Factor Xa
El factor Xa es una enzima crucial en la cascada de coagulación que convierte la protrombina en trombina, lo que lleva a la formación de coágulos sanguíneos. La inhibición del factor Xa es una estrategia terapéutica ampliamente utilizada para prevenir y tratar los trastornos tromboembólicos, como la trombosis venosa profunda, la embolia pulmonar y el accidente cerebrovascular. En CymitQuimica, ofrecemos inhibidores del factor Xa para apoyar su investigación en hematología, salud cardiovascular y terapia anticoagulante.
Se han encontrado 90 productos para "Factor Xa".
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Razaxaban
CAS:Razaxaban (also known as BMS-561389 or DPC 906) is an oral inhibitor of Factor Xa, initially developed for the treatment of thrombosis.Fórmula:C24H20F4N8O2Forma y color:SolidPeso molecular:528.46FXIa-6f
CAS:FXIa-6f is a high affinity, orally bioavailable macrocyclic FXIa inhibitor with antithrombotic activity in preclinical speciesFórmula:C31H29ClF2N4O4Forma y color:SolidPeso molecular:595.04FXIa-IN-10
FXIa-IN-10 is a potent, orally bioavailable inhibitor of Activator XI (FXIa) (Ki: 0.17 nM).Fórmula:C23H18Cl2F3N9O2Forma y color:SolidPeso molecular:580.35DX-9065A HCl hydrate
CAS:DX-9065a: Competitive fXa/prothrombinase inhibitor; blocks proinflammatory events; Ki ~10-20 nM.Fórmula:C26H39ClN4O8Pureza:98%Forma y color:SolidPeso molecular:571.06FXIa-IN-6
CAS:FXIa-IN-6: Potent, selective FXIa inhibitor (Ki=0.3 nM); strong PK with high oral bioavailability, low clearance preclinically.Fórmula:C31H29ClF2N4O4Forma y color:SolidPeso molecular:595.04BAY 3389934
CAS:BAY 3389934 is a dual inhibitor of factor IIa (factor IIa) and factor Xa (factor Xa), providing anticoagulant and organ-protective effects. It alleviates coagulopathy and organ dysfunction in baboon models of Staphylococcus aureus sepsis.Fórmula:C26H30ClN5O7S2Forma y color:SolidPeso molecular:624.129FXIa-IN-9
CAS:FXIa-IN-9, a potent FXIa inhibitor (K i : human 0.17 nM, rabbit 0.5 nM), forms hydrogen bonds and has anticoagulant properties.Fórmula:C23H18Cl2F3N9O2Forma y color:SolidPeso molecular:580.35Cbz-QFR-kbt
CAS:Cbz-QFR-kbt is a ketobenzothiazolone-based TMPRSS2 inhibitor with an IC50 of 0.42 nM. It also exhibits inhibitory activity against Matriptase, Hepsin, HGFA, and Factor Xa, with IC50 values of 1, 1.3, 85, and 85 nM, respectively. Furthermore, Cbz-QFR-kbt demonstrates significant inhibitory effects on SARS-CoV-2 and H1N1 (IC50= 60 nM) and is applicable for antiviral research.Fórmula:C35H40N8O6SPeso molecular:700.82FXIa-IN-8
FXIa-IN-8: potent FXIa blocker (IC50: 14.2 nM), anti-thrombotic, low bleeding/toxicity risk.Forma y color:SolidFXa-IN-3
CAS:FXa-IN-3 (compound 1a) is a potent inhibitor of coagulation factor Xa (FXa), exhibiting a Ki of 43 nM. It is applicable in the study of thromboembolic disorders.Fórmula:C20H17ClN4O3S2Peso molecular:460.96
