Deshidrogenasa
Las deshidrogenasas son enzimas involucradas en las reacciones de oxidación-reducción de las vías metabólicas, desempeñando un papel central en la producción de energía y la respiración celular. Estas enzimas son cruciales para procesos como el ciclo del ácido cítrico, la glucólisis y la oxidación de ácidos grasos. Los inhibidores de deshidrogenasas son herramientas importantes en el estudio de enfermedades metabólicas, cáncer y estrés oxidativo. En CymitQuimica, ofrecemos una selección completa de inhibidores de deshidrogenasas para apoyar su investigación en metabolismo, biología del cáncer y bioquímica.
Se han encontrado 319 productos para "Deshidrogenasa".
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LY 345899
CAS:LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM forFórmula:C20H21N7O7Pureza:99.7%Forma y color:SolidPeso molecular:471.42Ref: TM-T15827
1mg46,00€5mg152,00€1mL*10mM (DMSO)157,00€10mg224,00€25mg371,00€50mg522,00€100mg713,00€200mg982,00€Trilostane
CAS:Trilostane (Win 24540) is a synthetic derivative of androstane with adrenocortical suppressive properties.Fórmula:C20H27NO3Pureza:99.46% - >99.99%Forma y color:Tan CrystalsPeso molecular:329.43CAY10566
CAS:CAY10566 is a potent SCD1 inhibitor, orally bioavailable, with IC50s: HepG2 cells, 7.9nM; mouse, 4.5nM; human, 26nM.Fórmula:C18H17ClFN5O2Pureza:99.54% - 99.75%Forma y color:SolidPeso molecular:389.81Ref: TM-T14878
1mg48,00€1mL*10mM (DMSO)112,00€5mg131,00€10mg195,00€25mg353,00€50mg505,00€100mg710,00€200mg954,00€KPLH1130
CAS:KPLH1130, a PDK inhibitor, boosts glucose tolerance and reduces inflammation in high-fat diet mice.Fórmula:C15H13N3O3Pureza:99.07%Forma y color:SolidPeso molecular:283.28Ref: TM-T11765
1mg79,00€1mL*10mM (DMSO)178,00€5mg205,00€10mg333,00€25mg560,00€50mg797,00€100mg1.071,00€500mg2.187,00€MTHFD2-IN-1
MTHFD2-IN-1 (compound 12) is a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Fórmula:C24H21NO6Forma y color:SolidPeso molecular:419.4318β-Glycyrrhetyl-3-O-sulfate
CAS:18β-Glycyrrhetyl-3-O-sulfate (Glycyrrhetic acid 3-O-(hydrogen sulfate)), a major metabolite of Glycyrrhetinic acid (GA), serves as a potent inhibitor of type 2Fórmula:C30H46O7SForma y color:SolidPeso molecular:550.75Ascochlorin A
CAS:Ascochlorin A, a compound with a dissociation constant (K D) of 3.29 μM, serves as a novel and potent human dihydroorotate dehydrogenase (hDHODH) inhibitorFórmula:C23H31ClO4Forma y color:SolidPeso molecular:406.95Necroptosis-IN-3
CAS:Necroptosis-IN-3 (Cyclohexanecarboxamide, N-(2-thienylmethyl)-) (Compound 69) is a Necroptosis inhibitor that inhibits TNF-α induced necroptosis.Fórmula:C12H17NOSPureza:99.85%Forma y color:SoildPeso molecular:223.3311β-HSD1 inibitor 17
CAS:11β-HSD1 inibitor 17 is an inhibitor of 11β-hydroxysteroid dehydrogenase (11β-HSD1).Fórmula:C22H20F3N3O2SPureza:99.26% - 99.72%Forma y color:SolidPeso molecular:447.47DHODH-IN-18
CAS:DHODH-IN-18 is a human DHODH inhibitor ( IC 50 = 0.2 nM).Fórmula:C21H16ClF5N6O4Forma y color:SolidPeso molecular:546.84PDK-IN-3
PDK-IN-3 (compound 1) is a potent pan-inhibitor of PDK, with IC50 values of 109.3 nM, 135.8 nM, 458.7 nM, and 8.67 μM for PDK 1-4, respectively. Additionally, PDK-IN-3 induces proliferation and apoptosis in A549 cells.Fórmula:C16H19ClN2O5S2Forma y color:SolidPeso molecular:418.0423911β-HSD1-IN-11
CAS:11β-HSd1-in-11 is a potent and competitive inhibitor of 11-β-hydroxysteroid dehydrogenase 1 (11β-HSD1) IN rats and humans with IC50 values of 0.34 μM and 0.13Fórmula:C15H11F3O3SPureza:99.61%Forma y color:SolidPeso molecular:328.31Ref: TM-T60149
1mg109,00€1mL*10mM (DMSO)239,00€5mg241,00€10mg355,00€25mg532,00€50mg745,00€100mg1.018,00€500mg2.043,00€SCD1 inhibitor-3
CAS:SCD1 inhibitor-3 (ML-270) is a highly effective and orally available compound that inhibits SCD1 with remarkable safety.Fórmula:C19H16FN7O2Pureza:99.5%Forma y color:SolidPeso molecular:393.37Ref: TM-T38683
1mg87,00€5mg177,00€1mL*10mM (DMSO)195,00€10mg281,00€25mg480,00€50mg692,00€100mg973,00€MTHFD2-IN-2
MTHFD2-IN-2 (compound 13) serves as a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2) [1].Fórmula:C22H18N4O5Forma y color:SolidPeso molecular:418.4MTHFD2-IN-4 sodium
MTHFD2-IN-4 sodium, a potent inhibitor of MTHFD2 and a tricyclic coumarin derivative, is applicable in cancer research [1].Fórmula:C26H21F6N2NaO5Forma y color:SolidPeso molecular:578.44PHGDH-IN-5
CAS:Compound B12 (PHGDH-IN-5) acts as a covalent inhibitor of PHGDH, demonstrating an IC50 value of 0.29 μM. It has been shown to inhibit the proliferation of cancer cell lines that overexpress PHGDH and reduce the production of glucose-derived serine in MDA-MB-468 cells [1].Fórmula:C8H5NO4SForma y color:SolidPeso molecular:211.20MTHFD2-IN-3
MTHFD2-IN-3 (compound 10), a potent inhibitor of methylenetetrahydrofolate dehydrogenase (MTHFD2), demonstrates significant efficacy in obstructing the activityFórmula:C22H19NO7SForma y color:SolidPeso molecular:441.45LDH-IN-3
LDH-IN-3 (compound E38) is an inhibitor of lactate dehydrogenase (LDH) and a potential protective agent against ischemic neuronal damage in the eyes and brain. It functions through the HO-1/SIRT1 pathway.Fórmula:C32H27NO5Forma y color:SolidPeso molecular:505.56Succinate dehydrogenase-IN-4
Succinate dehydrogenase-IN-4 (Compound 4b) is an inhibitor of succinate dehydrogenase with an IC50 value of 3.38 μM. It exhibits antifungal activity against Physalospora piricola and Colletotrichum orbiculare, with EC50 values of 16.33 μM and 18.06 μM, respectively.Fórmula:C20H21N3O2S2Forma y color:SolidPeso molecular:399.53hDHODH-IN-12
hDHODH-IN-12 is a potent inhibitor of dihydroorotate dehydrogenase (DHODH), exhibiting an inhibitory concentration (IC50) of 0.421 μM.Fórmula:C22H15F3N4O3Pureza:98%Forma y color:SolidPeso molecular:440.37
