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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • Alpelisib hydrochloride
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    Alpelisib hydrochloride

    CAS:
    <p>Alpelisib hydrochloride (BYL-719) is an oral, selective PI3Kα inhibitor with anticancer properties.</p>
    Fórmula:C19H23ClF3N5O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:477.93

    Ref: TM-T14191

  • PI3Kδ-IN-1
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    PI3Kδ-IN-1

    CAS:
    <p>PI3Kδ-IN-1 is an efficacious PI3Kδ inhibitor (IC50 of 1.7 nM).</p>
    Fórmula:C22H20F3N7O2
    Pureza:99.85%
    Forma y color:Solid
    Peso molecular:471.44

    Ref: TM-T12462

  • EGFR-IN-29
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    EGFR-IN-29

    CAS:
    <p>EGFR-IN-29 is a potent EGFR inhibitor.</p>
    Fórmula:C36H46BrN8O2P
    Forma y color:Solid
    Peso molecular:733.68

    Ref: TM-T73106

  • 5-Iodo-indirubin-3'-monoxime
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    5-Iodo-indirubin-3'-monoxime

    CAS:
    <p>5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s</p>
    Fórmula:C16H10IN3O2
    Forma y color:Solid
    Peso molecular:403.17

    Ref: TM-T10172

  • Ampkinone
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    Ampkinone

    CAS:
    <p>Ampkinone is an indirect AMPK activator.</p>
    Fórmula:C31H23NO6
    Pureza:98%
    Forma y color:Solid
    Peso molecular:505.52

    Ref: TM-T10312

  • BPIQ-I
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    BPIQ-I

    CAS:
    <p>BPIQ-I (PD 159121), an ATP-competitive EGFR tyrosine kinase inhibitor, exhibits potent anti-proliferative activity.</p>
    Fórmula:C16H12BrN5
    Forma y color:Solid
    Peso molecular:354.2

    Ref: TM-T70227

  • LDHA/PDKs-IN-2
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    LDHA/PDKs-IN-2

    CAS:
    <p>Compound 20k is a dual LDHA/PDKs inhibitor; IC50: 0.7/1.6 μM. It boosts O2 use, cuts lactate, and slows A549 cancer cell growth (EC50: 15.7 μM).</p>
    Fórmula:C17H20N2O5
    Forma y color:Solid
    Peso molecular:332.35

    Ref: TM-T60995

  • PI3K/mTOR Inhibitor-6
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    PI3K/mTOR Inhibitor-6

    CAS:
    <p>Potent, stable PI3K/mTOR Inhibitor-6 surpasses gedatolisib in gastric fluid; 10 μM hinders PI3K/Akt/mTOR pathway, aids cancer research.</p>
    Fórmula:C30H34N10O4
    Forma y color:Solid
    Peso molecular:598.66

    Ref: TM-T64219

  • NVP-QAV-572
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    NVP-QAV-572

    CAS:
    <p>NVP-QAV-572 is a inhibitor of PI3K(IC50 of 10 nM).</p>
    Fórmula:C17H19F2N7O3S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:471.5

    Ref: TM-T12275

  • Lifirafenib
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    Lifirafenib

    CAS:
    <p>Lifirafenib (Beigene-283) is a potent inhibitor of RAF family kinases and EGFR in biochemical assays with IC50 of 23, 29 and 495 nM for the recombinant</p>
    Fórmula:C25H17F3N4O3
    Pureza:98% - 98.25%
    Forma y color:Solid
    Peso molecular:478.42

    Ref: TM-T22272

  • SAR502250
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    SAR502250

    CAS:
    <p>SAR502250: potent, selective GSK3 inhibitor, IC50=12nM, oral, brain-penetrant, potential for AD research, antidepressant-like properties.</p>
    Fórmula:C19H18FN5O2
    Forma y color:Solid
    Peso molecular:367.38

    Ref: TM-T35560

  • HER2-IN-5
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    HER2-IN-5

    CAS:
    <p>HER2-IN-5 is an effective inhibitor of orally active HER-2.</p>
    Fórmula:C27H33N7O3
    Forma y color:Solid
    Peso molecular:503.6

    Ref: TM-T63432

  • CC214-1
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    CC214-1

    CAS:
    <p>CC214-1 is an mTOR inhibitor that inhibits protein translation, induces autophagy, and is an in vitro tool compound for exploring the biology of mTOR kinases.</p>
    Fórmula:C20H21N7O2
    Pureza:97.16%
    Forma y color:Solid
    Peso molecular:391.43

    Ref: TM-T9314

  • Antitrypanosomal agent 14
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    Antitrypanosomal agent 14

    CAS:
    <p>Antitrypanosomal agent 14 (Compound 1), a potent T.</p>
    Fórmula:C14H23N3OS
    Pureza:98%
    Forma y color:Solid
    Peso molecular:281.42

    Ref: TM-T79254

  • A 1070722
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    A 1070722

    CAS:
    <p>A 1070722: potent GSK-3 inhibitor, Ki = 0.6 nM for both α/β isoforms, crosses BBB, potential brain GSK-3 PET radiotracer.</p>
    Fórmula:C17H13F3N4O2
    Pureza:99.9%
    Forma y color:Solid
    Peso molecular:362.31

    Ref: TM-T10202

  • PT-65
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    PT-65

    CAS:
    <p>PT-65, a potent and selective GSK3 degrader, demonstrates the highest degradation capacity for GSK3α (DC50 = 28.3 nM) and GSK3β (DC50 = 34.2 nM) in SH-SY5Y cells, making it applicable for Alzheimer's disease research [1].</p>
    Fórmula:C51H63N13O12S
    Forma y color:Solid
    Peso molecular:1082.19

    Ref: TM-T84913

  • PI5P4Kα-IN-1
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    PI5P4Kα-IN-1

    CAS:
    <p>PI5P4Kα-IN-1 (Compound 13) is a phosphatidylinositol 5-phosphate 4-kinase (PI5P4K) inhibitor, displaying IC50 values of 2 μM for PI5P4Kα and 9.4 μM for PI5P4Kβ</p>
    Fórmula:C20H17N3O2S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:363.43

    Ref: TM-T78178

  • PI3K/mTOR Inhibitor-5
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    PI3K/mTOR Inhibitor-5

    CAS:
    <p>PI3K/mTOR Inhibitor-5 is a potent dual inhibitor of PI3K and mTOR, displaying IC50 values of 86.9 nM (for PI3K) and 14.6 nM (for mTOR), respectively.</p>
    Fórmula:C32H40N10O3
    Forma y color:Solid
    Peso molecular:612.73

    Ref: TM-T72408

  • Nazartinib S-enantiomer
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    Nazartinib S-enantiomer

    CAS:
    <p>Nazartinib is an EGFR inhibitor. Nazartinib S-enantiomer is the less active S-enantiomer of Nazartinib.</p>
    Fórmula:C26H31ClN6O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:495.02

    Ref: TM-T11156

  • PI3Kγ inhibitor 2
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    PI3Kγ inhibitor 2

    CAS:
    <p>PI3Kγ inhibitor 2 is an orally bioavailable inhibitor of PI3Kγ(Ki of 4 nM).</p>
    Fórmula:C20H18F3N5O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:433.38

    Ref: TM-T12465