Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
- AMPK(171 productos)
- ATM / ATR(72 productos)
- ADN-PK(48 productos)
- EGFR(591 productos)
- MELK(7 productos)
- PDK(9 productos)
- PI3K(233 productos)
- Quinasa S6(8 productos)
- gsk-3(110 productos)
- mTOR(162 productos)
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Se han encontrado 1007 productos de "Señalización PI3K / Akt / mTOR"
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Barecetamab
CAS:Barecetamab (ISU-104) is a humanized monoclonal antibody against tyrosine protein kinase ErbB3 with anticancer activity.Pureza:97.1% (SDS-PAGE); 96.4% (SEC-HPLC) - 97.1% (SDS-PAGE); 96.4% (SEC-HPLC)Forma y color:LiquidSAR405 R enantiomer
CAS:SAR405 R enantiomer is the less active enantiomer of SAR405. SAR405 is an inhibitor of PIK3C3/Vps34.Fórmula:C19H21ClF3N5O2Pureza:98.04%Forma y color:SolidPeso molecular:443.85Ref: TM-T12831
1mg48,00€5mg92,00€10mg158,00€25mg261,00€50mg379,00€100mg530,00€200mg722,00€1mL*10mM (DMSO)89,00€LTURM34
CAS:LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM.Fórmula:C24H18N2O3SPureza:99.34%Forma y color:SolidPeso molecular:414.48Ref: TM-T15789
5mg46,00€10mg74,00€25mg145,00€50mg245,00€100mg364,00€200mg532,00€1mL*10mM (DMSO)49,00€BLU-945
CAS:<p>BLU-945 is a reversible, potent, highly selective, and orally available epidermal growth factor receptor tyrosine kinase inhibitor (TKIs).Cost-effective and quality-assured.</p>Fórmula:C28H37FN6O3SPureza:99.11% - 99.16%Forma y color:SolidPeso molecular:556.7O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Fórmula:C21H22ClFN4O3Pureza:97.17%Forma y color:SolidPeso molecular:432.88Ref: TM-T16369
1mg56,00€5mg111,00€10mg170,00€25mg343,00€50mg547,00€100mg783,00€1mL*10mM (DMSO)120,00€NSC781406
CAS:<p>NSC781406 is a highly effective inhibitor of PI3K and mTOR (IC50: 2 nM for PI3Kα).</p>Fórmula:C29H27F2N5O5S2Pureza:99.58%Forma y color:SolidPeso molecular:627.68Khellin
CAS:Khellin (Methafrone) is a vasodilator that also has bronchodilatory action.Fórmula:C14H12O5Pureza:99.89% - 99.95%Forma y color:Light Yellow CrystallinePeso molecular:260.24Lapatinib
CAS:Lapatinib (GW572016) is an inhibitor of ErbB2 and EGFR (IC50=9.2/10.8 nM) with oral activity.Fórmula:C29H26ClFN4O4SPureza:99.00% - 99.81%Forma y color:PowderPeso molecular:581.06Petosemtamab
CAS:<p>Petosemtamab (MCLA 158), a dual-action monoclonal antibody targets EGFR & LGR5, used in solid tumor research like HNSCC & CRC.</p>Pureza:> 95% - > 95%Forma y color:LiquidPeso molecular:145.97 kDaRociletinib
CAS:<p>Rociletinib (CNX-419) is an orally available small molecule, irreversible inhibitor of epidermal growth factor receptor (EGFR) with potential antineoplastic</p>Fórmula:C27H28F3N7O3Pureza:98.52% - 99.25%Forma y color:SolidPeso molecular:555.55Lapatinib ditosylate monohydrate
CAS:<p>Lapatinib ditosylate monohydrate: a drug for advanced breast cancer; may cause liver issues.</p>Fórmula:C29H26ClFN4O4S·2(C7H8O3S)·H2OPureza:98% - 99.41%Forma y color:Colourless To Light-Yellow CrystalPeso molecular:943.47Erlotinib hydrochloride
CAS:<p>Erlotinib hydrochloride (NSC 718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.</p>Fórmula:C22H23N3O4·HClPureza:99.78% - 99.85%Forma y color:White Or Off-White PowderPeso molecular:429.9Cyanoacetohydrazide
CAS:Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties.Fórmula:C3H5N3OPureza:99.78%Forma y color:Stout Prisms From Alcohol Slightly Brown PowderPeso molecular:99.09Tenalisib
CAS:Tenalisib (RP6530) (RP6530) is a potent and selective inhibitor of PI3Kδ and PI3Kγ(IC50 values of 25 and 33 nM, respectively.)Fórmula:C23H18FN5O2Pureza:99.71%Forma y color:SolidPeso molecular:415.42Ref: TM-T13119
1mg38,00€2mg49,00€5mg81,00€10mg111,00€25mg188,00€50mg304,00€100mg457,00€1mL*10mM (DMSO)88,00€Gancotamab
CAS:Gancotamab (MM-302) is a polyethylene glycolated liposome targeting HER2 with antitumor activity for the study of advanced HER2-positive breast cancer.Pureza:96.7% (SDS-PAGE); 98.4% (SEC-HPLC) - 96.7% (SDS-PAGE); 98.4% (SEC-HPLC)Forma y color:LiquidErlotinib
CAS:Erlotinib (NSC-718781) is an EGFR inhibitor (IC50: 2 nM). It is used for the treatment of non-small cell lung cancer.Fórmula:C22H23N3O4Pureza:98.19% - 99.98%Forma y color:White To Off-White PowderPeso molecular:393.44MELK-IN-1
CAS:MELK-IN-1 (MELK inhibitor 17) is a potent inhibitor of maternal embryonic leucine zipper kinase (MELK),(IC50:3nm;Ki:0.39 nM).Fórmula:C31H33N5O4Pureza:99.84%Forma y color:SolidPeso molecular:539.62Lapatinib Ditosylate
CAS:Lapatinib Ditosylate (Tykerb ditosylate) is an effective EGFR and ErbB2 inhibitor (IC50: 10.8/9.2 nM for EGFR/ErbB2).Fórmula:C29H26ClFN4O4S·2C7H8O3SPureza:99.41%Forma y color:Yellow SolidPeso molecular:925.46Intetumumab
CAS:Intetumumab (CNTO 95) is a fully humanized anti-α(v)-integrin monoclonal antibody that is a radiosensitizer for xenograft tumor-bearing mice.Pureza:97.6% (SDS-PAGE); 97.1% (SEC-HPLC) - 97.6% (SDS-PAGE); 97.1% (SEC-HPLC)Forma y color:LiquidPeso molecular:145.6 (kDa)IPI-3063
CAS:IPI-3063 is an effective and selective inhibitor of PI3K p110δ (IC50: 2.5 ± 1.2 nM).Fórmula:C25H25N7O2Pureza:98.00%Forma y color:SolidPeso molecular:455.51Ref: TM-T15592
1mg47,00€2mg64,00€5mg104,00€10mg170,00€25mg340,00€50mg472,00€100mg645,00€1mL*10mM (DMSO)113,00€
