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GluR

GluR

Inhibidores del Receptor de Glutamato son compuestos que bloquean la actividad de los receptores de glutamato, los principales receptores de neurotransmisores excitatorios en el cerebro. Estos receptores desempeñan un papel crucial en la transmisión sináptica, la plasticidad, el aprendizaje y la memoria. La desregulación de la señalización de glutamato está asociada con varios trastornos neurológicos, como la epilepsia, el accidente cerebrovascular y las enfermedades neurodegenerativas. Los inhibidores de los receptores de glutamato son esenciales para investigar los mecanismos de la excitotoxicidad y desarrollar estrategias neuroprotectoras. En CymitQuimica, ofrecemos una gama de inhibidores de receptores de glutamato para apoyar su investigación en la función sináptica, la neuroprotección y los trastornos cognitivos.

Se han encontrado 255 productos de "GluR"

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  • Troriluzole

    CAS:
    <p>Troriluzole is a glutamate modulator with anticancer activity and is used in the study of spinocerebellar ataxia.</p>
    Fórmula:C15H16F3N5O4S
    Pureza:97.14%
    Forma y color:Solid
    Peso molecular:419.38
  • Dipraglurant

    CAS:
    <p>Dipraglurant: a blood-brain permeable mGluR5 NAM, orally active, selective, IC50 = 21 nM, treats PD-LID.</p>
    Fórmula:C16H12FN3
    Pureza:98.7%
    Forma y color:Solid
    Peso molecular:265.29
  • LSN2463359

    CAS:
    <p>LSN2463359 is a positive allosteric modulators of the mGlu5 receptor.</p>
    Fórmula:C16H15N3O
    Pureza:99.26%
    Forma y color:Solid
    Peso molecular:265.31
  • (E/Z)-SIB-1893

    CAS:
    <p>(E/Z)-SIB-1893 (SIB 1893) is the racemate of (E)-SIB-1893 and (Z)-SIB-1893.</p>
    Fórmula:C14H13N
    Pureza:99.92%
    Forma y color:Solid
    Peso molecular:195.26
  • Dasolampanel

    CAS:
    <p>Dasolampanel (NGX-426) is an ionotropic glutamate receptor AMPA and Kainate receptor antagonist for the study of chronic pain disorders.</p>
    Fórmula:C17H20ClN5O3
    Pureza:98.70%
    Forma y color:Solid
    Peso molecular:377.83
  • LY-2300559

    CAS:
    <p>LY-2300559 is an agonist of metabotropic glutamate receptor 2 (mGluR2) and can be used in studies about the treatment of migraine.</p>
    Fórmula:C26H26O6
    Pureza:99.51%
    Forma y color:Solid
    Peso molecular:434.48
  • Valiglurax

    CAS:
    <p>Valiglurax (VU2957), potent mGlu4 PAM, crosses blood-brain barrier, orally available; promising for Parkinson's treatment.</p>
    Fórmula:C16H10F3N5
    Pureza:98.29%
    Forma y color:Solid
    Peso molecular:329.28
  • CBiPES hydrochloride

    CAS:
    <p>CBiPES hydrochloride (CBiPES HCl) is an orthosteric modulator of the mGlu2 receptor and is used to study neurological disorders like epilepsy.</p>
    Fórmula:C21H20ClN3O2S
    Pureza:99.66%
    Forma y color:Solid
    Peso molecular:413.92
  • CPCCOEt

    CAS:
    <p>CPCCOEt is a low affinity, selective, non-competitive and reversible antagonist of mGluR1b</p>
    Fórmula:C13H13NO4
    Pureza:99.91%
    Forma y color:Solid
    Peso molecular:247.25
  • S 18986

    CAS:
    <p>S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in</p>
    Fórmula:C10H12N2O2S
    Pureza:99.64%
    Forma y color:Solid
    Peso molecular:224.28
  • VU 0285683

    CAS:
    <p>VU 0285683 is a specific negative allosteric modulator of mGluR5 with a high affinity for the MPEP binding site. VU 0285683 shows anxiolytic-like activity.</p>
    Fórmula:C14H7FN4O
    Pureza:99.98%
    Forma y color:Solid
    Peso molecular:266.23
  • ABP688

    CAS:
    <p>ABP688 is a non-competitive and selective mGluR5 antagonist(Ki = 1.7 nM). ABP688 can be used as a PET tracer for clinical imaging.</p>
    Fórmula:C15H16N2O
    Pureza:98.63%
    Forma y color:Solid
    Peso molecular:240.3
  • AZD 9272

    CAS:
    <p>AZD 9272 is a brain-permeable mGluR5 antagonist for the study of gastroesophageal reflux.</p>
    Fórmula:C14H6F2N4O
    Pureza:98.29%
    Forma y color:Solid
    Peso molecular:284.22
  • AZD6538

    CAS:
    <p>AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease.</p>
    Fórmula:C15H6FN5O
    Pureza:98.68%
    Forma y color:Solid
    Peso molecular:291.24
  • MNI 137

    CAS:
    <p>MNI 137 is a negative allosteric modulator of mGlu2. MNI 137 inhibits glutamate-induced calcium mobilization with IC50s of 8.3 and 12.6 nM for human and rat.</p>
    Fórmula:C15H9BrN4O
    Pureza:97.49%
    Forma y color:Solid
    Peso molecular:341.16
  • VU0029251

    CAS:
    <p>VU0029251 serves as a partial antagonist of mGluR5, exhibiting a binding affinity with a K i of 1.07 μM.</p>
    Fórmula:C10H11N3S2
    Forma y color:Solid
    Peso molecular:237.34
  • MTPG

    CAS:
    <p>Group II/group III metabotropic glutamate receptor antagonist</p>
    Fórmula:C10H11N5O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:233.23
  • L-AP4

    CAS:
    <p>L-APB is an effective and specific agonist for the group III mGluRs (EC50s: 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6, and mGlu7 receptors, respectively).</p>
    Fórmula:C4H10NO5P
    Pureza:98%
    Forma y color:White To Off-White Crystalline Powder
    Peso molecular:183.1
  • mGluR5 antagonist-1

    CAS:
    <p>mGluR5 antagonist-1 (compound 10) is a potent mGluR5 inhibitor exhibiting an IC50 of 11.5 nM and demonstrates antidepressant effects [1].</p>
    Fórmula:C23H18N4O2
    Forma y color:Solid
    Peso molecular:382.41
  • VU0360172

    CAS:
    <p>VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM).</p>
    Fórmula:C18H15FN2O
    Pureza:99.56%
    Forma y color:Solid
    Peso molecular:294.32