Receptor sigma
Los receptores sigma son sitios de unión únicos que, a diferencia de los GPCR tradicionales, no encajan en las categorías clásicas de proteínas receptoras. Están involucrados en la modulación de los sistemas de neurotransmisores y se han implicado en varios trastornos neurológicos y psiquiátricos. Los receptores sigma también están asociados con la supervivencia celular, y sus ligandos se están explorando para aplicaciones terapéuticas en neuroprotección, cáncer y manejo del dolor. En CymitQuimica, ofrecemos una selección de moduladores de receptores sigma de alta calidad para apoyar su investigación en neurociencia, oncología y biología de receptores.
Se han encontrado 46 productos de "Receptor sigma"
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Roluperidone
CAS:<p>Roluperidone (CYR-101) is a novel cyclic amide derivative.</p>Fórmula:C22H23FN2O2Pureza:96.46% - 97.77%Forma y color:SolidPeso molecular:366.43Glycerol phenylbutyrate
CAS:<p>Glycerol phenylbutyrate (HPN-100) (GPB) is a new generation ammonia scavenger drug and it also is a sigma-2 (σ2) receptor ligand (pKi: 8.02).</p>Fórmula:C33H38O6Pureza:98.54% - 99.74%Forma y color:SolidPeso molecular:530.65Blonanserin
CAS:<p>Blonanserin (AD-5423), approved in Japan (2008), is an atypical antipsychotic with fewer side effects like EPS, sedation, or hypotension.</p>Fórmula:C23H30FN3Pureza:99.85%Forma y color:SolidPeso molecular:367.5AD353
<p>AD353 is a selective sigma-1 receptor ligand. It demonstrates high efficacy in models of capsaicin-induced allodynia and PGE2-induced mechanical hyperalgesia. Additionally, AD353 exhibits favorable pharmacokinetic properties.</p>Fórmula:C23H30N2O2Forma y color:SolidPeso molecular:366.5σ1 Receptor ligand 1
<p>σ1 Receptor ligand 1 (compound 5I) is a σ1 receptor ligand with a Ki value of 3.9 nM. It demonstrates a high plasma protein binding rate (89%) and exhibits good metabolic stability in the presence of mouse liver microsomes and NADPH. σ1 Receptor ligand 1 is applicable in neuroscience and cancer research.</p>Fórmula:C22H28N2O2Forma y color:SolidPeso molecular:352.47PD 144418 oxalate
CAS:<p>PD 144418 oxalate: σ1 receptor ligand, Ki=0.08 nM; 1377 nM for σ2, minimal affinity elsewhere; potential antipsychotic.</p>Fórmula:C20H24N2O5Pureza:98.76%Forma y color:SolidPeso molecular:372.42KB-5492 FA
<p>KB-5492 FA is a selective sigma receptor inhibitor with antiulcerogenic effects.CAS 번호128-52-56-8</p>Fórmula:C24H32N2O8Pureza:98.12%Forma y color:SolidPeso molecular:476.52UKH-1114
CAS:<p>UKH-1114 is a potent σ2 receptor/Tmem97 agonist with a Ki value of 46 nM, demonstrating antinociceptive effects against mechanical hypersensitivity. This compound alleviates mechanical hypersensitivity in mice caused by nerve injury without inducing motor impairment and is a promising candidate for neuropathic pain research.</p>Fórmula:C22H24F3NOForma y color:SolidPeso molecular:375.43AB21 oxalate
<p>AB21 oxalate, a potent and selective S1R antagonist, exhibits binding affinities (Kis) of 13 nM and 102 nM for S1R and S2R, respectively.</p>Fórmula:C25H30N2O5Pureza:98%Forma y color:SolidPeso molecular:438.52Sigma-1 receptor antagonist 4
<p>Sigma-1 receptor antagonist 4 (Compound 32) is a potent σ1R antagonist that significantly enhances morphine's analgesic effects and reverses morphine-induced</p>Fórmula:C22H26N2OForma y color:SolidPeso molecular:334.45σ1R-IN-1
<p>σ1R-IN-1 ((R,R)-1a) is an effective σ-1R inhibitor with an IC50 of 110 nM. It shows promising potential for use in research related to neuropsychiatric disorders.</p>Fórmula:C15H22N2Forma y color:SolidPeso molecular:230.35AD186
<p>AD186, a potent and selective S1R agonist, exhibits dissociation constants (Kis) of 2.7 nM for S1R and 27 nM for S2R.</p>Fórmula:C22H28N2Pureza:98%Forma y color:SolidPeso molecular:320.47AB21 HCl
<p>AB21 HCl: σ1 receptor antagonist, Ki 13 nM; less potent at σ2 (102 nM). Reduces mechanical hypersensitivity.</p>Fórmula:C23H29ClN2OPureza:99.91%Forma y color:SolidPeso molecular:384.2S1R agonist 2 hydrochloride
<p>Compound 8b hydrochloride, a selective S1R agonist, exhibits affinity with K i s of 1.1 nM for S1R and 88 nM for S2R.</p>Fórmula:C21H28ClNOPureza:98%Forma y color:SolidPeso molecular:345.914-IBP
CAS:<p>4-IBP is a selective σ1 agonist with a high level of affinity for the σ1 receptor (Ki = 1.7 nM) and a moderate affinity for the σ2 receptor (Ki = 25.2 nM) .</p>Fórmula:C19H21IN2OPureza:98.99%Forma y color:SolidPeso molecular:420.29Blarcamesine hydrochloride
CAS:<p>Blarcamesine hydrochloride (AVex-73 hydrochloride) is a Sigma-1 Receptor agonist (IC50: 860 nM).</p>Fórmula:C19H24ClNOPureza:99.57% - 99.9%Forma y color:SolidPeso molecular:317.85Cutamesine dihydrochloride
CAS:<p>Cutamesine dihydrochloride is a σ1 receptor agonist, selective over σ2, combating cardiomyocyte hypertrophy and improving stroke recovery.</p>Fórmula:C23H32N2O2·2HClPureza:99.96%Forma y color:SolidPeso molecular:441.43σ1 Receptor antagonist-1
CAS:<p>σ1 Receptor antagonist-1 is a selective sigma 1 receptor antagonist.</p>Fórmula:C21H23NOSPureza:99.8%Forma y color:SolidPeso molecular:337.48BD 1008 dihydrobromide
CAS:<p>BD 1008 dihydrobromide: selective σ1 receptor antagonist (Ki=2 nM), high σ1 and moderate σ2 affinity.</p>Fórmula:C15H24Br2Cl2N2Pureza:97.81%Forma y color:SolidPeso molecular:463.08PRE-084 hydrochloride
CAS:<p>PRE-084 hydrochloride is a selective agonist of σ1(IC50:44 nM, in the sigma receptor assay).</p>Fórmula:C19H28ClNO3Pureza:99.54%Forma y color:SolidPeso molecular:353.88
