c-Met / HGFR
Los inhibidores de c-Met/HGFR apuntan al Receptor del Factor de Crecimiento de Hepatocitos (c-Met), una tirosina quinasa involucrada en procesos celulares como el crecimiento, la motilidad y la morfogénesis. La señalización de c-Met está implicada en la progresión del cáncer, la metástasis y la resistencia a terapias. Inhibir c-Met puede interrumpir el crecimiento y la propagación del tumor, lo que hace que estos inhibidores sean valiosos en la investigación del cáncer. En CymitQuimica, ofrecemos inhibidores de c-Met/HGFR para apoyar su investigación en oncología, metástasis y terapias contra el cáncer dirigidas.
Se han encontrado 142 productos para "c-Met / HGFR".
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Altiratinib
CAS:Altiratinib (DCC-2701)(DCC-2701) is a novel c-MET/TIE-2/VEGFR inhibitor; effectively reduce tumor burden in vivo and block c-MET pTyr(1349)-mediated signaling,Fórmula:C26H21F3N4O4Pureza:99.67% - 99.75%Forma y color:SolidPeso molecular:510.46SCR-1481B1
CAS:SCR-1481B1 (c-Met inhibitor 2) has activity against cancers dependent on Met activation and also has activity against cancers as a VEGFR inhibitorFórmula:C32H40ClF2N6O13PPureza:98.07%Forma y color:SolidPeso molecular:821.12Ref: TM-T5349
1mg35,00€2mg50,00€5mg74,00€1mL*10mM (DMSO)102,00€10mg113,00€25mg200,00€50mg333,00€100mg495,00€Capmatinib 2HCl
CAS:Capmatinib 2HCl (INC-280 2HCl), a c-MET inhibitor, is potent (IC50 = 0.13 nM), highly specific, and induces apoptosis in tumor cells.Fórmula:C23H19Cl2FN6OPureza:98.80%Forma y color:SolidPeso molecular:485.34Ref: TM-T4260
2mg34,00€5mg49,00€1mL*10mM (DMSO)58,00€10mg64,00€25mg84,00€50mg92,00€100mg126,00€500mg303,00€Foretinib
CAS:Foretinib (GSK1363089) is a broad-spectrum tyrosine kinase inhibitor with IC50s of 0.4 nM and 0.9 nM for Met and KDR.Fórmula:C34H34F2N4O6Pureza:98.07% - 99.68%Forma y color:SolidPeso molecular:632.65Ref: TM-T3113
2mg37,00€5mg54,00€10mg74,00€1mL*10mM (DMSO)74,00€25mg126,00€50mg195,00€100mg335,00€500mg803,00€S49076
CAS:S49076 is a novel, potent inhibitor of MET, AXL/MER, and FGFR1/2/3, blocking cellular phosphorylation of MET, AXL, and FGFRs.Fórmula:C22H22N4O4SPureza:95.35% - 99.66%Forma y color:SolidPeso molecular:438.5Ref: TM-T3274
1mg34,00€2mg44,00€5mg58,00€1mL*10mM (DMSO)64,00€10mg93,00€25mg167,00€50mg260,00€100mg432,00€200mg618,00€SGX-523
CAS:SGX-523 is a selective Met inhibitor (IC50: 4 nM), no inhibitory to Abl, BRAFV599E, p38α, and c-Raf.Fórmula:C18H13N7SPureza:99% - >99.99%Forma y color:SolidPeso molecular:359.41Ref: TM-T2293
1mg34,00€2mg46,00€5mg84,00€1mL*10mM (DMSO)87,00€10mg114,00€25mg219,00€50mg349,00€100mg557,00€200mg790,00€BMS-2
CAS:BMS-2 is a Met/Flt-3/VEGFR2 tyrosine kinase inhibitor.Fórmula:C25H16F2N4O3Pureza:98.33%Forma y color:SolidPeso molecular:458.42Ref: TM-T8326
1mg67,00€2mg88,00€5mg148,00€1mL*10mM (DMSO)170,00€10mg230,00€25mg430,00€50mg622,00€100mg898,00€BMS817378
CAS:BMS817378 is a potent and selective inhibitor of MET(IC50 : 1.7 nM).Fórmula:C24H18ClF2N4O7PPureza:>99.99%Forma y color:White SolidPeso molecular:578.85SAR125884 hydrochlorid (1116743-46-4(free base))
CAS:SAR125844 is a potent and selective MET kinase inhibitor with a favorable preclinical toxicity profile,(IC50=4.2 nM).Fórmula:C25H23FN8O2S2·HClPureza:97.95%Forma y color:SolidPeso molecular:587Ref: TM-T5677
1mg35,00€5mg57,00€10mg95,00€1mL*10mM (DMSO)96,00€25mg178,00€50mg264,00€100mg374,00€200mg537,00€Merestinib dihydrochloride
CAS:Merestinib dihydrochloride (LY2801653 dihydrochloride) is a kinase inhibitor with antitumor activity that inhibits MET and MKNK1/2.Fórmula:C30H24Cl2F2N6O3Forma y color:White SolidPeso molecular:625.45Pamufetinib mesylate
CAS:Pamufetinib mesylate (TAS-115 mesylate) is a VEGFR antagonist and c-Met inhibitor used in the study of cancer and respiratory diseases.Fórmula:C28H27FN4O7S2Pureza:98.91%Forma y color:White SolidPeso molecular:614.67Tivantinib
CAS:Tivantinib (ARQ 197) is an orally bioavailable small molecule inhibitor of c-Met with potential antineoplastic activity.Fórmula:C23H19N3O2Pureza:98% - 99.41%Forma y color:Yellow SolidPeso molecular:369.42Ningetinib
CAS:Ningetinib (CT-053) (CT053PTSA) is an orally bioavailable tyrosine kinase inhibitor with IC50s of <1.0, 1.9 and 6.7 nM for Axl, VEGFR2, and c-Met, respectively.Fórmula:C31H29FN4O5Pureza:99.95% - 99.98%Forma y color:SolidPeso molecular:556.58Afatinib Dimaleate
CAS:Afatinib Dimaleate (BIBW 2992MA2) is an orally bioavailable anilino-quinazoline derivative and inhibitor of the EGFR family, with antineoplastic activity.Fórmula:C32H33ClFN5O11Pureza:98.11% - 99.87%Forma y color:White SolidPeso molecular:718.08NVP-BVU972
CAS:NVP-BVU972 is a selective and potent Met inhibitor with IC50 of 14 nM.Fórmula:C20H16N6Pureza:97.24% - >99.99%Forma y color:SolidPeso molecular:340.38Capmatinib 2HCl.H2O
CAS:Capmatinib 2HCl.H2O (NVP-INC280 2HCl.H2O) is an orally bioavailable inhibitor of the proto-oncogene c-Met (HGFR)with potential antineoplastic activity.Fórmula:C23H21Cl2FN6O2Pureza:99.77%Forma y color:SolidPeso molecular:503.36Ref: TM-T8825
2mg34,00€5mg48,00€1mL*10mM (DMSO)50,00€10mg63,00€25mg84,00€50mg92,00€100mg126,00€500mg250,00€NPS-1034
CAS:NPS-1034 is a dual Met/Axl inhibitor with IC50 of 48 nM and 10.3 nM, respectively.Fórmula:C31H23F2N5O3Pureza:98.48%Forma y color:SolidPeso molecular:551.54Hepln-13
CAS:Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.Fórmula:C17H13BrN2Pureza:97.67%Forma y color:SolidPeso molecular:325.2Ref: TM-T25492
1mg35,00€2mg52,00€5mg80,00€1mL*10mM (DMSO)92,00€10mg119,00€25mg231,00€50mg344,00€100mg480,00€200mg663,00€AMG-337
CAS:AMG-337 is an effective and highly specific ATP-competitive MET kinase inhibitor. In enzymatic assays, AMG-337 inhibits MET kinase activity (IC50: < 5 nM).Fórmula:C23H22FN7O3Pureza:99.26% - 99.9%Forma y color:White SolidPeso molecular:463.46Ref: TM-T3209
1mg38,00€2mg50,00€5mg80,00€1mL*10mM (DMSO)81,00€10mg117,00€25mg187,00€50mg333,00€100mg495,00€200mg710,00€X-376
CAS:X-376 (Ensartinib) is an orally available small molecule inhibitor of the receptor tyrosine kinase ALK with potential antineoplastic activity.Fórmula:C25H25Cl2FN6O3Pureza:97.87%Forma y color:SolidPeso molecular:547.41Ref: TM-T3550
1mg34,00€2mg48,00€5mg93,00€1mL*10mM (DMSO)100,00€10mg113,00€25mg244,00€50mg405,00€100mg550,00€
