DHFR
La dihidrofolato reductasa (DHFR) es una enzima que desempeña un papel crucial en el ciclo del folato, esencial para la síntesis, reparación y metilación del ADN. Los inhibidores de DHFR se utilizan ampliamente como agentes quimioterapéuticos en el tratamiento del cáncer y las enfermedades autoinmunes debido a su capacidad para inhibir la proliferación celular. En CymitQuimica, ofrecemos una variedad de inhibidores de DHFR para apoyar su investigación en terapia contra el cáncer, inmunología y biología molecular.
Se han encontrado 33 productos de "DHFR"
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P 218
CAS:<p>P 218 is a novel DHFR inhibitor with antimalarial activity and antifolate effects and can be used to study Buruli ulcer.</p>Fórmula:C18H25ClN4O4Pureza:98.83%Forma y color:SoildPeso molecular:396.87Diaveridine
CAS:<p>Diaveridine (AI3-23935) (DVD) is a popular antibacterial synergist that is widely used in combination with sulfonamide.</p>Fórmula:C13H16N4O2Pureza:99.10%Forma y color:White SolidPeso molecular:260.29Pemetrexed
CAS:<p>Pemetrexed (LY-231514 Disodium Hydrate), a guanine-derived antineoplastic agent, binds to and inhibits the enzyme thymidylate synthase (TS).</p>Fórmula:C20H21N5O6Pureza:98.1% - 99.92%Forma y color:Similar To White PowderPeso molecular:427.41Pyrimethamine
CAS:<p>Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug.</p>Fórmula:C12H13ClN4Pureza:99.67%Forma y color:CrystalsPeso molecular:248.71Sulfameter
CAS:<p>Sulfameter (Sulfametoxydiazine) is a long-acting sulfonamide antibacterial agent used to treat urinary tract infections and leprosy.</p>Fórmula:C11H12N4O3SPureza:99.46% - 99.90%Forma y color:Crystalline SolidPeso molecular:280.3DHFR-IN-20
<p>DHFR-IN-20 (Compound LA1) is an inhibitor of dihydrofolate reductase (DHFR) targeting the malignant strains of the malaria parasite. It exhibits inhibition constants (Kis) of 0.16 nM, 0.30 nM, and 6.6 nM for PfDHFR-WT, PfDHFR-QM, and HsDHFR, respectively. Additionally, DHFR-IN-20 demonstrates antimalarial activity, with IC50 values of 1.4 nM against parasites carrying the wild-type (TM4/8.2) PfDHFR enzyme and 1.6 μM against those with the quadruple mutation (V1/S)PfDHFR.</p>Forma y color:Odour SolidEGFR/HER2/DHFR-IN-2
<p>EGFR/HER2/DHFR-IN-2 (Compound 4b) serves as an inhibitor for EGFR, HER2, and DHFR, with IC50 values of 0.248, 0.156, and 0.138 μM, respectively.</p>Pureza:98%Forma y color:Odour Solid4-O-Methyldopamine hydrochloride
CAS:Compound PDK0318, with CAS No. 645-33-0, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. Compound PDK0318 provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.Fórmula:C9H13NO2Peso molecular:167.2DHFR-IN-16
<p>DHFR-IN-16 (compound 8d) is an inhibitor of dihydrofolate reductase (DHFR) with an IC50 of 0.199 μM, and is valuable for anti-infection research.</p>Fórmula:C32H34N4O4SPeso molecular:570.23008DHFR-IN-18
<p>DHFR-IN-18 (compound 19D) is a DHFR inhibitor utilized in leukemia-related research.</p>Fórmula:C24H22ClN7Peso molecular:443.16252EGFR/DHFR-IN-1
<p>EGFR/DHFR-IN-1 (Compound 10e) is a dual inhibitor of EGFR and DHFR, with IC50 values of 0.151 µM and 0.541 µM, respectively. It induces cell cycle arrest in the G0-G1 and S phases.</p>Fórmula:C24H26N4O5S2Peso molecular:514.13446DHFR-IN-21
<p>DHFR-IN-21 (compound 5p) is an inhibitor of dihydrofolate reductase.</p>Forma y color:Odour SolidDHFR-IN-11
<p>DHFR-IN-11 (compound 6b) is a DHFR inhibitor with demonstrated inhibitory efficacy against the M.</p>Forma y color:Odour SolidAnti-Dihydrofolate reductase Antibody (2V859)
<p>Anti-Dihydrofolate reductase Antibody (2V859) is an antibody targeting Dihydrofolate reductase. Anti-Dihydrofolate reductase Antibody (2V859) can be used in ELISA, WB, IHC, IP.</p>Forma y color:Odour LiquidFanotaprim
CAS:<p>Fanotaprim is a dihydrofolate reductase (DHFR) inhibitor.</p>Fórmula:C19H22N8OPureza:98.1%Forma y color:SolidPeso molecular:378.43WR99210 hydrochloride(47326-86-3 free base)
CAS:<p>WR99210 hydrochloride is a potent inhibitor of Plasmodium falciparum dihydrofolate reductase (pfDHFR), which is a major malarial drug target.</p>Fórmula:C14H19Cl4N5O2Pureza:97.77% - 99.8%Forma y color:SolidPeso molecular:431.14WR99210
CAS:<p>WR99210 (BRL 6231 free base) is a DHFR inhibitor with antiparasitic activity.</p>Fórmula:C14H18Cl3N5O2Pureza:98.8%Forma y color:SolidPeso molecular:394.68DHFR-IN-3
CAS:<p>DHFR-IN-3 (7-bromoquinazoline-2,4-diamine) is an active biochemical.</p>Fórmula:C8H7BrN4Pureza:99.521% - 99.65%Forma y color:SolidPeso molecular:239.07Dihydrofolate reductase Protein, S. aureus, Recombinant (His & Myc)
<p>Key enzyme in folate metabolism.</p>Forma y color:Lyophilized PowderPeso molecular:25.6 kDa (predicted)Dihydrofolate reductase Protein, Human, Recombinant (His)
<p>Key enzyme in folate metabolism.</p>Forma y color:Lyophilized PowderPeso molecular:25.5 kDa (predicted)Dihydrofolate reductase Protein, S. epidermidis, Recombinant (His)
<p>Key enzyme in folate metabolism.</p>Forma y color:Lyophilized PowderPeso molecular:22.0 kDa (predicted)(Rac)-Managlinat dialanetil
CAS:<p>Managlinat dialanetil, an orally available and potent inhibitor of fructose 1,6-bisphosphatase (FBPase) used in research 2 type diabetes.</p>Fórmula:C21H33N4O6PSPureza:98.52%Forma y color:SolidPeso molecular:500.55DHFR-IN-5
CAS:<p>DHFR-IN-5: potent, oral DHFR inhibitor, Ki 0.54 nM against mutant P. falciparum, anti-malarial.</p>Fórmula:C18H24N4O4Forma y color:SolidPeso molecular:360.4110-Deazaaminopterin
CAS:<p>10-Deazaaminopterin is a poly-gamma-glutamyl metabolite of the experimental anticancer drug, a folic acid antagonist, antineoplastic agent enzyme inhibitor.</p>Fórmula:C20H21N7O5Forma y color:SolidPeso molecular:439.42Clociguanil
CAS:<p>Clociguanil has antimalarial activity.</p>Fórmula:C12H15Cl2N5OForma y color:SolidPeso molecular:316.19Epiroprim
CAS:<p>Epiroprim (Ro11-8958) is a selective dihydrofolate reductase (DHFR) inhibitor with antibacterial activity, inhibiting Staphylococcus and Streptococcus.</p>Fórmula:C19H23N5O2Pureza:99.68% - >99.99%Forma y color:SolidPeso molecular:353.42Piritrexim
CAS:<p>Piritrexim (BW 301U) is an orally available fat-soluble dihydrofolate reductase inhibitor with pulmonary toxicity used in the study of uroepithelial carcinoma</p>Fórmula:C17H19N5O2Pureza:98.50% - >99.99%Forma y color:SolidPeso molecular:325.37Talotrexin ammonium
CAS:<p>Talotrexin ammonium, a non-polyglutamic antifolate, inhibits cancer by targeting DHFR.</p>Fórmula:C27H30N10O6Pureza:97.49%Forma y color:SolidPeso molecular:590.59Methotrexate-γ-aspartate
CAS:<p>Methotrexate-gamma-aspartate has growth inhibitory effects. It is used in antibody-targeted liposomes.</p>Fórmula:C24H27N9O8Pureza:98%Forma y color:SolidPeso molecular:569.53Phototrexate
CAS:<p>Phototrexate, a photochromic Methotrexate analog, is a UVA-activated, reversible DHFR inhibitor with antifolate properties (IC50: 6 nM cis vs. 34 μM trans).</p>Fórmula:C20H19N7O5Forma y color:SolidPeso molecular:437.414′-DTMP
CAS:<p>4′-DTMP (4-Demethyltrimethoprim) is a DHFR inhibitor with antimicrobial activity against Escherichia coli.</p>Fórmula:C13H16N4O3Pureza:98%Forma y color:SolidPeso molecular:276.29Brodimoprim
CAS:<p>Brodimoprim is an inhibitor of dihydrofolate reductase(DHFR).</p>Fórmula:C13H15BrN4O2Pureza:98% - 98.33%Forma y color:SolidPeso molecular:339.19DHFR-IN-4
CAS:<p>DHFR-IN-4 is a potent dihydrofolate reductase (DHFR) inhibitor with anti-tumour activity, inhibits EGFR and HER2 and can be used to study pancreatic cancer.</p>Fórmula:C18H21N5O2SPureza:99.41%Forma y color:SolidPeso molecular:371.46
