PKA
La proteína quinasa A (PKA) es una enzima clave en la cascada de señalización de los GPCR, activada por el AMP cíclico (cAMP) en respuesta a diversas señales extracelulares. La PKA regula una amplia gama de procesos celulares, incluidos el metabolismo, la expresión génica y el crecimiento celular. La desregulación de la actividad de la PKA está asociada con diversas enfermedades, como el cáncer, trastornos metabólicos y afecciones cardiovasculares. Los moduladores de PKA son herramientas valiosas en la investigación dirigida a comprender las vías de señalización de GPCR y desarrollar nuevas estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de moduladores de PKA de alta calidad para apoyar su investigación en transducción de señales, regulación celular y mecanismos de enfermedades.
Se han encontrado 57 productos para "PKA".
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STAD 2
CAS:STAD-2 is a cell permeable akap disruptor, selectively binding to pka-rii and blocking the interaction of pka-ri with akapFórmula:C102H182N24O22Forma y color:SolidPeso molecular:2096.724(2S,4R)-DS89002333
(2S,4R)-DS89002333 is an enantiomer of DS89002333 and functions as an orally active PRKACA inhibitor, exhibiting an IC50 of 0.3 nM.Fórmula:C22H20ClF2N3O3Peso molecular:447.11613PKA Inhibitor Fragment (6-22) amide TFA
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is an inhibitor of cAMP-dependent protein kinase A (PKA).Fórmula:C82H131F3N28O26Pureza:99.61% - 99.87%Forma y color:White SolidPeso molecular:1982.08Kemptide
CAS:Kemptide is a synthetic heptapeptide, acting as a substrate for cAMP-dependent protein kinase (PK).Fórmula:C32H61N13O9Pureza:98%Forma y color:SolidPeso molecular:771.91RI-STAD-2
RI-STAD-2 is a high-affinity peptide that interferes with the regulatory subunit RI of protein kinase A (PKA). It disrupts the binding between A-kinase anchoring proteins (AKAPs) and PKA-RI by mimicking the α-helical domain of AKAPs, interacting with the dimerization/docking (D/D) domain of PKA-RI. This disruption affects the activity and intracellular localization of PKA. RI-STAD-2 is utilized in studying the role of AKAPs and PKA-RI interactions in pathological processes such as cardiovascular diseases and cancer.Fórmula:C109H181N25O35Forma y color:SolidPeso molecular:2400.31519PKItide
CAS:PKItide demonstrates an inhibitory concentration 50 (IC50) of 0.2 μM against cAMP-dependent protein kinase (cAMP-PK) [1].Fórmula:C85H149N31O24Pureza:98%Forma y color:SolidPeso molecular:1989.29PKA-IN-1
CAS:PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to studyFórmula:C13H11N3OPureza:99.12%Forma y color:SolidPeso molecular:225.25AP-C2
CAS:AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.Fórmula:C18H16N4SPureza:99.99%Forma y color:SolidPeso molecular:320.41PKA/AKAP-IN-2
CAS:PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.Fórmula:C17H17NO3Pureza:99.82%Forma y color:SolidPeso molecular:283.32DT-3 acetate
DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.Fórmula:C152H258N52O28S·xC2H4O2Forma y color:SolidPeso molecular:3294.07 (free acid)Bilobetin
CAS:Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.Fórmula:C31H20O10Pureza:97% - 99.69%Forma y color:Yellow SolidPeso molecular:552.48Ref: TM-T4S2128
1mg44,00€2mg66,00€5mg137,00€1mL*10mM (DMSO)166,00€10mg236,00€25mg403,00€50mg582,00€100mg800,00€PKA inhibitor fragment (6-22) amide Acetate
PKA inhibitor fragment (6-22) amide Acetate is a synthetic peptide which selectively inhibits PKA activity by binding to its substrate site (IC50 < 2 nM).Fórmula:C82H134N28O26Pureza:99.72%Forma y color:SolidPeso molecular:1928.11Ref: TM-T21674L
1mg90,00€2mg116,00€5mg166,00€10mg264,00€1mL*10mM (DMSO)432,00€25mg442,00€50mg645,00€100mg888,00€Daphnetin
CAS:Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),Fórmula:C9H6O4Pureza:97.47% - 99.95%Forma y color:SolidPeso molecular:178.14Fasudil dihydrochloride
CAS:Fasudil dihydrochloride inhibits ROCK1/2, PKA, PKC, PKG, and acts as a Ca²⁺ channel blocker and vasodilator, supporting vascular, cardiovascular, and signaling research.Fórmula:C14H19Cl2N3O2SPureza:99.86%Forma y color:White SolidPeso molecular:364.29Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Forma y color:White SolidPeso molecular:327.83H-89 dihydrochloride
CAS:H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Forma y color:SolidPeso molecular:519.28Ref: TM-T6250
5mg37,00€1mL*10mM (DMSO)44,00€10mg55,00€25mg101,00€50mg192,00€100mg326,00€200mg485,00€500mg772,00€Staurosporine
CAS:Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-FgrFórmula:C28H26N4O3Pureza:99.24% - 99.82%Forma y color:SolidPeso molecular:466.53Ref: TM-T6680
1mg58,00€2mg82,00€5mg92,00€1mL*10mM (DMSO)103,00€10mg138,00€25mg234,00€50mg380,00€100mg565,00€500mg1.215,00€Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Fórmula:C8H11NO3·C5H7NO3Pureza:99.19%Forma y color:White SolidPeso molecular:298.298-Bromo-cAMP sodium salt
CAS:8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.Fórmula:C10H10BrN5NaO6PPureza:98% - 99.94%Forma y color:White SolidPeso molecular:430.08HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Forma y color:White SolidPeso molecular:277.34
