Señalización PI3K / Akt / mTOR
Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.
Subcategorías de "Señalización PI3K / Akt / mTOR"
- AMPK(164 productos)
- ATM / ATR(75 productos)
- ADN-PK(50 productos)
- EGFR(610 productos)
- MELK(7 productos)
- PDK(13 productos)
- PI3K(237 productos)
- Quinasa S6(5 productos)
- gsk-3(107 productos)
- mTOR(164 productos)
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Se han encontrado 1025 productos para "Señalización PI3K / Akt / mTOR".
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O-Desmethyl gefitinib
CAS:O-Desmethyl gefitinib is an active EGFR inhibitor (IC50: 36 nM), a metabolite of Gefitinib, formed by CYP2D6.Fórmula:C21H22ClFN4O3Pureza:97.17%Forma y color:White SolidPeso molecular:432.88Mevastatin
CAS:Mevastatin (ML236B) is an HMG-CoA reductase inhibitor that was initially isolated from the mold Pythium ultimum.Fórmula:C23H34O5Pureza:99.12%Forma y color:SolidPeso molecular:390.51EGFR-IN-127
EGFR-IN-127 is an ATP-competitive inhibitor targeting EGFR, with IC50 values of 136.3 nM for EGFRdel19 and 161.2 nM for EGFRdel19/T790M/C797S. This compound holds potential for the study of non-small cell lung cancer (NSCLC).Forma y color:Odour SolidEGFR-IN-124
EGFR-IN-124 (compound 10A) is an EGFR inhibitor with an IC50 value of 0.54 μM, utilized in cancer research.Forma y color:Odour SolidGSK-3β inhibitor 21
GSK-3β Inhibitor21 (compound 44) is an ATP-competitive inhibitor of GSK-3β with an IC50 value of 6.06 µM, characterized by its ability to inhibit tau phosphorylation and prevent amyloid protein aggregation. This compound is utilized in the research of Alzheimer's disease.Forma y color:Odour SolidDuvelisib (R enantiomer) hydrochloride
Duvelisib (R enantiomer) hydrochloride (INK1197 R enantiomer HCl) is a PI3K inhibitor.Fórmula:C22H18Cl2N6OPureza:99.86% - 99.88%Forma y color:White SolidPeso molecular:453.32Ref: TM-T11129L
1mg296,00€5mg718,00€1mL*10mM (DMSO)895,00€10mg982,00€25mg1.485,00€50mg2.008,00€100mg2.637,00€EGFR-IN-168
EGFR-IN-168 (Compound 9a) is a potent EGFR inhibitor with an IC50 of 0.069 μM and demonstrates antitumor activity.DS06652923
DS06652923 is an orally active inhibitor targeting EGFR triple mutations. It exhibits growth-inhibitory effects on Ba/F3EGFRdel19/T90M/C795S cells, with a GI50 value of 9.4 nM. Additionally, DS06652923 induces tumor regression in the Ba/F3 syngeneic transplantation model.Forma y color:Odour SolidHER2/neu (654-662) GP2
CAS:Phage display selected Affibody ligands for HER2/neu from a protein library based on a 58-residue Staphylococcal protein A Z domain.Fórmula:C42H77N9O11Pureza:98%Forma y color:SolidPeso molecular:884.11Tyrosine Kinase Inhibitor Library
A unique collection of xnum HIF-1 related small chemicals can be used for drug discovery in ischemic disease and cancer and related mechanism studies;Forma y color:Odour SolidRef: TM-L2200
1mgA consultar10μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultarGSK251
CAS:GSK251 is a novel, orally bioavailable inhibitor of PI3Kδ, exhibiting high potency and selectivity, with a unique binding mode.Fórmula:C29H37FN6O4SPureza:99.8%Forma y color:White SolidPeso molecular:584.71DNA Damage & Repair Compound Library
A unique collection of xnum DNA Damage & Repair related compounds for high throughput screening (HTS) and high content screening (HCS);
Forma y color:Odour SolidRMC-4529
CAS:RMC-4529 is a chemical compound that demonstrates potent inhibition, with an IC50 value of 1.0 nM, against p-4E-BP1-(T37/46) in mTOR kinase cellular assays.Fórmula:C90H139N13O23Forma y color:SolidPeso molecular:1771.17GW 583340
CAS:GW 583340 is a potent and selective dual inhibitor of EGFR/ErbB2 tyrosine kinase with the advantage of oral dosability and antitumor effects.Fórmula:C28H25ClFN5O3S2Pureza:98.68%Forma y color:SolidPeso molecular:598.11FDA-Approved Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for specific targeting of kinases, ready for high-throughput screening and high-content screening.Forma y color:LiquidRef: TM-L1610
1mgA consultar10μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultarUmbralisib R-enantiomer
CAS:Umbralisib R-enantiomer (RP5264 R-enantiomer) is a delta inhibitor of PI3K and a less active enantiomer of TGR-1202.Fórmula:C31H24F3N5O3Pureza:97.34%Forma y color:SolidPeso molecular:571.55Ref: TM-T13140
1mg177,00€5mg432,00€1mL*10mM (DMSO)532,00€10mg620,00€25mg1.108,00€50mg1.431,00€100mg1.783,00€Kinase Inhibitor Library
A unique collection of xnum kinase inhibitors/regulators for high throughput screening and high content screening for drug discovery in kinase related diseases;Forma y color:Odour SolidRef: TM-L1600
1mgA consultar10μL*10mM (DMSO)A consultar30μL*10mM (DMSO)A consultar50μL*10mM (DMSO)A consultar100μL*10mM (DMSO)A consultarWAY-270360
CAS:WAY-270360 (N-[4-(1H-benzimidazol-2-yl)phenyl]-2,4-dimethoxybenzamide) is a sirtuin modulator and an epidermal growth factor receptor (EGFR) inhibitor.Fórmula:C22H19N3O3Pureza:98.05%Forma y color:SolidPeso molecular:373.4046DA-143
DA-143 is a selective inhibitor of DNA-PKcs (IC50: 2.5 nM), demonstrating disparate inhibitory effects on mTOR, PI3KΔ, and ATM, with IC50 values of 280 nM, 106 nM, and 6,594 nM, respectively. This compound effectively blocks the phosphorylation of DNA-PKcs substrates and enhances the sensitivity of cancer cells to doxorubicin.Forma y color:Odour SolidPenetratin-PI3Kγ(126-150)
Penetratin-PI3Kγ(126-150) is a peptide inhibitor of PI3Kγ that plays a significant role in respiratory diseases.Fórmula:C229H362N76O57SForma y color:SolidPeso molecular:5120.74849
