c-Fms
Los inhibidores de c-Fms se dirigen al receptor del factor estimulante de colonias-1 (c-Fms), una tirosina quinasa involucrada en la regulación de los macrófagos y otras células inmunitarias. La señalización de c-Fms juega un papel en la proliferación, diferenciación y supervivencia de estas células. La desregulación de c-Fms está asociada con enfermedades como el cáncer, condiciones inflamatorias y osteoporosis. En CymitQuimica, ofrecemos inhibidores de c-Fms para apoyar su investigación en inmunología, oncología y enfermedades inflamatorias.
Se han encontrado 117 productos para "c-Fms".
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c-Fms-IN-10
CAS:c-Fms-IN-10 is a thieno[3,2-d]pyrimidine derivative, an FMS kinase inhibitor with IC50 of 2 nM, exhibiting anti-tumor properties.Fórmula:C22H19N7OSPureza:98%Forma y color:SolidPeso molecular:429.5CSF1R-IN-4
CAS:CSF1R-IN-4, a potent CSF-1R inhibitor, may impact TAM/glioma cell communication, with cancer research potential. (WO2021197276A1, compound 104)Fórmula:C23H20N6O3Forma y color:SolidPeso molecular:428.44JNJ-28312141
CAS:JNJ-28312141: oral CSF1R/FLT3 inhibitor, potential for treating acute myeloid leukemia, tumors, and bone events.Fórmula:C26H32N6O2Pureza:98%Forma y color:SolidPeso molecular:460.57c-Fms-IN-8
CAS:c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.Fórmula:C27H30N2O5Pureza:98%Forma y color:SolidPeso molecular:462.54c-Fms-IN-7
CAS:c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).Fórmula:C26H24N6OSPureza:98%Forma y color:SolidPeso molecular:468.57Leustroducsin A
CAS:Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.Fórmula:C32H52NO10PForma y color:SolidPeso molecular:641.73AZ683
CAS:AZ683 is a potent and selective CSF1R inhibitor, used as a PET tracer in [11C] form.Fórmula:C23H25F2N5O2Peso molecular:441.47Anti-CSF1R/CD115 Antibody (2-4A5-4)
The Anti-CSF1R/CD115 Antibody (2-4A5-4) is a chimeric IgG1, κ antibody derived from rats, targeting human CSF1R/CD115. The isotype control for the Anti-CSF1R/CD115 Antibody (2-4A5-4) is RatIgG1kappa, Isotype Control.Balugrastim
CAS:Balugrastim (CG 10639), a novel long-acting recombinant granulocyte colony-stimulating factor (G-CSF), results from the genetic fusion of recombinant humanForma y color:Liquidc-Fms-IN-9
CAS:c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45c-Fms-IN-6
CAS:c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).Fórmula:C22H25N7O2Pureza:98%Forma y color:SolidPeso molecular:419.48c-Fms-IN-2
CAS:c-Fms-IN-2 is an inhibitor of c-FMS kinase (IC50 = 24 nM).Fórmula:C19H21N3O3Pureza:99.56%Forma y color:SolidPeso molecular:339.39Ref: TM-T10775
1mg92,00€1mL*10mM (DMSO)180,00€5mg241,00€10mg355,00€25mg532,00€50mg750,00€100mg1.009,00€CSF1R-IN-6
CAS:CSF1R-IN-6, a compound, effectively inhibits macrophage CSF1R essential for survival and differentiation.Fórmula:C20H18N8O3Forma y color:SolidPeso molecular:418.41Chiauranib
CAS:Chiauranib, a potent anticancer agent, inhibits angiogenesis kinases (VEGFR1-3, PDGFRα, c-Kit), Aurora B, and CSF1R with IC50 values of 1-9 nM.Fórmula:C27H21N3O3Pureza:99.22%Forma y color:SolidPeso molecular:435.47Ref: TM-T35570
1mg66,00€5mg144,00€1mL*10mM (DMSO)157,00€10mg245,00€25mg492,00€50mg710,00€100mg973,00€CSF1R-IN-3
CAS:CSF1R-IN-3 is an orally effective CSF-1R inhibitor with an IC50 value of 2.1 nM.Fórmula:C30H38N8O4Pureza:98.4%Forma y color:Yellow SolidPeso molecular:574.67c-Fms-IN-3
CAS:c-Fms-IN-3 is a novel inhibitor of the c-FMS and can be used in studies about antirheumatic and anti-inflammatory diseases.Fórmula:C23H30N6OPureza:99.87%Forma y color:SolidPeso molecular:406.52Ref: TM-T10649
1mg52,00€5mg105,00€1mL*10mM (DMSO)110,00€10mg161,00€25mg264,00€50mg358,00€100mg522,00€Pimicotinib
CAS:Pimicotinib (ABSK021) is a potent CSF1R inhibitor with antitumor activity and can be used to study advanced solid tumors.Fórmula:C22H24N6O3Pureza:99.95%Forma y color:SolidPeso molecular:420.46Ref: TM-T79157
1mg50,00€5mg105,00€1mL*10mM (DMSO)117,00€10mg167,00€25mg313,00€50mg500,00€100mg800,00€c-Fms-IN-13
CAS:c-Fms-IN-13 (compound 14) is a potent FMS kinase inhibitor (IC50= 17 nM). c-Fms-IN-13 is an anti-inflammatory agent.Fórmula:C22H26N4O2Pureza:99.89% - 99.96%Forma y color:SolidPeso molecular:378.47JTE-952
CAS:JTE-952: oral, selective Type II CSF-1R inhibitor, IC50 = 13 nM for CSF1R, 261 nM for TrkA, effective in mouse arthritis model.Fórmula:C30H34N2O6Pureza:98%Forma y color:SolidPeso molecular:518.6Adrixetinib
CAS:Adrixetinib (Q702) is a CSF1R/Mer/Axl inhibitor used in tumor microenvironment research on macrophage polarization, immune infiltration, and cancer immunotherapy models.Fórmula:C25H24F3N5O5Forma y color:SolidPeso molecular:531.48
