c-Fms
Los inhibidores de c-Fms se dirigen al receptor del factor estimulante de colonias-1 (c-Fms), una tirosina quinasa involucrada en la regulación de los macrófagos y otras células inmunitarias. La señalización de c-Fms juega un papel en la proliferación, diferenciación y supervivencia de estas células. La desregulación de c-Fms está asociada con enfermedades como el cáncer, condiciones inflamatorias y osteoporosis. En CymitQuimica, ofrecemos inhibidores de c-Fms para apoyar su investigación en inmunología, oncología y enfermedades inflamatorias.
Se han encontrado 108 productos de "c-Fms"
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ARRY-382
CAS:ARRY-382 is a highly selective oral inhibitor of CSF-1R with an IC50 of 9 nM.
Fórmula:C32H36N8O2Pureza:99.76%Forma y color:SolidPeso molecular:564.68Enrupatinib
CAS:Enrupatinib is an inhibitor of the colony stimulating factor 1 receptor (CSF1R), exhibiting antitumor activity.Fórmula:C27H26N6O3Forma y color:SolidPeso molecular:482.53c-Fms-IN-15
CAS:c-Fms-IN-15 (compound 8g) is a potent inhibitor of FMS kinase, with an IC50 of 563 nM.Fórmula:C29H28F3N7O2Peso molecular:563.57Leustroducsin B
CAS:Leustroducsin B is a novel colony-stimulating factor (CSF) inducer extracted from Streptomyces platensis SANK 60191.Fórmula:C34H56NO10PForma y color:SolidPeso molecular:669.78GENZ-882706
CAS:GENZ-882706 is a potent colony stimulating factor-1 receptor (CSF-1R) Inhibitor.Fórmula:C26H25N5O3Pureza:98%Forma y color:SolidPeso molecular:455.51Pimicotinib hydrochloride
CAS:Pimicotinib hydrochloride is an inhibitor of CSF1R, displaying antitumor activity.Fórmula:C22H25ClN6O3Forma y color:SolidPeso molecular:456.925SJ-C1044
CAS:SJ-C1044 is an orally effective pan-RAF inhibitor demonstrating immunomodulatory and antitumor activities. It targets wild-type BRAF, wild-type CRAF, and BRAF(V600E) with IC50 values of 331, 257, and 187 nM, respectively. SJ-C1044 suppresses tumor cell proliferation by inhibiting kras activation and MEK-ERK phosphorylation. Additionally, it shows inhibition of VEGFR2, TIE2, and CSF1R, with IC50 values of 100, 23, and 235 nM respectively. The compound enhances the tumor immune microenvironment through inhibition of angiogenesis and modulation of macrophage function. SJ-C1044 is applicable for research in colorectal cancer.Fórmula:C25H14F7N7OForma y color:SolidPeso molecular:561.41JNJ-6204
CAS:JNJ-6204 is a deuterated compound that efficiently inhibits CSNK1D and CSNK1E.Fórmula:C19H11D6FN6OPureza:97.42% - 99.87%Forma y color:SolidPeso molecular:370.41
