AMPK
Los inhibidores de AMPK son compuestos que inhiben la Proteína Quinasa Activada por AMP (AMPK), una enzima clave en la homeostasis energética celular. La AMPK se activa en respuesta a bajos niveles de energía en las células y regula procesos como la captación de glucosa, la oxidación de ácidos grasos y la biogénesis mitocondrial. Inhibir la AMPK es fundamental para estudiar su papel en enfermedades metabólicas, cáncer y envejecimiento. En CymitQuimica, ofrecemos una variedad de inhibidores de AMPK para apoyar su investigación en metabolismo, oncología y enfermedades relacionadas con la edad.
Se han encontrado 168 productos de "AMPK"
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TMPA
CAS:TMPA is a nuclear receptor Nur77 and LKB1 interaction antagonist.Fórmula:C21H32O6Pureza:99.21%Forma y color:SolidPeso molecular:380.48AMPK activator 9
CAS:AMPK activator 9 (ZM-6) is a potent α2β1γ1 agonist with an EC50 of 1.1 µM, potential for type 2 diabetes research.Fórmula:C31H28F4N4O4Forma y color:SolidPeso molecular:596.57ML753286
CAS:ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions.Fórmula:C20H25N3O3Pureza:98%Forma y color:SolidPeso molecular:355.43ULK1-IN-2
CAS:<p>ULK1-IN-2, a potent anticancer agent, inhibits ULK1, induces apoptosis, blocks autophagy, and shows high cytotoxicity with an IC50 of 1.94 μM in A549 cells.</p>Fórmula:C19H16BrFN4O6Pureza:99.25% - 99.25%Forma y color:SolidPeso molecular:495.26JJO-1
CAS:JJO-1 is a bi-quinoline activating all AMPK αβγ isoforms except γ3; it requires low ATP and is unaffected by γ mutations or β deletions.Fórmula:C19H13N3Forma y color:SolidPeso molecular:283.33AMPK activator 8
CAS:<p>AMPK activator 8 targets rAMPK α1β1γ1/α2β1γ1/α1β2γ1 (EC50: 11/27/4 nM) for type 2 diabetes research.</p>Fórmula:C25H21ClN2O6Forma y color:SolidPeso molecular:480.9AMDE-1
CAS:<p>AMDE-1, an autophagy modulator, triggers Atg5-dependent autophagy, recruits Atg16, and induces LC3 lipidation.</p>Fórmula:C18H8ClF6N3Pureza:90%Forma y color:SolidPeso molecular:415.72SMTIN-T140
CAS:SMTIN-T140: strong TRAP1 inhibitor, IC50=1.646μM, anticancer; disrupts mitochondria, boosts ROS, activates AMPK, shrinks PC3 tumors, no in vivo toxicity.Fórmula:C36H34BrClFN5OPPureza:98%Forma y color:SolidPeso molecular:718.02IND 1316
CAS:IND 1316 is an activator of AMP-activated protein kinase (AMPK).Fórmula:C22H17NO3Forma y color:SolidPeso molecular:343.38OSU-53
CAS:OSU-53 is an AMPK activator, inhibiting mTOR signaling and autophagy stimulation. OSU-53 also activates mutations in RAS or BRAF.Fórmula:C25H24F3N3O6S2Forma y color:SolidPeso molecular:583.6AMPK activator 4
CAS:Potent, selective AMPK activator 4 enhances glucose tolerance and insulin sensitivity without affecting mitochondrial complex I.Fórmula:C24H21ClN2O3Pureza:99.97% - 99.99%Forma y color:SolidPeso molecular:420.89AMPK activator 1
CAS:AMPK activator 1 is an AMPK activator(compound No.1-75, EC50: <0.1μM).Fórmula:C32H33F3N4O3Pureza:98%Forma y color:SolidPeso molecular:578.62HL271
CAS:HL271, a derivative of metformin, is a potent AMPK activator that increases AMPK phosphorylation. HL271 attenuates aging-associated cognitive impairment.Fórmula:C13H17ClF3N5OPureza:98%Forma y color:SolidPeso molecular:351.76GL-V9
CAS:GL-V9 is an AMPK activator, protecting against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy.Fórmula:C24H27NO5Forma y color:SolidPeso molecular:409.47Galegine hydrochloride
CAS:Galegine hydrochloride, from G. officinalis, leads to weight loss, activates AMPK in various cells, and has antibacterial properties.Fórmula:C6H14ClN3Forma y color:SolidPeso molecular:163.65LRRK2/NUAK1/TYK2-IN-1
CAS:LRRK2/NUAK1/TYK2-IN-1 inhibits LRRK2, TYK2, NUAK1 with IC50 < 10 nM, useful in autoimmune research.Fórmula:C20H11F3N6Forma y color:SolidPeso molecular:392.34MARK-IN-4
CAS:MARK-IN-4 inhibits microtubule kinase (MARK) effectively (IC50: 1 nM), a target for Alzheimer's therapy.Fórmula:C21H23N7OSForma y color:SolidPeso molecular:421.52AMPK activator 12
CAS:AMPK activator 12 is an AMPK activator and GDF15 inducer that elevates the expression level of GDF15 protein for cancer research.Fórmula:C23H24BrNO2Pureza:99.55%Forma y color:SolidPeso molecular:426.35AMPK activator 11
CAS:<p>AMPK Activator 11 is a nanomolar potent inhibitor of cell proliferation in various colorectal carcinomas (CRCs), acting through the selective activation of AMP-</p>Fórmula:C25H20N4O2Pureza:98%Forma y color:SolidPeso molecular:408.45
