DUB
Los inhibidores de las deubiquitinasas (DUB) se dirigen a las enzimas que eliminan las moléculas de ubiquitina de las proteínas, regulando así la estabilidad, localización y actividad de las proteínas dentro de la célula. Las deubiquitinasas desempeñan roles esenciales en varios procesos celulares, incluidos la regulación del ciclo celular, la reparación del ADN y las respuestas inmunitarias. La desregulación de la actividad de las DUB está vinculada al cáncer, a los trastornos neurodegenerativos y a las infecciones virales. Los inhibidores de las DUB pueden modular estos procesos, ofreciendo enfoques terapéuticos potenciales para estas condiciones. En CymitQuimica, proporcionamos inhibidores de DUB para apoyar su investigación en homeostasis de proteínas, cáncer y neurobiología.
Se han encontrado 84 productos de "DUB"
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SJB2-043
CAS:<p>SJB2-043 is an inhibitor of USP1-UAF1 ( IC50 : 544 nM).</p>Fórmula:C17H9NO3Pureza:98.44%Forma y color:SolidPeso molecular:275.26USP1-IN-2
CAS:<p>USP1-IN-2 is a potent USP1 inhibitor with potential anti-tumor activity for the study of cancer.</p>Fórmula:C26H22F4N6OPureza:99.69% - 99.88%Forma y color:SolidPeso molecular:510.486BC-1471
CAS:<p>BC-1471 is a STAMBP deubiquitinase inhibitor that blocks NALP7 inflammasome activity.</p>Fórmula:C27H32N4O4SPureza:99.98%Forma y color:SolidPeso molecular:508.63POSH-IN-1
CAS:<p>POSH-IN-1 (Compound 108) is an inhibitor of the POSH polypeptide （e3 ligase) and has antiviral, anticancer, and neurodegenerative disease potential.</p>Fórmula:C14H8FNO3SPureza:99.29%Forma y color:SolidPeso molecular:289.28LCAHA
CAS:<p>LCAHA is a USP2a inhibitor. LCAHA inhibits growth of cyclin D1-dependent cells.</p>Fórmula:C24H41NO3Forma y color:SolidPeso molecular:391.59USP28-IN-3
CAS:<p>USP28-IN-3 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Fórmula:C23H20Cl2N2O3SPureza:99.92%Forma y color:SolidPeso molecular:475.39USP28-IN-4
CAS:<p>USP28-IN-4 is a USP28 inhibitor with anticancer activity that dose-dependently down-regulates cellular levels of c-Myc via the ubiquitin-proteasome system.</p>Fórmula:C22H18Cl2N2O3SPureza:98.48%Forma y color:SolidPeso molecular:461.368RK64
CAS:<p>8RK64 is a covalent UCHL1 inhibitor ( IC 50 : 0.32 μM) .</p>Fórmula:C14H16N8O2SForma y color:SolidPeso molecular:360.4USP7-IN-4
CAS:<p>USP7-IN-4 is a non-competitive, potent and selective inhibitor of USP7, up-regulates p53 and p21, down-regulates MDM2,anti-proliferativity RS4;11 (leukemia) .</p>Fórmula:C29H34N6O3Pureza:98.27% - 99.09%Forma y color:SolidPeso molecular:514.62FT827
CAS:<p>FT827 is a covalent inhibitor of USP7 that targets the catalytic center of the autoinhibitory apolipoprotein form of USP7 for cancer research.</p>Fórmula:C27H28N6O5SPureza:98.76%Forma y color:SolidPeso molecular:548.61HBX28258
CAS:<p>HBX28258, a human USP7 inhibitor, binds covalently and selectively deactivates USP7 in colon cancer and kidney cells.</p>Fórmula:C26H30ClN3OPureza:98%Forma y color:SolidPeso molecular:435.99MF-095
CAS:<p>MF-095 is a control probe for MF-094, which is a potent inhibitor of ubiquitin specific protease 30.</p>Fórmula:C27H31N3O4SForma y color:SolidPeso molecular:493.62XL-188
CAS:<p>XL-188: Potent, selective USP7 inhibitor, IC50 = 193 nM (domain), 90 nM (full). Boosts p53, p21; degrades HDM2. Unique among DUB inhibitors.</p>Fórmula:C32H42N6O4Forma y color:SolidPeso molecular:574.71Capzimin
CAS:<p>Capzimin is a selective inhibitor of proteasome isopeptidase Rpn11.</p>Fórmula:C30H24N6O2S4Pureza:98.31% - 99.32%Forma y color:SolidPeso molecular:628.81I-138
CAS:<p>I-138 is an orally active and reversible inhibitor of USP1-UAF1.I-138 induces mono-ubiquitination of FANCD2 and PCNA and inhibits USP1 auto-cleavage in cells.</p>Fórmula:C26H23F3N6OPureza:99.41%Forma y color:SolidPeso molecular:492.5USP28-IN-2
CAS:<p>USP28-IN-2 selectively inhibits USP28 (IC50=0.3 μM), degrades c-Myc, kills cancer cells, lowers ankyrin-1/2, and enhances Regorafenib effects.</p>Fórmula:C23H20Cl2N2O3SForma y color:SolidPeso molecular:475.39GSK2643943A
CAS:<p>GSK2643943A is a deubiquitylating enzyme (DUB) inhibitor, with an IC 50 of 160 nM for USP20/Ub-Rho. GSK2643943A has anti-tumor efficacy.</p>Fórmula:C17H12FN3Pureza:97.09%Forma y color:SolidPeso molecular:277.3SJB3-019A
CAS:<p>SJB3-019A is a potent, potent and novel ubiquitin-specific protease 1 (USP1) inhibitor, which promotes ID1 degradation and cytotoxicity in K562 cells 5 times</p>Fórmula:C16H8N2O3Pureza:99.72%Forma y color:SolidPeso molecular:276.25USP30 inhibitor 11
CAS:<p>USP30 inhibitor 11 (USP30-IN-11) is a USP30 inhibitor that inhibits SVA and can be used in studies of cancer, mitochondrial dysfunction and Parkinson's.</p>Fórmula:C17H16N6O2SPureza:98.84% - 99.59%Forma y color:SolidPeso molecular:368.416RK73
CAS:<p>6RK73 is a covalent irreversible and specific UCHL1 inhibitor (IC50: 0.23 µM). 6RK73 shows almost no inhibition of UCHL3 (IC50: 236 µM).</p>Fórmula:C13H17N5O2SPureza:99.91%Forma y color:SolidPeso molecular:307.37
