Hedgehog / Smoothened
La vía de señalización Hedgehog/Smoothened es una vía crucial relacionada con los GPCR, involucrada en el desarrollo embrionario, la regeneración de tejidos y el mantenimiento de células madre. Smoothened (SMO) es una proteína transmembrana clave que transduce señales de los ligandos Hedgehog (Hh) para activar cascadas de señalización aguas abajo. La desregulación de la vía Hedgehog/Smoothened está implicada en varios tipos de cáncer y trastornos del desarrollo, lo que la convierte en un objetivo significativo para la intervención terapéutica. En CymitQuimica, ofrecemos una gama de moduladores de alta calidad para la vía Hedgehog/Smoothened para apoyar su investigación en biología del desarrollo, oncología y medicina regenerativa.
Se han encontrado 44 productos de "Hedgehog / Smoothened"
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ALLO-2
CAS:<p>ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.</p>Fórmula:C18H12F3N5OPureza:99.19%Forma y color:SolidPeso molecular:371.32GANT 58
CAS:<p>GANT 58 (NSC-75503) is a potent antagonist of Gli. Which inhibits GLI1-induced transcription (IC50: 5 μM).</p>Fórmula:C24H16N4SPureza:99.53%Forma y color:SolidPeso molecular:392.48Dynarrestin
CAS:<p>Dynarrestin inhibits cytoplasmic dynein 1/2, preventing microtubule sliding without affecting ATP hydrolysis or ciliogenesis.</p>Fórmula:C22H23F2N3O2SPureza:99.64%Forma y color:SolidPeso molecular:431.5SAG dihydrochloride
CAS:<p>SAG dihydrochloride: potent Smo agonist, activates Hedgehog pathway, counters Cyclopamine. EC50=3 nM, Kd=59 nM.</p>Fórmula:C28H30Cl3N3OSPureza:>99.99%Forma y color:SoildPeso molecular:562.98HPP-9
<p>HPP-9, a Proteolysis-Targeting Chimera (PROTAC) derived from Hedgehog Pathway Inhibitor-1 (HPI-1) with a pIC50 value of 6.71, is designed to degrade BET</p>Fórmula:C49H52N6O11Forma y color:SolidPeso molecular:900.97HSP70-IN-3
<p>HSP70-IN-3: Strong HSP70 blocker; IC50=1.1μM/1.9μM (ASZ001/C3H10T1/2); hinders Hedgehog signaling and cancer cell growth, lowers GLI1 levels.</p>Fórmula:C48H78N6O7SForma y color:SolidPeso molecular:883.23CUR61414 hydrochloride
<p>CUR61414 hydrochloride: potent cell-permeable Hedgehog pathway inhibitor, IC50=100-200 nM, selectively targets Smo (Ki=44 nM), induces cancer cell apoptosis.</p>Fórmula:C31H43ClN4O5Pureza:94.05%Forma y color:SolidPeso molecular:587.15HL2-m5
CAS:<p>HL2-m5 is an inhibitor of the sonic hedgehog/patched (Shh/PTCH1) interaction, with a Kd for Shh of 170 nM. It effectively inhibits the activation of the Hedgehog signaling pathway and the transcription of Gli-controlled genes, with an IC50 of 230 nM.</p>Fórmula:C70H101N15O24S3Forma y color:SolidPeso molecular:1632.83GLI1-IN-3
<p>GLI1-IN-3 (Compound 11a) is a triterpenoid-like compound that inhibits Hedgehog signaling in cancer cells with GLI1 overexpression. It suppresses the proliferation of non-small cell lung cancer and prostate cancer cell lines with excessive Hh signaling activation. Additionally, GLI1-IN-3 reduces the expression of GLI1 protein and its target genes associated with tumor progression and proliferation in A549 and DU-145 cancer cells.</p>Forma y color:Odour SolidGI-560192
CAS:<p>GI-560192 (RL-0070933), a potent smo modulator, EC50: 0.02µM; affects smoothened in cilia via hedgehog signaling.</p>Fórmula:C20H16N2O2Pureza:99.53%Forma y color:SoildPeso molecular:316.35SANT 2
CAS:<p>SANT 2 is a Hedgehog (Hh) signaling pathway antagonist with potential anti-inflammatory and anti-cancer activities.</p>Fórmula:C26H26ClN3O4Pureza:99.23%Forma y color:SolidPeso molecular:479.96JK184
CAS:<p>JK184 is a potent Hedgehog (Hh) pathway inhibitor.</p>Fórmula:C19H18N4OSPureza:98.93% - 99.89%Forma y color:SolidPeso molecular:350.44SAG
CAS:<p>SAG (Smoothened Agonist) is a Smo receptor agonist (EC50=3 nM) that is cell-permeable and selective.</p>Fórmula:C28H28ClN3OSPureza:97.37% - 98.88%Forma y color:SolidPeso molecular:490.06HhAntag
CAS:<p>HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway with the anti-tumor activity</p>Fórmula:C24H23ClN4O3Pureza:95.73%Forma y color:SolidPeso molecular:450.92MRT-81
CAS:<p>MRT-81 blocks Smo receptors in Shh-light2 cells at 41 nM IC50, showing strong hedgehog pathway inhibition, useful in cancer research.</p>Fórmula:C31H29N3O5SPureza:99.72%Forma y color:SolidPeso molecular:555.64Glasdegib
CAS:<p>Glasdegib (PF-04449913) (PF-04449913) is a potent, and orally bioavailable Smoothened (Smo) inhibitor with IC50 of 5 nM. Phase 2.</p>Fórmula:C21H22N6OPureza:98.72%Forma y color:SolidPeso molecular:374.44SAG hydrochloride (912545-86-9(free base))
CAS:<p>SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) acts as an SMO agonist.</p>Fórmula:C28H29Cl2N3OSPureza:99.19% - 99.77%Forma y color:SolidPeso molecular:526.52MRT-10
CAS:<p>MRT-10 is a Smoothened (Smo) receptor antagonist.</p>Fórmula:C24H23N3O5SPureza:99.73%Forma y color:SolidPeso molecular:465.52HPI 1
CAS:<p>HPI 1 suppresses Hh pathway: IC50 = 1.5 μM (Shh, SAG), 4 μM (Gli2), 6 μM (Gli1) in Shh-LIGHT2 cells.</p>Fórmula:C27H29NO6Pureza:97.6%Forma y color:SolidPeso molecular:463.52SANT-1
CAS:<p>SANT-1 directly binds to Smoothened (Smo) receptor (Kd: 1.2 nM) and inhibits Smo agonist effects (IC50: 20 nM).</p>Fórmula:C23H27N5Pureza:99.98% - >99.99%Forma y color:SolidPeso molecular:373.49
