PKA
La proteína quinasa A (PKA) es una enzima clave en la cascada de señalización de los GPCR, activada por el AMP cíclico (cAMP) en respuesta a diversas señales extracelulares. La PKA regula una amplia gama de procesos celulares, incluidos el metabolismo, la expresión génica y el crecimiento celular. La desregulación de la actividad de la PKA está asociada con diversas enfermedades, como el cáncer, trastornos metabólicos y afecciones cardiovasculares. Los moduladores de PKA son herramientas valiosas en la investigación dirigida a comprender las vías de señalización de GPCR y desarrollar nuevas estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de moduladores de PKA de alta calidad para apoyar su investigación en transducción de señales, regulación celular y mecanismos de enfermedades.
Se han encontrado 48 productos de "PKA"
Ordenar por
Pureza (%)
0
100
|
0
|
50
|
90
|
95
|
100
Kiss2 peptide acetate
<p>Kiss2 peptide acetate is the acetate form of Kiss2 peptide, serving as a positive regulator of reproduction. It binds to its homologous receptor Kiss2R (GPR54) in COS-7 cells, activating the PKA and PKC signaling pathways through Gas and Gaq proteins. This activation enhances the activity of both cAMP response element-dependent luciferase (CRE-luc) and serum response element-dependent luciferase (SRE-luc).</p>Fórmula:C63H84N16O12·xC2H4O2Forma y color:SolidPeso molecular:1257.44 (free base)PKA-IN-1
CAS:<p>PKA-IN-1 is a selective and potent cyclic AMP-dependent protein kinase (PKA) catalytic subunit (cAK) inhibitor (IC50: 0.03 μM).PKA-IN-1 can be used to study</p>Fórmula:C13H11N3OPureza:97.52%Forma y color:SolidPeso molecular:225.25AP-C2
CAS:<p>AP-C2 is a potent small molecule guanosine 3',5'-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) inhibitor with a pIC50 of 5.2 for cGKII.</p>Fórmula:C18H16N4SPureza:99.87%Forma y color:SoildPeso molecular:320.41PKA/AKAP-IN-2
CAS:<p>PKA/AKAP-IN-2 (WAY-298350) is a PKA and AKAP interaction inhibitor, used in metabolic disease research.</p>Fórmula:C17H17NO3Pureza:99.82%Forma y color:SoildPeso molecular:283.32Aplithianines A
<p>Aplithianines A effectively inhibits J-PKAcα with an IC50 value of 1 μM and displays higher potency against wild-type PKA, achieving an IC50 of 84 nM by</p>Pureza:98%Forma y color:Odour SolidDT-3 acetate
<p>DT-3 acetate is a cell-permeable peptide that acts as an inhibitor of protein kinase G (PKGIα), effectively blocking the cGMP-PKG signaling pathway.</p>Fórmula:C152H258N52O28S·xC2H4O2Forma y color:SolidPeso molecular:3294.07 (free acid)CCG215022
CAS:<p>CCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.15±0.07 μM, 0.38±0.06 μM and 3.9±1 μM for GRK2, 5 and 1, respectively.</p>Fórmula:C26H22FN7O3Pureza:97.63% - 99.69%Forma y color:SolidPeso molecular:499.5Metadoxine
CAS:<p>Metadoxine (Metadoxil) is a neurotransmitter stimulant.</p>Fórmula:C8H11NO3·C5H7NO3Pureza:99.19%Forma y color:Off-White PowderPeso molecular:298.29AT7867
CAS:<p>AT7867 inhibits Akt1/2/3 & p70S6K/PKA (IC50: 32/17/47 nM & 85/20 nM), minimal effect beyond AGC kinases.</p>Fórmula:C20H20ClN3Pureza:99.63%Forma y color:SolidPeso molecular:337.85Daphnetin
CAS:<p>Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),</p>Fórmula:C9H6O4Pureza:97.47% - 99.8%Forma y color:SolidPeso molecular:178.14HA-100
CAS:<p>HA-100 is an inhibitor of protein kinase</p>Fórmula:C13H15N3O2SPureza:99.44%Forma y color:Pale Yellow Crystalline SolidPeso molecular:277.34Iso-H7 dihydrochloride
CAS:<p>Iso-H7 dihydrochloride is a less potent inhibitor of phosphokinase C than H-7.</p>Fórmula:C14H19Cl2N3O2SPureza:99.53%Forma y color:White Crystalline SolidPeso molecular:364.29Bilobetin
CAS:<p>Bilobetin ameliorates insulin resistance by PKA-mediated phosphorylation of PPARα in rats fed a high-fat diet.</p>Fórmula:C31H20O10Pureza:97.74% - 99.69%Forma y color:SolidPeso molecular:552.48Fasudil hydrochloride
CAS:<p>Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.</p>Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Forma y color:White SolidPeso molecular:327.83PKG drug G1
CAS:<p>PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.</p>Fórmula:C13H11N3OSPureza:97.57% - 97.67%Forma y color:SolidPeso molecular:257.31AT13148
CAS:<p>AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.</p>Fórmula:C17H16ClN3OPureza:98.04% - ≥95%Forma y color:SolidPeso molecular:313.78H-89 dihydrochloride
CAS:<p>H-89 dihydrochloride (5-Isoquinolinesulfonamide) is a potent inhibitor of protein kinase A (PKA; IC50: 0.14 μM, Ki: 48 nM).</p>Fórmula:C20H20BrN3O2S·2HClPureza:98.22% - >99.99%Forma y color:SolidPeso molecular:519.28Staurosporine
CAS:<p>Staurosporine (AM-2282) is a protein kinase inhibitor with ATP-competitive and non-selective inhibitory activity (IC50=6/15/2/3/3000 nM) against PKC, PKA, c-Fgr</p>Fórmula:C28H26N4O3Pureza:99.24% - 99.82%Forma y color:Off-White PowderPeso molecular:466.538-Bromo-cAMP sodium salt
CAS:<p>8-Bromo-cAMP sodium salt (8-Br-Camp sodium salt) is a long-acting derivative of cyclic AMP. 8-Bromo-cAMP is an activator of cyclic AMP-dependent protein kinase.</p>Fórmula:C10H10BrN5NaO6PPureza:98% - 99.94%Forma y color:Off-White PowderPeso molecular:430.08H-8 hydrochloride
CAS:<p>H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.</p>Fórmula:C12H17Cl2N3O2SPureza:99.93%Forma y color:White To Off-White Crystalline SolidPeso molecular:338.25
