Antibacteriano

Anti-MRSA agent 9 (compound 39) exhibits antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) isolated from clinical samples, with a minimum inhibitory concentration (MIC) of 1 μg/ml. Additionally, Anti-MRSA agent 9 demonstrates anti-MRSA efficacy in vivo.

Minocycline is a useful organic compound for research related to life sciences. The catalog number is T131626 and the CAS number is 10118-90-8.

Polyunsaturated anacardic acid diene from cashew shells fights MRSA, S. mutans, and S. mansoni; inhibits soybean lipoxygenase-1.

Linearmycin B, a polyene antibiotic from Streptomyces, causes B. subtilis lysis in Streptomyces Mg1 extract.

Antibacterial 128, a siderophore-Ciprofloxacin blend with cleavable linker, targets P. aeruginosa and B. pseudomallei.

Siomycin A: thiopeptide antibiotic, selectively inhibits FOXM1, anti-tumor, induces apoptosis.

Urease-IN-21 (Compound 11b) is a urease inhibitor with an IC50 of 0.12 μM. It exhibits potent antibacterial activity against Helicobacter pylori (H. pylori) and inhibits P450 enzymes (CYP2C19, CYP2C9, and CYP3A4). Urease-IN-21 is applicable in research related to H. pylori infections.

LasR agonist 1 (9) is a LasR activator with an EC50 value of 0.7 μM. This compound is useful for research involving Pseudomonas aeruginosa.

Dalfopristin (RP54476) mesylate is a semi-synthetic sulfonamide antibiotic with limited antibacterial activity on its own. However, it exhibits significant bactericidal activity against many pathogenic Gram-positive cocci when used in synergy with Quinupristin.

Antitubercular agent-43 (compound A11) is a potent, orally active antitubercular drug. It exhibits high metabolic stability against human and murine cytochrome P450 enzymes. In an acute tuberculosis mouse model, Antitubercular agent-43 demonstrates antibacterial activity.

Citrullinated LL-37 5cit is a modified form of the LL-37 peptide. Its antiviral and antibacterial activities are significantly reduced compared to the natural LL-37. Additionally, Citrullinated LL-37 5cit is unable to decrease LPS-mediated TNF-α release due to its lack of LPS binding capability.

(Rac)-Bedaquiline is the racemic form of Bedaquiline. Bedaquiline (TMC207) acts as a diarylquinoline agent that targets the c- and ε-subunits to inhibit Mycobacterium tuberculosis (Mtb) F1FO-ATP synthase. It possesses uncoupler activity and is employed in the treatment of multidrug-resistant tuberculosis.

IDD-8E is an effective anti-pseudomonal agent (MIC = 4.4 µM) with no cytotoxicity. It demonstrates significant killing of Pseudomonas and disruption of its biofilm. IDD-8E targets the ATP-binding pocket of WaaP and also inhibits other ESKAPE pathogens.

NRC-16 is a biologically active peptide with characteristics similar to pleurocidin, a cationic antimicrobial peptide (cationic AMP).

GaSal-2 is a water-soluble anti-Pseudomonas agent that targets the extracellular heme-binding protein, HasAp. By tightly binding to HasAp, GaSal-2 inhibits the growth of Pseudomonas aeruginosa by blocking the transcriptional activation of signal cascades on the bacterial cell surface.

Vancomycin prodrug (compound 13c) is a prodrug of Vancomycin. It exhibits antibacterial activity against Staphylococcus aureus (S. aureus) 330041, methicillin-resistant Staphylococcus aureus (MRSA) USA 300, and MRSA 3390, with minimum inhibitory concentrations (MICs) of 0.78 μM, 0.78 μM, and 1.56 μM, respectively. This prodrug can rapidly bind to the Cys-34 residue in plasma. It demonstrates therapeutic efficacy in mice infected with MRSA USA300, comparable to Vancomycin. As an albumin-binding, acid-sensitive prodrug, Vancomycin prodrug maintains Vancomycin's effectiveness against gram-positive bacterial infections while significantly reducing nephrotoxicity.

Gosteganan is an antimicrobial agent.

Cethromycin (ABT-773) is an antibiotic of ketolide.

LEAP-2 (Human liver expressed antimicrobial peptide-2) is an antimicrobial peptide, a growth hormone-releasing peptide antagonist, and a GHS-R1a inverse agonist

N14G-Fe, the Fe3+ chelated form of N14G, can identify Mycobacterium tuberculosis in sputum samples from tuberculosis patients, exhibiting exceptional fluorescence properties. Additionally, N14G-Fe effectively traverses the cell wall and the inner membrane region where IrtAB is located.

FtsZ-IN-12 (Compound 16e) is an inhibitor of filamentous temperature-sensitive mutant Z (FtsZ) that promotes the polymerization of the FtsZ protein and suppresses its GTPase activity, thus disrupting the bacterial cell division process. This compound exhibits broad-spectrum antibacterial activity, effectively inhibiting B. subtilis ATCC 9372, B. pumilus CMCC 63202, S. aureus ATCC 25923, E. coli BW25113, and A. baumannii ATCC 19606 with MIC values ranging from 0.062-1 µg/mL. Additionally, FtsZ-IN-12 can inhibit biofilm formation and eliminate mature biofilms. It possesses bactericidal properties and shows no hemolytic toxicity to mammalian red blood cells at a dosage of 15 mg/kg.

Nitrofurantoin-13C3: internal standard for GC/LC-MS quantification of the antibiotic nitrofurantoin.

PPO-allene is a covalent inhibitor of botulinum neurotoxin (BoNT) light chain with an IC50 of 20.9 μM. In mice, PPO-allene has a half-life of approximately 1.5 hours when administered intravenously at a dose of 0.3 mg/kg.

Pyrazine-2-amidoxime, a structural analogue of pyrazine-2-carboxamide, exhibits antibacterial activity. It is effective in killing and inhibiting Candida albicans, fungal pathogens, and Gram-positive bacteria.

Fobrepodacin (SPR720) is an orally active and potent phosphate prodrug of SPR719 (VXc-486). Fobrepodacin has potent bactericidal activities in vivo.

Antibiofilm agent-17 is a dual-action biofilm inhibitor (IC50 = 0.33 μM) targeting Pseudomonas aeruginosa. It inhibits biofilm growth by reducing virulence production regulated by the quorum sensing system and decreasing iron acquisition capability. In a mouse wound infection model, Antibiofilm agent-17 shows synergistic antibacterial activity. This compound is useful for research on combating Pseudomonas aeruginosa infections.

Antibacterialagent 280 (Compound 7af) is an antimicrobial compound designed specifically to target methicillin-resistant and vancomycin-resistant Staphylococcus aureus (MRSA, VRSA). It shows promise for research applications involving S. aureus infections.

Renierone is an antimicrobial metabolite isolated from the marine sponge, Reniera sp.

SrtA-IN-1 (Compound T10) is an inhibitor of Streptococcus pyogenes sortase A (SpSrtA) with an IC50 value of 0.7 μM. It is applicable for research in the field of anti-infective agents.

Antibiofilm agent prodrug 1 (Compound 5c) demonstrates antibacterial properties by inhibiting biofilm formation and iron uptake. It effectively suppresses Pseudomonas aeruginosa PAO1 with a minimum inhibitory concentration (MIC) of 1.07 μM. In addition, Antibiofilm agent prodrug 1 exhibits anti-infective activity in Caenorhabditis elegans, enhancing the survival rate of the nematodes.

Lysobactin (katanosin B) is an antibiotic effective against S. aureus, S. pneumoniae, and blocks PG biosynthesis.

Cyclacillin (Wy-4508), an oral aminopenicillin, fights many gram-positive/negative bacteria.

Efflux pump-IN-3 inhibits AcrB, potentiates antibiotics, and is non-toxic to membranes and nematodes.

MRSA/VRE-IN-1 (Compound 3e) is an inhibitor targeting methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), with MIC/MBC values of 3.6/7.3 µM for VRE and 7.3/14.6 µM for MRSA. It is applicable in research focused on anti-infection studies.

Antimycobacterial agent-11 (Compound QM7) is a bacteriostatic compound with anti-tuberculosis properties, exhibiting a minimum inhibitory concentration (MIC) of 5.58 μg/mL against Mycobacterium tuberculosis (Mtb). This agent is applicable in the field of anti-infective research, particularly for studies focusing on tuberculosis.

Skatole-D3 is the deuterated form of Skatole. Skatole (T5281) is a compound produced by gut microbiota that influences intestinal epithelial cell function by activating aryl hydrocarbon receptors (aryl hydrocarbon receptors) and regulating p38.

Antibacterial agent 243 is a potent antimicrobial compound with EC50 values of 0.64 mg/L for Valsa mali, 26 mg/L for allicin, and 0.33 mg/L for tebuconazole. It induces hyphal contraction and collapse, triggers the accumulation of reactive oxygen species within cells, modulates antioxidant enzyme activity, initiates lipid peroxidation, and ultimately causes irreversible oxidative damage to Valsa mali cells.

Dusquetide acetate: innate immune modulator with anti-inflammatory and antibacterial properties.

Ciprofloxacin-13C3,15N monohydrochloride is the 13C and 15N labeled form of Ciprofloxacin monohydrochloride (TMSM-0759).

Nv-CATH, an antibacterial peptide derived from frogs, exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria, and significantly

[5-(2-Thienyl)-3-isoxazolyl]methanol ,with CAS No. 194491-44-6, is a fragment molecule that serves as an important scaffold for molecular linking, expansion, and modification. [5-(2-Thienyl)-3-isoxazolyl]methanol provides a structural basis and research tool for the design and screening of novel drug candidates, and is commonly used in drug discovery, drug synthesis, and related research.

ANT3310 inhibits several Serine β-Lactamases (IC50: 1-175 nM); useful for bacterial infection research.

Ibezapolstat hydrochloride is an antibacterial agent.

G(IIKK)3I-NH2 is an antimicrobial peptide with potent efficacy against both Gram-negative and Gram-positive bacteria. It demonstrates low toxicity in primary cells and mice, and has a minimal tendency to induce bacterial resistance. G(IIKK)3I-NH2 is applicable in the study of anti-infective drugs.

Onc112 is a proline-rich antimicrobial peptide that exhibits potent activity against Gram-negative bacteria. It functions by inhibiting translation through blocking and destabilizing the initiation complex.

Bismuth Subcitrate is an antibiotic used to treat stomach ulcers associated with Helicobacter pylori, a bacterial infection.

Dermaseptin is a peptide expressed by the frog skin glands with a potent antimicrobial activity against bacteria, fungi and protozoa.

SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.

N-Acetyl-D-mannosamine-13C is the carbon-13 labeled version of N-Acetyl-D-mannosamine. N-Acetyl-D-mannosamine (T19655) (ManNAc) is a critical precursor to N-acetylneuraminic acid (NeuAc) and plays a role as a specific monomer of bacterial capsular polysialic acid (PA). It is metabolized into ManNAc-6-phosphate and GlcN through the actions of GNE and GlcNAc 2-epimerase (renin-binding protein, RnBP).

Aurein 3.1 is an antibiotic antimicrobial peptide, whereas Aurein 2.6 demonstrates activity against Gram-positive bacteria, exhibiting minimum inhibitory