c-Fms
Los inhibidores de c-Fms se dirigen al receptor del factor estimulante de colonias-1 (c-Fms), una tirosina quinasa involucrada en la regulación de los macrófagos y otras células inmunitarias. La señalización de c-Fms juega un papel en la proliferación, diferenciación y supervivencia de estas células. La desregulación de c-Fms está asociada con enfermedades como el cáncer, condiciones inflamatorias y osteoporosis. En CymitQuimica, ofrecemos inhibidores de c-Fms para apoyar su investigación en inmunología, oncología y enfermedades inflamatorias.
Se han encontrado 108 productos de "c-Fms"
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Cerdulatinib hydrochloride
CAS:Cerdulatinib hydrochloride is an oral tyrosine kinase inhibitor targeting JAK1/2/3, TYK2, Syk, and 19 others with IC50 < 200 nM.Fórmula:C20H28ClN7O3SPureza:99.85%Forma y color:SolidPeso molecular:482Lenzilumab
CAS:Lenzilumab (KB 003) is a humanized GM-CSF neutralizing antibody for the study of COVID-19.Pureza:98.9% (SDS-PAGE); 98.5% (SEC-HPLC) - 98.9% (SDS-PAGE); 98.5% (SEC-HPLC)Forma y color:LiquidPeso molecular:146.81 kDaCabiralizumab
CAS:Cabiralizumab is an anti-CSF1R monoclonal antibody that enhances T cell infiltration, inhibits osteoclasts, and is used in RA and immune-oncology research.Pureza:95% - 98.2% (SDS-PAGE); 98.1% (SEC-HPLC)Forma y color:LiquidNamilumab
CAS:Namilumab (AMG203) is a humanised IgG1 monoclonal antibody that neutralises GM-CSF. rheumatoid arthritis and active axial spondyloarthritis.Pureza:95%Forma y color:LiquidTrabikibart
CAS:Trabikibart (CSL311) is a human βc-specific antibody inhibiting IL-3, GM-CSF and IL-5, regulating eosinophil survival in chronic inflammatory disease research.Pureza:95% - 95.6% (SDS-PAGE); 99.3% (SEC-HPLC)Forma y color:LiquidPeso molecular:144.64 kDaCSF1R-IN-19
CAS:CSF1R-IN-19 is a robust inhibitor of CSF1R that influences the exchange of inflammatory factors between TAMs and glioma cells. It holds potential for cancer research [1].Fórmula:C20H27N7OForma y color:SolidPeso molecular:381.47c-Fms-IN-6
CAS:c-Fms-IN-6 is a potent inhibitor of c-FMS (IC50 ≤10 nM for unphosphorylated c-FMS) and also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50: > 1 μM).Fórmula:C22H25N7O2Pureza:98%Forma y color:SolidPeso molecular:419.48c-Fms-IN-9
CAS:c-Fms-IN-9 inhibits c-FMS/uFMS and uKIT with IC50 <0.01μM and 0.1-1μM, from patent WO2014145023A1.Fórmula:C21H23N7O2Pureza:98%Forma y color:SolidPeso molecular:405.45Leustroducsin A
CAS:Leustroducsin A is an inducer of colony-stimulating factors (CSFs) extracted from Streptomyces platensis SANK 60191.Fórmula:C32H52NO10PForma y color:SolidPeso molecular:641.73c-Fms-IN-7
CAS:c-Fms-IN-7 is a cFMS inhibitor (IC50: 18.5 nM).Fórmula:C26H24N6OSPureza:98%Forma y color:SolidPeso molecular:468.57c-Fms-IN-8
CAS:c-Fms-IN-8 is a colony-stimulating factor-1 receptor (CSF-1R, c-FMS) Type II inhibitor (IC50: 9.1 nM). It is compound 4a in the reference.Fórmula:C27H30N2O5Pureza:98%Forma y color:SolidPeso molecular:462.54JNJ-28312141
CAS:JNJ-28312141: oral CSF1R/FLT3 inhibitor, potential for treating acute myeloid leukemia, tumors, and bone events.Fórmula:C26H32N6O2Pureza:98%Forma y color:SolidPeso molecular:460.57CSF1R-IN-4
CAS:CSF1R-IN-4, a potent CSF-1R inhibitor, may impact TAM/glioma cell communication, with cancer research potential. (WO2021197276A1, compound 104)Fórmula:C23H20N6O3Forma y color:SolidPeso molecular:428.44c-Fms-IN-10
CAS:c-Fms-IN-10 is a thieno[3,2-d]pyrimidine derivative, an FMS kinase inhibitor with IC50 of 2 nM, exhibiting anti-tumor properties.Fórmula:C22H19N7OSPureza:98%Forma y color:SolidPeso molecular:429.5CSF1R-IN-13
CAS:CSF1R-IN-13: potent cancer research CSF1R inhibitor impacting cell growth regulation.Fórmula:C21H20N4O3Forma y color:SolidPeso molecular:376.41CSF1R-IN-8
CAS:CSF1R-IN-8 (Compound 22) is a CSF-1R inhibitor (IC50: 0.012 μM).Fórmula:C24H22N4O4Forma y color:SolidPeso molecular:430.46CSF1R-IN-10
CAS:CSF1R-IN-10 (Compound 48) is a CSF-1R inhibitor (IC50: 0.005 μM).Fórmula:C25H22N4O3Forma y color:SolidPeso molecular:426.47Leustroducsin C
CAS:Leustroducsin C is an inducer of colony-stimulating factors CSF extracted from Streptomyces platensis SANK 60191.Fórmula:C34H56NO10PForma y color:SolidPeso molecular:669.78CSF1R-IN-14
CAS:CSF1R-IN-14, an isoindolinone derivative, powerfully inhibits CSF1R, with potential in cancer research. See WO2019134662A1, compound 1.Fórmula:C23H22F3N5OForma y color:SolidPeso molecular:441.45CSF1R-IN-12
CAS:CSF1R-IN-12 is an effective CSF1R inhibitor. CSF1R-IN-12 has research potential in cancer diseases.Fórmula:C21H17F3N4OForma y color:SolidPeso molecular:398.38
