PKA
La proteína quinasa A (PKA) es una enzima clave en la cascada de señalización de los GPCR, activada por el AMP cíclico (cAMP) en respuesta a diversas señales extracelulares. La PKA regula una amplia gama de procesos celulares, incluidos el metabolismo, la expresión génica y el crecimiento celular. La desregulación de la actividad de la PKA está asociada con diversas enfermedades, como el cáncer, trastornos metabólicos y afecciones cardiovasculares. Los moduladores de PKA son herramientas valiosas en la investigación dirigida a comprender las vías de señalización de GPCR y desarrollar nuevas estrategias terapéuticas. En CymitQuimica, ofrecemos una selección de moduladores de PKA de alta calidad para apoyar su investigación en transducción de señales, regulación celular y mecanismos de enfermedades.
Se han encontrado 61 productos de "PKA"
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Fasudil hydrochloride
CAS:Fasudil hydrochloride (HA-1077) is a potent inhibitor of ROCK1, PKA, PKC, and MLCK with Ki of 0.33 μM, 1.0 μM, 9.3 μM and 55 μM, respectively.Fórmula:C14H18ClN3O2SPureza:99.54% - ≥95%Forma y color:White SolidPeso molecular:327.83PKG drug G1
CAS:PKG drug G1 targets PKG Iα C42. PKG drug G1 can couple to vasodilation and blood pressure lowering by a C42 PKG Iα-independent mechanism.Fórmula:C13H11N3OSPureza:97.57% - 97.67%Forma y color:SolidPeso molecular:257.31CREBtide acetate(149155-45-3 free base)
CREBtide acetate is a synthetic substrate for PKA (Km=3.9 μM), which is based on the phosphorylation sequence in d-CREB (cAMP response element binding protein).Fórmula:C75H133N29O21Pureza:96.13%Forma y color:SolidPeso molecular:1777.07PKI 14-22 amide, myristoylated Acetate
PKI 14-22 amide, myristoylated Acetate inhibit cAMP-dependent protein kinase (PKA) and blocks hyperalgesia produced by spinal administration of 8-bromo-cAMP.Fórmula:C55H104N20O14Pureza:96.34%Forma y color:SolidPeso molecular:1269.54Ref: TM-T21983L
1mg167,00€5mg363,00€10mg538,00€1mL*10mM (DMSO)695,00€25mg800,00€50mg1.071,00€100mg1.449,00€PKG inhibitor peptide TFA (82801-73-8 free base)
PKG inhibitor peptide TFA (82801-73-8 free base) is an inhibitor of ATP-competitive cGMP-dependent protein kinase (PKG).Fórmula:C40H75F3N18O12Pureza:98%Forma y color:SolidPeso molecular:1057.13PKI (5-24) Acetate(99534-03-9 free base)
PKI (5-24) Acetate is a high affinity PKA inhibitor (Ki = 2.3 nM).Fórmula:C96H152N32O33Pureza:99.47%Forma y color:SolidPeso molecular:2282.43PKG Substrate acetate(81187-14-6 free base)
PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG).PKG Substrate is a selective substrate for protein kinase G (PKG) with aFórmula:C37H71N17O13Pureza:99.30%Forma y color:SolidPeso molecular:962.08Hydroxyfasudil
CAS:Hydroxyfasudil (Hydroxy-Fasudil) is a ROCK inhibitor(IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively).Fórmula:C14H17N3O3SPureza:98.13%Forma y color:SolidPeso molecular:307.37Malantide acetate(86555-35-3 free base)
Malantide acetate is a dodecapeptide phosphorylated by cyclic AMP-dependent protein kinase (PKA), and increases PKA activity.Malantide is a synthetic peptideFórmula:C74H128N22O23Pureza:>99.99%Forma y color:SolidPeso molecular:1693.97HA-100
CAS:HA-100 is an inhibitor of protein kinaseFórmula:C13H15N3O2SPureza:99.44%Forma y color:Pale Yellow Crystalline SolidPeso molecular:277.34Metadoxine
CAS:Metadoxine (Metadoxil) is a neurotransmitter stimulant.Fórmula:C8H11NO3·C5H7NO3Pureza:99.19%Forma y color:Off-White PowderPeso molecular:298.29H-8 hydrochloride
CAS:H-8 hydrochloride is a reversible and ATP-competitive PKA inhibitor. It can be used to study metabolic diseases.Fórmula:C12H17Cl2N3O2SPureza:99.93%Forma y color:White To Off-White Crystalline SolidPeso molecular:338.256-Bn-cAMP
CAS:6-Bn-cAMP is a selective activator of cAMP-dependent protein kinase (PKA) that does not activate Epac. Compared to cAMP, 6-Bn-cAMP enhances hydrolytic stability against PDE, esterases, and amidases, and significantly increases membrane permeability.Fórmula:C17H18N5O6PForma y color:SolidPeso molecular:419.338-Chloro-cAMP sodium
CAS:8-Chloro-cAMP sodium is a cAMP analog that induces growth arrest and modulates cAMP-dependent PKA activity. This compound also exhibits anticancer activity.Fórmula:C10H10ClN5NaO6PForma y color:SolidPeso molecular:385.638-MA-cAMP
CAS:8-MA-cAMP (8-Methylamino-cAMP) is a cyclic adenosine monophosphate analog that acts as a site-selective PKA agonist, exhibiting similar affinity for the B site of both Type I and Type II protein kinase A. When used in conjunction with analogs that preferentially target site A, such as 8-piperidinyl cAMP, 8-MA-cAMP facilitates selective stimulation of Type I enzymes.Fórmula:C11H15N6O6PForma y color:SolidPeso molecular:358.25Rp-cAMPS triethylammonium salt
CAS:Rp-cAMPS triethylammonium salt is a competitive inhibitor of cAMP-dependent protein kinase I and II.Fórmula:C16H27N6O5PSPureza:98%Forma y color:SolidPeso molecular:446.46BGC201531
CAS:BGC201531 (AP-1531) is a EP4 antagonist for the treatment of acute migraine.Fórmula:C26H28N2O6SPureza:98.51% - 99.33%Forma y color:SolidPeso molecular:496.58FMP-API-1
CAS:FMP-API-1 is an inhibitor of the A-kinase anchoring protein (AKAP)-PKA interaction. It binds to the allosteric site of the PKAR subunit, enhancing the activity of PKA and AQP2 in PKA knockout cell lines of the renal cortex collecting duct (mpkCCD cells). FMP-API-1 holds potential for studying nephrogenic diabetes insipidus (NDI).Fórmula:C13H14N2O2Forma y color:SolidPeso molecular:230.2628-Br-cGMP-AM
CAS:8-Br-cGMP-AM, a derivative of 8-Br-cGMP, acts as an activator of PKG (cGMP-dependent protein kinase), inducing various biological effects such as vasodilation and platelet inhibition. This compound is utilized in the research of cardiovascular diseases.Fórmula:C13H15BrN5O9PForma y color:SolidPeso molecular:496.16Protein kinase inhibitor 7
CAS:Protein kinase inhibitor 7 functions as an inhibitor of protein kinase A (PKA) and protein kinase C (PKC). It impacts the autocrine motility factor (AMF) signaling pathway without affecting cell motility.Fórmula:C12H15N3O2SPeso molecular:265.33
