AMPK
Los inhibidores de AMPK son compuestos que inhiben la Proteína Quinasa Activada por AMP (AMPK), una enzima clave en la homeostasis energética celular. La AMPK se activa en respuesta a bajos niveles de energía en las células y regula procesos como la captación de glucosa, la oxidación de ácidos grasos y la biogénesis mitocondrial. Inhibir la AMPK es fundamental para estudiar su papel en enfermedades metabólicas, cáncer y envejecimiento. En CymitQuimica, ofrecemos una variedad de inhibidores de AMPK para apoyar su investigación en metabolismo, oncología y enfermedades relacionadas con la edad.
Se han encontrado 162 productos para "AMPK".
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YLF-466D
CAS:YLF-466D (C24) is a newly developed AMPK activator, which inhibits platelet aggregation.Fórmula:C29H20ClNO3Pureza:97.74%Forma y color:SolidPeso molecular:465.93Ref: TM-T13368
1mg34,00€5mg79,00€1mL*10mM (DMSO)82,00€10mg111,00€25mg188,00€50mg269,00€100mg371,00€200mg512,00€DK419
CAS:DK419 is an orally active inhibitor of Wnt/β-catenin signaling, with an IC50 of 0.19 μM.Fórmula:C16H8ClF6N3OPureza:99.63%Forma y color:White SolidPeso molecular:407.7AMPK-α1β1γ1 activator 1
CAS:AMPK-α1β1γ1 activator 1 (M1), an acyl glucuronide metabolite derived from an Indole-3-carboxylic Acid-based AMPK activator, selectively activates the β1Fórmula:C25H24ClNO9Pureza:98%Forma y color:SolidPeso molecular:517.91Butylate
CAS:Butylate is a herbicide of thiocarbamate.Fórmula:C11H23NOSForma y color:SolidPeso molecular:217.37MARK-IN-2
CAS:MARK-IN-2 is a potent microtubule affinity regulating kinase (MARK) inhibitor,(IC50:5 nM).Fórmula:C18H18ClF2N5OSPureza:98%Forma y color:SolidPeso molecular:425.88ZLN024
CAS:ZLN024 is an activator of AMPK allosteric.Fórmula:C13H13BrN2OSPureza:99.75%Forma y color:SolidPeso molecular:325.22Ref: TM-T13411
1mg93,00€5mg177,00€1mL*10mM (DMSO)178,00€10mg269,00€25mg429,00€50mg610,00€100mg820,00€200mg1.071,00€MK-0626
CAS:MK-0626 is an orally available dipeptidyl peptidase IV (DPP-4) inhibitor enhancing AMP, restoring the expression of GLP-1R. promoting neoangiogenesis.Fórmula:C22H24F2N6O2Pureza:99.47% - >99.99%Forma y color:SolidPeso molecular:442.46MARK-IN-1
CAS:MARK-IN-1 is a potent microtubule affinity regulating kinase (MARK) inhibitor, (IC50<0.25 nM).Fórmula:C22H23F2N7OSPureza:98%Forma y color:SolidPeso molecular:471.53AMPK activator 7
CAS:AMPK activator 7 (I-3-24, EC50: 8.8 nM) targets AMPK-related disorders like type 2 diabetes and obesity.Fórmula:C23H22F3N3O5Forma y color:SolidPeso molecular:477.43PF-06679142
CAS:PF-06679142 is an effective AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption.Fórmula:C20H17F2NO3Pureza:98%Forma y color:SolidPeso molecular:357.35AMPK-IN-1
CAS:AMPK-IN-1 is an activator of the AMP-activated protein kinase (AMPK) enzyme, specifically targeting the α2β2γ1 isoform with an EC50 of 551 nM.Fórmula:C24H18ClN3O3Forma y color:SolidPeso molecular:431.87Ampkinone
CAS:Ampkinone is an indirect AMPK activator.Fórmula:C31H23NO6Pureza:98%Forma y color:SolidPeso molecular:505.52MRT199665
CAS:MRT199665, a selective MARK/SIK/AMPK inhibitor, blocks SIK CRTC3 S370 phosphorylation and triggers apoptosis in AML cells.Fórmula:C28H31N5O2Forma y color:SolidPeso molecular:469.58Tezampanel etibutil
CAS:Tezampanel etibutil is an orally active AMPA/GluR antagonist. It is utilized in research related to pain, migraines, and neurological disorders.Fórmula:C19H33N5O2Peso molecular:363.50Galegine hemisulfate
CAS:Galegine hemisulfate, a guanidine derivative, aids in weight reduction in mice. It activates AMPK in 3T3-L1 adipocytes, L6 myotubes, H4IIE rat hepatoma cells, and HEK293 human renal cell lines. Galegine hemisulfate also exhibits antibacterial activity, with a minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains.Fórmula:C6H15N3O4SForma y color:SolidPeso molecular:225.27EGFR-IN-146
CAS:EGFR-IN-146 is an EGFR inhibitor that suppresses the EGFR signaling pathway and improves insulin sensitivity by activating the AMPK pathway. It effectively reduces blood glucose levels and body weight, showing great potential in the study of diabetes and obesity.Fórmula:C20H16N4Forma y color:SolidPeso molecular:312.368NPC26
CAS:NPC26 is a small molecule that disrupts mitochondrial function and exhibits antitumor activity. It shows significant antiproliferative and cytotoxic effects on CRC cell lines (HCT-116, DLD-1, and HT-29). NPC26 induces mitochondrial permeability transition pore (mPTP) opening, generates reactive oxygen species (ROS), and triggers cell death. Additionally, NPC26 kills CRC cells by activating the AMP-activated protein kinase (AMPK) signaling pathway.Fórmula:C19H23N3O5S2Forma y color:SolidPeso molecular:437.533AMPK activator 15
CAS:AP39 Prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. In hepatocytes, it induces ROS-dependent mild mitochondrial uncoupling, activates mitochondria-associated AMPK, and inhibits Palmitic acid (PA)-induced lipid accumulation.Fórmula:C53H51BrNO10PSForma y color:SolidPeso molecular:1004.92UCB9386
CAS:UCB9386 is a brain-penetrant and selective inhibitor of Nuak1, with a pIC50 of 10.1. It also inhibits Nuak2 and Kak2, showing approximately 50% inhibition at 10 nM.Fórmula:C27H26N8OForma y color:SolidPeso molecular:478.548HDAC11-IN-2
CAS:HDAC11-IN-2 (compound B6) is a highly selective inhibitor of Histone Deacetylase 11 (HDAC11). It demonstrates IC50 values of 51.1 ×10^-3 μM for HDAC11 and 5 μM for HDAC8. HDAC11-IN-2 reduces de novo lipogenesis (DNL) and enhances fatty acid oxidation, which alleviates hepatic lipid accumulation and pathological symptoms in MASLD mice. By inhibiting HDAC11, HDAC11-IN-2 enhances the phosphorylation of AMPKα1 at the Thr172 site, thereby modulating de novo lipogenesis and fatty acid oxidation in the liver.Fórmula:C25H35N3O3Forma y color:SolidPeso molecular:425.564
