Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1489 productos de "Autofagia"
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Erlotinib-13C6
CAS:Erlotinib-13C6 (CP-358774-13C6), a 13C-labeled direct EGFR inhibitor, IC50: 2 nM.Fórmula:C22H23N3O4Forma y color:SolidPeso molecular:399.397CXCL12 ligand 1
CAS:CXCL12 ligand 1 is the first ligand of the sY12-binding pocket on chemokine CXCL12 .Fórmula:C11H14N4O5S2Forma y color:SolidPeso molecular:346.38NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Fórmula:C56H68ClN9O5S2Forma y color:SolidPeso molecular:1046.78Dusquetide TFA
Dusquetide TFA (SGX942) is an IDR that modulates immunity by targeting p62, reducing inflammation, and enhancing bacterial clearance.Fórmula:C27H48F3N9O7Forma y color:SolidPeso molecular:667.72MRL828
MRL828 is a compound that combines a Tau pathology-binding ligand with a guanine group modified by ATTEC technology, allowing it to selectively target aggregated tau proteins for clearance via the autophagy-lysosome pathway (ALP). MRL828 reduces intracellular Tau aggregates and facilitates the secretion of Tau.Fórmula:C46H51FN14O5SForma y color:SolidPeso molecular:930.38716Tigecycline hydrochloride
CAS:Tigecycline hydrochloride is a first-in-class, broad-spectrum antibiotic. It also has activity against antibiotic-resistant organisms.Fórmula:C29H40ClN5O8Pureza:98%Forma y color:SolidPeso molecular:622.11Clionamine B
CAS:Clionamine B, an aminosteroid from Cliona celata, enhances autophagy in MCF-7 breast cancer cells.Fórmula:C27H45NO3Forma y color:SolidPeso molecular:431.65Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Fórmula:C38H42Cl2N6O2Forma y color:SolidPeso molecular:685.69Hoechst 33342 analog trihydrochloride
CAS:Hoechst 33342 analog trihydrochloride, an analog of Hoechst 33342, serves as a fluorochrome by binding to the minor groove of DNA, facilitating theFórmula:C32H38Cl3N7Forma y color:SolidPeso molecular:627.05Cabergoline
CAS:<p>Cabergoline (FCE-21336), an ergot-derived dopamine D2-like agonist, targets D2/D3/5-HT2B, normalizes prolactin, controls pituitary tumors.</p>Fórmula:C26H37N5O2Pureza:97.69% - 99.86%Forma y color:White Crystalline SolidPeso molecular:451.6DB1113
CAS:DB1113 is a bifunctional kinase degrader, targeting ABL1, ABL2, CDK4, MAPKs, and more for disease research.Fórmula:C59H68F3N13O6SForma y color:SolidPeso molecular:1144.31Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Fórmula:C23H26ClI2NO3Pureza:98%Forma y color:SolidPeso molecular:653.72Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Fórmula:C43H52N6O19P3Forma y color:SolidPeso molecular:1049.82ALX 40-4C Trifluoroacetate
Alx40-4C trifluoroacetate inhibits CXCR4 and is an APJ antagonist with IC50 of 2.9M.Fórmula:C58H114F3N37O12Pureza:98%Forma y color:SolidPeso molecular:1578.76G-quadruplex DNA fluorescence probe 1
<p>Compound E1 selectively targets G-quadruplex DNA, fluoresces, enters cells with low toxicity.</p>Fórmula:C27H31IN2O3Forma y color:SolidPeso molecular:558.45YTK-105
CAS:YTK-105 is a ligand targeting autophagy that binds to p62.Fórmula:C16H19NO2Pureza:98.31%Forma y color:SoildPeso molecular:257.33cGMP-HTL
cGMP-HTL, an AUTAC, promotes K63-linked mitochondrial ubiquitination with a Cys-S-cGMP tag and target-specific warhead.Fórmula:C31H51ClN7O14PSForma y color:SolidPeso molecular:844.27TC14012 TFA
TC14012 TFA is a peptide-mimetic CXCR4 antagonist and CXCR7 agonist that promotes the recruitment of β-arrestin by CXCR7 .Fórmula:C92H141F3N34O21S2Pureza:96.31%Forma y color:SolidPeso molecular:2180.44Cyanine 5 Tyramide methyl indole
Cyanine 5 Tyramide is a red dye used in HRP assays and nucleic acid hybridization. Store away from light.Fórmula:C40H47N3O8S2Forma y color:SolidPeso molecular:761.95PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Fórmula:C27H31NO4SPureza:99.02%Forma y color:SolidPeso molecular:465.6
