Lipoxigenasa

Aminosalicylic Acid is an analog of para-aminobenzoic acid (PABA) with antitubercular activity.

Diethylcarbamazine citrate is an anthelmintic used primarily as the citrate in the treatment of filariasis, …

Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks …

Meclofenoxate hydrochloride is an ester of DIMETHYLAMINOETHANOL and para-chlorophenoxyacetic acid. It has been shown to …

Abietic Acid is the primary component of resin acid isolated from rosin.

Mesalamine is an anti-inflammatory agent, structurally related to the SALICYLATES, which is active in INFLAMMATORY …

Resveratrol is a polyphenolic phytoalexin with antioxidant and chemopreventive activities. It has a wide spectrum …

CJ-13,610 hydrochloride is an orally active nonredox-type inhibitor of 5-LOX and can be used in …

Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value …

Isotachioside has15-lipoxygenase (15-LO) inhibitory activities.

Setileuton is a specific 5-LOX inhibitor and can be used in research on asthma and …

Aureusidin shows antioxidant and lipoxygenase inhibitory activity with anti-inflammatory effects.

Sigmoidin A has moderate antioxidant, antimicrobial and anti-inflammatory activity.

Croconazole exhibited dose-dependent inhibitory activity on the 5-lipoxygenase (5-LOX) of neutrophils. Croconazole is an antimycotic …

RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.

Balsalazide is an anti-inflammatory compound used in the treatment of Inflammatory Bowel Disease.

Ligustroside shows little antioxidant, and anti-inflammatory properties, it shows a significant inhibition effect on prostaglandin …

Trichosanatine and squamosamide, as potential candidates as lead compounds for further study in drug development …

1-Naphthyl 3,5-dinitrobenzoate is an inhibitor of 5-LOX can be used in studies about inflammatory therapy.

PF-4191834 is a noniron chelating and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) with an IC50 …

A-69412 is a reversible, specific inhibitor of the hydrophilic 5-lipoxygenase. It has the potential to …

Picralinal has anti-inflammatory and analgesic effects.

SKF-86002 is an effective inhibitor of p38 MAP kinase (IC50: 0.5-1 uM); inhibits LPS-induced IL-1 …

BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.

ML351 is a potent and selective inhibitor of human 15-lipoxygenase-1 (15 LOX)(IC50: 200 nM).

LOX-IN-3 dihydrochloride is an inhibitor of lysyl oxidase (LOX). LOX-IN-3 dihydrochloride inhibited bovine LOX (IC50 …

Indirubin-3'-oxime is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( …

3-O-Acetyl-11-hydroxy-beta-boswellic acid is the precursor of 3-O-acetyl-9, 11-dehydro-beta-boswellic acid(a 5-lipoxygenase inhibitor ).

Nordihydroguaiaretic acid (NDGA) is a phenolic antioxidant found in the leaves and twigs of the …

3'-Demethylnobiletin has chemopreventive effects on colon carcinogenesis, it can significantly inhibit the growth of human …

CAY10698 is a 12-lipoxygenase inhibitor (12-LO; IC50 of 5.1 μM).

PD146176 is an inhibitor of 15-Lipoxygenase (15-LO) , it inhibits rabbit reticulocyte 15-LO with Ki …

Beta-boswellic acid and its derivatives (the major constituents of Boswellin) have anti-carcinogenic, anti-tumor, and anti-hyperlipidemic …

BI-0115 is a selective small molecule inhibitor of LOX-1 that blocks cellular uptake of oxLDL. …

Benoxaprofen is a non-steroidal anti-inflammatory drug.

1. Pectolinarigenin exhibits hepatoprotective activity mainly via SOD antioxidant mechanism. 2. Pectolinarigenin possesses anti-inflammatory activity …

Phenidone is a dual inhibitor of cyclooxygenases and lipoxygenases that ameliorates rat paralysis in experimental …

3-Hydroxycoumarin is a natural compound, and is human 15-LOX-1 inhibitors

1. 6-Shogaol has antipyretic and analgesic effects in addition to inhibitory effect on lipoxygenase activity. …

1. 4-Methyldaphnetin is a potent inhibitor (low micromolar) of lipid peroxidation and scavengers of superoxide …

Malotilate is a medicine used for the therapy of liver cirrhosis.

15-Lipoxygenase Inhibitor 1 is a selective inhibitor of 15-lipoxygenase, with an IC50 of 18 μM. …

Wedelolactone inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα.

1. Xanthatin has cytotoxic activity. 2. Xanthatin has antibacterial and antifungal activies against MRSA. 3. …

Caffeic Acid 3-Methyl Phenethyl Ester has chemopreventive properties against chemically induced colon carcinogenesis. It enhances …

Montelukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis …

Silychristin is a plant growth regulator. Silychristin is an anti-hepatotoxic agent. Silychristin is the inhibitor …

11-Keto-beta-boswellic acid, a novel Nrf2 activator, and a selective 5-lipoxygenase (5-LOX) inhibitor; it exerts dose …

Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.

Licofelone is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis. Licofelone is both …

Marmesin is a coumarin originally isolated from the mature bark of A. marmelos,exhibiting COX-2/5-LOX dual …

PGS-IN-1 is a potent inhibitor of prostaglandin synthetase (PGS, IC50: 0.28 μM) and 5-lipoxygenase (IC50: …

Psoralidin inhibits Akt phosphorylation and phosphatidylinositol 3-kinase activation and transcriptionally. Psoralidin possesses anticancer and chemopreventive …

Embelin, isolated from the Japanese Ardisia herb, is an inhibitor of the X-linked inhibitor of …

NNK is a procarcinogen and a major tobacco-specific toxicant. It inhibits the expression of lysyl …

Linoleyl alcohol, fatty alcohol, is a structural analog of Linoleic acid with no a-carboxyl group[1].

Kukoamine A possesses anticancer, cytoprotective, antioxidant, and anti-inflammatory activities, and inhibits trypanothione reductase as a …

U73122, an effective PLC inhibitor, reduces agonist-induced Ca2+ increases in platelets and PMN.

Esculetin is a coumarin derivative from various natural plant products with various biological and pharmaceutical …

4',5-Dihydroxyflavone is a soybean LOX-1(Ki: 102.6 μM) and yeast α-Glucosidase inhibitor (IC50: 66 μM).

BHQ is an effective and selective endoplasmic reticulum Ca2+-ATPase inhibitor.

Tepoxalin is a 5-lipoxygenase inhibitor potentially for the treatment of asthma, osteoarthritis. Tepoxalin inhibits COX-1, …

5-DEMETHYLNOBILETIN is a natual product, has anti-inflammatory activity, it may act through a direct inhibition …

FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 …