GlyT
Inhibidores del Transportador de Glicina (GlyT) son compuestos que bloquean la recaptación de glicina, un importante neurotransmisor inhibidor en la médula espinal y el tronco encefálico. Al inhibir los transportadores de glicina, estos compuestos aumentan la disponibilidad de glicina en la hendidura sináptica, mejorando sus efectos inhibitorios sobre la actividad neuronal. Los inhibidores de GlyT son de interés por su potencial aplicación terapéutica en condiciones como el dolor crónico, la espasticidad y la esquizofrenia. En CymitQuimica, ofrecemos inhibidores de GlyT para apoyar su investigación en el manejo del dolor, el control motor y los trastornos neuropsiquiátricos.
Se han encontrado 27 productos para "GlyT".
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LY2365109 hydrochloride
CAS:LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing hGlyT1a.Fórmula:C22H28ClNO5Pureza:98.27%Forma y color:White SolidPeso molecular:421.91Iclepertin
CAS:Iclepertin (BI-425809) is a GlyT1 inhibitor.Iclepertin is used for the treatment of Alzheimer;s disease and other CNS disorders.Fórmula:C20H18F6N2O5SPureza:99.21% - 99.66%Forma y color:SolidPeso molecular:512.423DCCCyb
CAS:DCCCyb: oral GlyT1 inhibitor with high in vivo occupancy in rhesus monkeys, confirmed by PET tracer displacement.Fórmula:C22H29Cl2NO3SPureza:98%Forma y color:SolidPeso molecular:458.448-hydroxy Amoxapine
CAS:8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2Fórmula:C17H16ClN3O2Forma y color:SolidPeso molecular:329.78MPDC hydrochloride
MPDC hydrochloride is a competitive inhibitor of Na+-dependent, high-affinity glutamate transporters in forebrain synaptosomes.Fórmula:C7H10ClNO4Peso molecular:207.02984(Rac)-Oleoylcarnitine
CAS:(Rac)-Oleoylcarnitine, an endogenous acylcarnitine, acts as a potential non-competitive inhibitor of glycine transporter 2 (GLYT2) and can be used as a pain suppressant.Fórmula:C25H47NO4Peso molecular:425.65Org 24598 lithium salt
CAS:Org 24598 lithium salt is a GlyT-1 inhibitor of glycine transporter 1.Fórmula:C19H19F3LiNO3Forma y color:SolidPeso molecular:373.3SSR504734 HCl
CAS:SSR504734 inhibits GlyT1 in humans, rats, mice (IC50=18, 15, 38 nM); treats schizophrenia, anxiety, depression orally.Fórmula:C20H21Cl2F3N2OPureza:98.05% - 99.93%Forma y color:SolidPeso molecular:433.295Org 25543 hydrochloride
CAS:Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2).Fórmula:C24H33ClN2O4Pureza:99.26%Forma y color:White SolidPeso molecular:448.983Opiranserin hydrochloride
CAS:Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μMFórmula:C21H35ClN2O5Pureza:99.33%Forma y color:SolidPeso molecular:430.966Sarcosine
CAS:Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.Fórmula:C3H7NO2Pureza:99.90%Forma y color:SolidPeso molecular:89.0932SSR504734
CAS:SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.Fórmula:C20H20ClF3N2OForma y color:SolidPeso molecular:396.83Bitopertin
CAS:Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nMFórmula:C21H20F7N3O4SPureza:98.57% - 98.71%Forma y color:SolidPeso molecular:543.455GSK931145
CAS:GSK931145 is a positron emission tomography (PET) radioligand, it is suitable for quantifying glycine transporter (GlyT1) availability in the living brain.Fórmula:C23H30N2OPureza:98%Forma y color:SolidPeso molecular:350.5PF-03463275
CAS:PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNSFórmula:C19H22ClFN4OPureza:99.95%Forma y color:SolidPeso molecular:376.856Tilapertin
CAS:Tilapertin is an oral glycine transporter type-1 inhibitor.Fórmula:C20H21F3N2O2Pureza:98%Forma y color:SolidPeso molecular:378.39Opiranserin
CAS:Opiranserin is a development as an injectable agent for the treatment of postoperative pain.Fórmula:C21H34N2O5Pureza:98%Forma y color:SolidPeso molecular:394.51ASP2535
CAS:ASP2535 is a potent, selective, orally bioavailable, brain permeable and centrally-active glycine transporter-1 (GlyT1) inhibitor.ASP2535 can improve cognitiveFórmula:C22H18N6OPureza:98%Forma y color:SolidPeso molecular:382.42GlyT1 Inhibitor 1
CAS:GlyT1 Inhibitor 1 is a selective and potent GlyT1 inhibitor, inhibiting rGlyT1, used in research on neurological disorders.Fórmula:C22H21N5O2Forma y color:SolidPeso molecular:387.4344Org 24598
CAS:Potent GlyT1b inhibitor, IC50 = 6.9 nM; little effect on GlyT-2, adrenoceptors, dopamine, 5HT receptors, GABA transporters.Fórmula:C19H20F3NO3Forma y color:SolidPeso molecular:367.3622
