Proteasoma
Los inhibidores del proteasoma son compuestos que inhiben el proteasoma, un gran complejo proteico responsable de degradar proteínas no deseadas o dañadas dentro de la célula. La inhibición del proteasoma conduce a la acumulación de proteínas, lo que puede inducir la detención del ciclo celular y la apoptosis, especialmente en células que se dividen rápidamente, como las células cancerosas. Los inhibidores del proteasoma son cruciales en la investigación y terapia contra el cáncer, especialmente en el tratamiento del mieloma múltiple y otras malignidades hematológicas. En CymitQuimica, ofrecemos inhibidores del proteasoma para apoyar su investigación en oncología, biología celular y desarrollo de fármacos.
Se han encontrado 84 productos para "Proteasoma".
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Calpastatin subdomain B
CAS:Calpastatin subdomain B is a bioactive peptide that inhibits calpain activity.Fórmula:C140H227N35O44SPureza:98%Forma y color:SolidPeso molecular:3136.57Proteasome-IN-7
Proteasome-IN-7 (Compound 6f) is a macrolactam-based epoxyketone proteasome inhibitor with an IC50 value of 37.92 nM against the 20S proteasome ChT-L subunit. It exhibits potent antiproliferative effects on multiple myeloma, acute lymphoblastic leukemia, and non-small cell lung cancer.Fórmula:C48H56N6O10SForma y color:SolidPeso molecular:909.06Acetyl-Calpastatin(184-210)(human), Negative Control
Acetyl-Calpastatin(184-210)(human), Negative Control is a control scrambled peptide corresponding to Acetyl-Calpastatin(184-210)(human). Acetyl-Calpastatin(184-210)(human) functions as a potent, selective, and reversible calpain inhibitor.Fórmula:C142H230N36O44SForma y color:SolidPeso molecular:3175.65874DPP8/9-IN-1
DPP8/9-IN-1 (Compound 16) is a selective covalent inhibitor of dipeptidyl peptidase 8 and 9 (DPP8/9), with IC50 values of 14 nM and 298 nM, respectively. It irreversibly binds to the active site serine (such as S730 in DPP9) through a phosphate ester warhead, blocking substrate binding and inhibiting DPP8/9-mediated protein processing. DPP8/9-IN-1 holds potential for research in cancer and inflammatory diseases.Forma y color:Odour SolidDazcapistat
CAS:Dazcapistat is a potent calpain inhibitor, with IC50s of <3 μM for calpain 1, calpain 2 and calpain 9, respectively.Fórmula:C21H18FN3O4Pureza:99.11%Forma y color:SolidPeso molecular:395.38Ref: TM-T9710
1mg92,00€5mg192,00€1mL*10mM (DMSO)212,00€10mg289,00€25mg522,00€50mg732,00€100mg1.018,00€Phepropeptin D
CAS:Phepropeptin D is a secondary metabolite produced by microorganisms and acts as a proteasome (proteasome) inhibitor, with an IC50 of 7.8 μg/mL.Fórmula:C41H58N6O6Forma y color:SolidPeso molecular:730.94VAMP
VAMP is a tetrapeptide that acts as a competitive dipeptidyl peptidase IV (DPP-IV) inhibitor, exhibiting an IC50 of 1.00 μM and a Kd of 6.89 μM. It effectively targets the DPP-IV-GLP-1 axis and is utilized in the research of type 2 diabetes.Fórmula:C18H32N4O5SForma y color:SolidPeso molecular:416.535Protease Inhibitor Library
A unique collection of 343 protease and proteasome inhibitors for research in chemical genomics, and drug screening;Forma y color:Odour SolidRef: TM-L1100
1mgA consultar10μL*10mM (DMSO)A consultar20μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultar250μL*10mM (DMSO)A consultarPhepropeptin C
CAS:Phepropeptin C is a microbial secondary metabolite that acts as a proteasome (proteasome) inhibitor, with an IC50 of 12.5 μg/mL.Fórmula:C38H60N6O6Forma y color:SolidPeso molecular:696.92LMP7/LMP2-IN-1
CAS:LMP7/LMP2-IN-1 (Compound 19) is an orally effective inhibitor targeting the immunoproteasome subunits LMP7 and LMP2, with respective IC50 values of 257 and 10 nM. This compound reduces the production of antibodies and downregulates the B cells in the germinal centers of the spleen and plasma cells in NP-OVA immunized mice. It has potential applications in the study of autoimmune diseases.Fórmula:C16H27BN4O3Forma y color:SoildPeso molecular:334.22Alogliptin-13CD3
CAS:Alogliptin (SYR-322) 13CD3 is the deuterium-labeled Alogliptin. Alogliptin is a selective inhibitor of DPP-4.Fórmula:C18H21N5O2Pureza:98%Forma y color:SolidPeso molecular:343.4Teneligliptin-D8
CAS:Teneligliptin D8 a deuterium labeled Teneligliptin (MP-513). Teneligliptin is a potent, orally available, competitive, and long-lasting inhibitor of DPP-4.Fórmula:C22H30N6OSPureza:98%Forma y color:SolidPeso molecular:434.635-Amino-8-hydroxyquinoline
CAS:5-Amino-8-hydroxyquinoline(5A8HQ),Proteasome inhibitor. Potential anticancer agent.Fórmula:C9H8N2OPureza:99.69%Forma y color:SolidPeso molecular:160.17H-Pro-Lys-OH TFA
H-Pro-Lys-OH TFA is a dipeptide composed of proline and lysine, serving as a substrate for imino dipeptidase (prolinase). Additionally, it can be utilized in peptide synthesis.Fórmula:C13H22F3N3O5Forma y color:SolidPeso molecular:357.33ONX-0914
CAS:ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.Fórmula:C31H40N4O7Pureza:98.24% - 99.31%Forma y color:SolidPeso molecular:580.67MDL-28170
CAS:MDL-28170 (Calpain Inhibitor III) is a Cysteine protease.Fórmula:C22H26N2O4Pureza:95.06%Forma y color:SolidPeso molecular:382.45Ref: TM-T2470
1mg34,00€2mg49,00€5mg71,00€1mL*10mM (DMSO)75,00€10mg90,00€25mg128,00€50mg167,00€100mg284,00€Alloxan monohydrate
CAS:Alloxan Monohydrate is a glucose analog used to induce diabetes by destroying beta-cells.Fórmula:C4H4N2O5Pureza:99.01% - 99.42%Forma y color:SolidPeso molecular:160.09ISOGINKGETIN
CAS:ISOGINKGETIN (4',4'''-Dimethylamentoflavone), a compound derived from the leaves of Ginkgo biloba, to up-regulate adiponectin secretion.Fórmula:C32H22O10Pureza:98% - 99.75%Forma y color:Yellow SolidPeso molecular:566.514'-Hydroxychalcone
CAS:4'-Hydroxychalcone (2-Benzal-4-Hydroxyacetophenone) is a chalcone metabolite with hepatoprotective activityFórmula:C15H12O2Pureza:99.86% - 99.87%Forma y color:Yellow-Cream PowderPeso molecular:224.25PI-1840
CAS:PI-1840 is a reversible and selective chymotrypsin-like (CT-L) inhibitor, with little proteasome proteolytic effects on trypsin-like (T-L) and PGPH-L.Fórmula:C22H26N4O3Pureza:98.82%Forma y color:SolidPeso molecular:394.47
