Proteasoma
Los inhibidores del proteasoma son compuestos que inhiben el proteasoma, un gran complejo proteico responsable de degradar proteínas no deseadas o dañadas dentro de la célula. La inhibición del proteasoma conduce a la acumulación de proteínas, lo que puede inducir la detención del ciclo celular y la apoptosis, especialmente en células que se dividen rápidamente, como las células cancerosas. Los inhibidores del proteasoma son cruciales en la investigación y terapia contra el cáncer, especialmente en el tratamiento del mieloma múltiple y otras malignidades hematológicas. En CymitQuimica, ofrecemos inhibidores del proteasoma para apoyar su investigación en oncología, biología celular y desarrollo de fármacos.
Se han encontrado 94 productos de "Proteasoma"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Proteasome-IN-5
CAS:<p>Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].</p>Fórmula:C20H30BN5O7Pureza:98%Forma y color:SolidPeso molecular:463.29Proteasome β2c/i-IN-1
CAS:<p>Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].</p>Fórmula:C32H48N4O7Pureza:98%Forma y color:SolidPeso molecular:600.75LU-002i
CAS:<p>LU-002i is a selective inhibitor targeting the human proteasome subunits β2c and β2i, demonstrating an inhibitory concentration (IC50) of 220 nM for β2i [1].</p>Fórmula:C35H52N4O7Pureza:98%Forma y color:SolidPeso molecular:640.81TCL1
CAS:<p>TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.</p>Fórmula:C19H14BrClN4O2SForma y color:SolidPeso molecular:477.762ZINC09518833
CAS:<p>ZINC09518833 is an α-ketoamide non-peptide proteasome inhibitor with an IC50 value of 12.4 μM. It can bind with both the active and inactive sites of the proteasome. ZINC09518833 shows promise for use in research related to multiple myeloma (MM).</p>Fórmula:C24H25N3O5Forma y color:SolidPeso molecular:435.47RBx-0597
CAS:<p>RBx-0597 is a selective DPP-IV inhibitor with IC50 values of 32 nM, 31 nM, and 39 nM for human, mouse, and rat plasma DPP-IV, respectively. It is utilized in research focused on type 2 diabetes.</p>Fórmula:C19H20F2N4O2Forma y color:SolidPeso molecular:374.384(2S,4R)-Teneligliptin
CAS:<p>(2S,4R)-Teneligliptin is a selective inhibitor of dipeptidyl peptidase IV (DPP-4). It increases the concentration of active glucagon-like peptide-1 (GLP-1) in plasma, which in turn stimulates insulin secretion when blood glucose levels are elevated, thereby exhibiting hypoglycemic effects. (2S,4R)-Teneligliptin is a promising candidate for research in type 2 diabetes.</p>Fórmula:C22H30N6OSForma y color:SolidPeso molecular:426.578DPP-4-IN-15
CAS:<p>DPP-4-IN-15 (Compound 22) is a non-competitive inhibitor of dipeptidyl peptidase-4 (DPP-4) with an IC50 value of 8.24 μM.</p>Fórmula:C17H14F3N3O2SForma y color:SolidPeso molecular:381.372Boc3Arg
<p>Boc 3 Arg is a tert-butyl carbamate-protected arginine compound. It serves as an efficient tag that induces degradation by directly targeting proteins to the 20S proteasome.</p>Fórmula:C21H39N5O7Forma y color:SolidPeso molecular:473.56Marizomib
CAS:<p>Marizomib is a novel irreversible brain-permeable proteasome inhibitor that inhibits CT-L, CT-T-laspase-like, and trypsin-like 20S proteasomes.Cost-effective and quality-assured.</p>Fórmula:C15H20ClNO4Pureza:98.03% - 99.41%Forma y color:SolidPeso molecular:313.78Immunoproteasome activator 1
CAS:Immunoproteasome Activator 1 (compound A) is a selective immunoproteasome activator that enhances the presentation of individual MHC-I binding peptides by over 100 times. It binds to the proteasomal structural subunit PSMA1 and facilitates the association of the proteasome activators PA28α/β (PSME1/PSME2) with the immunoproteasome.Fórmula:C24H23N3O3Forma y color:SolidPeso molecular:401.46PB01
CAS:<p>PB01 is a DPP-4 inhibitor with an IC50 of 15.66 nM. It effectively suppresses high glucose-induced ROS generation and mitochondrial superoxide production while significantly reducing the cellular expression of DPP-4. Additionally, PB01 notably lowers blood glucose levels in diabetic mice. It demonstrates excellent safety, exhibiting almost no cytotoxicity at a concentration of 100 μM. PB01 holds promise for research in the diabetes field.</p>Fórmula:C18H21N5O3Forma y color:SolidPeso molecular:355.391BI-1942
CAS:<p>BI-1942 is a chymase inhibitor with an IC50 value of 0.4 nM against human chymase. It is applicable for research in ophthalmic diseases.</p>Fórmula:C24H26N4O4Forma y color:SolidPeso molecular:434.488Davelizomib
CAS:<p>Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].</p>Fórmula:C21H26BF2N3O7Pureza:98%Forma y color:SolidPeso molecular:481.25
