Beta amiloide
Beta amyloid inhibitors are compounds that specifically target and inhibit the formation or aggregation of beta-amyloid peptides, which are critically involved in the pathogenesis of Alzheimer's disease. The accumulation of beta-amyloid plaques in the brain is one of the key pathological features of Alzheimer's, contributing to neuronal dysfunction, synaptic loss, and cognitive decline. By preventing the aggregation of beta-amyloid, these inhibitors are being actively researched as potential therapeutic agents aimed at slowing down or even halting the progression of Alzheimer's disease. At CymitQuimica, we offer a variety of high-quality beta-amyloid inhibitors to support your research in neurodegenerative disorders, protein aggregation, and the development of Alzheimer's therapies.
Se han encontrado 220 productos de "Beta amiloide"
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γ-secretase modulator 6
CAS:Gamma-secretase modulator 6 (Example 50) is a gamma-secretase modulator. It inhibits Aβ42 secretion in HEK cell lines stably expressing APP (Aβ amyloid precursor protein) with a pIC50 of 8.1. This compound is applicable in Alzheimer's disease research.Fórmula:C25H26N6O2Forma y color:SolidPeso molecular:442.513BF-168
CAS:BF-168 is a candidate probe for PET and specifically recognizes both neuritic and diffuse plaques (Ki: 6.4 nM for Aβ1-42).Fórmula:C18H17FN2O2Forma y color:SolidPeso molecular:312.34Aβ42 agonist-1
CAS:Aβ42 agonist-1 is a small molecule compound with anti-cancer activity and NF-κB inhibitory properties, inducing Aβ42 aggregation.Fórmula:C15H11NO2Pureza:99.77%Forma y color:SolidPeso molecular:237.25cSPM
cSPM (Cyclic spermine) is an Aβ42 inhibitor. cSPM inhibits the aggregation of three different peptides, Aβ42, tryptophan and insulin, and reduces cytotoxicity.Fórmula:C27H57N7Forma y color:SolidPeso molecular:479.79Buntanetap L-Tartrate
CAS:Buntanetap (L-Tartrate) functions as an oral small molecule inhibitor targeting multiple neurotoxic proteins. It decreases the production of amyloid precursor protein (APP) by inhibiting the translation of its mRNA [1].Fórmula:C24H29N3O8Forma y color:SolidPeso molecular:487.50MAO-B-IN-10
MAO-B-IN-10: Potent, selective MAO-B inhibitor; crosses blood-brain barrier; IC50 5.3 μM; reduces Aβ aggregation 58.2%, disaggregates 43.3%.Fórmula:C23H26N2O4Forma y color:SolidPeso molecular:394.46QP5020
CAS:QP5020 is a QPCTL inhibitor with an IC50 value of 15 nM, demonstrating antitumor efficacy.Fórmula:C20H19FN6Peso molecular:362.40Thiazolo[5,4-c]pyridin-4(5H)-one
CAS:Thiazolo[5,4-c]pyridin-4(5H)-one is a compound used for diagnostic imaging of TDP-43, in PET imaging of neurodegenerative diseases ALS、AD、FTD、LATE.Fórmula:C22H22FN5O2SPureza:98.75%Forma y color:SolidPeso molecular:439.51Antioxidant agent-8
Antioxidant agent-8, an oral Aβ 1-42 inhibitor, reduces fibril aggregation & promotes disaggregation; it's neuroprotective & BBB permeable.Fórmula:C13H12O5Forma y color:SolidPeso molecular:248.23Glutaminyl Cyclase Inhibitor 3
CAS:Designed anti-Alzheimer’s compound; potent Glutaminyl Cyclase inhibitor; IC50 at 4.5 nM; reduces brain Aβ; improves cognition.Fórmula:C24H32N6O2SPureza:98%Forma y color:SolidPeso molecular:468.612002-G12
CAS:2002-G12 (compound 5a) is an Aβ42 inhibitor that can reduce Aβ42 toxicity by 76%. It is applicable in Alzheimer's research.Fórmula:C20H16N6Forma y color:SolidPeso molecular:340.381Amyloid-β-IN-2
CAS:Amyloid-β-IN-2 (Compound EX.112) is a selective inhibitor of γ-secretase. In H4 cells, it demonstrates inhibitory activity on Aβ42 secretion, with an EC50 value of 226 nM. Amyloid-β-IN-2 holds potential for research in Alzheimer's disease (AD) and diseases associated with Aβ deposition.Fórmula:C22H21F2N3O2Forma y color:SolidPeso molecular:397.42Anti-Aβ agent 1A
Anti-Aβ agent 1A is a potent anti-amyloid-β agent.Fórmula:C35H49NO4Forma y color:SolidPeso molecular:547.77(9R)-RO7185876
CAS:(9R)-RO7185876 (Compound example 16) is a γ-secretase inhibitor. It reduces the secretion of Αβ42. This compound can be employed in the research of Alzheimer's disease, cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, multi-infarct dementia, senile dementia, or Down syndrome.Fórmula:C25H28F3N7Forma y color:SolidPeso molecular:483.532Amyloid-β-IN-3
CAS:Amyloid-β-IN-3 (EX.113) is a selective inhibitor of γ-secretase. It demonstrates inhibitory activity on Aβ42 secretion in H4 cells, with an EC50 value of 148 nM. By modulating the catalytic activity of γ-secretase, Amyloid-β-IN-3 decreases Aβ42 production, thereby alleviating neurotoxicity caused by Aβ deposition. It holds potential for Alzheimer's disease (AD) research.Fórmula:C22H21F2N3O2Forma y color:SolidPeso molecular:397.42Aβ aggregation-IN-1
CAS:Aβ aggregation-IN-1 (Compound 1b) is an inhibitor of amyloid-beta precursor protein. It suppresses the aggregation and disaggregation of amyloid-beta fibrils with IC50 values of 3.92 and 7.19 M, respectively. Additionally, Aβ aggregation-IN-1 reduces malondialdehyde formation in neuronal cells, increases intracellular levels of reduced glutathione (GSH), and inhibits caspase 3.Fórmula:C9H8BF3O2Forma y color:SolidPeso molecular:215.965IXA62
CAS:IXA62 is an orally active, selective IRE1/XBP1s agonist (EC50= 0.31 μM) that can reduce Aβ secretion.Fórmula:C24H23N3O3Forma y color:SolidPeso molecular:401.458BMS 299897
CAS:BMS 299897, a sulfonamide γ-secretase inhibitor, inhibits Aβ production with an IC50 of 7 nM in HEK293 cells overexpressing APP.Fórmula:C24H21ClF3NO4SPureza:99.82%Forma y color:SolidPeso molecular:511.94BF 227
CAS:BF 227 is a candidate for an amyloid imaging probe for PET [Ki: 4.3 nM for Aβ1-42 fibrils].Fórmula:C16H16FN3O2SForma y color:SolidPeso molecular:333.38Xanthocillin X permethyl ether
CAS:Xanthocillin X permethyl ether, a natural product extracted from fungal sources, exhibits Aβ-42 lowering activity.Fórmula:C20H16N2O2Pureza:98%Forma y color:SolidPeso molecular:316.35
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