Células madre y Derivados
Los inhibidores de células madre son compuestos que se dirigen específicamente a las vías de señalización y proteínas involucradas en el mantenimiento, diferenciación y proliferación de células madre. Estos inhibidores son cruciales para comprender la biología de las células madre y para desarrollar estrategias que permitan manipularlas con fines terapéuticos, como en la medicina regenerativa y el tratamiento del cáncer. Al controlar el destino de las células madre, estos inhibidores pueden ayudar a guiar la diferenciación de células madre en tipos celulares específicos o prevenir el crecimiento celular no deseado. En CymitQuimica, ofrecemos una selección de inhibidores de células madre de alta calidad para apoyar su investigación en biología de células madre, biología del desarrollo y medicina regenerativa.
Subcategorías de "Células madre y Derivados"
- Gamma-secretasa(66 productos)
- Hedgehog / Smoothened(49 productos)
- Hippo pathway(7 productos)
- JAK(236 productos)
- Porcupine (Puerco espín)(8 productos)
- ROCK(61 productos)
- STAT(102 productos)
- Células madre(119 productos)
- TGF-beta / Smad(69 productos)
- Wnt / beta-catenina(63 productos)
Mostrar 2 subcategorías más
Se han encontrado 416 productos para "Células madre y Derivados".
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
CIA-1 (Free base)
CAS:CIA-1, a COUP-TFII inhibitor, has IC50 of 1.2-7.6 μM in prostate cancer cells; inhibits tumor growth in mouse prostate cancer.Fórmula:C17H19N3O2SPureza:99%Forma y color:SolidPeso molecular:329.42Axltide
CAS:Axltide mimics mouse Insulin receptor substrate 1, amino acids 979-989 with sequence KKSRGDYMTMQIG.Fórmula:C63H107N19O20S2Pureza:98%Forma y color:SolidPeso molecular:1514.77Depiperazine-DM3189
CAS:Depiperazine-DM3189 inhibits the phosphorylation of SMAD 1/5/8 induced by bone morphogenetic protein 4 and can be used in biochemical experiments .Fórmula:C21H14N4Pureza:99.69%Peso molecular:322.36γ-Secretase modulator 10
CAS:γ-Secretase modulator 10 is a novel γ-secretase modulator.Fórmula:C25H23F3N4O2Forma y color:SolidPeso molecular:468.48Baricitinib-D3
CAS:Baricitinib-D3 is the deuterated form of Baricitinib. Baricitinib (T2485) (LY3009104; INCB028050) acts as a selective and orally administered inhibitor of JAK1 and JAK2, with IC50 values of 5.9 nM and 5.7 nM, respectively.Fórmula:C16H17N7O2SForma y color:SolidPeso molecular:374.44PSEN1-IN-2
PSEN1-IN-2 (Compound 13K) is a potent inhibitor of both PSEN1-APH1A and PSEN1-APH1B complexes, exhibiting IC50 values of 6.9 nM and 2.4 nM, respectively.Fórmula:C20H18ClFN2O3SForma y color:SolidPeso molecular:420.88OICR41114
OICR41114 (PROTAC4) is a PROTAC degrader targeting WDR5. It effectively degrades endogenous WDR5 with an EC50 of 40 nM and a Dmax of 49%. The degradation of HiBiT-tagged WDR5 by OICR41114 occurs in a proteasome-dependent manner. This compound is composed of a target protein ligand, Dimethyl-F-OICR-9429-COOH, an E3 ligase ligand, OICR-8268-acrylic acid, and a PROTAC linker, Amino-PEG9-amine. Notably, the conjugate of the E3 ligase ligand and the linker is OICR-8268-acrylic acid-amino-PEG9-amine.Fórmula:C70H83Cl2F6N9O15Forma y color:SolidPeso molecular:1475.36OPN-9652
CAS:OPN-9652 is a covalent TEAD inhibitor reversing drug resistance in BRAF-mutant tumors.Fórmula:C19H15F4NO2Pureza:99.78%Forma y color:White SolidPeso molecular:365.32Notch 1
CAS:Notch1 (Notchhomolog 1, translocation-associated) encodes a protein that is a member of the NOTCH family. This type I transmembrane protein family is characterized by common structural features, including an extracellular domain made up of multiple epidermal growth factor-like (EGF) repeats and an intracellular domain composed of various types of domains.Fórmula:C62H97N15O22S3Forma y color:SolidPeso molecular:1500.72SAHM1
CAS:Notch pathway inhibitor - stabilized hydrocarbon-stapled alpha helical peptide. Targets the protein-protein interface and prevents Notch complex assembly.Fórmula:C94H162N36O23SPureza:98%Forma y color:SolidPeso molecular:2196.58NIBR-LTSi
NIBR-LTSi is a selective LATS kinase inhibitor that also activates YAP signaling, promotes tissue stem cell expansion and tissue regeneration in vitro/vivo.Fórmula:C18H20N4OPureza:99.87%Forma y color:Brown SolidPeso molecular:308.38SAHM1 TFA
SAHM1 TFA inhibits the Notch pathway, stabilizes alpha helices, and blocks Notch complex formation.Fórmula:C96H163N36F3O25SForma y color:SolidPeso molecular:2310.6MR44397
MR44397 is a ligand for WD40 repeat (WDR) 5 and is applicable in cancer research.Fórmula:C23H26N4O2SForma y color:SolidPeso molecular:422.54TGF-β1/Smad3-IN-1
CAS:TGF-β1/Smad3-IN-1 is an orally administrable dual inhibitor of TGF-β1/Smad3 with anti-fibrotic activity, idiopathic pulmonary fibrosis (IPF).Fórmula:C30H34N4O6SPureza:99.83%Peso molecular:578.68Adenosine receptor modulator 1
Adenosine receptor modulator 1 acts as an inducer of collagen VII (C7). It enhances the expression of COL7A1 mRNA in donor-derived keratinocytes and, in synergy with Gentamicin, increases the overall levels of C7.Fórmula:C25H28N6O3Forma y color:SolidPeso molecular:460.53Tubastatin
CAS:Tubastatin inhibits TGF-β1-induced S6K phosphorylation, HIF-1α expression and VEG F expression.Fórmula:C21H22N2O2Pureza:98.23%Forma y color:SolidPeso molecular:334.41WDR5 ligand 2
CAS:WDR5ligand 2 is a ligand for WDR5 and can be utilized in the synthesis of PROTAC WDR5degrader 1.Fórmula:C29H31F3N4O4Forma y color:SolidPeso molecular:556.576YAP-IN-1
YAP-IN-1 (Compound (+)-1) is an autophagy inhibitor specifically targeting YAP1. It binds to the Hippo pathway transcription factor YAP1 with a Kd of 9.13 μM, promoting its degradation through the chaperone-mediated autophagy (CMA) pathway. This process inhibits the Rab7-mediated fusion of autophagosomes with lysosomes and decreases autophagy levels without affecting lysosomal function. YAP-IN-1 shows potential for cancer research, including in hepatocellular carcinoma and breast cancer.Forma y color:Odour SolidYAP/TEAD-IN-1
YAP/TEAD-IN-1 (compound 4) is a potent inhibitor of YAP and TEAD, exhibiting antioxidant properties. It demonstrates antiproliferative effects on tumor cells while showing minimal cytotoxic activity towards normal human cells.Fórmula:C32H30N8OForma y color:SolidPeso molecular:542.634PROTAC TYK2 degrader-1
CAS:PROTAC TYK2 degrader-1 (CPD-155) functions as a selective degrader of TYK2, demonstrating a degradation maximum (D max) greater than 60%. This compound effectively targets TYK2 for degradation, utilizing a linker to connect the TYK2 ligand with the VHL ligand Thalidomide, each color-coded for identification.Fórmula:C40H41N13O7Forma y color:SolidPeso molecular:815.84SJ10542
CAS:SJ10542: potent JAK2/3-targeting PG-PROTAC; DC50s: JAK2 - 14 nM, JAK3 - 11 nM, JAK2-fusion ALL - 24 nM; CRBN recruiter.Fórmula:C41H46N12O5SForma y color:SolidPeso molecular:818.95Itacitinib adipate
CAS:Itacitinib adipate: oral JAK1 inhibitor, tested in phase II myelofibrosis trial.Fórmula:C32H33F4N9O5Forma y color:SolidPeso molecular:699.66Anti-5T4/TPBG Antibody (9P872)
Anti-5T4/TPBG Antibody (9P872) is an antibody targeting 5T4/TPBG. Anti-5T4/TPBG Antibody (9P872) can be used in ELISA, FCM.Forma y color:Odour LiquidAnti-NANOG Antibody (1M448)
Anti-NANOG Antibody (1M448) is a Mouse antibody targeting NANOG. Anti-NANOG Antibody (1M448) can be used in ELISA, WB, ICC, IF, FCM.Pureza:>95%Forma y color:Odour LiquidAnti-SOST Antibody (3R170)
Anti-SOST Antibody (3R170) is an antibody targeting SOST. Anti-SOST Antibody (3R170) can be used in ELISA, IHC.Forma y color:Transparent LiquidAtinvicitinib
CAS:Atinvicitinib, a selective JAK1 inhibitor, blocks cytokine signaling, modulating itch, allergy, and inflammatory responses, immune and therapeutic studies.Fórmula:C16H17FN6O3Pureza:99.36%Forma y color:White SolidPeso molecular:360.35Ref: TM-T39646
1mg138,00€1mL*10mM (DMSO)264,00€5mg334,00€10mg550,00€25mg1.063,00€50mg1.738,00€100mg2.547,00€Ifidancitinib
CAS:Ifidancitinib (ATI-50002) is a JAK kinase 1/3 inhibitor used to study autoimmune diseases.Fórmula:C20H18FN5O3Pureza:98.05%Forma y color:SolidPeso molecular:395.39IBS008738
CAS:IBS008738 is a TAZ activator that stabilises TAZ and increases unphosphorylated TAZ levels in C2C12 cells, upregulates MyoD-dependent gene transcription.Fórmula:C22H22N4O2Pureza:99.44%Forma y color:Yellow SolidPeso molecular:374.44Legumain inhibitor 1
CAS:Legumain inhibitor 1 is a highly potent and specific Legumain inhibitor with potential anticancer activity for cancer research.Fórmula:C23H25N5O4SPureza:98.14%Forma y color:Yellow SolidPeso molecular:467.54γ-secretase modulator 3
CAS:Gamma-secretase modulator 3 (γ-secretase modulator 3) is a γ-secretase modulator that reduces Aβ production.Fórmula:C24H23FN4OSPureza:98%Forma y color:SolidPeso molecular:434.53CHZ868
CAS:CHZ868 is a type II JAK inhibitor with potential antitumor activity that reverses the persistence of type I JAK inhibitors and can be used to study leukemia.Fórmula:C22H19F2N5O2Pureza:99.38%Forma y color:SolidPeso molecular:423.42YAP/TAZ inhibitor-1
CAS:YAP/TAZ inhibitor-1 is a YAP/TAZ inhibitor (IC50 <0.100 μΜ) for the study of abnormal immune function and cancer.Fórmula:C33H39N3O5S2Pureza:99.72%Forma y color:White SolidPeso molecular:621.81DTP3
CAS:DTP3 is a selective MKK7/GADD45β inhibitor, which inhibits cancer-selective NF-κB survival pathway.Fórmula:C26H35N7O5Forma y color:SolidPeso molecular:525.6Ilunocitinib
CAS:Ilunocitinib is a non-selective and orally active Janus kinase (JAK) inhibitor for pruritus and atopic dermatitis caused by atopic dermatitis in dogs.Fórmula:C17H17N7O2SPureza:99.88%Forma y color:SolidPeso molecular:383.43Ref: TM-T38571
1mg92,00€5mg230,00€1mL*10mM (DMSO)251,00€10mg356,00€25mg713,00€50mg1.189,00€100mg1.791,00€200mg2.412,00€Enoticumab
CAS:Enoticumab (REGN421) is a fully human IgG1 monoclonal antibody with anticancer activity that inhibits cancer cell growth.Pureza:98.2% (SDS-PAGE); 98.9% (SEC-HPLC) - 98.2% (SDS-PAGE); 98.9% (SEC-HPLC)Forma y color:LiquidPeso molecular:146.22 kDaAnti-GPC3 Antibody (4L576)
Anti-GPC3 Antibody (4L576) is an antibody targeting GPC3. Anti-GPC3 Antibody (4L576) can be used in ELISA, WB, IF.Forma y color:Odour LiquidBaricitinib
CAS:Baricitinib (INCB028050) is an orally JAK1 and JAK2 inhibitor. Baricitinib has anti-inflammatory and anti-tumor activity. Cost-effective and quality-assured.Fórmula:C16H17N7O2SPureza:99% - >99.99%Forma y color:SolidPeso molecular:371.42Ref: TM-T2485
5mg48,00€1mL*10mM (DMSO)65,00€10mg70,00€25mg95,00€50mg109,00€100mg137,00€200mg178,00€500mg295,00€GDC-0214
CAS:GDC-0214 is an inhaled small-molecule JAK1 inhibitor and reduces fractional exhaled nitric oxide (Feno).Fórmula:C28H28ClF2N9O3Pureza:99.75%Forma y color:White SolidPeso molecular:612.03Ref: TM-T9826
1mg93,00€5mg182,00€1mL*10mM (DMSO)245,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.099,00€FM-381
CAS:FM381, a JAK3 inhibitor with 127 pM IC50, is 410-3600x more selective over JAK1/2/TYK2.Fórmula:C24H24N6O2Pureza:98.44%Forma y color:SolidPeso molecular:428.49Ref: TM-T5091
1mg47,00€2mg62,00€5mg92,00€1mL*10mM (DMSO)107,00€10mg128,00€25mg212,00€50mg319,00€100mg485,00€IMR-1
CAS:IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μMol/L.Fórmula:C15H15NO5S2Pureza:97.96% - 99.65%Forma y color:SolidPeso molecular:353.41GLPG0634 analog
CAS:GLPG0634 analog (GLPG0634 analogue) is a specific JAK1 inhibitor with IC50 of 10/28/810/116 nM for JAK1/2/3 and TYK2, respectively.Fórmula:C23H18N6O2Pureza:99.52% - >99.99%Forma y color:SolidPeso molecular:410.43Ref: TM-T3076
1mg38,00€2mg50,00€5mg84,00€1mL*10mM (DMSO)93,00€10mg137,00€25mg250,00€50mg442,00€100mg623,00€500mg1.305,00€Lats-IN-1
CAS:Lats-IN-1 is a potent and ATP-competitive Lats1 and Lats2 kinases inhibitor. It promotes Yap-dependent proliferation in postmitotic mammalian tissues.Fórmula:C18H14N4OSPureza:97.54% - 99.79%Forma y color:White SolidPeso molecular:334.39Ref: TM-T9053
1mg50,00€2mg70,00€5mg100,00€1mL*10mM (DMSO)112,00€10mg159,00€25mg294,00€50mg394,00€100mg560,00€200mg798,00€XL019
CAS:XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, 100 fold selectivity over JAK1.Fórmula:C25H28N6O2Pureza:99.19%Forma y color:SolidPeso molecular:444.53Ref: TM-T3072
2mg43,00€5mg63,00€1mL*10mM (DMSO)69,00€10mg92,00€25mg150,00€50mg215,00€100mg321,00€200mg477,00€Cucurbitacin I
CAS:Cucurbitacin I (JSI-124), a natural compound, is a selective inhibitor of JAK2/STAT3 with anti-cancer activity.Fórmula:C30H42O7Pureza:96.69% - 99.8%Forma y color:SolidPeso molecular:514.65Lumiflavine
CAS:Lumiflavine (Lumilactoflavin) inhibits riboflavin uptake. It is produced by the photolysis of vitamin B2.Fórmula:C13H12N4O2Pureza:97.09% - 98.01%Forma y color:Yellow SolidPeso molecular:256.26XMU-MP-1
CAS:XMU-MP-1 is a reversible and selective MST1/2 kinase inhibitor, IC50 values for MST1 and MST2 are 71.1 nM and 38.1 nM, respectively. High-Quality, Low-Cost!Fórmula:C17H16N6O3S2Pureza:99.68% - 99.97%Forma y color:SolidPeso molecular:416.48Ref: TM-T4212
1mg50,00€2mg74,00€1mL*10mM (DMSO)89,00€5mg92,00€10mg144,00€25mg289,00€50mg485,00€100mg628,00€Atractylenolide I
CAS:Atractylenolide-I reduces inflammation, improves sepsis, liver, and kidney function, and enhances EOC cell sensitivity to paclitaxel.Fórmula:C15H18O2Pureza:97.55% - 99.92%Forma y color:White SolidPeso molecular:230.30SRI-011381 hydrochloride
CAS:SRI-011381 hydrochloride, a new-type agonist of the TGF-beta signaling pathway, is utilized in the treatment of Alzheimer's disease.Fórmula:C20H32ClN3OPureza:99.32% - 99.41%Forma y color:SolidPeso molecular:365.94Ref: TM-T5129
1mg34,00€2mg44,00€5mg66,00€1mL*10mM (DMSO)73,00€10mg105,00€25mg215,00€50mg334,00€100mg497,00€200mg755,00€MK-0752 Sodium
CAS:Sodium MK-0752 is a novel and potent gamma-secretase inhibitor that has been evaluated in clinical trials for the treatment of various types of cancer.Fórmula:C21H21ClF2NaO4SForma y color:SolidPeso molecular:465.89MRT-14
CAS:MRT-14 is a potent Smo antagonist and can be used in several types of cancers linked to abnormal Hh signaling studies.Fórmula:C24H24N4O5Pureza:99.54%Forma y color:SolidPeso molecular:448.47
