Autofagia
Los inhibidores de la autofagia se dirigen al proceso celular de la autofagia, que implica la degradación y el reciclaje de componentes celulares a través de lisosomas. La autofagia es un mecanismo crítico para mantener la homeostasis celular, pero su desregulación está implicada en diversas enfermedades, incluyendo el cáncer, la neurodegeneración y las infecciones. Los inhibidores de la autofagia pueden bloquear este proceso, lo que los convierte en herramientas valiosas para estudiar el papel de la autofagia en enfermedades y desarrollar estrategias terapéuticas. En CymitQuimica, ofrecemos inhibidores de la autofagia para apoyar su investigación en biología celular, oncología y enfermedades neurodegenerativas.
Se han encontrado 1489 productos de "Autofagia"
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Fe-TMPyP
CAS:Fe-TMPyP binds to the prion protein PrP and inhibits misfolding. Fe-TMPyP is also a peroxynitrite decomposition catalyst.Fórmula:C44H36Cl5FeN8Forma y color:SolidPeso molecular:909.92vMIP-II (1-21) TFA
vMIP-II (1-21) (NT21MP) TFA (TFA is a potent inhibitor of CXCR4. This compound interacts broadly with CC and CXC chemokine receptors. Furthermore, vMIP-II (1-21) TFA inhibits CXCR4 by competing for binding sites with 125I-SDF-1R, exhibiting an IC50 value of 190 nM.Forma y color:Odour SolidCXCL-CXCR1/2-IN-1
CAS:<p>CXCL-CXCR1/2-IN-1 is an ELR+CXCL-CXCR1/2 pathway inhibitor with anticancer activity and can be used in the study of cardiovascular disease.</p>Fórmula:C14H8Cl2N4O3SPureza:99.4%Forma y color:SoildPeso molecular:383.21Tat-beclin 1 acetate
Tat-beclin 1 acetate is a potent inducer of autophagy and interacts with the negative regulator of autophagy, GAPR-1.Pureza:99.44%Forma y color:Soild(S)-Sitagliptin phosphate
CAS:(S)-Sitagliptin phosphate, less active enantiomer, is a potent DPP4 inhibitor with an IC50 of 19 nM.Fórmula:C16H18F6N5O5PForma y color:SolidPeso molecular:505.314PF-543
CAS:PF-543 (Sphingosine Kinase 1 Inhibitor II), a novel sphingosine-competitive inhibitor of SphK1, inhibits SphK1 with IC50 and Ki of 2.0 nM and 3.6 nM.Fórmula:C27H31NO4SPureza:99.02%Forma y color:SolidPeso molecular:465.6Acridine homodimer
CAS:Acridine homodimer (NSC 219743), a blue-green fluorescent dye, binds DNA, preferring AT-rich areas, useful for chromosome banding.Fórmula:C38H42Cl2N6O2Forma y color:SolidPeso molecular:685.69HDAC6-IN-58
<p>HDAC6-IN-58 (compound 24c) is a selective HDAC6 inhibitor with IC50 values of 9.5 nM for HDAC6 and 7374.5 nM for HDAC1. It enhances tubulin acetylation, exhibits antiproliferative effects, and induces autophagy (autophagy).</p>Forma y color:Odour SolidFDW028
CAS:FDW028 is a FUT8 inhibitor with antitumor activity that works by promoting B7-H3 lysosomal degradation through defucosylation and CMA pathways.Fórmula:C22H24N6OPureza:98.73% - 99.55%Forma y color:SoildPeso molecular:388.47Ref: TM-T77809
1mg70,00€5mg150,00€10mg227,00€25mg378,00€50mg547,00€100mg747,00€1mL*10mM (DMSO)166,00€Desethylamiodarone hydrochloride
CAS:Desethylamiodarone HCl, CYP3A product, antiarrhythmic inhibiting K+ channels, IC50 19.1 μM, main amiodarone metabolite.Fórmula:C23H26ClI2NO3Pureza:98%Forma y color:SolidPeso molecular:653.72Cytochalasin E
CAS:Cytochalasin E, from Aspergillus, disrupts actin, inhibits angiogenesis, and halts tumor growth.Fórmula:C28H33NO7Pureza:98%Forma y color:Crystals From Acetone-Hexane White PowderPeso molecular:495.56NAMPT degrader-1
Compound A3, an NAMPT degrader, has 0.023 μM IC50 and promotes NAMPT breakdown via autophagy, exhibiting strong anticancer effects.Fórmula:C56H68ClN9O5S2Forma y color:SolidPeso molecular:1046.78Flavopiridol
CAS:Flavopiridol (Alvocidib) blocks CDK1/2/4/6 by competing with ATP (IC50 ~40 nM); 7.5x selectivity over CDK7; also inhibits EGFR, PKA. In Phase 1/2 trials.Fórmula:C21H20ClNO5Pureza:97.74% - 99.99%Forma y color:SolidPeso molecular:401.84CCR7 antagonist 1
CCR7 antagonist1 (30c) functions as a dual antagonist, targeting CXCR2 with an IC50 of 11.02 μM and CCR7 with an IC50 of 0.43 μM.Fórmula:C13H22N6OSPeso molecular:310.15758STO-609 acetate
CAS:STO-609 acetate is selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (Ki: 80/15 ng/ml, for CaM-KKα/KKβ); competes for theFórmula:C19H10N2O3·C2H4O2Pureza:99.75%Forma y color:SolidPeso molecular:374.35TSPO Ligand-Linker Conjugates 1
TSPO Ligand-Linker Conjugates 1: a compound linking TSPO ligands to AUTACs for targeted mitophagy, aiding research in mitochondrial diseases.Fórmula:C32H55N3O10SForma y color:SolidPeso molecular:673.86(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc
<p>(1R,4R)-Thalidomide-2,5-diazabicyclo[2.2.1]heptane-(1R,4r)-cyclohexane-NH-Boc is a conjugate of an E3 ligase ligand and linker (E3LigaseLigand-Linker Conjugates), composed of Thalidomide and the corresponding linker. It acts as a Cereblon ligand, recruiting CRBN proteins, and serves as a crucial intermediate in the synthesis of complete PROTAC molecules.</p>Fórmula:C30H39N5O6Peso molecular:565.29003CXCL8 (54-72)
CXCL8 (54-72) is a C-terminal peptide segment of the chemokine CXCL8. This peptide features a long, highly positively charged C-terminal region that interacts with the negative charges on glycosaminoglycans (GAG) to facilitate binding. CXCL8 (54-72) inhibits neutrophil adhesion and migration, as well as adhesion to endothelial cells. It is useful in studying the role of chemokines in inflammatory responses.Fórmula:C107H173N33O30Peso molecular:2400.30261RK-682 (calcium salt)
CAS:RK-682 inhibits PTPs, crucial in cell signaling, with IC50s: CD45 (54 μM), VHR (2 μM), and heparanase (17 μM), halting G1/S cell cycle transition.Fórmula:C42H74CaO10Forma y color:SolidPeso molecular:779.122Tetramethylrhodamine-dUTP
Tetramethylrhodamine-dUTP (TAMRA-dUTP) is used for end-labeling of DNA [1] .Fórmula:C43H52N6O19P3Forma y color:SolidPeso molecular:1049.82
