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AMPK

AMPK

Los inhibidores de AMPK son compuestos que inhiben la Proteína Quinasa Activada por AMP (AMPK), una enzima clave en la homeostasis energética celular. La AMPK se activa en respuesta a bajos niveles de energía en las células y regula procesos como la captación de glucosa, la oxidación de ácidos grasos y la biogénesis mitocondrial. Inhibir la AMPK es fundamental para estudiar su papel en enfermedades metabólicas, cáncer y envejecimiento. En CymitQuimica, ofrecemos una variedad de inhibidores de AMPK para apoyar su investigación en metabolismo, oncología y enfermedades relacionadas con la edad.

Se han encontrado 165 productos para "AMPK".

productos por página.
  • Logo de CymitQuimica
    Targetmol
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    HK2-IN-4

    CAS:
    HK2-IN-4 is a selective hexokinase 2 (HK2) inhibitor with an IC50 value of 0.79 μM and a Kd value of 0.41 μM. It disrupts the interaction between HK2 and the voltage-dependent anion channel 1 (VDAC1). HK2-IN-4 reduces lactate and ATP levels in cancer cells and induces apoptosis markers, including increased p-AMPK/AMPK ratio and Bax levels, along with decreased Bcl2 levels. Additionally, HK2-IN-4 inhibits the proliferation of cancer cells with high HK2 expression and can be utilized in research related to colorectal cancer and non-small cell lung cancer.
    Fórmula:C24H25NO4
    Peso molecular:391.46

    Ref: TM-T218671

  • EGFR-IN-146
    Targetmol
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    EGFR-IN-146

    CAS:
    EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.
    Fórmula:C20H16N4
    Forma y color:Solid
    Peso molecular:312.368

    Ref: TM-T206146

  • Tezampanel etibutil
    Targetmol
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    Tezampanel etibutil

    CAS:
    Tezampanel etibutil is an orally active AMPA/GluR antagonist. It is utilized in research related to pain, migraines, and neurological disorders.
    Fórmula:C19H33N5O2
    Peso molecular:363.50

    Ref: TM-T211640

  • Aldometanib
    Targetmol
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    Aldometanib

    CAS:
    Aldometanib (LXY-05-029) is an oral aldolase inhibitor that maintains metabolic balance by blocking FBP and activating lysosomal AMPK.
    Fórmula:C27H43Cl2IN2
    Pureza:99.32% - 99.55%
    Forma y color:White Solid
    Peso molecular:593.454

    Ref: TM-T60122

  • XMD-17-51 Trifluoroacetate
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    XMD-17-51 Trifluoroacetate

    CAS:
    XMD-17-51 Trifluoroacetate is a pyrimido-diazepinone compound that regulates protein kinases.
    Fórmula:C23H25F3N8O3
    Pureza:99.65%
    Forma y color:Solid
    Peso molecular:518.4916

    Ref: TM-T9191