Lipoxigenasa
Las lipoxigenasas son una familia de enzimas que catalizan la oxigenación de ácidos grasos poliinsaturados, llevando a la producción de mediadores lipídicos bioactivos como los leucotrienos y las lipoxinas. Estos mediadores desempeñan roles cruciales en la inflamación, las respuestas inmunitarias y el cáncer. Los inhibidores de la lipoxigenasa se utilizan para estudiar su papel en enfermedades inflamatorias, asma y cáncer. En CymitQuimica, ofrecemos una variedad de inhibidores de lipoxigenasa para apoyar su investigación en inflamación, oncología y metabolismo de los lípidos.
Se han encontrado 155 productos de "Lipoxigenasa"
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Zileuton
CAS:Zileuton (A 64077) inhibits 5-lipoxygenase, reduces leukotrienes, aids bronchodilation, lessens mucus/edema, and helps manage asthma symptoms.Fórmula:C11H12N2O2SPureza:98.72% - 99.43%Forma y color:Crystalline SolidPeso molecular:236.29CJ-13,610 hydrochloride
CAS:CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in studies about the prevention of untoward pathophysiologicalFórmula:C22H24ClN3O2SPureza:98.5%Forma y color:SoildPeso molecular:429.96Ref: TM-T27026L
1mg52,00€5mg92,00€1mL*10mM (DMSO)148,00€10mg158,00€25mg335,00€50mg500,00€100mg705,00€500mg1.485,00€Myxochelin A
CAS:Myxochelin A from A. disciformis fights Gram-positive bacteria, inhibits 5-LO with IC50 of 1.9 μM, and is cytotoxic to colon cancer cells.Fórmula:C20H24N2O7Forma y color:SolidPeso molecular:404.419KKII5
CAS:KKII5 is a potent inhibitor of the lipoxygenase LOX-1 with an IC50 of 19 μM.KKII5 inhibits lipid peroxidation and enhances the ability of the active centers ofFórmula:C16H14N2SPureza:99.44%Forma y color:SolidPeso molecular:266.36Ref: TM-T77288
2mg34,00€5mg52,00€1mL*10mM (DMSO)55,00€10mg79,00€25mg119,00€50mg187,00€100mg314,00€200mg447,00€5-Lipoxygenase-IN-3
CAS:Compound 14, a <1 μM 5-lipoxygenase inhibitor, researches inflammation, cancer, stroke, Alzheimer's.Fórmula:C19H16ClN5OForma y color:SolidPeso molecular:365.82mPGES-1/5-LOX-IN-1
mPGES-1/5-LOX-IN-1 (compound 3j) is a potent, orally active dual inhibitor of mPGES-1 and 5-LOX, with IC50 values of 0.92 and 1.89 µM, respectively. Additionally, mPGES-1/5-LOX-IN-1 exhibits anti-inflammatory properties.Fórmula:C20H22N4O6SPeso molecular:446.12601ThioLox
CAS:ThioLox, a 15-LOX-1 inhibitor (IC50: 12 μM), has anti-inflammatory, neuroprotective benefits, and guards against glutamate toxicity.
Fórmula:C15H18N2OSPureza:99.98%Forma y color:SoildPeso molecular:274.38Caffeoylcalleryanin
CAS:Caffeoylcalleryanin demonstrated potent inhibitory activity against 15-lipoxygenase (15-LOX), with an IC50 value of 1.59 μM. Furthermore, ethanol extract from A. pulchra leaves (EEAPL) was found to contain compounds exhibiting antiviral properties, particularly effective against Dengue virus type 2 (DENV-2). Among these compounds, Caffeoylcalleryanin emerged as the most potent anti-DENV-2 agent, achieving a selectivity index (SI) of 20.0.Fórmula:C22H24O11Forma y color:SolidPeso molecular:464.415-LOX-1 inhibitor 1
CAS:9c(i472) blocks 15-LO-1 (IC50=0.19μM), lowers NF-κB in RAW-Blue cells, & cuts Nos2/lipid peroxidation in RAW 264.7 at 0.2-5μM.Fórmula:C22H21ClN2O4Forma y color:SolidPeso molecular:412.87CMI977
CAS:CMI977 is a potent inhibitor of 5-Lipoxygenase (5-LO).Fórmula:C16H19FN2O4Pureza:98%Forma y color:SolidPeso molecular:322.33Ferroleuton
Ferroleuton is a selective competitive inhibitor of 5-lipoxygenase with an IC50 of 0.21 μM. It demonstrates antioxidant properties, clearing 86% of DPPH at 50 μM and exhibiting activities in ABTS (EC50 = 19.42 μM) and FRAP (EC50 = 3.32 μM) assays.Fórmula:C13H16FeN2O2Forma y color:SolidPeso molecular:288.12DKI5
CAS:DKI5, a LOX-1 inhibitor with 22.5 μM IC50, may exhibit anti-inflammatory, antioxidant, and anti-lipid peroxidation effects in vitro.Fórmula:C8H10N4SPureza:97.08%Forma y color:SoildPeso molecular:194.26Lagunamycin
CAS:Lagunamycin is used as a novel 5-lipoxygenase inhibitor.Fórmula:C19H21N3O4Forma y color:SolidPeso molecular:355.39(±)15-HEDE
CAS:(±)15-HEDE is produced by non-enzymatic oxidation of 11,14-eicosadienoic acid.Fórmula:C20H36O3Forma y color:SolidPeso molecular:324.50513-epi-12-oxo Phytodienoic Acid
CAS:13-epi-12-oxo PDA is a lipoxygenase derivative of α-linolenic acid in green plant leaves, often isomerizing during extraction and storage.Fórmula:C18H28O3Forma y color:SolidPeso molecular:292.412-Methyl-1-naphthol
CAS:2-Methyl-1-naphthol is a prostaglandin G/H synthase and polyunsaturated fatty acid 5-lipoxygenase inhibitor, suitable for biochemical experiments.Fórmula:C11H10OPureza:98.33%Forma y color:SolidPeso molecular:158.2LOX-IN-5
CAS:LOX-IN-5 (compound 22) is a non-selective LOX inhibitor.Fórmula:C21H25FN4O2SForma y color:SolidPeso molecular:416.515-LOX-IN-5
Compound 29, also known as 5-LOX-IN-5, is a 5-lipoxygenase (5-LOX) inhibitor with an inhibitory concentration 50 (IC50) of 56 nM, utilized in researchFórmula:C19H18BrN3O2SPureza:98%Forma y color:SolidPeso molecular:432.331-Naphthyl 3,5-dinitrobenzoate
CAS:1-Naphthyl 3,5-dinitrobenzoate (JMC-4) is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.Fórmula:C17H10N2O6Pureza:99.79%Forma y color:SolidPeso molecular:338.27Ref: TM-T21838
5mg54,00€1mL*10mM (DMSO)55,00€10mg86,00€25mg161,00€50mg245,00€100mg346,00€200mg474,00€(-)-Dihydroguaiaretic acid
(-)-Dihydroguaiaretic acid is a useful organic compound for research related to life sciences and the catalog number is T126154.Fórmula:C20H26O4Forma y color:SolidPeso molecular:330.4245-LOX/NO-IN-1
5-LOX/NO-IN-1 (Compound 7e) is a dual inhibitor of 5-LOX and nitric oxide release. It exhibits an IC50 value of 2.833 μM for 5-LOX and demonstrates anti-inflammatory properties.Fórmula:C22H18N6O4Forma y color:SolidPeso molecular:430.42BLX3887
CAS:BLX3887 selectively inhibits 15-LO-1 (IC50 = 32 nM), not 15-LO-2, less on 5-LO/12-LO, and affects eosinophils and dendritic cells.Fórmula:C10H5Cl3FN3OForma y color:SolidPeso molecular:308.52ZD-2138
CAS:ZD-2138: Selective 5-LOX inhibitor, eases allergen-induced asthma attacks and airway constriction in guinea pigs.Fórmula:C23H24FNO4Pureza:99.68% - >99.99%Forma y color:SolidPeso molecular:397.44Lipoxygenase
CAS:Lipoxygenase (LOX) is a dioxygenase that catalyzes the peroxidation of linoleic acid (LA) or arachidonic acid (AA) in the presence of molecular oxygen.Forma y color:SolidE 6080 HCl
CAS:E 6080 HCl is a 5-lipoxygenase inhibitor and can be used to study bronchial diseases.Fórmula:C17H20ClN3O3S2Pureza:99.80%Forma y color:SoildPeso molecular:413.94Ruthenoleuton
Ruthenoleuton is a 5-lipoxygenase (5-LOX) inhibitor with an IC50 of 3.49 μM and a Ki of 0.80 μM. It possesses antioxidant properties and is applicable in research on inflammatory diseases.Fórmula:C13H16N2O2RuForma y color:SolidPeso molecular:333.35h15-LOX-2 inhibitor 2
Compound 10 (h15-LOX-2 inhibitor 2) suppresses h15-LOX activity, exhibiting IC 50 and K i values of 26.9 μM and 16.4 μM, respectively.Fórmula:C22H30Cl2N6O3Forma y color:SolidPeso molecular:497.42Enazadrem phosphate
CAS:Enazadrem phosphate is a bio-active chemical. Detailed information has not been published.Fórmula:C18H28N3O5PForma y color:SolidPeso molecular:397.413-Chloroiminodibenzyl
CAS:Compound PDK0184, with CAS No. 32943-25-2, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0184 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C14H12ClNPeso molecular:229.78(S)-HEPE
CAS:8(S)-HEPE, derived from EPA via lipoxygenase, aids barnacle egg hatching at 10 nM, but it's not confirmed as the natural hatching factor.Fórmula:C20H30O3Forma y color:SolidPeso molecular:318.457CBS-1114 HCl
CAS:CBS-1114 HCl: 5-lipoxygenase inhibitor, anti-inflammatory, improves heart function, reduces heart's fat.Fórmula:C13H14ClN3Pureza:99.93%Forma y color:SoildPeso molecular:247.72Damnacanthol
Damnacanthol is a useful organic compound for research related to life sciences and the catalog number is T131609.Fórmula:C16H12O5Forma y color:SolidPeso molecular:284.267Aureusidin
CAS:Aureusidin (Auresidin) shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.Fórmula:C15H10O6Pureza:98.95% - 99.18%Forma y color:SolidPeso molecular:286.24Ref: TM-TN5634
1mg197,00€1mL*10mM (DMSO)384,00€5mg400,00€10mg590,00€25mg888,00€50mg1.243,00€100mg1.693,00€Zileuton sodium
CAS:Zileuton sodium (A 64077 sodium) is a potent and selective inhibitor of 5-lipoxygenase with anti-inflammatory activities.Fórmula:C11H11N2NaO2SForma y color:SolidPeso molecular:258.27Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
CAS:Cinnamyl-3,4-dihydroxy-α-cyanocinnamate (CDC), 12/15-LO inhibitor for diabetes. Affordable Excellence: Reliable Quality You Can TrustFórmula:C19H15NO4Forma y color:SolidPeso molecular:321.33Chebulagic acid
CAS:Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Fórmula:C41H30O27Pureza:97.82% - 99.8%Forma y color:SolidPeso molecular:954.66Ref: TM-TQ0180
1mg74,00€5mg157,00€10mg225,00€1mL*10mM (DMSO)244,00€25mg376,00€50mg560,00€100mg798,00€4-MMPB
CAS:15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM.Fórmula:C16H19N5SPureza:97.18%Forma y color:SolidPeso molecular:313.42Ref: TM-T8794
2mg34,00€5mg52,00€1mL*10mM (DMSO)58,00€10mg86,00€25mg156,00€50mg245,00€100mg403,00€200mg568,00€Phenidone
CAS:Phenidone inhibits COX/LOX, reducing rat autoimmune paralysis and lowering blood pressure in hypertensive rats.Fórmula:C9H10N2OPureza:97.24%Forma y color:White Solid Solid CrystallinePeso molecular:162.19SKF-86002
CAS:SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50: 1 μM).Fórmula:C16H12FN3SPureza:98% - 99.85%Forma y color:SolidPeso molecular:297.35Phenethyl ferulate
CAS:Phenethyl ferulate is a chemopreventive against colon cancer, enhancing apoptosis in tumors and inhibiting COX/5-LOX (IC50: 4.35/5.75 μM).Fórmula:C18H18O4Pureza:99.88% - 99.91%Forma y color:SolidPeso molecular:298.33Ref: TM-TN2330
1mg56,00€1mL*10mM (DMSO)114,00€5mg119,00€10mg192,00€25mg323,00€50mg475,00€100mg687,00€Malotilate
CAS:Malotilate (Kantec) is a medicine used for the therapy of liver cirrhosis.Fórmula:C12H16O4S2Pureza:99.79% - 99.79%Forma y color:SolidPeso molecular:288.38Psoralidin
CAS:Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally.Fórmula:C20H16O5Pureza:98% - 99.61%Forma y color:SolidPeso molecular:336.34Ref: TM-T3399
2mg34,00€5mg50,00€1mL*10mM (DMSO)55,00€10mg81,00€25mg152,00€50mg230,00€100mg340,00€200mg497,00€PGS-IN-1
CAS:PGS-IN-1 (KME-4) is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: 1.05 μM).Fórmula:C19H26O3Pureza:99.39%Forma y color:SolidPeso molecular:302.41BI-0115
CAS:BI-0115 inhibits LOX-1, preventing oxLDL uptake by triggering receptor inhibition and dimer formation.Fórmula:C15H14ClN3OPureza:99.34%Forma y color:SolidPeso molecular:287.74S-(+)-Marmesin
CAS:S-(+)-Marmesin (marmesin) is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual inhibitory activity.Fórmula:C14H14O4Pureza:98.00% - ≥98%Forma y color:SolidPeso molecular:246.26Xanthatin
CAS:Xanthatin exhibits cytotoxic, antibacterial, antifungal properties, may treat NSCLC, and inhibits melanoma by targeting Wnt/β-catenin and angiogenesis.Fórmula:C15H18O3Pureza:98.48% - 99.96%Forma y color:SolidPeso molecular:246.3Pectolinarigenin
CAS:Pectolinarigenin has hepatoprotective and anti-inflammatory properties, acting through SOD and inhibiting eicosanoids.Fórmula:C17H14O6Pureza:98.67% - 99.88%Forma y color:SolidPeso molecular:314.29Ref: TM-T6S0413
1mg46,00€5mg89,00€1mL*10mM (DMSO)110,00€10mg154,00€25mg265,00€50mg409,00€100mg620,00€Indirubin-3'-monoxime
CAS:Indirubin-3'-monoxime (Indirubin-3'-oxime) is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/Fórmula:C16H11N3O2Pureza:99.55%Forma y color:Dark Red SolidPeso molecular:277.28ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE
CAS:ETHYL 5-HYDROXY-2-METHYLINDOLE-3-CARBOXYLATE is useful for preparation and study of hypoxia-selective cytotoxicity of indolequinone antitumor agents.Fórmula:C12H13NO3Pureza:98.9%Forma y color:Off-White To Light Tan Crystalline PowderPeso molecular:219.243-O-Acetyl-11-hydroxy-β-boswellic acid
CAS:3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).Fórmula:C32H50O5Pureza:98.24%Forma y color:SolidPeso molecular:514.74
