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Señalización PI3K / Akt / mTOR

Señalización PI3K / Akt / mTOR

Los inhibidores de la señalización PI3K/Akt/mTOR son compuestos que se dirigen a las vías de la fosfoinositida 3-cinasa (PI3K), la cinasa Akt y el blanco de la rapamicina en mamíferos (mTOR). Estas vías son reguladores críticos del crecimiento celular, la supervivencia, el metabolismo y la autofagia, lo que las convierte en objetivos clave en la investigación del cáncer y los trastornos metabólicos. Inhibir estas vías puede ayudar a controlar el crecimiento y la proliferación tumoral, ofreciendo potenciales estrategias terapéuticas para varios tipos de cáncer y otras enfermedades caracterizadas por una señalización celular desregulada. En CymitQuimica, ofrecemos una amplia selección de inhibidores de alta calidad de PI3K/Akt/mTOR para apoyar su investigación en oncología, señalización celular y enfermedades metabólicas.

Subcategorías de "Señalización PI3K / Akt / mTOR"

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Se han encontrado 1038 productos de "Señalización PI3K / Akt / mTOR"

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  • BX-320
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    BX-320

    CAS:
    <p>BX-320, a PDK1 inhibitor (IC50=30nM), selectively blocks Akt/p70S6K1 phosphorylation, induces apoptosis, and inhibits cancer cell growth.</p>
    Fórmula:C23H31BrN8O3
    Forma y color:Solid
    Peso molecular:547.45

    Ref: TM-T37561

  • BEBT-109
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    BEBT-109

    CAS:
    <p>BEBT-109 is a selective epidermal growth factor receptor (EGFR) inhibitor that shows anti-tumor activity in EGFR-mutant non-small cell lung cancer.</p>
    Fórmula:C27H32N8O3
    Pureza:97.26%
    Forma y color:Solid
    Peso molecular:516.6

    Ref: TM-T80643

  • EGFR-IN-30
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    EGFR-IN-30

    CAS:
    <p>EGFR-IN-30 is an EGFR inhibitor (IC50: 1-10 nM, &lt;1 nM WT/mutants) with potential in cancer research.</p>
    Fórmula:C28H33BrN7O2P
    Forma y color:Solid
    Peso molecular:610.49

    Ref: TM-T73108

  • EGFR-IN-61
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    EGFR-IN-61

    CAS:
    <p>EGFR-IN-61 inhibits EGFR kinase (IC50: 42 nM L858R/T790M, 137 nM L858R/T790M/C797S, 743 nM WT) and slows A549 &amp; H1975 cell growth (IC50: 2.14 &amp; 1.82 μM).</p>
    Fórmula:C33H37ClN8O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:629.15

    Ref: TM-T73128

  • EGFR-IN-85
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    EGFR-IN-85

    CAS:
    <p>EGFR-IN-85 (Compound 1), an EGFR inhibitor, exhibits potent activity with an IC50 of 0.19 μM against EGFRvⅢ phosphorylation and can suppress intratumoral EGFR</p>
    Fórmula:C26H30N8O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:486.57

    Ref: TM-T78574

  • JGK-068S
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    JGK-068S

    CAS:
    <p>Compound I (JGK-068S) is a potent inhibitor of the epidermal growth factor receptor (EGFR) [1].</p>
    Fórmula:C22H23BrFN5O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:488.35

    Ref: TM-T79124

  • PI3K/mTOR Inhibitor-12
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    PI3K/mTOR Inhibitor-12

    CAS:
    <p>PI3K/mTOR Inhibitor-12: oral, potent, selective; IC50: PI3Kα 0.06 nM, mTOR 3.12 nM; strong antitumor; less liver toxicity.</p>
    Fórmula:C27H27F2N9O4S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:611.62

    Ref: TM-T72374

  • Simotinib
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    Simotinib

    CAS:
    <p>Simotinib (AL-6802) is an EGFR tyrosine kinase inhibitor (IC50 : 19.9 nM) with antitumour activity for the study of non-small cell lung cancer.</p>
    Fórmula:C25H26ClFN4O4
    Pureza:99.7%
    Forma y color:Solid
    Peso molecular:500.95

    Ref: TM-T35916

  • Logo de CymitQuimica
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    EGFR/CSC-IN-1

    CAS:
    <p>EGFR/CSC-IN-1 is a dual inhibitor targeting both the epidermal growth factor receptor (EGFR [IC50 10.52 nM]) and cancer stem cells (CSC), with potential</p>
    Fórmula:C54H54Cl2FN7O7S2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:1067.08

    Ref: TM-T73995

  • 2′-Thioadenosine
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    2′-Thioadenosine

    CAS:
    <p>2'-Thioadenosine (PD157432) serves as a selective and irreversible inhibitor of ErbB-1 and ErbB-2 tyrosine kinases, demonstrating an IC50 value of 45 µM against</p>
    Fórmula:C10H13N5O3S
    Pureza:98%
    Forma y color:Solid
    Peso molecular:283.31

    Ref: TM-T78634

  • DZD1516
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    DZD1516

    CAS:
    <p>DZD1516, a potent and selective HER2 inhibitor (IC50 = 0.56 nM), demonstrates good blood-brain barrier permeability and exhibits antitumor activity in both</p>
    Fórmula:C28H27F2N7O3
    Pureza:98%
    Forma y color:Solid
    Peso molecular:547.56

    Ref: TM-T79297

  • EGFR mutant-IN-1
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    EGFR mutant-IN-1

    <p>EGFR mutant-in-1, a 5-methylpyrimidopyridone, selectively inhibits EGFRL858R/T790M/C797S mutants with an IC50 of 27.5 nM, lessening EGFRWT impact.</p>
    Fórmula:C34H39ClFN7O2
    Pureza:98%
    Forma y color:Solid
    Peso molecular:632.17

    Ref: TM-T11164

  • GSK-3β inhibitor 8
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    GSK-3β inhibitor 8

    CAS:
    <p>GSK-3β inhibitor 8 (GSK3β Inhibitor XVIII) is a potent and selective GSK-3β inhibitor with an IC50 value of 64 nM.GSK-3β inhibitor 8 is a thienopyrimidine</p>
    Fórmula:C20H20ClN5OS
    Pureza:98.46%
    Forma y color:Solid
    Peso molecular:413.92

    Ref: TM-T35556

  • EGFR-IN-36
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    EGFR-IN-36

    CAS:
    <p>EGFR-IN-36 inhibits EGFR, HER2, &amp; mutants with IC50s: 19.09 nM (EGFR WT), 120.01 nM (HER2 WT), 2.35 nM (HER2 mutant).</p>
    Fórmula:C26H25ClN6O2
    Forma y color:Solid
    Peso molecular:488.97

    Ref: TM-T63265

  • EGFR-IN-32
    Targetmol
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    EGFR-IN-32

    CAS:
    <p>EGFR-IN-32, a potent EGFR blocker, shows promise for EGFR-mutated illnesses. (Patent WO2021185297A1, compound 2)</p>
    Fórmula:C31H34N6O3
    Forma y color:Solid
    Peso molecular:538.64

    Ref: TM-T63798

  • AMPK-α1β1γ1 activator 1
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    AMPK-α1β1γ1 activator 1

    CAS:
    <p>AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1</p>
    Fórmula:C25H24ClNO9
    Pureza:98%
    Forma y color:Solid
    Peso molecular:517.91

    Ref: TM-T83125

  • EGFR-IN-87
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    EGFR-IN-87

    CAS:
    <p>EGFR-IN-87 is an EGFR tyrosine kinase inhibitor with potent inhibitory activity, exhibiting IC50 values of 3.1 nM, 1.3 nM, and 7.1 nM against EGFR_d746-750,</p>
    Fórmula:C28H33N7O2
    Pureza:98.64%
    Forma y color:Solid
    Peso molecular:499.61

    Ref: TM-T79888

  • EGFR-IN-1 hydrochloride
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    EGFR-IN-1 hydrochloride

    CAS:
    <p>EGFR-IN-1 HCl targets L858R/T790M EGFR mutants over wild-type; IC50: 4 nM in H1975, 28 nM in mutant HCC827 cells.</p>
    Fórmula:C28H31ClN6O4
    Pureza:99.16%
    Forma y color:Solid
    Peso molecular:551.04

    Ref: TM-T11157L

  • BGB-8035
    Targetmol
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    BGB-8035

    CAS:
    <p>BGB-8035 is a BTK inhibitor with antitumor activity that inhibits BTK, TEC, and EGFR.BGB-8035 is used in the study of tumors and autoimmune diseases.</p>
    Fórmula:C24H31N5O4
    Pureza:96.74%
    Forma y color:Solid
    Peso molecular:453.53

    Ref: TM-T73381

  • EGFR/ErbB-2 inhibitor-1
    Targetmol
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    EGFR/ErbB-2 inhibitor-1

    CAS:
    <p>EGFR/ErbB-2 inhibitor-1 is a selective ErbB2/HER2 inhibitor that effectively blocks ErbB2 and HER2 signaling.</p>
    Fórmula:C23H15ClFN3OS2
    Pureza:98.93%
    Forma y color:Solid
    Peso molecular:467.97

    Ref: TM-T79861