinase1δ. It is applicable in research related to neurodegenerative diseases such as Alzheimer's disease.Fórmula:C19H15N3O3SForma y color:SolidPeso molecular:365.406Casein kinase 1δ-IN-13
CAS:Casein kinase1δ-IN-13 (compound 401) is an inhibitor of Casein kinase1δ. It is utilized in the research of neurodegenerative diseases.Fórmula:C15H13N3O2SForma y color:SolidPeso molecular:299.35TMX-4113
TMX-4113 has potential to be used in cancer that is a phosphodiesterase 6D(PDE6D) and casein kinase 1α(CK1α) degrader [1].Fórmula:C12H12N4O2S2Forma y color:SolidPeso molecular:308.38Casein kinase 1δ-IN-17
CAS:Casein kinase1δ-IN-17 (compound 753) is an inhibitor of casein kinase 1δ (CK1δ). It is applicable in research related to neurodegenerative diseases.Fórmula:C14H14N4SForma y color:SolidPeso molecular:270.353Casein kinase 1δ-IN-28
CAS:Casein kinase1δ-IN-28 (Compound 4) is an inhibitor of CK1ε, with an IC50 of 0.0146 μM. The human liver microsome metabolism rate for Casein kinase1δ-IN-28 is 52%.Fórmula:C23H23FN6Forma y color:SolidPeso molecular:402.467CK1δ-IN-6
CAS:CK1δ-IN-6 (Compound 303) is an inhibitor of Casein kinase 1δ, with potential applications in Alzheimer's disease research.Fórmula:C23H17N3O4Forma y color:SolidPeso molecular:399.399WAY-606344
CAS:WAY-606344 (Compound 97) is an inhibitor of Casein kinase 1δ and shows potential for Alzheimer's disease research.Fórmula:C14H8ClN3O2Forma y color:SolidPeso molecular:285.685CK1δ-IN-5
CAS:CK1δ-IN-5 (Compound 24) is an inhibitor of casein kinase 1δ (CK1δ) and can be used in the study of neurodegenerative diseases.Fórmula:C22H21N5Forma y color:SolidPeso molecular:355.436Casein kinase 1δ-IN-27
CAS:Casein kinase1δ-IN-27 (Compound 8) is an inhibitor of casein kinase 1 (CK1), effectively inhibiting CK1α, CK1δ, CK1ε, and p38α with IC50 values of 22, 16.5, 9.41, and 14.8 nM, respectively. It also suppresses DUX4 expression, with an IC50 of 10 nM.Fórmula:C21H19FN6Forma y color:SolidPeso molecular:374.414CK1δ-IN-7
CAS:CK1δ-IN-7 (Compound 488) is an inhibitor of casein kinase 1δ (CK1δ).Fórmula:C23H23N5OForma y color:SolidPeso molecular:385.462p38α inhibitor 8
CAS:p38α inhibitor8 (Compound 1) demonstrates inhibitory activity against p38αMAPK and CK1δ, with IC50 values of 0.21 µM and 0.202 µM, respectively.Fórmula:C17H13FN6Forma y color:SolidPeso molecular:320.324BMS-135
CAS:BMS-135 is a potent and selective ATP-competitive inhibitor of casein kinase 2 (CK2), with IC50 values of 0.8 nM for CK2α and 0.3 nM for CK2α' isoforms. It mimics the structure of ATP, binding to the active site of CK2 and inhibiting its serine/threonine phosphorylating activity. BMS-135 effectively inhibits cell proliferation and demonstrates antitumor properties, making it useful for research in colon cancer.Fórmula:C22H23ClN10O3Peso molecular:510.94dCK1α-2
dCK1α-2 is an orally effective CK1α molecular glue (Molecular Glue) degrader that targets p53 pathway-related targets. It demonstrates antitumor efficacy in mouse models by enhancing the expression of p53-related genes.Fórmula:C24H24ClN5O4Forma y color:SolidPeso molecular:481.93CK1δ-IN-9
CAS:CK1δ-IN-9 (Compound 8) is an inhibitor of casein kinase 1 (CK1), specifically targeting CK1δ with an IC50 of 1.4 nM. The compound also inhibits p38α and p38β with IC50 values of 0.25 μM and 0.78 μM, respectively. CK1δ-IN-9 exhibits favorable pharmacokinetic properties, including high oral bioavailability (70%) and moderate clearance.Fórmula:C16H12FN5Forma y color:SolidPeso molecular:293.298
