PKA
La proteína quinasa A (PKA) es una enzima clave en la cascada de señalización de los GPCR, activada por el AMP cíclico (cAMP) en respuesta a diversas señales extracelulares. La PKA regula una amplia gama de procesos celulares, incluidos el metabolismo, la expresión génica y el crecimiento celular. La desregulación de la actividad de la PKA está asociada con diversas enfermedades, como el cáncer, trastornos metabólicos y afecciones cardiovasculares. Los moduladores de PKA son herramientas valiosas en la investigación dirigida a comprender las vías de señalización de GPCR y desarrollar nuevas estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de moduladores de PKA de alta calidad para apoyar su investigación en transducción de señales, regulación celular y mecanismos de enfermedades.
Se han encontrado 58 productos de "PKA"
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A-3 hydrochloride
CAS:A-3 hydrochloride: potent, reversible kinase antagonist; permeable; inhibits PKC, CKI, PKA, CKII, MLCK; Ki: 4.3-80 μM.
Fórmula:C12H14Cl2N2O2SPureza:99.32%Forma y color:SolidPeso molecular:321.22MR-L2
CAS:MR-L2 is a reversible and noncompetitive allosteric activator of long-isoform phosphodiesterase-4 (PDE4).Fórmula:C19H16Cl3FN4OPureza:98.09% - 98.94%Forma y color:SolidPeso molecular:441.71Ref: TM-T12103
1mg138,00€2mg197,00€5mg334,00€10mg500,00€25mg807,00€50mg1.099,00€100mg1.485,00€500mg2.962,00€1mL*10mM (DMSO)358,00€Bucladesine sodium
CAS:Bucladesine sodium (DC2797) is a cAMP analog with cell-permeable properties.Fórmula:C18H23N5NaO8PPureza:96.56% - 99.76%Forma y color:White PowderPeso molecular:491.37KT5720
CAS:KT5720 is a cell-permeable, reversible, and ATP-competitive inhibitor of protein kinase A (PKA) (Ki: 60 nM).Fórmula:C32H31N3O5Pureza:98%Forma y color:SolidPeso molecular:537.61Kemptide
CAS:Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).Fórmula:C32H61N13O9Pureza:98%Forma y color:SolidPeso molecular:771.91PKG inhibitor peptide
CAS:PKG inhibitor; mimics H2B phosphorylation site; Ki=86mM; blocks synthetic substrates, not histone phosphorylation; stops PKA activity on histones.Fórmula:C38H74N18O10Pureza:98%Forma y color:SolidPeso molecular:943.12PKA Inhibitor Fragment (6-22) amide TFA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of cAMP-dependent protein kinase A (PKA).Fórmula:C82H131F3N28O26Pureza:99.61% - 99.87%Forma y color:SolidPeso molecular:1982.08PKI(5-24)
CAS:High affinity PKA inhibitor (Ki = 2.3 nM).Fórmula:C76H129N31O28Pureza:98%Forma y color:SolidPeso molecular:1925.057Gliotoxin
CAS:Gliotoxin, a mycotoxin, inhibits Wnt pathway, causing apoptosis in mutated colorectal cancer cells and blocks NF-κB by preserving IκB.Fórmula:C13H14N2O4S2Pureza:98%Forma y color:SolidPeso molecular:326.39(2S,4R)-DS89002333
(2S,4R)-DS89002333 is an enantiomer of DS89002333 and functions as an orally active PRKACA inhibitor, exhibiting an IC50 of 0.3 nM.Fórmula:C22H20ClF2N3O3Peso molecular:447.11613Vasonatrin Peptide (VNP)
CAS:Vasonatrin peptide (VNP) is a chimera of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) with potent venodilating and natriuretic activityFórmula:C123H198N36O36S3Pureza:98%Forma y color:SolidPeso molecular:2865.37Aplithianines A
Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM byPureza:98%Forma y color:Odour SolidMalantide
CAS:Malantide, a synthetic dodecapeptide, boosts and measures PKA activity by undergoing PKA-induced phosphorylation.Fórmula:C72H124N22O21Pureza:98%Forma y color:SolidPeso molecular:1633.89Calcineurin substrate
CAS:Calcineurin Substrate is a Peptide from the regulatory RII subunit of cAMP-dependent protein kinase.Fórmula:C92H150N28O29Pureza:98%Forma y color:SolidPeso molecular:2112.35CREBtide
CAS:CREBtide is a synthetic substrate for PKA (Km=3.9 µM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Fórmula:C73H129N29O19Pureza:98%Forma y color:SolidPeso molecular:1716.99Kemptide Phospho-Ser5
Kemptide (Phospho-Ser5) is a phosphoreceptor peptide that is a specific substrate for camp-dependent protein kinase (PKA).Fórmula:C32H62N13O12PPureza:98%Forma y color:SolidPeso molecular:851.89PKG Substrate
CAS:PKG Substrate is selective for PKG, favors PKG Iα (Km=59µM) over PKG II (Km=305µM).Fórmula:C35H67N17O11Pureza:98%Forma y color:SolidPeso molecular:902.01PKA/AKAP-IN-2
CAS:PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.Fórmula:C17H17NO3Pureza:99.82%Forma y color:SoildPeso molecular:283.32Ref: TM-T201919
1mg185,00€5mg459,00€10mg657,00€25mg1.026,00€50mg1.415,00€100mg1.872,00€200mg2.555,00€Malantide TFA
Malantide TFA: synthetic dodecapeptide, PKA-specific with Km 15 μM, >90% PKI blockage, also PKC substrate, Km 16 μM.Fórmula:C74H125F3N22O23Forma y color:SolidPeso molecular:1747.91H1-7 (histone H1 phosphorylation site), PKA Substrate
CAS:H1-7 (histone H1 phosphorylation site), a synthetic polypeptide serving as a PKA substrate, demonstrates utility in PKA substrate applications [1] [2].Fórmula:C31H58N14O9Forma y color:SolidPeso molecular:770.88AP-C2
CAS:AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Fórmula:C18H16N4SPureza:99.99%Forma y color:SoildPeso molecular:320.41PKI (5-24),amide
CAS:PKI (5-24),amide is a 20-residue peptide, a potent PKA inhibitor with a Ki of 2.3 nM, derived from a cAMP inhibitor protein.Fórmula:C94H149N33O30Forma y color:SolidPeso molecular:2221.4PKA-IN-1
CAS:PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to studyFórmula:C13H11N3OPureza:99.12%Forma y color:SolidPeso molecular:225.25STAD 2
CAS:STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFórmula:C102H182N24O22Forma y color:SolidPeso molecular:2096.724Fasudil
CAS:Fasudil (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK.Fórmula:C14H17N3O2SPureza:99.79% - 99.84%Forma y color:SolidPeso molecular:291.37RI-STAD-2
RI-STAD-2 is a high-affinity peptide that interferes with the regulatory subunit RI of protein kinase A (PKA). It disrupts the binding between A-kinase anchoring proteins (AKAPs) and PKA-RI by mimicking the α-helical domain of AKAPs, interacting with the dimerization/docking (D/D) domain of PKA-RI. This disruption affects the activity and intracellular localization of PKA. RI-STAD-2 is utilized in studying the role of AKAPs and PKA-RI interactions in pathological processes such as cardiovascular diseases and cancer.Fórmula:C109H181N25O35Peso molecular:2400.31519JAK1/2/3 Inhibitor 1
CAS:JAK1/2/3 Inhibitor 1 is a potent protein kinase inhibitor.JAK1/2/3 Inhibitor 1 has antitumor activity that inhibits the growth of a variety of cancer cell linesFórmula:C6H2Cl2N2SPureza:99.99%Forma y color:SolidPeso molecular:205.06DT-3 acetate
DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.Fórmula:C152H258N52O28S·xC2H4O2Forma y color:SolidPeso molecular:3294.07 (free acid)HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Forma y color:Pale Yellow Crystalline SolidPeso molecular:277.34AT13148
CAS:AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Forma y color:SolidPeso molecular:313.78Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFórmula:C28H26N4O3Pureza:99.24% - 99.82%Forma y color:Off-White PowderPeso molecular:466.53Ref: TM-T6680
1mg62,00€2mg87,00€5mg97,00€10mg145,00€25mg246,00€50mg401,00€100mg597,00€500mg1.283,00€1mL*10mM (DMSO)109,00€8-Bromo-cAMP sodium salt
CAS:8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Fórmula:C10H10BrN5NaO6PPureza:98% - 99.94%Forma y color:Off-White PowderPeso molecular:430.08Iso-H7 dihydrochloride
CAS:Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.Fórmula:C14H19Cl2N3O2SPureza:99.53%Forma y color:White Crystalline SolidPeso molecular:364.29CCG215022
CAS:CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Forma y color:SolidPeso molecular:499.5Ref: TM-T3498
1mg56,00€5mg114,00€10mg178,00€25mg394,00€50mg655,00€100mg1.035,00€1mL*10mM (DMSO)127,00€AT7867
CAS:AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.Fórmula:C20H20ClN3Pureza:99.63%Forma y color:SolidPeso molecular:337.85Ref: TM-T6304
2mg42,00€5mg62,00€10mg81,00€25mg128,00€50mg198,00€100mg296,00€200mg427,00€1mL*10mM (DMSO)62,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),
Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14Bilobetin
CAS:Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Fórmula:C31H20O10Pureza:97% - 99.69%Forma y color:SolidPeso molecular:552.48Ref: TM-T4S2128
1mg44,00€2mg66,00€5mg137,00€10mg236,00€25mg403,00€50mg582,00€100mg800,00€1mL*10mM (DMSO)177,00€PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Fórmula:C82H134N28O26Pureza:99.30%Forma y color:SolidPeso molecular:1928.11Ref: TM-T21674L
1mg95,00€2mg123,00€5mg170,00€10mg279,00€25mg467,00€50mg680,00€100mg938,00€1mL*10mM (DMSO)457,00€Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Fórmula:C14H19Cl2N3O2SPureza:99.86%Forma y color:SolidPeso molecular:364.29Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Forma y color:White SolidPeso molecular:327.83PKG drug G1
CAS:PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Fórmula:C13H11N3OSPureza:97.57% - 97.67%Forma y color:SolidPeso molecular:257.31CREBtide acetate(149155-45-3 free base)
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Fórmula:C75H133N29O21Pureza:96.13%Forma y color:SolidPeso molecular:1777.07PKI 14-22 amide, myristoylated Acetate
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.Fórmula:C55H104N20O14Pureza:96.34%Forma y color:SolidPeso molecular:1269.54Ref: TM-T21983L
1mg167,00€5mg363,00€10mg538,00€25mg800,00€50mg1.071,00€100mg1.449,00€1mL*10mM (DMSO)695,00€PKG inhibitor peptide TFA (82801-73-8 free base)
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).Fórmula:C40H75F3N18O12Pureza:98%Forma y color:SolidPeso molecular:1057.13PKI (5-24) Acetate(99534-03-9 free base)
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).Fórmula:C96H152N32O33Pureza:99.47%Forma y color:SolidPeso molecular:2282.43PKG Substrate acetate(81187-14-6 free base)
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with aFórmula:C37H71N17O13Pureza:99.30%Forma y color:SolidPeso molecular:962.08H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Forma y color:SolidPeso molecular:519.28Ref: TM-T6250
5mg39,00€10mg58,00€25mg106,00€50mg202,00€100mg344,00€200mg512,00€500mg815,00€1mL*10mM (DMSO)52,00€Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Fórmula:C8H11NO3·C5H7NO3Pureza:99.19%Forma y color:Off-White PowderPeso molecular:298.29H-8 hydrochloride
CAS:H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.Fórmula:C12H17Cl2N3O2SPureza:99.93%Forma y color:White To Off-White Crystalline SolidPeso molecular:338.256-Bn-cAMP
CAS:6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.Fórmula:C17H18N5O6PForma y color:SolidPeso molecular:419.338-Chloro-cAMP sodium
CAS:8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.Fórmula:C10H10ClN5NaO6PForma y color:SolidPeso molecular:385.638-MA-cAMP
CAS:8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.Fórmula:C11H15N6O6PForma y color:SolidPeso molecular:358.25Rp-cAMPS triethylammonium salt
CAS:Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Fórmula:C16H27N6O5PSPureza:98%Forma y color:SolidPeso molecular:446.46BGC201531
CAS:BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.
Fórmula:C26H28N2O6SPureza:98.51% - 99.33%Forma y color:SolidPeso molecular:496.58FMP-API-1
CAS:FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).Fórmula:C13H14N2O2Forma y color:SolidPeso molecular:230.2628-Br-cGMP-AM
CAS:8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.Fórmula:C13H15BrN5O9PForma y color:SolidPeso molecular:496.16Protein kinase inhibitor 7
CAS:Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Fórmula:C12H15N3O2SPeso molecular:265.33PET-cGMP
CAS:PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.
Fórmula:C18H16N5O7PForma y color:SolidPeso molecular:445.323
