c-Met / HGFR
Los inhibidores de c-Met/HGFR apuntan al Receptor del Factor de Crecimiento de Hepatocitos (c-Met), una tirosina quinasa involucrada en procesos celulares como el crecimiento, la motilidad y la morfogénesis. La señalización de c-Met está implicada en la progresión del cáncer, la metástasis y la resistencia a terapias. Inhibir c-Met puede interrumpir el crecimiento y la propagación del tumor, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer. En CymitQuimica, ofrecemos inhibidores de c-Met/HGFR para apoyar su investigación en oncología, metástasis y terapias contra el cáncer dirigidas.
Se han encontrado 143 productos de "c-Met / HGFR"
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Umikibart
Umikibart is a humanized IgG4κ antibody targeting HGF, with the corresponding isotype control being HumanIgG4(S228P) kappa, Isotype Control.Forma y color:Odour LiquidLMTK3-IN-1
CAS:Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway.Fórmula:C18H11F3N4OPureza:99.58%Forma y color:SoildPeso molecular:356.3Caveolin-1 (82-101) amide (human, mouse, rat)
CAS:Caveolin-1 (82-101) amide (human, mouse, rat), also known as Caveolin-1 scaffolding domain peptide, mitigates aging-related detrimental alterations in variousFórmula:C124H170N28O29Pureza:98%Forma y color:SolidPeso molecular:2516.85BMS-777607
CAS:BMS-777607 is a Met-related inhibitor for c-Met, Axl, Ron and Tyro3.Fórmula:C25H19ClF2N4O4Pureza:98.16% - 98.56%Forma y color:SolidPeso molecular:512.89Ref: TM-T2658
2mg59,00€5mg86,00€10mg135,00€25mg251,00€50mg388,00€100mg690,00€200mg1.034,00€500mg1.550,00€Antitumor agent-111
Antitumor Agent-111 (Compound 46), a c-Met kinase inhibitor (IC50 = 46 nM), exhibits both antitumor and antiproliferative effects.Fórmula:C34H29ClF2N6O5Pureza:98%Forma y color:SolidPeso molecular:675.08c-Met-IN-18
C-Met-IN-18, an ATP-competitive type-III inhibitor, targets both wild-type (WT) and D1228V mutant c-MET with IC50 values of 0.013 µM and 0.20 µM, respectively.Fórmula:C21H15FN4O2Pureza:98%Forma y color:SolidPeso molecular:374.37c-Met-IN-23
c-Met-IN-23 (Compound 12g) functions as a c-Met inhibitor with an IC50 of 0.052 μM against c-Met. It also inhibits the MDR1 and MRP1/2 pumps in cancerous HepG2 and BxPC3 cells. As such, c-Met-IN-23 serves as an anticancer agent.Fórmula:C16H13N7OPeso molecular:319.11816PROTAC c-Met degrader-2
CAS:PROTACc-Met degrader-2 (PROTAC2) is a c-Met degrader developed using PROTAC technology, with a DC50 value of 50 nM.Fórmula:C51H50F2N6O13Forma y color:SolidPeso molecular:992.97Narnatumab
CAS:Narnatumab (IMC-RON8) is a humanized antibody targeting the macrophage-stimulating receptor (RON) with antitumor activity, used in advanced malignant solid tumors research.Pureza:>95%Forma y color:LiquidPeso molecular:145.8 kDaNorleual
CAS:Angiotensin IV analog, potent HGF/c-MET inhibitor (IC50=3 pM), halts MDCK cell growth and invasion, AT4 antagonist, impairs LTP, antiangiogenic.
Fórmula:C41H58N8O7Pureza:98%Forma y color:SolidPeso molecular:774.95SYN1143
CAS:SYN1143 (AMG-1) strongly inhibits RON & c-Met with IC50s: 9 & 4 nmol/L.Fórmula:C31H29FN4O5Pureza:99.69%Forma y color:SolidPeso molecular:556.58PF-04217903 methanesulfonate
CAS:PF-04217903 methanesulfonate is a potent ATP-competitive inhibitor of c-Met kinase (Ki of 4.8 nM for human c-Met).Fórmula:C20H20N8O4SPureza:98%Forma y color:SolidPeso molecular:468.49Norleual TFA
Norleual TFA, Ang IV analog, inhibits HGF/c-Met (IC50: 3 pM), blocks AT4, and has strong antiangiogenic effects.Fórmula:C43H59F3N8O9Peso molecular:888.97S49076
CAS:S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Fórmula:C22H22N4O4SPureza:95.35% - 97.4%Forma y color:SolidPeso molecular:438.5Ref: TM-T3274
1mg34,00€2mg44,00€5mg58,00€10mg93,00€25mg167,00€50mg260,00€100mg432,00€200mg618,00€1mL*10mM (DMSO)64,00€DS-1205
CAS:DS-1205: AXL kinase inhibitor (IC50=1.3 nM), also targets MER, MET, TRKA (IC50s: 63, 104, 407 nM), hinders cell migration and tumor growth.Fórmula:C41H42FN5O7Pureza:99.75%Forma y color:SolidPeso molecular:735.8Ensartinib hydrochloride
CAS:Ensartinib hydrochloride (X-396 dihydrochloride) is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of knownFórmula:C26H29Cl4FN6O3Pureza:98.73%Forma y color:SolidPeso molecular:634.36Ref: TM-T22324
1mg54,00€5mg114,00€10mg177,00€25mg356,00€50mg580,00€100mg888,00€1mL*10mM (DMSO)158,00€NVP-BVU972
CAS:NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.Fórmula:C20H16N6Pureza:97.24% - >99.99%Forma y color:SolidPeso molecular:340.38Ref: TM-T2680
2mg44,00€5mg74,00€10mg97,00€25mg178,00€50mg255,00€100mg359,00€200mg510,00€1mL*10mM (DMSO)84,00€AMG-208
CAS:AMG-208 is a highly selective c-Met inhibitor with IC50 of 9 nM. Phase 1.Fórmula:C22H17N5O2Pureza:98.56%Forma y color:SolidPeso molecular:383.4Capmatinib 2HCl
CAS:Capmatinib 2HCl (INC-280 2HCl), a c-MET inhibitor, is potent (IC50 = 0.13 nM), highly specific, and induces apoptosis in tumor cells.Fórmula:C23H19Cl2FN6OPureza:98.80%Forma y color:SolidPeso molecular:485.34Ref: TM-T4260
2mg34,00€5mg49,00€10mg64,00€25mg84,00€50mg92,00€100mg126,00€500mg303,00€1mL*10mM (DMSO)58,00€Ningetinib
CAS:Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Fórmula:C31H29FN4O5Pureza:99.95% - 99.98%Forma y color:SolidPeso molecular:556.58
