Inhibidores de ciclooxigenasa (COX)
Cyclooxygenase (COX) inhibitors are a class of compounds that inhibit the activity of COX enzymes, which play a critical role in the biosynthesis of prostaglandins—lipid compounds that mediate inflammation, pain, and fever. In the field of neuroscience, COX inhibitors are extensively studied for their potential to alleviate neuroinflammation, a key factor in the progression of various neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis. By blocking COX activity, these inhibitors may help reduce inflammation in the brain, thereby protecting neurons from damage and slowing disease progression. At CymitQuimica, we offer a wide range of high-quality COX inhibitors to support your research in neuroinflammation, pain management, and the study of neurodegenerative disorders.
Se han encontrado 592 productos de "Inhibidores de ciclooxigenasa (COX)"
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Chlorotrianisene
CAS:<p>Chlorotrianisene, a synthetic SERM, is orally active, lipophilic, and has estrogenic and antiestrogenic effects.</p>Fórmula:C23H21ClO3Pureza:98.88% - 99.03%Forma y color:Crystals From Methanol Physical Description Small White Crystals Or White Powder Softens At 226°F Odorless (Ntp 1992)Peso molecular:380.863-TERT-BUTYL-4-HYDROXYANISOLE
CAS:<p>3-tert-Butyl-p-hydroxyanisole is an antioxidant which is produced via water chlorination.</p>Fórmula:C11H16O2Pureza:99.65%Forma y color:White Solid WaxyPeso molecular:180.24[8]-Shogaol
CAS:[8]-Shogaol is a component of ginger and maintains anti-inflammatory activity as a cyclooxygenase-2 inhibitor.Fórmula:C19H28O3Pureza:97.01%Forma y color:SolidPeso molecular:304.42Chebulagic acid
CAS:Chebulagic acid, isolated from the Terminalia chebula Retz, is a COX-LOX dual inhibitor.Fórmula:C41H30O27Pureza:97.82% - 99.8%Forma y color:SolidPeso molecular:954.66AX-024 hydrochloride
CAS:AX-024 hydrochloride (AX-024 HCl) is an cytokine release inhibitor which can strongly inhibit the production of IL-6, TNFα, IFN-γ, IL-10 and IL-17A.Fórmula:C21H23ClFNO2Pureza:99.74%Forma y color:SolidPeso molecular:375.87Loxoprofen sodium (dihydrate)
CAS:Loxoprofen sodium dihydrate: Non-steroidal anti-inflammatory with analgesic, antipyretic, antitumor effects; COX-1/COX-2 inhibitor. IC50: 6.5/13.5 μM.Fórmula:C15H21NaO5Forma y color:SolidPeso molecular:304.318Dexamethasone Sodium Phosphate
CAS:Dexamethasone Sodium Phosphate (Dexadreson) is a powerful anti-inflammatory and immunosuppressant synthetic glucocorticoid.Fórmula:C22H30FO8P·2NaPureza:99.01% - 99.81%Forma y color:SolidPeso molecular:516.4FPL 62064
CAS:<p>FPL 62064 is a potent dual inhibitor of 5-lipoxygenase (5-LOX) and COX (IC50 of 3.5 μM and 3.1 μM for RBL-1 cytosolic 5-lipoxygenase and prostaglandin</p>Fórmula:C16H15N3OPureza:98.79%Forma y color:SolidPeso molecular:265.31Dehydroevodiamine
CAS:<p>Dehydroevodiamine (DHED), a constituent of Evodia rutaecarpa, has various biological effects such as hypotensive, negative chronotropic, ion channel depressant</p>Fórmula:C19H15N3OPureza:99.54%Forma y color:SolidPeso molecular:301.34Diclofenac deanol
CAS:Diclofenac deanol: a phenylacetic acid NSAID with anti-inflammatory, analgesic, and antipyretic effects; favors COX-2 inhibition.Fórmula:C18H22Cl2N2O3Forma y color:SolidPeso molecular:385.29CAFESTOL
CAS:<p>Cafestol, an ERK inhibitor, suppresses PGE2 and COX-2 by blocking NF-kB in LPS-stimulated RAW264.7 cells.</p>Fórmula:C20H28O3Pureza:97.06% - 99.08%Forma y color:SolidPeso molecular:316.43Licofelone
CAS:Licofelone (ML-3000) is a dual COX/LOX inhibitor potentially for the treatment of osteoarthritis.Fórmula:C23H22ClNO2Pureza:99.25%Forma y color:Yellowish SolidPeso molecular:379.88Zaltoprofen
CAS:Zaltoprofen (Soleton) is a Cox-1 and Cox-2 inhibitor, which is used for the treatment of arthritis.Fórmula:C17H14O3SPureza:99.72%Forma y color:Off-White To Pale Yellow Crystalline SolidPeso molecular:298.36Metyrosine
CAS:Metyrosine: antihypertensive, tyrosine hydroxylase inhibitor, controls COX-2, lowers blood pressure.Fórmula:C10H13NO3Pureza:98.68% - 99.72%Forma y color:SolidPeso molecular:195.22RHC 80267
CAS:<p>RHC 80267 (U-57908) is a selective inhibitor of DAGL (IC50 : 4 μM in canine platelets)</p>Fórmula:C20H34N4O4Pureza:99.54%Forma y color:White SolidPeso molecular:394.51γ-Tocopherol
CAS:(+)-γ-Tocopherol ((+)-γ-Tocopherol) is one of the naturally occurring forms of Vitamin E. It is the most abundant Tocopherol in soybean and corn oils.Fórmula:C28H48O2Pureza:99.31% - 99.39%Forma y color:Clear Viscous Pale Yellow Oil Which Oxidises And Darkens On Exposure To Air Or LightPeso molecular:416.68Fenoprofen Calcium
CAS:Fenoprofen Calcium is a nonsteroidal, anti-inflammatory antiarthritic agent.Fórmula:C30H26CaO6Pureza:99.24% - 99.66%Forma y color:SolidPeso molecular:522.6Ginsenoside Rd
CAS:<p>Ginsenoside Rd (Gypenoside VIII) may have properties that inhibit or prevent the growth of tumors.</p>Fórmula:C48H82O18Pureza:99.13% - 99.92%Forma y color:SolidPeso molecular:947.15Sulindac sulfone
CAS:Sulindac sulfone is a metabolite of the nonsteroidal anti-inflammatory drug sulindac. Sulindac sulfone is an inhibitor of aldose reductase (IC50 =367 nM).Fórmula:C20H17FO4SPureza:98.2% - 98.83%Forma y color:SolidPeso molecular:372.41Otenaproxesul
CAS:Otenaproxesul (ATB 346) is a novel hydrogen sulphide-releasing derivative of naproxen with markedly reduced toxicity.Fórmula:C21H19NO3SPureza:98.76% - 99.13%Forma y color:SolidPeso molecular:365.45Teriflunomide impurity 3
CAS:<p>Teriflunomide impurity 3 (4-Amino-N-(4-trifluoromethylphenyl)benzamide) is a selective COX-1 inhibitor(IC50 of 30 μM).</p>Fórmula:C14H11F3N2OPureza:99.62%Forma y color:SolidPeso molecular:280.25Propyphenazone
CAS:Propyphenazone: an anti-inflammatory, analgesic, antipyretic pyrazolone; prodrug; COX-2 inhibitor.Fórmula:C14H18N2OPureza:99.64%Forma y color:SolidPeso molecular:230.31FK 3311
CAS:<p>FK 3311 (COX-2 Inhibitor V) is a cell permeable and orally available sulfonanilide that acts as a COX-2 inhibitor and non-steroidal anti-inflammatory drug (</p>Fórmula:C15H13F2NO4SPureza:97.98%Forma y color:SolidPeso molecular:341.33Revaprazan hydrochloride
CAS:Revaprazan hydrochloride (YH1885) is the hydrochloride salt form of a lipophilic, weak base with potassium-competitive acid blocking (P-CAB) activity.Fórmula:C22H24ClFN4Pureza:99.62% - 99.91%Forma y color:SolidPeso molecular:398.9Lumiracoxib
CAS:<p>Lumiracoxib (Prexige) is a novel, selective COX-2 inhibitor with IC50 and Ki of 0.14 μM and 0.06 μM, exhibits 515-fold selectivity over COX-1. Phase 4.</p>Fórmula:C15H13ClFNO2Pureza:96.64% - 99.77%Forma y color:Pale Yellow SolidPeso molecular:293.72Indomethacin farnesil
CAS:Indomethacin farnesil (Infree) is a prodrug of indomethacin. It acts as a nonsteroidal anti-inflammatory drug (NSAID) and disease-modifying anti-rheumatic drug.Fórmula:C34H40ClNO4Pureza:97.29%Forma y color:SolidPeso molecular:562.14(-)-Catechin gallate
CAS:(-)-Catechin gallate inhibits 6PGD, IDH, Beta-secretase, and fights chloroquine-sensitive/resistant Plasmodium falciparum.Fórmula:C22H18O10Pureza:97.74% - >99.99%Forma y color:SolidPeso molecular:442.37Byakangelicol
CAS:<p>Byakangelicol may reduce P-gp at BBB and has anti-inflammatory effects by hindering COX-2 and PGE2 in A549 cells.</p>Fórmula:C17H16O6Pureza:98.78% - 99.55%Forma y color:SolidPeso molecular:316.31N-trans-Feruloyltyramine
CAS:<p>NTF is hepatoprotective, antioxidant, inhibits COX, prevents platelet aggregation, and reduces melanin by downregulating tyrosinase.</p>Fórmula:C18H19NO4Pureza:99.56% - >99.99%Forma y color:SolidPeso molecular:313.35Pectolinarigenin
CAS:<p>Pectolinarigenin has hepatoprotective and anti-inflammatory properties, acting through SOD and inhibiting eicosanoids.</p>Fórmula:C17H14O6Pureza:98.67% - 99.88%Forma y color:SolidPeso molecular:314.29Ampiroxicam
CAS:<p>Ampiroxicam (Flucam) is a nonselective cyclooxygenase inhibitor uesd as anti-inflammatory drug.</p>Fórmula:C20H21N3O7SPureza:97.27% - 99.2%Forma y color:PowderPeso molecular:447.46Adelmidrol
CAS:Adelmidrol is an anti-inflammatory ethanolamide derivative of azelaic acid.Fórmula:C13H26N2O4Pureza:99.35% - 99.73%Forma y color:SolidPeso molecular:274.36Compound Lup-20(29)-en-3-yl acetate
<p>Lupeol acetate, a derivative of Lupeol, inhibits the progression of rheumatoid arthritis by downregulating TNF-α, IL-1β, MCP-1, COX-2, VEGF and granzyme B.</p>Fórmula:C32H52O2Pureza:98%Forma y color:SolidPeso molecular:468.75N-tert-butyl-α-Phenylnitrone
CAS:N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity.Fórmula:C11H15NOPureza:99.46% - 99.84%Forma y color:SolidPeso molecular:177.24CAY10404
CAS:<p>CAY10404: potent COX-1/2 inhibitor; blocks PKB/Akt, MAPK pathways; triggers NSC-LC apoptosis; analgesic, anti-inflammatory, anti-cancer.</p>Fórmula:C17H12F3NO3SPureza:99.02%Forma y color:SolidPeso molecular:367.34Hamaudol
CAS:Hamaudol, from Saposhnikovia divaricata, has pain-relief and anti-inflammatory effects, inhibits COX-1/COX-2 (0.30/0.57 mM).Fórmula:C15H16O5Pureza:99.62% - 99.76%Forma y color:SolidPeso molecular:276.28Isofraxidin
CAS:<p>Isofraxidin combats leukemia, ALI, and inflammation by modulating ROS, COX-2, PGE2, TNF-α, and p38/ERK1/2 pathways.</p>Fórmula:C11H10O5Pureza:99.51% - ≥95%Forma y color:SolidPeso molecular:222.19Avicularin
CAS:Avicularin reduces inflammation via ERK pathway in RAW 264.7 cells and hinders lipid buildup in adipocytes by limiting glucose uptake and fatty acid synthesis.Fórmula:C20H18O11Pureza:97.02% - 99.94%Forma y color:White PowderPeso molecular:434.35Cis-5-Dodecenoic Acid
CAS:<p>Cis-5-Dodecenoic Acid is a monounsaturated fatty acid that has a C12 chain as a backbone and a cis double bond at the C5 position.</p>Fórmula:C12H22O2Pureza:98% - 99.37%Forma y color:SolidPeso molecular:198.3α-Demethylnaproxen
CAS:α-Demethylnaproxen is a competitive inhibitor of COX(Ki values of 21 and 19 μM for ovine COX-1 and -2, respectively)Fórmula:C13H12O3Pureza:97.57%Forma y color:Off-White SolidPeso molecular:216.23Mofezolac
CAS:<p>Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000</p>Fórmula:C19H17NO5Pureza:99.29%Forma y color:SolidPeso molecular:339.34Firocoxib
CAS:<p>Firocoxib (ML 1785713) is a selective non-steroidal inhibitor of cycooxygenase-2 (COX-2) (IC50 of 0.13 μM), with anti-inflammatory for use in dogs and horses.</p>Fórmula:C17H20O5SPureza:99.84%Forma y color:SolidPeso molecular:336.4Parecoxib
CAS:Parecoxib (SC 69124) is an effective and selective COX-2 inhibitor.Fórmula:C19H18N2O4SPureza:99.71% - 99.78%Forma y color:SolidPeso molecular:370.42Tenidap
CAS:Tenidap (CP-66248) is a selective COX-1 and SLC26A3 inhibitor with anti-inflammatory, analgesic, and anti-rheumatic activities.Fórmula:C14H9ClN2O3SPureza:98.56% - 99.42%Forma y color:SolidPeso molecular:320.75(S)-(+)-Ibuprofen
CAS:<p>(S)-(+)-Ibuprofen (Dexibuprofen) , is a non-steroidal anti-inflammatory drug (NSAID), inhibiting cyclooxygenase (COX).</p>Fórmula:C13H18O2Pureza:99.51% - 99.86%Forma y color:Colourless Crystalline SolidPeso molecular:206.28Meloxicam
CAS:<p>Meloxicam (Metacam) is a Nonsteroidal Anti-inflammatory Drug.</p>Fórmula:C14H13N3O4S2Pureza:97.09% - 99.60%Forma y color:Light Yellow SolidPeso molecular:351.40Bromfenac sodium hydrate
CAS:Bromfenac sodium hydrate (Bromfenac monosodium salt sesquihydrate) is the sodium salt form of bromfenac, a NSAID with analgesic and anti-inflammatory effects.Fórmula:C15H12BrNO3H2O·NaPureza:91.85% - 99.65%Forma y color:SolidPeso molecular:383.17Oxyphenbutazone
CAS:Oxyphenbutazone: Non-selective COX inhibitor, anti-inflammatory, kills dormant Mycobacterium tuberculosis.Fórmula:C19H20N2O3Pureza:99.41% - 99.88%Forma y color:White To Yellowish White Crystalline Powder SolidPeso molecular:324.37Fenoprofen
CAS:Fenoprofen (LILLY-5385) is a non-steroidal anti-inflammatory compound and a modifier enhancer of the melanocortin receptor, increasing ERK1/2 activation.Fórmula:C15H14O3Pureza:98.4%Forma y color:SolidPeso molecular:242.27NF-κB/MAPK-IN-1
CAS:NF-κB/MAPK-IN-1 is an NF-κB and MAPK pathway inhibitor. NF-κB/MAPK-IN-1 is used to prevent rheumatoid arthritis (RA).Fórmula:C27H27NO7Pureza:97.03%Forma y color:SolidPeso molecular:477.51Paradol
CAS:<p>Paradol, a spicy compound in ginger, offers anti-cancer, anti-inflammatory, antioxidant, and neuroprotective benefits.</p>Fórmula:C17H26O3Pureza:98.4% - 98.98%Forma y color:SolidPeso molecular:278.39Cadonilimab
CAS:<p>Cadonilimab (AK104) is a tetravalent PD-1/CTLA-4 bispecific humanised antibody that activates T cells by enhancing IL-2 and IFN-γ secretion.</p>Pureza:95% - 95%Forma y color:LiquidAspirin DL-lysine
CAS:<p>Aspirin DL-lysine: a water-soluble, injectable NSAID that may also hinder cancer growth.</p>Fórmula:C15H22N2O6Forma y color:Crystalline SolidPeso molecular:326.35Imidazole Salicylate
CAS:Imidazole Salicylate, a non-steroidal anti-inflammatory drug, has limited inhibitory effects on prostaglandin synthesis.Fórmula:C10H10N2O3Pureza:98%Forma y color:SolidPeso molecular:206.2Fontolizumab
CAS:Fontolizumab (HuZAF) is a humanised IgG1 monoclonal anti-IFN-gamma (IFN-γ) antibody for the study of Crohn's disease.Pureza:95%Forma y color:LiquidPeso molecular:150 (kDa)Anti-IL-12 p70 Antibody (20C2)
Anti-IL-12 p70 Antibody (20C2), an IgG1 monoclonal, suppresses interferon-gamma, IL-12-mediated inflammation, paired with a Rat IgG1 kappa control.Pureza:95%Indometacin Farnesil
CAS:Fórmula:C34H40ClNO4Pureza:>98.0%(HPLC)Forma y color:Light yellow to Yellow to Orange clear liquidPeso molecular:562.15Ketorolac-d5
CAS:Ketorolac-d5 is a deuterated compound of ketorolac for isotope tracing. Ketorolac is a non-steroidal anti-inflammatory agent and inhibitor of COX-1 and COX-2.Fórmula:C15H8D5NO3Pureza:98.99%Forma y color:SolidPeso molecular:260.3Nepafenac-d5
CAS:<p>Nepafenac D5 is the deuterium labeled Nepafenac, which is a selective inhibitor of COX-2 .</p>Fórmula:C15H14N2O2Pureza:98%Forma y color:SolidPeso molecular:259.31AHR-10037
CAS:AHR-10037, a NSAID, offers pain relief, fever reduction, safety, and low stomach risk, acting as a prodrug for COX inhibitors.Fórmula:C15H13ClN2O2Pureza:98%Forma y color:SolidPeso molecular:288.73Amfenac
CAS:Amfenac promotes apoptosis in ARPE-19 cell culture.Fórmula:C15H13NO3Forma y color:SolidPeso molecular:255.27Pelubiprofen
CAS:Pelubiprofen is a non-steroidal anti-inflammatory agent and a COX-2 inhibitor, which effectively reduces PGE(2) production by inhibiting COX activity.Fórmula:C16H18O3Pureza:99.69%Forma y color:SolidPeso molecular:258.31Miroprofen
CAS:Miprofen is an analgesic and non-steroidal anti-inflammatory, which means it has anti-inflammatory, antipyretic, and anti-platelet aggregation activities.Fórmula:C16H14N2O2Forma y color:SolidPeso molecular:266.3Loxoprofenol-SRS tromethamine
CAS:Loxoprofenol-SRS tromethamine (HR1405-01), a metabolite of Loxoprofen, is a safe IV NSAID with strong anti-inflammatory and pain relief properties.Fórmula:C19H31NO6Forma y color:SolidPeso molecular:369.45COX-2-IN-26
CAS:COX-2-IN-26: Oral, selective COX-2 inhibitor, low IC50s; anti-inflammatory with GI safety.Fórmula:C23H21N7OS3Forma y color:SolidPeso molecular:507.65COX-2-IN-2
CAS:COX-2-IN-2 selectively inhibits COX2 (IC50: 0.24 μM); COX-2-IN-1 offers anti-inflammatory and pain relief.Fórmula:C17H12FN3O2SPureza:97.62%Forma y color:SolidPeso molecular:341.36K-80001
CAS:<p>K-80001 is a selective RXRα ligand and a COX-1/2 inhibitor, exhibiting IC50 values of 82.9μM for RXRα, 3.4μM for COX-1, and 1.2μM for COX-2, respectively [1].</p>Fórmula:C20H17FO2Forma y color:SolidPeso molecular:308.35COX-2-IN-17
CAS:COX-2-IN-17 is a potent, blood-brain barrier permeable COX-2 (cyclooxygenase-2) inhibitor (IC50: 0.02 μM) with anti-inflammatory and analgesic activity.Fórmula:C20H23ClN6O2Forma y color:SolidPeso molecular:414.89FR-188582
CAS:<p>FR-188582 is a highly selective cyclooxygenase (COX)-2 inhibitor (IC50: 17 nM).</p>Fórmula:C16H13ClN2O2SPureza:98%Forma y color:SolidPeso molecular:332.8MK-0703
CAS:MK-0703 is a selective cyclooxygenase-2 inhibitor.Fórmula:C17H22O5SPureza:98%Forma y color:SolidPeso molecular:338.42COX-2/5-LOX-IN-1
CAS:COX-2/5-LOX-IN-1, a benzothiophen-2-yl pyrazole, inhibits COX-2 & 5-LOX with IC50: COX-1 (12.13μM), COX-2 (0.4μM), 5-LOX (4.96μM). Better than Celecoxib.Fórmula:C14H10ClN3O4S2Forma y color:SolidPeso molecular:383.83Heterophdoid A
CAS:Heterophdoid A is an anti-inflammatory agent that inhibits NO production in BV-2 cells (IC50: 5.93 μM).Fórmula:C26H42O10Forma y color:SolidPeso molecular:514.61Nitroflurbiprofen
CAS:<p>Nitroflurbiprofen (Nitroxybutyl flurbiprofen) is a NO-releasing COX inhibitor and modulates the increased intrahepatic vascular tone in portal hypertensive</p>Fórmula:C19H20FNO5Pureza:99.88%Forma y color:SolidPeso molecular:361.36Timegadine
CAS:Timegadine is a competitive inhibitor of COX and lipo-oxygenase, with IC50s ranging from 5 nM (washed rabbit platelets) to 20 μM (rat brain) for COX and 100 μMFórmula:C20H23N5SPureza:98%Forma y color:SolidPeso molecular:365.5COX-2-IN-18
CAS:COX-2-IN-18 is a potent COX-2 inhibitor similar to Celecoxib, showing promise in cancer research. IC50=0.775μM.Fórmula:C18H19N3O3S2Forma y color:SolidPeso molecular:389.49AL-8417
CAS:AL-8417 is an enzyme inhibitor with antioxidant, anti-inflammatory, and cytostatic properties; prevents vitrectomy-induced lens alterations.Fórmula:C29H34O5Pureza:98%Forma y color:SolidPeso molecular:462.58Safrole oxide
CAS:<p>Safrole oxide inhibits neuronal growth, induces apoptosis, elevates COX-2, IL-8, ROS, promoting endothelial-to-neuron-like cell transdifferentiation.</p>Fórmula:C10H10O3Pureza:100%Forma y color:SolidPeso molecular:178.18COX-2/15-LOX-IN-1
CAS:<p>COX-2/15-LOX-IN-1 is a dual inhibitor for COX-2/15-LOX with anti-inflammatory properties (IC50: COX-1 10.65μM, COX-2 0.075μM, 15-LOX 2.98μM).</p>Fórmula:C21H21N7S3Forma y color:SolidPeso molecular:467.63COX-2-IN-11
CAS:<p>COX-2-IN-11 (compound 7b2) is a potent and selective COX-2 inhibitor. COX-2-IN-11 has the potential in inflammation disease research[1].</p>Fórmula:C12H12OS3Forma y color:SolidPeso molecular:268.42Carpro-AM1
CAS:Carpro-AM1, dual FAAH/COX inhibitor, IC50: 94 nM.Fórmula:C21H18ClN3OForma y color:SolidPeso molecular:363.84ASP-6537
CAS:ASP-6537 is a selective and reversible inhibitor of cyclooxygenase-1.Fórmula:C17H17N3O3Pureza:98%Forma y color:SolidPeso molecular:311.34L 748780
CAS:<p>L 748780 is a selective inducible COX-2 inhibitor.</p>Fórmula:C19H14Cl3NO4Pureza:98%Forma y color:SolidPeso molecular:426.68LY 150310
CAS:LY 150310, a histamine H1-receptor antagonist, can alter prostanoid concentrations in vitro and in vivo.Fórmula:C13H14N2Forma y color:SolidPeso molecular:198.26ZXX2-77
CAS:ZXX2-77 is a cyclooxygenase-1 inhibitor.Fórmula:C13H13ClN2O2SPureza:98%Forma y color:SolidPeso molecular:296.77LY 25648
CAS:LY 25648 is an antagonist of leukotriene B4.Fórmula:C19H27NO2SForma y color:SolidPeso molecular:333.49Lobeglitazone Sulfate
CAS:Lobeglitazone Sulfate (CKD-501) is an anti-inflammatory thiazolidinedione that prevents NLRP3 inflammasome activation and is used in T2DM research.Fórmula:C24H26N4O9S2Pureza:99.6%Forma y color:SolidPeso molecular:578.61AHR-6293
CAS:AHR-6293 is used to distinguishing the effect of anti-platelet aggregating drug properties and the effect of anti-inflammatory properties.Fórmula:C15H12ClNO3Forma y color:SolidPeso molecular:289.71Flosulide
CAS:Flosulide is an effective selective COX-2 inhibitor for the treatment of inflammatory diseases.Fórmula:C16H13F2NO4SPureza:98%Forma y color:SolidPeso molecular:353.34NCX 466
CAS:cyclooxygenase (COX)-inhibiting nitric oxide (NO) donorFórmula:C20H24N2O9Pureza:98%Forma y color:SolidPeso molecular:436.41PD 127443
CAS:PD 127443 is a Leukotriene B4 antagonist, it is also a dual inhibitor of cyclooxygenase and 5-lipoxygenase.Fórmula:C20H28N2OForma y color:SolidPeso molecular:312.45Etoricoxib HCl
CAS:<p>Etoricoxib HCl is a synthetic NSAID that inhibits COX-2, blocking prostaglandin production.</p>Fórmula:C18H16Cl2N2O2SForma y color:SolidPeso molecular:395.30PC407-ws
CAS:PC407-ws is a water-soluble novel COX-2 inhibitor.Fórmula:C24H18F3N3Na2O5SPureza:98%Forma y color:SolidPeso molecular:563.46Isonixin
CAS:Isonixin is used for the treatment of inflammation and pain associated with musculoskeletal and joint disorders.Fórmula:C14H14N2O2Pureza:98%Forma y color:SolidPeso molecular:242.27Tenosal
CAS:Tenosal obtained by esterifying salicylic acid with 2-thiophene-carboxylic acid, and with analgesic and antipyretic properties, anti-inflammatory.Fórmula:C12H8O4SPureza:98%Forma y color:SolidPeso molecular:248.25RWJ 63556
CAS:RWJ 63556 is an orally active inhibitor of COX-2 selective/5-lipoxygenase, shows anti-inflammatory activities.Fórmula:C11H10FNO3S2Pureza:99.92%Forma y color:SolidPeso molecular:287.33Eicosatetraynoic acid
CAS:ETYA activates PPARα/γ at 10μM, inhibits cyclooxygenase (ID50=8μM) and lipoxygenase (ID50=4μM).Fórmula:C20H24O2Pureza:98%Forma y color:SolidPeso molecular:296.4ATB-346, (S)-
CAS:ATB-346(S) is a hydrogen sulfide-releasing anti-inflammatory that triggers melanoma cell death and inhibits tumor growth.Fórmula:C21H19NO3SForma y color:SolidPeso molecular:365.45PPHP
CAS:PPHP is a substrate for the measurement of peroxidase enzymes. PPHP has been used to quantitate the peroxidase activity of COX-1 and COX-2.Fórmula:C11H14O2Forma y color:SolidPeso molecular:178.23Naproxen etemesil
CAS:Naproxen, a COX-1/2 inhibitor, has IC50s of 8.72/5.15 μM. Its prodrug, naproxen etemesil, is lipophilic and converts to active form upon absorption.Fórmula:C17H20O5SPureza:98%Forma y color:SolidPeso molecular:336.4Tilmacoxib
CAS:Tilmacoxib is a highly selective, time-dependent, and irreversible inhibitor of human COX-2 ( IC50: 85 nM in an enzyme assay).Fórmula:C16H19FN2O3SPureza:98%Forma y color:SolidPeso molecular:338.4COX-2-IN-1
CAS:<p>COX-2-IN-1 is a potent and selective COX-2 inhibitor (IC50: 3.9 μM).</p>Fórmula:C18H14ClF3N4O2SPureza:>99.99%Forma y color:SolidPeso molecular:442.84CAY10416
CAS:CAY10416: dual COX-2/5-LO inhibitor, IC50: COX-2 (50 nM), 5-LO (3 nM); >200x selectivity for COX-2; anti-inflammatory, prostate cancer agent.Fórmula:C29H29FN2O5SForma y color:SolidPeso molecular:536.61Insulin levels modulator
CAS:Insulin level regulators can be used to treat diabetes.Fórmula:C21H23N7OSPureza:98%Forma y color:SolidPeso molecular:421.52COX-2-IN-28
CAS:COX-2-IN-28 is a potent and selective COX-2 inhibitor capable of acting on COX-2 (IC50: 0.054 μM), 15-LOX (IC50: 2.14 μM) and COX-1 (IC50: 13.21 μM).Fórmula:C30H27N7S3Forma y color:SolidPeso molecular:581.78(-)-Ibuprofenamide
CAS:(-)-Ibuprofenamide is an amide prodrug of Ibuprofen with anti-inflammatory activity.Fórmula:C13H19NOPureza:98%Forma y color:SolidPeso molecular:205.3Naproxcinod
CAS:Naproxcinod is a derivative of naproxen, analgesic and anti-inflammatory, a COX-inhibitory nitric oxide donor (CINOD), osteoarthritis and inflammatory.Fórmula:C18H21NO6Pureza:99.85%Forma y color:SolidPeso molecular:347.36GW-406381
CAS:GW-406381 is a highly selective COX-2 inhibitor peripherally and centrally, reducing spontaneous ectopic discharges following chronic compressive injury.Fórmula:C21H19N3O3SPureza:99.54%Forma y color:SolidPeso molecular:393.46ADU-S100
CAS:ADU-S100 (MIW815) is a STING agonist that significantly induces the production of IFN-β,TNF-α,IL-6,and MCP-1,induces TBK1 and IRF3 phosphorylation,antitumour.Fórmula:C20H24N10O10P2S2Pureza:99.83%Forma y color:SolidPeso molecular:690.54Anti-inflammatory agent 56
CAS:Anti-inflammatory agent 56 (Compound 9), a selective COX-2 inhibitor with an IC50 of 0.54 μM, exhibits anti-oxidant and anti-inflammatory properties byFórmula:C21H15F3N4O4SPureza:98%Forma y color:SolidPeso molecular:476.43LY 178002
CAS:LY 178002 inhibits 5-LPO (IC50: 0.6 μM), PLA2, and LTB4 production; weak on cyclooxygenase.Fórmula:C18H25NO2SPureza:98%Forma y color:SolidPeso molecular:319.46COX/5-LO-IN-1
CAS:COX/5-LO-IN-1 is a cyclooxygenase and 5-lipoxygenase (5-LO) inhibitor, and used for inflammatory and allergic disease states.Fórmula:C16H15FN2O2SPureza:98%Forma y color:SolidPeso molecular:318.37COX-2-IN-16
CAS:<p>COX-2-IN-16: potent, selective oral COX-2 blocker, IC50=102 μM, reduces NO, anti-inflammatory.</p>Fórmula:C19H12BrN3O2Forma y color:SolidPeso molecular:394.22Thiazolinobutazone
CAS:<p>Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.</p>Fórmula:C22H26N4O2SForma y color:SolidPeso molecular:410.53COX-2-IN-14
CAS:<p>COX-2-IN-14 (2a) is a potent, selective COX-2 inhibitor with high affinity and notable anti-inflammatory effects in mice.</p>Fórmula:C18H18N4O6Forma y color:SolidPeso molecular:386.364Apricoxib
CAS:<p>Apricoxib: oral NSAID with antiangiogenic, antineoplastic properties; inhibits COX-2, may reduce tumor growth and angiogenesis.</p>Fórmula:C19H20N2O3SForma y color:SolidPeso molecular:356.44Anti-inflammatory agent 8
CAS:Anti-inflammatory agent 8 targets COX-2 over COX-1, IC50 of 0.09 nM, orally bioavailable.Fórmula:C18H15N5OS2Forma y color:SolidPeso molecular:381.47SC57666
CAS:SC57666 is a highly selective COX2 inhibitor (IC50 at 26 nM) that shows no activity against COX1.Fórmula:C18H17FO2SPureza:98.83%Forma y color:SolidPeso molecular:316.39COX-2-IN-32
CAS:COX-2-IN-32 (Compound 2f) is a dual inhibitor of iNOS and COX-2, known to downregulate NF-κB expression.Fórmula:C25H24O6Pureza:98%Forma y color:SolidPeso molecular:420.45Naproxen glucuronide
CAS:Naproxen glucuronide: NSAID, propionic class, eases pain, fever, inflammation. Nonselective COX blocker.Fórmula:C20H22O9Forma y color:SolidPeso molecular:406.38COX-2/sEH-IN-1
CAS:COX-2/sEH-IN-1, oral dual inhibitor: COX-2 (IC50=1.24 μM), sEH (IC50=0.40 μM); boosts anti-inflammatory action, cuts heart risk.Fórmula:C23H18F3N5O3SForma y color:SolidPeso molecular:501.48COX-1/2-IN-1
CAS:"COX-1/2-IN-2: Strong dual inhibitor of COX-1 (IC50 = 13.9 μM) and COX-2 (IC50 = 6.4 μM)."Fórmula:C15H10BrClN2OForma y color:SolidPeso molecular:349.61COX-1/2-IN-3
CAS:COX-1/2-IN-3 (Compound 7a) is a dual inhibitor of COX-1 and COX-2. COX-1/2-IN-3 has anti-inflammatory activity with low toxicity [1].Fórmula:C14H8N2O8Forma y color:SolidPeso molecular:332.22COX-2-IN-23
CAS:COX-2-IN-23 selectively inhibits COX-2 (IC50=0.28μM), weakly affects COX-1 (IC50=20.14μM), and has anti-inflammatory and low ulcerogenic properties.Fórmula:C24H25N5O3S2Forma y color:SolidPeso molecular:495.62COX-2-IN-24
CAS:COX-2-IN-24 is an orally active COX-2 inhibitor (IC50: 0.17 μM) with anti-inflammatory and hypo-ulcerogenic effects.Fórmula:C24H24BrN5O3S2Forma y color:SolidPeso molecular:574.51COX-2-IN-19
CAS:COX-2-IN-19, a potent COX-2 inhibitor, IC50 of 1.76 μM, has strong anti-inflammatory effects in vivo.Fórmula:C18H18N4O2SForma y color:SolidPeso molecular:354.43COX-2/5-LOX-IN-2
CAS:COX-2/5-LOX-IN-2, a benzothiophen derivative, inhibits COX-1, COX-2, 5-LOX with IC50s of 5.40, 0.01, 1.78 μM. More effective than Celecoxib, Indomethacin.Fórmula:C18H13N3O4S2Forma y color:SolidPeso molecular:399.44Piroxicam cinnamate
CAS:<p>Cinnoxicam is a COX inhibitor used for bone/joint inflammation, rheumatic issues, and varicocele-related oligospermia.</p>Fórmula:C24H19N3O5SForma y color:SolidPeso molecular:461.49APHS
CAS:APHS is a cyclooxygenase-2 (COX-2) inhibitor with anti-inflammatory action. It also more potent than aspirin in the inhibition of COX-1.Fórmula:C15H18O2SForma y color:SolidPeso molecular:262.37COX-2-IN-21
CAS:COX-2-IN-21 (Compound 5c) is an orally active, selective COX-2 inhibitor (IC50: 0.039 μM). COX-2-IN-21 has good anti-inflammatory potential.Fórmula:C21H22N6O4Forma y color:SolidPeso molecular:422.44SC58451
CAS:SC58451 is a novel potent, orally active and selective COX-2 inhibitor.SC58451 showed anti-inflammatory activity in a rat model of arthritis.Fórmula:C20H19FO2SPureza:>99.99%Forma y color:SolidPeso molecular:342.43Enflicoxib
CAS:Enflicoxib is an effective treatment for canine osteoarthritis pain and inflammation, with faster onset than mavacoxib, improving veterinary outcomes.Fórmula:C16H12F5N3O2SPureza:99.88%Forma y color:SolidPeso molecular:405.34Prostaglandin G/H synthase 1 inhibitor
CAS:<p>Prostaglandin G/H synthase 1 inhibitor (CP 74006) is a selective D5D inhibitor with an IC(50) value of 20 nM.</p>Fórmula:C13H11ClN2OPureza:99.76%Forma y color:SolidPeso molecular:246.69Feprazone
CAS:Feprazone (DA-2370) possesses anti-inflammatory and antiadipogenic properties. Feprazone can be used in studies about the treatment of joint and muscular pain.Fórmula:C20H20N2O2Pureza:99.6% - 99.89%Forma y color:SolidPeso molecular:320.39COX-2-IN-20
CAS:COX-2-IN-20 (Compound 5d) is a selective and orally active inhibitor of COX-2 (IC 50 = 17.9 nM) with anti-inflammatory activity [1].Fórmula:C11H9ClFN3O2Forma y color:SolidPeso molecular:269.66ATB-337
CAS:S-Diclofenac, an NSAID with H2S-releasing moiety, protects gastric mucosa while inhibiting prostaglandins.Fórmula:C23H15Cl2NO2S3Forma y color:SolidPeso molecular:504.47COX-2/5-LOX-IN-3
CAS:COX-2/5-LOX-IN-3 inhibits COX-2/5-LOX with IC50s: COX-1 45.73μM, COX-2 5.45μM, 5-LOX 4.33μM; promising for inflammation research.Fórmula:C17H16ClN3O2SForma y color:SolidPeso molecular:361.85Pifoxime
CAS:Pifoxime: a NSAID with COX-1/2 inhibition, used in anti-inflammatory treatment and neuropsychiatric studies.Fórmula:C15H20N2O3Forma y color:SolidPeso molecular:276.33COX/5-LOX-IN-1
CAS:Compound 6b is a potent dual inhibitor of COX/5-LOX with IC50s: 1.07μM (COX-1), 0.55μM (COX-2), 0.28μM (5-LOX) for inflammation research.Fórmula:C18H30O3Forma y color:SolidPeso molecular:294.43Sudoxicam
CAS:<p>Sudoxicam (4-Hydroxy-2-methyl-N-2-thiazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide) is a reversible antagonist of COX with anti-inflammatory, anti-edema</p>Fórmula:C13H11N3O4S2Pureza:99.93%Forma y color:SolidPeso molecular:337.37L 651896
CAS:L 651896 is an inhibitor of 5-lipoxygenase.Fórmula:C18H18O3Pureza:96.06% - 99.85%Forma y color:SolidPeso molecular:282.33Biofor 389
CAS:<p>Biofor 389 (BF389) has anti-inflammatory activity and can be used to study arthritis.</p>Fórmula:C20H29NO3Pureza:98.84% - 99.97%Forma y color:SolidPeso molecular:331.45SC-75416
CAS:SC-75416, a cyclooxygenase-2 (COX-2) inhibitor, is used potentially for the treatment of postoperative inflammation.Fórmula:C15H14ClF3O3Pureza:98.67% - 98.67%Forma y color:SolidPeso molecular:334.72LM-1685
CAS:<p>LM-1685是一种有效且具有选择性的人单核细胞和全血中COX-2抑制剂，IC50分别为0.65 µM 和IC50 = 4.3 μM，是治疗炎症的潜在化合物。</p>Fórmula:C18H16ClNO4SPureza:98.16%Forma y color:SolidPeso molecular:377.84ABT-963
CAS:ABT-963: COX-2 inhibitor for osteoarthritis/pain with high selectivity, potency, and gastric safety.Fórmula:C22H22F2N2O5SPureza:98% - 99.85%Forma y color:SolidPeso molecular:464.48BN-82451 2HCl
CAS:BN-82451, a cyclooxygenase inhibitor, is used potentially for the treatment of Huntington’s disease.Fórmula:C18H28Cl2N2OSPureza:99.84% - >99.99%Forma y color:SolidPeso molecular:391.4S-2474
CAS:S-2474, an inhibitor of COX-2 and 5-lipoxygenase, has anti-inflammatory and neuroprotective activities, and inhibits cell death.Fórmula:C20H31NO3SPureza:99.03%Forma y color:SolidPeso molecular:365.53Eltenac
CAS:<p>Eltenac, a cyclooxygenase (COX) inhibitor, is used potentially for the treatment of pain.</p>Fórmula:C12H9Cl2NO2SPureza:98.53%Forma y color:SolidPeso molecular:302.18Indazole-Cl
CAS:<p>Indazole-Cl is a selective ERß agonist and a selective estrogen receptor modifier (SERM).</p>Fórmula:C13H9ClN2O2Pureza:99.02% - 99.86%Forma y color:SolidPeso molecular:260.68ER-34122
CAS:<p>ER-34122, a novel orally available dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity.</p>Fórmula:C27H26ClN3O5Pureza:>99.99%Forma y color:SolidPeso molecular:507.96Apyramide
CAS:<p>Apyramide, an NSAID and prodrug of indomethacin, inhibits COX1/COX2 and permeates the blood-brain barrier.</p>Fórmula:C27H23ClN2O5Pureza:99.93%Forma y color:SolidPeso molecular:490.93Tilomisole
CAS:Tilomisole (Wy 18251) is an oral anti-inflammatory and immunomodulatory benzimidazole thiazole, used in cancer and inflammation research.Fórmula:C17H11ClN2O2SPureza:99.21%Forma y color:SolidPeso molecular:342.8Antioxidant agent-15
CAS:Antioxidant agent-15 (Compound 4) demonstrates potent antioxidant inhibition activity, exhibiting an IC50 value of 15.44 nM.Fórmula:C19H14O2Pureza:98%Forma y color:SolidPeso molecular:274.31(±)11-HEDE
CAS:"(±)11-HEDE, a racemic mixture comprising the monohydroxy fatty acids 11(S)-HEDE and 11(R)-HEDE, is synthesized from eicosadienoic acid via cyclooxygenase (COX) activity and within macrophages."Fórmula:C20H36O3Forma y color:SolidPeso molecular:324.54'-Aarboxylic acid imrecoxib
CAS:Imrecoxib-4'-carboxylic acid is a metabolite of Imrecoxib, which acts as a selective COX-II inhibitor [1].Fórmula:C21H21NO5SForma y color:SolidPeso molecular:399.46Prostaglandin E2 Ethanolamide
CAS:Prostaglandin E2 Ethanolamide (PGE 2 -EA), an analog of PGE2, is enzymatically synthesized through COX-2 oxygenation of endocannabinoids. It has the potential to modulate the production of the proinflammatory cytokine TNF-α in human blood and monocytic cells [1] [2].Fórmula:C22H37NO5Forma y color:SolidPeso molecular:395.5411(R)-HEDE
CAS:11(R)-HEDE is synthesized from 11Z,14Z-eicosadienoic acid through a lipoxygenase-type reaction mediated by COX. Spectrophotometric analysis, specifically measuring the absorbance of the conjugated diene in 11(R)-HEDE, serves as an occasional method for quantifying COX activity.Fórmula:C20H36O3Forma y color:SolidPeso molecular:324.56-hydroxy Etodolac
CAS:6-Hydroxy Etodolac, a metabolite of the non-steroidal anti-inflammatory drug (NSAID) and COX inhibitor etodolac, causes false positives in diazo diagnostic tests for urinary bilirubin.Fórmula:C17H21NO4Forma y color:SolidPeso molecular:303.35BW 755C
CAS:BW 755C is a dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways.Fórmula:C10H10F3N3Pureza:96.52%Forma y color:SolidPeso molecular:229.2Kuwanon T
CAS:Kuwanon T, an isoprenylated flavonoid extracted from the root bark of Morus alba, exhibits protective effects against t-BHP-induced oxidative stress, presentingFórmula:C25H26O6Forma y color:SolidPeso molecular:422.47Thioflosulide
CAS:<p>Thioflosulide (L-745337) is a selective and potent COX2 inhibitor (IC50: 2.3 nM) with anti-inflammatory activity for the study of gastric ulcers.</p>Fórmula:C16H13F2NO3S2Pureza:>99.99%Forma y color:SolidPeso molecular:369.41(-)-Bornyl ferulate
CAS:(-)-Bornyl ferulate is a dual inhibitor of 5-lipoxygenase and cyclooxygenase (COX), exhibiting half-maximal inhibitory concentrations (IC50s) of 10.4 μM for 5-Fórmula:C20H26O4Pureza:98%Forma y color:SolidPeso molecular:330.42Cimicoxib
CAS:<p>Cimicoxib (UR8880) is a potent and selective inhibitor of COX-2 with anti-inflammatory and analgesic activity.</p>Fórmula:C16H13ClFN3O3SPureza:98.22%Forma y color:SolidPeso molecular:381.81Amtolmetin guacil
CAS:Amtolmetin guacil (ST-679) 抑制前列腺素合成和环氧合酶。 Amtolmetin guacil 具有与托美汀类似的 NSAID 特性，具有额外的镇痛、解热和胃保护特性。Fórmula:C24H24N2O5Pureza:99.85%Forma y color:White Needle-Shaped CrystalPeso molecular:420.46Benoxaprofen
CAS:Benoxaprofen (NSC-299582) is a non-steroidal anti-inflammatory drug.Fórmula:C16H12ClNO3Pureza:98.87%Forma y color:SolidPeso molecular:301.72Thromboxane B3
CAS:Thromboxane B3 (TXB3), the stable hydrolysis product of TXA3, is synthesized from eicosapentaenoic acid (EPA) through the action of COX and thromboxane synthase enzymes. This compound is biosynthesized in several tissues, including seminal vesicles, lungs, polymorphonuclear leukocytes (PMNL), and ocular tissues.Fórmula:C20H32O6Forma y color:SolidPeso molecular:368.5Anticancer agent 166
CAS:Compound 166, also referred to as compound 3, exhibits potent anticancer properties, demonstrating significant inhibitory activity against Caco-2 cells with anFórmula:C19H14OSForma y color:SolidPeso molecular:290.38XO/COX/LOX-IN-1
<p>XO/COX/LOX-IN-1 targets XO/COX/LOX, used in research of inflammation, cancer, and metabolic disorders.</p>Fórmula:C24H20N4O2SForma y color:SolidPeso molecular:428.51COX-2/PI3K-IN-2
<p>COX-2/PI3K-IN-2 (5f): anti-inflammatory & anti-cancer, selectively inhibits COX-2 (Ki=3.02nM), potently blocks PI3K (IC50=2.78nM).</p>Fórmula:C16H17N5O2Forma y color:SolidPeso molecular:311.34COX-2-IN-13
COX-2-IN-13 is a potent, selective COX-2 inhibitor with 0.98 μM IC50; shows strong anti-inflammatory properties and low acute toxicity.Fórmula:C19H18N2O5SForma y color:SolidPeso molecular:386.42(R)-Ketoprofen
CAS:<p>(R)-Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) that exhibits oral activity and analgesic properties. Unlike its counterpart, (R)-Ketoprofen does not significantly enhance the increase of inflammatory cytokines (such as Tumor Necrosis Factor (TNF) and Interleukin-1 (IL-1)) induced by LPS. However, it can inhibit the anti-inflammatory activity of (S)-Ketoprofen.</p>Fórmula:C16H14O3Forma y color:SolidPeso molecular:254.28COX-2-IN-9
COX-2-IN-9: potent oral COX-2 blocker, selective over Celecoxib, IC50 10.17 μM, less ulcers, strong anti-inflammatory.Fórmula:C25H23N5O4S2Forma y color:SolidPeso molecular:521.61COX-2/PI3K-IN-1
COX-2/PI3K-IN-1 (compound 5d) is a potent inhibitor of PI3K (IC50: 1.14 nM). COX-2/PI3K-IN-1 is a selective inhibitor of COX-2 (Ki: 3.24 nM).Fórmula:C19H14ClN5S2Forma y color:SolidPeso molecular:411.93Ambuic acid
CAS:Ambuic acid: cyclohexanone with antifungal, quorum-inhibiting, antibacterial properties, blocks cyclic peptides; reduces MRSA abscesses in mice.Fórmula:C19H26O6Forma y color:SolidPeso molecular:350.41COX-1/2-IN-2
COX-1/2-IN-2, a potent dual inhibitor, has IC50s: COX-1 at 9.7μM & COX-2 at 4.6μM.Fórmula:C15H10ClIN2OForma y color:SolidPeso molecular:396.61COX-2-IN-47
CAS:COX-2-IN-47 (compound 6c) is a selective inhibitor of COX-2, exhibiting an IC50 of 0.03 μM. This compound also displays antiedema activity.Fórmula:C18H18N2O4Forma y color:SolidPeso molecular:326.35Anti-inflammatory agent 9
Benzimidazothiazole-derived Compound 28 from tilomisole targets COX-2, has potent anti-inflammatory effects & is orally bioavailable.Fórmula:C18H15N5O2SForma y color:SolidPeso molecular:365.41COX-2/15-LOX-IN-5
CAS:<p>COX-2/15-LOX-IN-5 (Compound 4f) functions as a dual inhibitor of COX-2 and 15-LOX, demonstrating both anti-inflammatory and antioxidant properties [1]. This compound effectively reduces NF-κB activation in RAW 264.7 macrophages that is induced by lipopolysaccharide.</p>Fórmula:C25H21N3O3SForma y color:SolidPeso molecular:443.52COX-2-IN-10
COX-2-IN-10 is a potent COX-2 inhibitor, reducing IL-6, TNF-α, IL-1β, PGE2 (IC50=2.54 μM), and iNOS expression.Fórmula:C31H32FN5O2SForma y color:SolidPeso molecular:557.68COX-2-IN-8
<p>COX-2-IN-8 (Compound 6a) is a potent, selective, orally active COX-2 inhibitor (IC50: 6.585 μM) with a higher COX-2 selectivity than Celecoxib.</p>Fórmula:C19H19N3O4S2Forma y color:SolidPeso molecular:417.5COX-2-IN-6
CAS:COX-2-IN-6: Potent, selective COX-2 inhibitor; oral; IC50 0.84μM, Ki 69nM; blocks PGE2 synthesis; prevents colorectal cancer.Fórmula:C20H27NO6SPureza:99.29% - 99.32%Forma y color:SoildPeso molecular:409.5Neral
CAS:Neral, a monoterpenoid compound, exhibits anti-inflammatory and anticancer activities. It inhibits TNF-α and IL-6, along with inflammatory mediators such as pro-IL-1β, iNOS, COX-2, and NLRP-3.Fórmula:C10H16OForma y color:SolidPeso molecular:152.23Sabialimon P
CAS:<p>Sabialimon P (compound 16), with an IC50 of 18.12 μM, functions as a NO release inhibitor and exhibits anti-inflammatory properties. It effectively diminishes the secretion of TNF-α, iNOS, IL-6, and NF-κB, and suppresses the expression of COX-2 and NF-κB/p65 in LPS-induced RAW264.7 cells.</p>Fórmula:C31H50O4Forma y color:SolidPeso molecular:486.73COX-2-IN-12
COX-2-IN-12: Potent, selective COX-2 inhibitor, IC50=19.98μM, safe anti-inflammatory with low acute toxicity.Fórmula:C17H19NO3Forma y color:SolidPeso molecular:285.34COX-2-IN-29
<p>COX-2-IN-29 is a selective inhibitor of orally active COX-2 (IC50: 0.005 μM).</p>Fórmula:C22H23FN2O6S2Forma y color:SolidPeso molecular:494.56COX-2-IN-7
<p>COX-2-IN-7: potent, orally active COX-2 inhibitor with higher selectivity than Celecoxib, IC50 6.585 uM, anti-inflammatory, low ulcer risk.</p>Fórmula:C15H13N3O2S2Forma y color:SolidPeso molecular:331.41STAT1/3-IN-1
CAS:<p>STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.</p>Fórmula:C28H25ClN6O5Forma y color:SolidPeso molecular:560.988NLRP3-IN-69
CAS:NLRP3-IN-69 (Compound 23) inhibits the activation of NF-κBp65 and the formation of the NLRP3 inflammasome. It suppresses the overexpression of IL-1β, iNOS, and COX-2 induced by LPS, and inhibits the production of NO (IC50=5.66 μM), thereby demonstrating anti-inflammatory activity.Fórmula:C25H24O7Forma y color:SolidPeso molecular:436.454COX-2-IN-51
CAS:<p>COX-2-IN-51 (E25) is a potent COX-2 inhibitor with an IC50 of 70.7 nM. It significantly suppresses LPS-induced release of NO and PGE2, the expression of COX-2 and iNOS, and the activation of the NF-κB pathway. Displaying anti-inflammatory and analgesic effects in various mouse models through NF-κB pathway inhibition, COX-2-IN-51 has lower gastrointestinal side effects compared to Indomethacin.</p>Fórmula:C23H18F4O3SForma y color:SolidPeso molecular:450.446COX-2/NO-IN-1
COX-2/NO-IN-1: oral iNOS & NO blocker (IC50=3.52μM), COX-2 supressor, anti-inflammatory, protects kidneys.Fórmula:C15H15NO3Forma y color:SolidPeso molecular:257.28Soquelitinib
CAS:Soquelitinib (CPI-818) is a selective ITK inhibitor， inhibits tumor growth,T-cell, up-regulatCXCR3, IFNγ, TNFα, and CD107a expression in normal CD8 cells.Fórmula:C25H30N4O4S2Pureza:99.54%Forma y color:SolidPeso molecular:514.66Anti-inflammatory agent 10
Tilomisole-derived benzimidazole-thiazole, orally active, favors COX-2 inhibition over COX-1.Fórmula:C17H13BrN4O3S2Forma y color:SolidPeso molecular:465.34Racemic Naproxen
CAS:Racemic Naproxen is a biochemical substance.Fórmula:C14H14O3Pureza:98%Forma y color:Crystals From Acetone-Hexane White SolidPeso molecular:230.26
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